Puritan's Pride Milk Thistle Silymarin 4:1 Concentration Extract 250mg Review

Milk Thistle 250 mg 4:1 Extract from Puritan's Pride is listed as item 001946 and is sold as softgels. The page describes Milk Thistle as a spiky, purple flower that has been used in Greek practices for thousands of years. The product page states that the exceptional benefits of Milk Thistle are attributed to its antioxidant properties, which help to optimize health and well being. Milk Thistle has been traditionally used to help maintain healthy liver function. The page lists the feature points that it contains antioxidant properties, is traditionally used for healthy liver function, and contains up to a six-month supply of softgels. The product carries the labels Rapid Release and Gluten Free. Each serving size is one softgel, and the Supplement Facts panel lists Milk Thistle Extract at 250 mg from Silybum marianum seed, described as a 4:1 extract equivalent to 1,000 mg whole herb. The daily value is not established. Directions say adults can take one softgel once or twice daily, preferably with meals. The other ingredients are soybean oil, maltodextrin, gelatin, and vegetable glycerin, with less than 2 percent of paprika color and soy lecithin, and the label notes it contains soy ingredients and may vary in color and appearance over time. The label states no artificial flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no gluten, no wheat, no yeast, no fish, and it is sodium free. The warning advises pregnant or nursing women, people taking medications, or people with medical conditions to consult a doctor before use, and to avoid the product if allergic to ragweed or daisy-like flowers. It is not intended for persons under 18, should be kept out of reach of children, and stored at room temperature. Do not use if the seal under the cap is broken or missing. The page also offers purchase options: buy 1 get 2 free for 3 for $31.49, buy 2 get 4 free for 6 for $62.98, one-time purchase or subscribe to save with 5 percent off and free shipping on orders of $30 or more. The page also includes a section about Puritan's Pride, which says the company has helped families for more than 50 years and that its products are tested or inspected as many as 15 times during manufacturing.

Product Focus: Liver HealthAlso graded for:Gallbladder and Fat DigestionAlso covers:Digestion
Tier ⓘ
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Evidence ⓘ
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
Biohacker Mentions
Cost per month
$2

Study, Trial or Testing Result Summary

MembersHuman studies

Milk thistle is taken here at 500 milligrams a day, the lowest dose that in studies, though the label gives a 4 to 1 seed extract and does state how much silymarin, the active part, it contains. A 2025 review of 55 trials with 3545 people with liver injury found silymarin two main liver enzymes, with in drug or alcohol related liver disease. …

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Review Totals and Summary

Members889 reviews
889 reviews · Puritan's Pride website 543 · EBay 346

Across both stores, Puritan's Pride Milk Thistle Silymarin 4:1 Concentration Extract 250mg softgels have received a total of 889 ratings. The following themes are drawn from the written reviews that were visible on their respective product pages, noting that the Puritan's Pride website specifically highlighted that its themes reflected the eight reviews shown rather than the set of 543 ratings. …

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Biohacker Summary

MembersWhat our biohacker panel says

Doses came up a times: one suggested 200 to 400mg of silymarin, another 70 to 140mg taken 30 to 60 minutes before hot-cold contrast therapy, and another 200mg a day for allergy symptoms. Some pair it with NAC, vitamin C and water, and others take it around drinking or when exposed to toxins. …

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RAL Summary

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More Details

MembersBody systems · Combine with · Possible side effects

Body systems: Digestive system, Liver. Combine with and possible side are for members.

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Supplement Facts

Milk Thistle Extract 250 mg
Supplement Facts
Serving Size 1 Softgel
Servings Per Container none
Amount Per Serving% Daily Value
Milk Thistle Extract (Silybum marianum) (seed) (a 4:1 Extract, equivalent to 1,000 mg whole herb)250 mg†
† Daily Value not established.

Other ingredients: Soybean Oil, Maltodextrin, Gelatin, Vegetable Glycerin. Contains <2% of: Paprika (Color), Soy Lecithin. Contains soy ingredients.

Directions: For adults, take one (1) softgel once or twice daily, preferably with meals.

Label source: Puritan · Report a label change

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Our articles on this subject

Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.