Reverse Age Lab Logo
La Roche-Posay Retinol B3 Pure Retinol Serum bottle
+ Add to ProtocolAsk Rala about it

La Roche-Posay Retinol B3 Pure Retinol Serum Review

An anti-aging pure retinol face and neck serum designed to leave skin feeling smoother, hydrated, and renewed. It targets fine lines, wrinkles, and premature sun damage.

Product Focus: Younger-Looking Skin for Men
Tier ⓘ
Members
Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
Members
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
Members
Biohacker Mentions
Members
Cost per month
$23
+ Add to ProtocolAsk Rala about it
Study, Trial or Testing Result SummaryMembersHuman studies

6 of these 66 human studies gave the ingredient by injection, not the way this product is used.

The label does list how much of each ingredient this serum contains, so we cannot say whether any of them match the strengths used in studies. Retinol has the support: a review of 23 trials in 3905 people found it fine wrinkles and sun spots, and a one year trial at 0.1 percent crow's feet lines by 44 percent. …

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

Review Totals and SummaryMembers3,636 reviews
3,636 reviews · Laroche-posay 2,241 · Walmart 1,316 · Ulta 764 · Walgreens 691 · Lovelyskin 158

The La Roche-Posay Retinol B3 Pure Retinol Serum has built a reputation among users for its noticeable results in smoothing skin texture and overall complexion. Across major retailers, users frequently mention that the serum feels lightweight and absorbs easily, making it an appealing addition to their nightly routine. …

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

Biohacker SummaryMembersWhat our biohacker panel says

The main ingredients here are adenosine and glycerin, and the panel says little about either as a skin ingredient. Only one panelist mentioned glycerin, and he was , calling it a sweet sugar alcohol used as a sweetener. …

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

RAL SummaryMembersThe tier and why

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

More DetailsMembersBody systems · Combine with · Possible side effects

Body systems: Skin. Combine with and possible side are for members.

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

Supplement FactsAQUA /WATER / EAU 0 · GLYCERIN 0 · CYCLOHEXASILOXANE 0
Supplement Facts
Serving Size none
Servings Per Container none
Amount Per Serving% Daily Value
AQUA /WATER / EAU0†
GLYCERIN0†
CYCLOHEXASILOXANE0†
ALCOHOL DENAT.0†
PENTYLENE GLYCOL0†
NIACINAMIDE0†
DIMETHICONE0†
GLYCINE SOJA OIL / SOYBEAN OIL0†
PPG-6-DECYLTETRADECETH-300†
SODIUM HYALURONATE0
RETINOL0†
ADENOSINE0†
AMMONIUMPOLYACRYLOYLDIMETHYLTAURATE0†
CAPRYLYL GLYCOL0†
CITRIC ACID0†
TRISODIUM ETHYLENEDIAMINE DISUCCINATE0†
XANTHAN GUM0†
POLYSILICONE-110†
RETINYL PALMITATE0†
TOCOPHEROL0†
PHENOXYETHANOL0†
PARFUM/ FRAGRANCE0†
† Daily Value not established.

Directions: 3-4 Drops EVENING After cleansing face ON FACE & NECK Taking care to avoid eye area Gently massage the serum with your finger tips. It can be used alone or under a moisturizer. Follow with a daily moisturizer and SPF.

Label source: Laroche-posay · Report a label change

Where to BuyLa Roche-Posay · Walmart · CVS
La Roche-PosayBuy ↗
WalmartBuy ↗
CVSBuy ↗

We sell no supplements. Prices change; check the store.

Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.