MB Herbals Cissus Powder Review
MB Herbals Cissus Powder is a premium herbal supplement derived from the stem of *Cissus quadrangularis*, a succulent vine belonging to the Vitaceae family, widely recognized in traditional healing systems like Ayurveda. Known as "Hadjod" in Indian Ayurvedic texts, as well as Asthisanghata, Kandavalli, and Vajrangi, this plant has been revered for centuries for its profound medicinal properties, particularly concerning bone and joint health. MB Herbals ensures a pure product, consisting of 100% *Cissus quadrangularis* Stem Powder, free from preservatives, additives, GMOs, and gluten. The efficacy of *Cissus quadrangularis* is attributed to its rich phytochemical profile, which includes flavonoids, triterpenoids, phytosterols, glycosides, carotenoids, tannins, phenols, calcium, and vitamin C. These bioactive compounds work synergistically to exert a range of pharmacological activities within the body. Primarily, *Cissus quadrangularis* is celebrated for its potent anti-inflammatory, analgesic (pain-reducing), and antioxidant properties. One of the most significant mechanisms involves its role in bone metabolism and regeneration. The plant's constituents, including anabolic meds, are believed to influence gene expression related to bone remodeling, promoting osteoblast proliferation (bone formation cells) and enhancing the differentiation of mesenchymal stem cells into osteoblastic lineages. This action accelerates the early generation of connective tissue, leading to faster healing of fractures and potentially reducing bone loss associated with conditions like osteoporosis. Studies suggest it can restore normal bone composition more quickly than natural healing alone. Furthermore, *Cissus quadrangularis* acts as a natural anti-inflammatory agent by suppressing specific inflammatory pathways and reducing levels of inflammatory markers such as TNF-α. This mechanism contributes to its ability to alleviate joint pain and swelling, making it beneficial for individuals suffering from arthritis and other inflammatory joint conditions. Its analgesic properties can provide relief from both acute and chronic pain, sometimes within as little as 30 minutes of ingestion. Beyond musculoskeletal support, *Cissus quadrangularis* has demonstrated potential in metabolic health. It may aid in weight management by influencing appetite control and enhancing fat metabolism, with some studies observing reductions in body weight, body fat, and improvements in blood parameters like fasting blood sugar, triglycerides, and cholesterol levels. The plant also exhibits hepatoprotective activity, potentially due to its antioxidant properties, and has shown anti-ulcerative effects, protecting the gastrointestinal lining. The recommended dosage for MB Herbals Cissus Powder is typically 1g to 3g daily, divided into two doses.
Study, Trial or Testing Result SummaryMembersHuman studies
11 of these 33 human studies gave the ingredient by drip or injection, not by mouth.
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Review Totals and SummaryMembers90 reviews
Biohacker SummaryMembersWhat our biohacker panel says
RAL SummaryMembersThe tier and why
More DetailsMembersBody systems · Combine with · Possible side effects
Supplement FactsTotal Calories 0 · Carbohydrate 1 g · Fat 40 mg
| Total Calories | 0 | 0% |
| Carbohydrate | 1 g | 0.3% |
| Protein | 250 mg | 0.5% |
| Fat | 40 mg | 0.1% |
| Dietary Fibre | 25 mg | 0.1% |
| Calcium | 36 mg | 1.5% |
| Phosphorus | 37 mg | 3.7% |
| Potassium | 18 mg | 0.8% |
| Zinc | 2 mg | 0.2% |
| Magnesium | 3 mg | 0.6% |
| Iron | 2 mg | 25% |
Directions: 2g with water once daily.
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Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.

