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Avène RetrinAL 0.1 Intensive Cream bottle
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Avène RetrinAL 0.1 Intensive Cream Review

Avene RetrinAL 0.1 Intensive Cream is a powerful anti-aging skincare product formulated with Retinaldehyde, a potent vitamin A derivative, to visibly reduce the appearance of fine lines and wrinkles, improve skin texture, and restore radiance.

Product Focus: Younger-Looking Skin for Men
Tier ⓘ
Members
Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
Members
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
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Biohacker Mentions
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Cost per month
$20
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Study, Trial or Testing Result SummaryMembersHuman studies

6 of these 39 human studies gave the ingredient by injection, not the way this product is used.

The label does state how much of any ingredient this cream contains, so can be confirmed at a studied strength. Glycerin applied to the skin hydration and dryness in trials, including a review of 77 trials in people with eczema and a review of studies in people aged 50 and over. …

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Review Totals and SummaryMembers817 reviews
817 reviews · Ulta 434 · Walgreens 274 · Target 108 · Frenchpharmacy 1

Real user reviews of Avène RetrinAL 0.1 Intensive Cream reveal a product that garners feedback, with customers sharing their experiences across platforms like Ulta, Walgreens, and Target. A portion of reviewers its noticeable results in skin texture and the appearance of fine lines, particularly highlighting its gentle approach when compared to other similar products. …

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Biohacker SummaryMembersWhat our biohacker panel says

Two of them only explain that it builds up in the brain through the day and makes you sleepy, and one of those two adds that caffeine blocks that . One panelist uses it in a topical mix with caffeine and other ingredients on his head for hair growth, and gave a dose. …

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RAL SummaryMembersThe tier and why

The ingredient amounts are disclosed, and the main active, retinal, has only animal evidence. …

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More DetailsMembersBody systems · Combine with · Possible side effects

Body systems: Skin. Combine with and possible side are for members.

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Supplement FactsAVENE THERMAL SPRING WATER 0 · CAPRYLIC/CAPRIC TRIGLYCERIDE 0 · GLYCERIN 0
Supplement Facts
Serving Size none
Servings Per Container none
Amount Per Serving% Daily Value
AVENE THERMAL SPRING WATER (AVENE AQUA)0†
CAPRYLIC/CAPRIC TRIGLYCERIDE0†
GLYCERIN0†
SQUALANE0†
BUTYROSPERMUM PARKII (SHEA) BUTTER (BUTYROSPERMUM PARKII BUTTER)0†
CARTHAMUS TINCTORIUS (SAFFLOWER) SEED OIL (CARTHAMUS TINCTORIUS SEED OIL)0†
PENTAERYTHRITYL TETRACAPRYLATE/TETRACAPRATE0†
CETEARYL ALCOHOL0†
BEHENYL ALCOHOL0†
NIACINAMIDE0†
C20-22 ALKYL PHOSPHATE0†
C20-22 ALCOHOLS0†
ACACIA SENEGAL GUM0†
ADENOSINE0†
CETEARYL GLUCOSIDE0†
HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL (HELIANTHUS ANNUUS SEED OIL)0†
RED 33 (CI 17200)0†
RETINAL0†
SODIUM BENZOATE0
SODIUM HYALURONATE0
SODIUM HYDROXIDE0
TERMINALIA CHEBULA FRUIT EXTRACT0†
TOCOPHEROL0†
TOCOPHERYL GLUCOSIDE0†
XANTHAN GUM0†
† Daily Value not established.

Directions: Apply to the face, neck and decollete in the evening. Can be used after 7 days post-superficial aesthetic procedure or once skin has re-epithelialized.

Label source: Walgreens · Report a label change

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Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.