NOW E-400 Review

NOW E-400 100% Natural Mixed Tocopherols Softgels come in a 100 count bottle priced at $11.98 each, which breaks down to $0.12 per count, though prices may vary between in-store, curbside, and delivery options such as Aisle 1 at Victoria H-E-B plus. The primary function of this supplement is to provide antioxidant protection. According to the product description, 100% Natural Mixed Tocopherols Vitamin E is a major antioxidant and serves as the primary defense against lipid peroxidation. It is particularly important in protecting the body's cells from free radical and oxidative damage. The page notes that these protective benefits are achievable with supplemental intakes that are higher than what is normally consumed in the average diet. Regarding nutrition facts and ingredients, the product delivers 268 mg of Vitamin E, which represents 1787% of the Daily Value. The other ingredients listed for the formulation include a Softgel Capsule made of Gelatin, Water, and Glycerin, along with Organic Extra Virgin Olive Oil. For allergens and safety warnings, the page specifies that the product contains soy derived from non-GMO sources and also contains gelatin. However, it is not manufactured with yeast, wheat, gluten, milk, egg, fish, or shellfish ingredients, though it is produced in a GMP facility that processes other ingredients containing these allergens. The caution statement advises that this supplement is for adults only, and individuals should consult a physician if they are pregnant or nursing, taking medication, or have a medical condition. Furthermore, users are instructed to keep the product out of reach of children, not to eat the freshness packet, and to keep the softgels stored inside the bottle.

Product Focus: Kidney HealthAlso graded for:Bone HealthAlso covers:Heart
Tier ⓘ
Members see this product's tier and why. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
Biohacker Mentions
Cost per month
$4

Study, Trial or Testing Result Summary

MembersHuman studies

This product gives 268 milligrams of natural vitamin E a day, the studied dose of 400 units. The longest trial at that daily dose followed 993 people with mild to moderate kidney and heart for about four and a half years and found on protein in the urine, heart or death. …

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Review Totals and Summary

Members25,368 reviews
25,368 reviews · IHerb 13,882 · Heb 11,101 · Amazon 335 · Walmart 48 · QFC 2

This summary compiles customer feedback on NOW E-400 softgels, which have garnered approximately 14267 ratings across various stores, with of star ratings being 4 or 5 out of 5. Overall, buyers express with this vitamin E supplement. **What it did for them:** users report after incorporating NOW E-400 into their routine. …

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Biohacker Summary

MembersWhat our biohacker panel says

The panel is split on vitamin E, the main ingredient in this product, and only a of the ten use or it. Two panelists take it, one through a daily multivitamin and one by giving his kids a little each day, and others it for skin cell , hair , or aging, with one preferring whole food or tocotrienol forms over plain alpha-tocopherol. …

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RAL Summary

MembersThe tier and why

The tier cites meta-analyses as as 20,655 people that are in the evidence given, and the studies given : the only long trial at this exact daily dose found kidney , one supporting review pooled antioxidants, and the contrast-dye come from short pre-procedure use. …

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More Details

MembersBody systems · Combine with · Possible side effects

Body systems: Urinary system, Cardiovascular system. Combine with and possible side are for members.

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Supplement Facts

Vitamin E 268 mg
Supplement Facts
Serving Size 1 Softgel
Servings Per Container 100
Amount Per Serving% Daily Value
Vitamin E (as d-alpha Tocopheryl Acetate)268 mg1787%

Other ingredients: Softgel Capsule [bovine gelatin (BSE-free), glycerin, water] and Organic Extra Virgin Olive Oil. Contains soy (Vitamin E from non-GMO soy). Not manufactured with yeast, wheat, gluten, milk, egg, fish, shellfish or sesame ingredients.

Directions: Take 1 softgel daily with a meal.

Label source: Nowfoods · Report a label change

Where to Buy

iHerb · Heb · Qfc
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Our articles on this subject

Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.