Thorne Berberine 500 mg Review

Berberine is a supplement derived from various plants, commonly used to support metabolic health, including maintaining healthy blood sugar and cholesterol levels.

Product Focus: CholesterolAlso covers:HeartDigestionMetabolism

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Evidence ⓘ

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How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.

Positive Reviews

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Biohacker Mentions

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Cost per month

$30

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Study, Trial or Testing Result SummaryMembersHuman studies

Berberine, taken here at 900 mg a day, is the 600 mg daily dose that in studies, and the research on it for cholesterol is . A pooled analysis of 18 placebo-controlled trials with 1788 adults treated for 4 to 24 weeks found berberine bad cholesterol, total cholesterol and blood fats called triglycerides compared with placebo, though it caused stomach side . …

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Review Totals and SummaryMembers11,910 reviews

11,910 reviews · IHerb 5,834 · Amazon 5,661 · Thorne 283 · Walmart 113 · Target 19

Berberine 500mg receives reviews across major retailers like Amazon, iHerb, Walmart, and Target, with users frequently highlighting in their and wellness routines. customers mention taking Berberine 500mg for its purported metabolic support and describe seeing noticeable results in areas like blood sugar management, energy levels, and digestive comfort. …

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Biohacker SummaryMembersWhat our biohacker panel says

of the panel or uses berberine, and the main reason is blood sugar control, with also pointing to insulin resistance, cholesterol, and heart . Two of them take 500 mg with meals, one cites 500 mg three times a day with meals, and like the absorbable forms, including dihydroberberine. …

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RAL SummaryMembersOur verdict

Berberine is present the studied dose, and eight pooled analyses, the largest covering 13,062 people, show it bad and total cholesterol compared with placebo.

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More DetailsMembersBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system, Digestive system, Metabolic system. Combine with and possible side are for members.

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Supplement FactsBerberine HCl 450 mg · Berberine Phytosome / Phospholipid Complex from Pea, Sunflower, Grape Seed) 550 mg

Supplement Facts

Serving Size Two Capsules

Servings Per Container 30

Amount Per Serving% Daily Value

Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata)	450 mg	†
Berberine Phytosome (Berberis aristata Extract (Root) / Phospholipid Complex from Pea, Sunflower, Grape Seed)	550 mg	†

† Daily Value not established.

Directions: Take 1-2 capsules two times daily with food or as recommended by your health-care practitioner.

Barcode (UPC) 693749048008 · Label source: Pureformulas · Report a label change

Where to BuyThorne · Amazon · iHerb

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Graded October 22, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.