Life Extension No Flush Niacin Review

No-Flush Niacin contains a special form of niacin, inositol hexanicotinate, consisting of six molecules of niacin chemically linked to an inositol molecule. It is hydrolyzed in the body to free niacin and inositol, which is a very slow process. Its novel properties allow for true niacin activity without the characteristic niacin flush.

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Product Focus: CholesterolAlso graded for:CirculationHormone Balance for WomenHealthy AgingAlso covers:HeartMetabolism

Tier ⓘ

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Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →

Evidence ⓘ

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How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.

Positive Reviews

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Biohacker Mentions

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Cost per month

$14 at 3 servings

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Study, Trial or Testing Result SummaryMembersHuman studies

This product supplies niacin bound to inositol, a -flush form called inositol hexanicotinate. niacin studies used regular or extended-release niacin, this bound form. …

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Review Totals and SummaryMembers4,528 reviews

4,528 reviews · IHerb 3,523 · Amazon 943 · Life Extension 61 · Pure Formulas 1

Life Extension Flush Niacin has gathered widespread user feedback across platforms, and real-world reviews generally lean toward the end of the spectrum. customers mention that they specifically sought out a niacin supplement that would cause them to experience the uncomfortable flushing sensation that comes with traditional niacin, and were pleased that this product delivered on that promise. …

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Biohacker SummaryMembersWhat our biohacker panel says

Two it, mainly as a raw material for making NAD, with one saying the cheap kind that causes a flush blood NAD than costly NAD products. One takes to flush about half an hour before a sauna session, and he also advised only occasional amounts and that doses can burden the body's methylation system. …

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RAL SummaryMembersThe tier and why

Regular niacin cholesterol numbers without heart events, and the -flush bound form did than placebo in one trial. …

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More DetailsMembersBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system, Metabolic system. Combine with and possible side are for members.

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Supplement FactsNiacin 640 mg · Inositol 160 mg

Supplement Facts

Serving Size 1 capsule

Servings Per Container 100

Amount Per Serving% Daily Value

Niacin (from 800 mg of inositol hexanicotinate)	640 mg
Inositol (from 800 mg of inositol hexanicotinate)	160 mg	†

† Daily Value not established.

Directions: Take one (1) capsule with food, or as recommended by a healthcare practitioner.

Barcode (UPC) 737870373100 · Label source: the brand's label · Report a label change

Where to BuyLife Extension · Amazon · iHerb

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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.