Transparent Labs Creatine HMB Review
Transparent Labs Creatine HMB is presented as an evidence-based step forward for creatine supplementation, which the page says is well known to enhance muscle growth and athletic performance, including muscle endurance and strength. The formula combines creatine monohydrate, described as the most studied form of creatine, with beta-hydroxy-beta-methylbutyrate (HMB), a naturally occurring metabolite that the page says helps reduce muscle damage and muscle protein breakdown. Creatine HMB is also rounded out with BioPerine, an absorption enhancer, and vitamin D3 for comprehensive muscle recovery and support of lean tissue mass. The key ingredients listed are creatine monohydrate at 5,000 mg, myHMB at 1,500 mg, vitamin D3 at 12.5 mcg (500 IU), and BioPerine black pepper fruit extract at 5 mg. The page explains that BioPerine is a standardized extract containing a minimum of 95 percent piperine, so a small dose provides piperine comparable to a much larger amount of ground black pepper, and that it helps increase absorption of the creatine and HMB. The creatine monohydrate section cites the International Society of Sports Nutrition's view that creatine monohydrate is among the most effective ergogenic supplements available, and notes that combining it with resistance training can support performance, lean mass, strength gains, and recovery. The HMB section states that HMB may reduce muscle protein breakdown, accelerate regeneration of skeletal muscle after intense or prolonged exercise, and provide additive effects when combined with creatine. The product is sold as a flavored or unflavored powder in 30 and 60 serving sizes. Directions say to add one level scoop to a shaker with 10 to 12 ounces of cold water, shake until fully dissolved, and consume within 30 minutes after training, or take one scoop in the morning on rest days. The FAQ says cycling is unnecessary, loading is not recommended because of excess vitamin D intake, and one serving daily is the recommended approach. The page also states that the product is third-party tested and offers a 45-day satisfaction guarantee.
Study, Trial or Testing Result Summary
MembersHuman studies
2 of these 193 human studies gave the ingredient by drip or injection, not by mouth.
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Review Totals and Summary
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Biohacker Summary
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RAL Summary
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More Details
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Supplement Facts
Total Carbohydrates 1 g · Vitamin D 12.5 mcg (500IU) · Calcium 200 mg
| Calories | 10 | |
| Total Carbohydrates | 1 g | <1% |
| Vitamin D (as Cholecalciferol) | 12.5 mcg (500IU) | 63% |
| Calcium | 200 mg | 16% |
| Creatine Monohydrate | 5,000 mg | † |
| β-Hydroxy β-Methylbutyrate (HMB) (as patented myHMB® calcium β-Hydroxy β-Methylbutyrate monohydrate) | 1,500 mg | † |
| BioPerine® (Black Pepper Extract) (95% Piperine) (Piper nigrum) (fruit) | 5 mg | † |
Other ingredients: Citric Acid (920mg), Natural Flavors (700mg), L-Malic Acid (555mg), Stevia Extract (300mg), Beet Root Powder (for color) (40mg).
Label source: Vitacost · Report a label change
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Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.

