Double Wood Supplements Apigenin Review
Apigenin is a plant flavone bioflavonoid found throughout the plant kingdom, most abundantly in chamomile flower, the same compound responsible for much of chamomile tea's calming character. This supplement delivers a more concentrated form of the flavonoid than a cup of tea provides, in a single precise 50mg capsule. The page states that apigenin binds to GABA-A receptors in the brain, supporting a calming effect without the heavy sedation associated with pharmaceutical sleep aids. The page also describes apigenin's phytoestrogenic activity, meaning it can weakly interact with estrogen receptors. It notes preclinical research, mainly in animal and cell models, into apigenin's role in supporting ovarian function by helping protect ovarian cells against oxidative stress, and it states that human evidence in this area is still developing. Each bottle holds 120 capsules, a four-month supply at the standard one-capsule evening serving. The page says apigenin is naturally fat-soluble and recommends taking it alongside a meal or a small snack containing fat, such as a handful of nuts or a spoonful of yogurt, to support bioavailability. The product is listed as NSF Contents Certified and audited to NSF/ANSI 173. The page says every batch is tested for purity, potency, heavy metals and microbial safety, and that certificates of analysis are published openly. The directions suggest taking one capsule (50mg) 30 to 60 minutes before bedtime with a small source of dietary fat. Those who find 50mg insufficient may take two capsules before bed, and the page advises not to exceed two capsules per day. It notes that morning use is possible for daytime calm, although two morning capsules may be too sedating for some people. The page recommends pairing apigenin with Magnesium L-Threonate for brain-centred relaxation and with L-Theanine for mental quiet and physical relaxation. The certificate of analysis for lot 2617400 lists 48.30 mg apigenin against a 45 to 62.5 mg specification, a capsule weight of 138 mg, passing disintegration, and absent E. coli, Salmonella and Staphylococcus aureus. The page advises consulting a healthcare provider before use for anyone taking prescription sedatives, meds or meds, and for pregnant or nursing people, or those with estrogen-sensitive conditions.
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Supplement Facts
Apigenin 50 mg
| Apigenin | 50 mg | † |
Other ingredients: Hypromellose (capsule), Microcrystalline Cellulose, Vegetable Stearate and Silica.
Directions: Take 1 capsule per day. To support sleep, take at dinner or before bed with a source of dietary fat.
Label source: Doublewoodsupplements · Report a label change
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Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.

