Life Extension 5-LOX Inhibitor with AprèsFlex® bottle

Life Extension 5-LOX Inhibitor with AprèsFlex® Review

A dietary supplement featuring AprèsFlex®, a potent extract of Boswellia serrata, designed to support joint health and inhibit the 5-lipoxygenase (5-LOX) enzyme, which affects inflammatory responses.

More ▾Less ▴

Product Focus: Joints and MobilityAlso covers:Immune system

Tier ⓘ

Members

Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →

Evidence ⓘ

Members

How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.

Positive Reviews

Members

Biohacker Mentions

Members

Cost per month

+ Add to Protocol Ask Rala about it

Study, Trial or Testing Result SummaryMembersHuman studies

This product gives 100 milligrams a day of a standardized Boswellia (frankincense) extract, a dose that matches what in studies. In a placebo-controlled trial of 70 adults with knee arthritis, 100 milligrams a day of this extract for about one month pain by about 45 percent, joint function, and blood markers of inflammation and cartilage breakdown compared with a dummy pill, with side . …

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

Review Totals and SummaryMembers4,600 reviews

4,600 reviews · IHerb 4,063 · Lifeextension 291 · Walmart 122 · Amazon 68 · Swanson 56

Across multiple platforms like iHerb, Amazon, Walmart, and the official Life Extension site, users reviewing Life Extension 5-LOX Inhibitor with AprèsFlex® express a largely experience, with the highlighting comfort and noticeable , especially for joint-related . A common sentiment among the reviews is appreciation for how the supplement seems to manage everyday stiffness and support easier movement— users mention they feel discomfort during activity or upon waking up. …

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

Biohacker SummaryMembersWhat our biohacker panel says

Our biohacker panel has discussed this product yet.

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

RAL SummaryMembersThe tier and why

A placebo-controlled trial of 70 adults with knee arthritis found this extract at 100 milligrams a day pain and function, supported by reviews of Boswellia for arthritis and customer ratings.

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

More DetailsMembersBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system, Immune system. Combine with and possible side are for members.

Members see the full analysis, checked against their own meds and goals. Start My 7-Day Free Trial →

Supplement FactsAprèsFlex® extract [std. to 20% 3-O-acetyl-11-keto-ß-boswellic acid ] 100 mg

Supplement Facts

Serving Size 1 vegetarian capsule

Servings Per Container 60

Amount Per Serving% Daily Value

AprèsFlex® (Boswellia serrata) extract (gum resin) [std. to 20% 3-O-acetyl-11-keto-ß-boswellic acid (AKBA)]

100 mg

†

† Daily Value not established.

Directions: To inhibit the 5-lipoxygenase enzyme, take one (1) capsule daily, or as recommended by a healthcare practitioner.

Barcode (UPC) 737870163961 · Label source: the brand's label · Report a label change

Where to BuyLife Extension · Amazon · iHerb

Life ExtensionBuy ↗

AmazonBuy ↗

iHerbBuy ↗

We sell no supplements. Prices change; check the store.

Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.