Ortho Molecular Products CM Core Review
CM Core® provides multidimensional support for cardiovascular health by maintaining healthy cholesterol levels and supporting blood sugar balance already within normal levels. The product is listed under Cardiovascular Health, Endocrine Health, and Top Practitioner's Pick categories. Clinical applications named on the page include multidimensional support for cardiometabolic health, enhancing cell signaling for efficient ATP production, supporting blood sugar balance already within normal levels, and maintaining healthy cholesterol levels already within the normal range. The page describes the formula as backed by extensive clinical research and designed to address several factors associated with ideal cardiometabolic health. The powerful combination of berberine and alpha lipoic acid (ALA) is said to help maintain heart function, metabolism, antioxidant status, and lipid and glucose levels. Berberine is described as a plant extract used in Chinese and Ayurvedic medicine for over 2,500 years, found in roots and stems of goldenseal, goldenthread, Oregon grape, and barberry. The page states that clinical trials have shown berberine supports cardiovascular health by maintaining blood pressure, supporting healthy heart contraction and rhythm, and supporting healthy cholesterol levels. Alpha lipoic acid is described as a nutrient required for cellular metabolism, involved in breaking down carbohydrates and fatty acids, that supports blood sugar balance already within normal levels by activating AMPK, and that acts as an antioxidant while aiding regeneration of vitamin C, vitamin E, and glutathione. Suggested use is 3 capsules per day or as recommended by a health care professional. The package is listed as 90 count. The page notes that these statements have not been evaluated by the Food and Drug Administration and that the products are not intended to diagnose, treat, cure, or prevent any disease. Related products shown are Diaxinol, Lipoic Acid 300 mg, and Cardio MET Pack. The product is sold to licensed health care practitioners through the Ortho Molecular Products practitioner program.
Study, Trial or Testing Result SummaryMembersHuman studies
4 of these 127 human studies gave the ingredient by drip, not by mouth.
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Review Totals and SummaryMembers1 reviews
Biohacker SummaryMembersWhat our biohacker panel says
RAL SummaryMembersThe tier and why
More DetailsMembersBody systems · Combine with · Possible side effects
Supplement FactsCalcium 80 mg · Berberine Hydrochloride Hydrate 1 g · Alpha Lipoic Acid 200 mg
| Calcium | 80 mg | 6% |
| Berberine Hydrochloride Hydrate | 1 g | † |
| Alpha Lipoic Acid (as R-Lipoic Acid) | 200 mg | † |
Other ingredients: Hypromellose (Natural Vegetable Capsules), Tricalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Ascorbyl Palmitate and Silicon Dioxide.
Directions: 3 capsules per day or as recommended by your health care professional.
Label source: the brand's label · Report a label change
Where to BuyOrtho Molecular Products
We sell no supplements. Prices change; check the store.
Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.

