Double Wood Supplements Apigenin Review

Apigenin is a plant flavone bioflavonoid found throughout the plant kingdom, most abundantly in chamomile flower, the same compound responsible for much of chamomile tea's calming character. This supplement delivers a more concentrated form of the flavonoid than a cup of tea provides, in a single precise 50mg capsule. The page states that apigenin binds to GABA-A receptors in the brain, supporting a calming effect without the heavy sedation associated with pharmaceutical sleep aids. The page also describes apigenin's phytoestrogenic activity, meaning it can weakly interact with estrogen receptors. It notes preclinical research, mainly in animal and cell models, into apigenin's role in supporting ovarian function by helping protect ovarian cells against oxidative stress, and it states that human evidence in this area is still developing. Each bottle holds 120 capsules, a four-month supply at the standard one-capsule evening serving. The page says apigenin is naturally fat-soluble and recommends taking it alongside a meal or a small snack containing fat, such as a handful of nuts or a spoonful of yogurt, to support bioavailability. The product is listed as NSF Contents Certified and audited to NSF/ANSI 173. The page says every batch is tested for purity, potency, heavy metals and microbial safety, and that certificates of analysis are published openly. The directions suggest taking one capsule (50mg) 30 to 60 minutes before bedtime with a small source of dietary fat. Those who find 50mg insufficient may take two capsules before bed, and the page advises not to exceed two capsules per day. It notes that morning use is possible for daytime calm, although two morning capsules may be too sedating for some people. The page recommends pairing apigenin with Magnesium L-Threonate for brain-centred relaxation and with L-Theanine for mental quiet and physical relaxation. The certificate of analysis for lot 2617400 lists 48.30 mg apigenin against a 45 to 62.5 mg specification, a capsule weight of 138 mg, passing disintegration, and absent E. coli, Salmonella and Staphylococcus aureus. The page advises consulting a healthcare provider before use for anyone taking prescription sedatives, meds or meds, and for pregnant or nursing people, or those with estrogen-sensitive conditions.

Product Focus: SleepAlso covers:Brain
Tier ⓘ
Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
Biohacker Mentions
Cost per month
$5

Study, Trial or Testing Result Summary

MembersHuman studies

Only one human study has looked at apigenin for sleep, and it did test apigenin on its own. In this placebo-controlled trial, 103 , active adults took an evening blend for 2 weeks. …

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Review Totals and Summary

Members75 reviews
75 reviews · Double Wood Supplements store 40 · Walmart 34 · Target 1

Across both stores, the Double Wood Supplements Apigenin product has received 40 ratings. The themes are drawn from the written reviews visible on their respective product pages, which included three written reviews on the Double Wood Supplements website and a number of written reviews on the Double Wood Supplements store page. …

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Biohacker Summary

MembersWhat our biohacker panel says

Apigenin is the only ingredient here, and the panel leans toward using or it: of the ten, six currently use it, two it, and three are . The main reason is sleep, with taking 50 mg before bed, though one takes 400 mg about 45 minutes before bed away from the evening meal and another suggests 100 mg a day for fat and longevity. …

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RAL Summary

MembersThe tier and why

The grade rests on a single short trial that tested apigenin only inside a blend with magnesium L-threonate and L-theanine, so it cannot show that apigenin alone does , and the evidence is thin rather than . …

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More Details

MembersBody systems · Combine with · Possible side effects

Body systems: Nervous system. Combine with and possible side are for members.

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Supplement Facts

Apigenin 50 mg
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 120 Servings
Amount Per Serving% Daily Value
Apigenin50 mg†
† Daily Value not established.

Other ingredients: Hypromellose (capsule), Microcrystalline Cellulose, Vegetable Stearate and Silica.

Directions: Take 1 capsule per day. To support sleep, take at dinner or before bed with a source of dietary fat.

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Our articles on this subject

Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.