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Nature's Way St. John's Wort bottle
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Nature's Way St. John's Wort Review

Nature's Way St. John's Wort is a traditional herbal supplement intended to support a positive mood.

Product Focus: MoodAlso covers:Brain
Tier ⓘ
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Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
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How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
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Biohacker Mentions
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Cost per month
$4
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Study, Trial or Testing Result Summary

MembersHuman studies

1 of these 57 human studies gave st. john's wort by drip, not by mouth.

St. John's wort is the only active ingredient here, at 1400 milligrams a day, the 600 milligrams that in studies. A review of 35 trials with 6993 adults with major depression found it people than placebo and about as as a med drugs in mild to moderate depression, with side . …

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Review Totals and Summary

Members4,722 reviews
4,722 reviews · IHerb 4,588 · Pay-less 37 · Metromarket 37 · Vitacost 13 · Smithsfoodanddrug 12 · Fredmeyer 11 · Kroger 8 · Marianos 8 · Kingsoopers 8

Nature's Way St. John's Wort has earned a considerable following among users, with thousands of reviews suggesting a generally experience for . reviewers the product for what they describe as noticeable in mood and overall emotional -being. …

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Biohacker Summary

MembersWhat our biohacker panel says

The main reason given is mood: one it for depression and says it has side than meds, another used it for a while for people who wanted to avoid pharmaceutical options, and another said it depression and stress. Others mentioned it for seasonal mood, for sleep, and for support when quitting smoking, and one makes a tincture from the fresh flower while another recalled family drinking it as a dried tea. …

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RAL Summary

MembersThe tier and why

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More Details

MembersBody systems · Combine with · Possible side effects

Body systems: Nervous system. Combine with and possible side are for members.

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Supplement Facts

St. John's Wort 700 mg
Supplement Facts
Serving Size 2 Capsules
Servings Per Container 50
Amount Per Serving% Daily Value
St. John's Wort (stem, leaf, flower)700 mg†
† Daily Value not established.

Directions: Adults take 2 capsules twice daily. For best results, use for at least two months.

Barcode (UPC) 033674173008 · Label source: Vitacost · Report a label change

Where to Buy

iHerb · Kroger
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Our articles on this subject

Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.