Life Extension Mega Vitamin K2 Review
Mega Vitamin K2 High Potency for Strong Bones is a gluten-free, non-GMO dietary supplement formulated by Life Extension to support healthy bone density and heart health. Each bottle contains 30 capsules, providing a 30-day supply when taken at the recommended dosage of one capsule daily with food. Every single-capsule serving delivers a strong, clinically studied 45,000 mcg (45 mg) dose of vitamin K2 in the specific form of menaquinone-4 (MK-4), alongside other ingredients including microcrystalline cellulose, a gelatin capsule, vegetable stearate, and silica. Vitamin K2 is essential for maintaining healthy bone mineral density because it encourages the cellular activity of osteoblasts, which are the specialized bone-building cells that regulate the mineralization of the lattice-like bone matrix support structure. Specifically, vitamin K acts as a vital cofactor for the carboxylation of osteocalcin, a protein produced by osteoblasts that is responsible for binding calcium and depositing it directly into the bone during the process of bone mineralization. Although the human body has a built-in process for maintaining healthy bone structure, this natural capability begins to decline over time with age. If an individual does not get enough vitamin K2, osteocalcin does not undergo carboxylation and instead remains in its inactive form, meaning it cannot bind to calcium or play its necessary role in bone formation. Clinical studies have demonstrated that the MK-4 form of vitamin K2 supports the biological processes that maintain bone mineral density in populations that need that support the most, such as postmenopausal women. Because this formula delivers a high potency of vitamin K, the manufacturer includes a caution advising anyone taking a vitamin K antagonist, such as a med, to consult their healthcare practitioner before taking this product, as well as standard warnings to consult a physician if pregnant, lactating, or undergoing treatment for a medical condition.
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Supplement Facts
Vitamin K2 [as menaquinone-4 ] 45000 mcg
| Vitamin K2 [as menaquinone-4 (45 mg)] | 45,000 mcg |
Other ingredients: Microcrystalline cellulose, gelatin (capsule), vegetable stearate, silica.
Directions: Take one (1) capsule daily with food, or as recommended by a healthcare practitioner.
Label source: Lifeextension · Report a label change
Where to Buy
Life Extension · Amazon · iHerb
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Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.

