Regularity: Long-Term Relief: supplements ranked by the human studies
We graded 16 regularity: long-term relief products in our catalog against the human studies of their ingredients, the dose that worked and what the reviews say, then we rank them based on the evidence. This page is educational, not medical advice.
What the studies sayMembersThe ingredients that work, strongest evidence first
shows a clear improvement in meta-analyses, the largest of people, from a day. shows a clear improvement in meta-analyses, the largest of people, from a day. shows a clear improvement in meta-analysis of 268,606 people. shows a clear improvement in meta-analysis of 1,405 people, from a day. shows a clear improvement in controlled trials, the largest of people. shows a clear improvement in controlled trials, the largest of people, from a day.
Ingredients with evidenceMembersThe 9 strongest of 16
| Ingredient | Studies read | What they show | Dose that worked |
|---|---|---|---|
| Polyethylene Glycol 3350 | 56 | ||
| Psyllium | 62 | ||
| Thiamin | 6 | – | |
| Soluble Fiber | 30 | ||
| Calcium | 15 | – | |
| Vitamin B6 | 4 | ||
| Pantothenic Acid | 1 | – | |
| Selenium | 5 | – | |
| Niacin | 2 |
Products – highest ranked firstMembersThe top 3 of 14 ranked, by the studies, then reviews
Biohacker panelMembersHow many of our 10 biohackers recommend each ingredient
Questions people askMembers
What is the best supplement for regularity: long-term relief?
Answer for members.
How much polyethylene glycol 3350 a day?
Answer for members.
Can I take these with my meds?
Answer for members.
Members see the answers, checked against their own meds and goals. Start My 7-Day Free Trial →
Educational, not medical advice. Grades come from human studies on PubMed, the dose that worked, store reviews we read ourselves and our biohacker panel. Updated as new studies arrive. How we grade →