Life Extension Optimized Folate L-Methylfolate 1700 mcg DFE Review
Life Extension's Optimized Folate L-Methylfolate 1700 mcg DFE is a meticulously formulated dietary supplement designed to bolster both cardiovascular and cognitive health. This advanced formula delivers 1,700 mcg of folate in the highly bioavailable form of 5-MTHF, which is the metabolically active form of folic acid. A primary function of this B vitamin is to assist in maintaining already healthy levels of homocysteine, a metabolic byproduct that serves as a crucial biomarker for overall cardiovascular and cognitive well-being. By helping to inhibit excess homocysteine, Optimized Folate actively supports the healthy functioning of the heart and brain. The importance of folate, particularly 5-MTHF, is underscored by its role in preventing the accumulation of homocysteine, which, when elevated, has been linked to an increased risk of cognitive decline. This makes the supplement especially beneficial for aging individuals who are focused on preserving their cognitive faculties. The product adheres to high quality standards, being certified gluten-free, non-GMO, and suitable for vegetarians. Life Extension, with over four decades of experience, prides itself on delivering science-backed supplements, emphasizing product transparency and a strong commitment to customer health and wellness, reflected in a 98% customer recommendation rate. Each bottle contains 100 vegetarian tablets, with a convenient serving size of one tablet daily, ideally taken with food. While the recommended daily allowance (RDA) for folate for non-pregnant or lactating adults is 400 mcg, this formula provides a robust 1,700 mcg of 5-MTHF folate to ensure comprehensive support. For those seeking even higher doses, Life Extension offers a High Potency Optimized Folate formula. This supplement can be effectively integrated into a broader nutritional regimen, and can be combined with other B vitamins such as methylcobalamin (vitamin B12), pyridoxal 5’-phosphate or pyridoxine hydrochloride (vitamin B6), and/or riboflavin for enhanced synergistic effects. Consumers are advised to consult their healthcare provider if they are at risk of vitamin B12 deficiency, as high-dose folate may mask certain signs. It is important to note that these products are not intended to diagnose, treat, cure, or prevent any disease, and the statements made have not been evaluated by the Food and Drug Administration. The supplement is a key offering within Life Extension's health goal categories, including Anti-Aging & Longevity, Brain Health, and Heart Health, reflecting its broad spectrum of benefits.
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Supplement FactsFolate [as -5-Methyltetrahydrofolate, calcium salt] 1700 mcg DFE
| Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt] | 1,700 mcg DFE | 425% |
Directions: Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.
Barcode (UPC) 737870193913 · Label source: iHerb · Report a label change
Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.

