Advanced Clinicals Anti-Wrinkle Retinol Serum Review
Advanced Clinicals Retinol Serum, 1.75 fl oz (52 ml), is an anti-aging Retinol serum described as professionally formulated to reveal fresh, soft skin. The page calls it a rejuvenating anti-wrinkle concentrate and says it is safe for daily use. It is presented as diminishing the look of deep wrinkles and sun damage. The encapsulated Retinol is highlighted as the key ingredient for ultimate efficiency. Nourishing Aloe Vera and Green Tea are included, with Aloe Vera described as defending against visible redness and irritation, and Antioxidant Green Tea described as guarding against environmental damage. Glycerin is described as attracting moisture to the skin for a visibly plump appearance. The page says the retinol conceals the look of deep wrinkles and jowls, visibly replenishes volume to mature skin, and improves the look of sagging, sun damaged skin. The serum is described as lightweight and fast absorbing, allowing easy application and layering with other skincare products. It is described as gentle, with soothing and calming ingredients that minimize the appearance of irritation for sensitive skin. Replenishing anti-aging ingredients are said to visibly restore volume to areas prone to sagging and wrinkles, softening the look of harsh lines and deep wrinkles, and promoting a more youthful looking skin tone by concealing the appearance of sun damage. Results are described as instant tightness, flushing or redness that may occur on first use and is described as normal. With nightly use, the page says wake up daily to visibly softened wrinkles and smoother looking skin. Suggested use is to apply after cleansing and allowing skin to dry, patting over the face with focus on problem areas, wiping excess onto the tops of hands, and using every night before bed. If irritation persists, the page advises reducing frequency to every other night. The page states the product is made in USA with globally sourced materials and carries a warning that for external use only, with discontinuation if irritation develops.
Study, Trial or Testing Result Summary
MembersHuman studies
Review Totals and Summary
Members67,310 reviews
Biohacker Summary
MembersWhat our biohacker panel says
RAL Summary
MembersThe tier and why
More Details
MembersBody systems · Combine with · Possible side effects
Supplement Facts
Aqua/Water/Eau 0 no unit · Isopropyl Myristate 0 no unit · Glycerin 0 no unit
| Aqua/Water/Eau | 0 no unit | † |
| Isopropyl Myristate | 0 no unit | † |
| Glycerin | 0 no unit | † |
| Ethylhexyl Olivate | 0 no unit | † |
| Cetearyl Alcohol | 0 no unit | † |
| Pyrus Malus (Apple) Fruit Extract | 0 no unit | † |
| Squalane | 0 no unit | † |
| Aloe Barbadensis Leaf Juice Powder | 0 no unit | † |
| Propanediol | 0 no unit | † |
| Avena Sativa (Oat) Bran Extract | 0 no unit | † |
| Retinol | 0 no unit | † |
| Tocopherol | 0 no unit | † |
| Camellia Sinensis Leaf Extract | 0 no unit | † |
| Oryza Sativa (Rice) Bran Extract | 0 no unit | † |
| Citrus Aurantium Dulcis (Orange) Peel Extract | 0 no unit | † |
| Helianthus Annuus (Sunflower) Extract | 0 no unit | † |
| Humulus Lupulus (Hops) Extract | 0 no unit | † |
| Rosmarinus Officinalis (Rosemary) Leaf Extract | 0 no unit | † |
| Helianthus Annuus (Sunflower) Seed Oil | 0 no unit | † |
| Ammonium Acryloyldimethyltaurate/VP Copolymer | 0 no unit | † |
| Phenoxyethanol | 0 no unit | † |
| Caprylyl Glycol Ethylhexylglycerin | 0 no unit | † |
| Hexylene Glycol | 0 no unit | † |
| Cyamopsis Tetragonoloba (Guar) Gum | 0 no unit | † |
| Copernicia Cerifera (Carnauba) Wax | 0 no unit | † |
| Polysorbate 20 | 0 no unit | † |
| Tetrasodium Glutamate Diacetate | 0 no unit | † |
| 1,2-Hexanediol | 0 no unit | † |
| Disodium Cocoamphodipropionate | 0 no unit | † |
| Xanthan Gum | 0 no unit | † |
| Ethyl Ferulate | 0 no unit | † |
| Parfum/Fragrance | 0 no unit | † |
| Limonene | 0 no unit | † |
Directions: Apply a thin layer to clean face and neck at night. Follow with your favorite Advanced Clinicals face cream. Avoid using alongside Vitamin C. Use Vitamin C in the morning and Retinol at night.
Label source: Advancedclinicals · Report a label change
Where to Buy
iHerb
We sell no supplements. Prices change; check the store.
Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.

