NOW Foods UC-II Joint Health with Undenatured Type II Collagen bottle

NOW Foods UC-II Joint Health with Undenatured Type II Collagen Review

NOW UC-II is a nutritional supplement designed to support joint health, mobility, and flexibility. Its primary ingredient is undenatured type II collagen, a patented form of collagen derived from chicken sternum cartilage that works with the immune system to promote healthy joints.

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Product Focus: Joints and MobilityAlso covers:Immune system

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Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →

Evidence ⓘ

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How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.

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Study, Trial or Testing Result SummaryMembersHuman studies

The main ingredient, undenatured type two collagen, is at the dose used in studies, and human studies find it joints. A 2025 pooled analysis of 23 placebo-controlled trials in 2455 people with osteoarthritis ranked it third of 21 supplements for joint pain, though the evidence quality was . …

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Review Totals and SummaryMembers22,742 reviews

22,742 reviews · IHerb 18,608 · Amazon 4,019 · Walmart 69 · Nowfoods 46

NOW Foods UC-II Joint with Undenatured Type II Collagen, 120 Veg Capsules has amassed a substantial number of user reviews across platforms like iHerb, Amazon, and Walmart, and the sentiment from these testimonies is quite . users note in joint comfort and flexibility after introducing this supplement to their daily routines. …

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Biohacker SummaryMembersWhat our biohacker panel says

Collagen is the main ingredient here, and of the panel is on it, though the panel did about undenatured type II collagen specifically. Doses given were 10 grams a day by three people, 15 grams before bed by one, and 2.5 to 5 grams a day by another who said effective doses run from 5 to 15 grams. …

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RAL SummaryMembersOur verdict

The calcium and seaweed mineral evidence is thin and adds little. …

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More DetailsMembersBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system, Immune system. Combine with and possible side are for members.

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Supplement FactsCalcium 80 mg · UC-II® Standardized Chicken Cartilage 40 mg · Aquamin® 250 mg

Supplement Facts

Serving Size 1 Capsule

Servings Per Container 120

Amount Per Serving% Daily Value

Calcium (from Aquamin)	80 mg	6%
UC-II® Standardized Chicken Cartilage (Providing 10 mg Total Collagen, including Undenatured Type II Collagen)	40 mg	†
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)	250 mg	†

† Daily Value not established.

Directions: Take 1 capsule daily at bedtime on an empty stomach.

Barcode (UPC) 733739031365 · Label source: the brand's label · Report a label change

Where to BuyNOW Foods · iHerb

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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.