Thorne NiaCel 400 Review

Thorne NiaCel 400 is presented as a supplement that supports the vitality of the brain and body with Nicotinamide Riboside, sold as 60 capsules for $74 or $66.60 with a subscription that saves 10 percent. The page explains that everyday life, including lack of sleep, sitting at a desk, late nights, sun exposure, an unbalanced diet, and the natural aging process, can lower NAD+, a coenzyme found in every cell. As NAD+ declines, the page says, integral body functions slow down, leading to reduced vitality and early aging. NiaCel 400 is described as a way to boost the body's level of NAD+ using an exclusive form of NR, which the page says is ideal for athletes and for people who need more robust support for NAD+ levels. The page lists daily benefits including support for exercise efficiency, cellular energy production in every cell, a normal sleep-wake cycle, and optimal methylation supported by betaine, which the page links to healthy daily detox processes and balanced brain chemicals. It also lists longer-term benefits such as support for healthy cellular repair and metabolism, cellular energy production in the mitochondria, support for a weight management program, helping protect DNA from damage, and betaine helping to reduce body fat without negatively affecting muscle mass. The page describes NAD+ as fuel for the cellular gas tank that influences everyday energy and the regulation of the sleep-wake cycle. Each capsule contains 415mg of Nicotinamide Riboside Hydrogen Malate and 85mg of Betaine Anhydrous. The product is NSF Certified for Sport, and the page states that every batch is tested for compliance with label claims and for the absence of nearly 300 substances banned by many major athletic organizations. The warnings section states that the product is contraindicated for individuals with a history of hypersensitivity to any of its ingredients, that pregnant people should consult a health-care practitioner before using it, and that there are no known adverse interactions or contraindications at publication date. The page also offers HSA or FSA payment through Truemed, although the widget showed an error at the time of capture. Subscription options range from every 2 weeks to every 4 months, with free shipping within the contiguous United States and a 20 percent discount for subscribing to three or more different products.

Product Focus: Healthy AgingAlso covers:BrainImmune systemMusclesBreathing
Tier ⓘ
Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
Biohacker Mentions
Cost per month
$74 at 2 servings

Study, Trial or Testing Result Summary

MembersHuman studies

Nicotinamide riboside is the main ingredient. At two capsules a day it comes close to the 1 gram daily dose used in the studies. …

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Review Totals and Summary

Members796 reviews
796 reviews · Mayo Clinic Store 643 · Thorne 90 · Walmart 58 · Thefeed 5

Thorne NiaCel 400 capsules generally receive feedback from customers, with about of ratings being 4 or 5 stars across approximately 63 ratings. users report noticeable , though some find the product expensive or experience . **What buyers say it did for them** Customers frequently the product for energy and cognitive function. …

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Biohacker Summary

MembersWhat our biohacker panel says

People take it to support NAD, a molecule tied to cellular energy, and to get energy, recovery, mitochondrial , and skin ; one panelist said his energy rose almost right away, and another noticed a big difference when he skipped it. Doses mentioned ran from 300 milligrams to about a gram a day, and some prefer the Niagen form, with a pairing it with NMN or CoQ10 and one comparing it to NMN as equally effective. …

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RAL Summary

MembersThe tier and why

A placebo-controlled trial found nicotinamide riboside estimated biological age on two DNA aging clocks. The aging-clock results come from , exploratory analyses. …

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More Details

MembersBody systems · Combine with · Possible side effects

Body systems: Cellular metabolism, Nervous system, Immune system, Muscular system, Respiratory system. Combine with and possible side are for members.

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Supplement Facts

Betaine Anhydrous 85 mg · Nicotinamide Riboside Hydrogen Malate 415 mg
Supplement Facts
Serving Size 1 Capsule(s)
Servings Per Container 60
Amount Per Serving% Daily Value
Betaine Anhydrous (Trimethylglycine)85 mg†
Nicotinamide Riboside Hydrogen Malate415 mg†
† Daily Value not established.

Other ingredients: Hypromellose (derived from cellulose) capsule, Ascorbyl Palmitate.

Label source: Thorne · Report a label change

Where to Buy

Thorne · Mayo Clinic Store · Thefeed
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Our articles on this subject

Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.