SAM-e: what it does, by goal, and the dose that worked
What the 48 human studies of SAM-e we graded show for each goal, the dose that worked, and the products that hold it. This page is educational, not medical advice.
What it does, by goalMembersThe top 1 of 1 goals
7 of these 48 human studies gave SAM-e by drip or injection, not by mouth.
| Goal | What the studies show | Studies | Dose that worked |
|---|---|---|---|
| Improved in studies 48 studies, 13 showed an improvement, 13 found none, 14 pooled analyses, 7 by drip, injection or inhaler | 48 | 200 mg |
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Products – highest ranked firstMembersThe top 1 of 1
Dose and safetyThe dose that worked and the upper limit
The studies taken by mouth that showed an improvement gave 200 mg to 1.6 g a day.
Biohacker panelMembersWhat our 10 biohackers say about SAM-e
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Questions people askMembersAnswered from the figures on this page
What is SAM-e good for?
Answer for members.
How much SAM-e a day?
Answer for members.
Can I take SAM-e with my meds?
Answer for members.
Members see the answers, checked against their own meds and goals. Start My 7-Day Free Trial →
Educational, not medical advice. Figures come from the human studies on PubMed we have graded; a study counts for a form when it names the form it used. Updated as new studies arrive. How we grade →