| LipirinenLipirinen Note: providing | 167 mg | |
| Phosphatidylserine | 75 mg | |
| Eicosapentaenoic Acid | 21.5 mg | |
| Docosahexaenoic Acid | 8.5 mg |
Other ingredients: Phosphatidylserine, Hypromellose, Silicon Dioxide, Rosemary extract, Mixed Tocopherols, Ascorbyl Palmitate, Titanium Dioxide, Caramel
% Daily Values for: Adults and children 4 or more years of age.
Where this label comes from
An original label of the NIH's Dietary Supplement Label Database, entered there on 24 September 2019, shown here as it was entered. The NIH's record
General information
- Product name
- Vayarin
- Brand
- VAYA Pharma
- Barcode (UPC)
- Not printed
- Net contents
- N/A
- Market status
- Off market
- DSLD ID
- 206959
Classification
- Supplement form
- Capsule
- Product type
- Other Combinations
- Claim types on the label
- Nutrient, All Other
- Intended for
- Adult (18 - 50 Years), Gluten Free, Sugar Free
Label statements
Formula: Contains: Vayarin capsules contain shellfish (krill). May contain soy and fish.
Precautions: Allergies: Vayarin capsules contain shellfish (krill). May contain soy and fish.
Formulation: Does NOT Contain: Vayarin capsules do not contain sugar, lactose, yeast or gluten.
Formula: Contains: Pharmacology Vayarin is composed of Lipirinen, a proprietary composition containing phosphatidylserine-omega-3, EPA enriched.
Formula: Contains: Mechanism of action Omega-3 long chain polyunsaturated fatty acids (LC-PUFA) have an important role in brain and central nervous system development and functioning [1-4]. Decreased omega-3 fatty acids levels, mainly DHA and EPA, are associated with the occurrence of psychiatric, neurodegenerative, and other neurodevelopmental disorders such as dyspraxia, dyslexia, autism [3], peroxisolmal disorders [5], Alzheimer's disease [6], and ADHD [3]. Administration of phosphatidylserine (PS) enriched with omega-3 fatty acids was found to significantly increase DHA level in rat brains [7]. While the extract mechanism by which Vayarin exerts its effects is not fully understood, PS present in the mammalian nervous system, which is characterized by its substantial levels of omega-3 fatty acids, has been implicated in numerous membrane related functions, such as maintaining the integrity of cell membranes, cell excitability, cell-to-cell recognition and communication [8]. PS has been found to regulate key proteins in neuronal membranes, including sodium/calcium ATPase [9] and protein kinase C [10] which undertake crucial functions in diverse signal transduction pathways. Similarly, PS interacts with Raf-1 protein kinase to promote a cascade of reactions that are believed to be involved in cell survival [11]. Additionally, PS has been found to influence neurotransmitters activity, such as the release of acetylcholine, dopamine and noradrenaline [12, 13] and to increase brain glucose levels. Absorption an metabolism Following dietary ingestion of phospholipids, pancreatic digestive enzymes cleave specific fatty acids, leading to the formation of lysophospholipids that are absorbed by the mucosal cells of the intestine and could be reacylated into phospholipids [14]. The fatty acids released can be further used for triglyceride synthesis. Because of the high activity of decarboxylases in the mucosal cells, the majority of the PS in converted into other phospholipids, primarily to phosphatidylethanolamine [15]. The reacylated PS, phosphatidylethanolamine and other phospholipids enter the lymph and circulation, and are redistributed. Drug interactions PS can potentially interact with some anticholinergic and cholinergic medications. It is recommended to consult with a physician about Vayarin interactions that may apply to specific medical conditions.
Precautions: All Other: Vayarin is a medical food product dispensed by prescription and must be used under physician supervision.
Precautions: All Other: Contraindications Vayarin is contraindicated in patients with know hypersensitivity (e.g., anaphylactic reaction) to Vayarin or any of its components.
Precautions: Pregnant or Nursing or Prescription Medications: Precaution Safety and effectiveness of Vayarin in pregnant or lactating patients have not been established. Therefore, Vayarin is not recommended for these populations.
Precautions: Allergies: Vayarin should be used with caution in patients with known hypersensitivity to shellfish.
Directions: Dosage and administration Usual dose is 2 capsules daily or as directed by a physician.
Storage: Storage Dispense and keep in original bottle. Store at up to 77(0)F (25(0)). Protect from light and moisture.
Precautions: Children: Warning Keep this product out of the reach of children.
Formula: Contains: Vayarin is composed of Lipirinen, a proprietary composition containing phosphatidylserine-omega-3, EPA enriched.
Brand information
Distributed by: VAYA Pharma Inc.
Labels only: each label is shown as printed on the bottle, with no grades, rankings or advice. A label in this database is not an endorsement of the product. Read the label on the bottle you buy: makers change their formulas. Reverse Age Lab is not affiliated with, or endorsed by, the National Institutes of Health or its Office of Dietary Supplements. The original labels come from the NIH’s public-domain data; the labels since are read by us. Search the Dietary Supplement Label Database.