Bluebonnet Targeted Choice Wellness Support Review
Targeted Choice Wellness Support by Bluebonnet is a whole food-based formula positioned for immune defense support. The product is described as a wholesomely crafted immune defense formula that combines non-GMO nutrients with sustainably sourced herbal extracts. According to the product details, the blend includes vitamins A, C and D3, NAC, quercetin, zinc, andrographis, astragalus, elderberry, odor-less garlic, olive leaf, stinging nettle and turmeric. The supplement facts list vitamin A at 2500 IU (50 percent daily value), with half from beta-carotene and half from vitamin A palmitate. Vitamin C is supplied as calcium ascorbate at 500 mg, and vitamin D3 as cholecalciferol at 1000 IU. Zinc is provided as zinc bisglycinate chelate at 15 mg. Botanical extracts include andrographis stem and leaf extract 300 mg standardized to andrographolides, fresh garlic bulb extract 300 mg, turmeric root extract 150 mg, astragalus root extract 100 mg standardized to polysaccharides, elderberry fruit extract 100 mg in a 4:1 ratio, olive leaf extract 100 mg standardized to oleuropein, quercetin 100 mg, echinacea root extract 75 mg, bromelain 25 mg from pineapple, and stinging nettle leaf extract 25 mg in a 4:1 ratio. The suggested use is two caplets once daily, preferably with a meal or as recommended by a healthcare professional. Each container holds 30 servings. The label lists the product as soy-free, gluten-free, kosher, non-GMO, vegetarian friendly and dairy-free. It states that it contains no GMOs, milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, yeast, gluten, barley or sugar. Other ingredients are vegetable cellulose, vegetable magnesium stearate, stearic acid and vegetable glaze. Minerals are shown in their elemental value. Storage guidance says to keep the product in a cool, dry place and to use it only if the safety seal is intact. The 60 caplet size is listed at a one-time purchase price of $29.99, with a subscription option at $28.49 per delivery and free priority shipping on refills. The page notes HSA and FSA eligibility through Truemed, although the Truemed widget showed a loading error at the time of capture. Free standard shipping applies to US orders of $35 or more, and a 30-day return policy is listed. No customer reviews were posted on the page when it was captured.
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Study, Trial or Testing Result Summary
Members Only127 human studies · 46 improved
2 of these 127 human studies gave the ingredient by drip or injection, not by mouth.
This is a broad immune formula, and only a few of its ingredients come at doses studied for the thyroid. Zinc at the two-caplet serving is the best-supported ingredient. A pooled analysis found that adding zinc to meds raised active thyroid hormone, though certainty was low [1]. Other zinc trials were mixed, and one review called the evidence inconclusive [2][3][4]. Vitamin C at 500 mg lowered thyroid stimulating hormone in an open study of people on meds [5]. A larger placebo-controlled trial found no difference from placebo [6]. Vitamin D lowered thyroid antibodies in pooled trials of people with Hashimoto's [7], but another pooled analysis found no clear effect [8]. Vitamin A here is only a trace amount, far below the doses that helped in trials [9]. Turmeric is also well below the studied curcumin dose [10]. Garlic, astragalus, elderberry, quercetin and N-acetyl-cysteine have little or no direct human thyroid evidence [11][12][13][14][15]. Olive leaf and purple coneflower have been tested only in animals [16][17]. Animal and cell studies are never counted.
See all 127 studies →Hide the studies
- A pooled analysis of 114 observational studies found lower zinc in thyroid cancer tissue, but it did not test zinc supplements and is about cancer rather than thyroid health.Serum and tissue zinc in epithelial malignancies: a meta-analysis.
- In a pooled analysis of 35 trials with 3,508 people with underactive thyroid, adding zinc, magnesium and vitamin A to a med raised free thyroxine compared with placebo, though exercise combined with a med did best for thyroid-stimulating hormone and quality of life.Additional treatment strategies for hypothyroidism: a network meta-analysis.
- In a pooled analysis of 35 trials with 2828 people with Graves' disease, Astragalus injection was not among the Chinese medicines found to improve cure rates or thyroid hormone and antibody levels compared with Western medicine.Effect of traditional Chinese medicine on Graves' disease: a network meta-analysis.
- Across 12 trials with 862 people with Hashimoto's thyroiditis, vitamin D lowered thyroid antibody levels and raised thyroid hormones (FT3, FT4) compared with placebo or no treatment, with larger effects after more than 12 weeks.Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A …
- In a network analysis of 10 studies in people with Hashimoto's thyroiditis, six months of vitamin D alone did not significantly lower thyroid antibodies, while selenium did.Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.
- A pooled analysis of 32 observational studies found people with underactive thyroid had lower blood zinc than healthy people, but it did not test zinc supplements.Trace Element Status and Hypothyroidism: A Systematic Review and Meta-analysis.
- A pooled analysis of 10 observational studies found blood zinc was not significantly lower in people with thyroid cancer than in healthy controls.Zinc Status and Occurrence of Thyroid Cancer: Systematic Review and Meta-Analysis.
- A review of 11 studies found conflicting results for vitamin A supplements and thyroid cancer risk, so the evidence was inconclusive.Vitamin and mineral supplements and thyroid cancer: a systematic review.
- A review of 57 studies on micronutrients and thyroid hormones found trials did not confirm links between selenium, zinc and iron and iodine status, and concluded more research is needed; vitamin A was not singled out with a clear result.Micronutrients, iodine status and concentrations of thyroid hormones: a systematic review.
- A review of 67 studies on environmental factors and autoimmune thyroid disease linked vitamin D deficiency to the relationship and suggested vitamin D might help, but it did not test supplementation directly.Epidemiological and experimental evidence of environmental factor-related autoimmune thyroid disease: A systematic revie…
- A review of eight zinc supplementation studies and ten blood zinc studies found the evidence on whether zinc changes thyroid hormone levels inconclusive because results differed and came only from people with illness.Relation Between Zinc and Thyroid Hormones in Humans: a Systematic Review.
- A review of 13 trials in people with overweight or obesity found zinc raised free triiodothyronine, but this rested on one study in people with underactive thyroid and the overall effect on thyroid function could not be determined.The Effects of Zinc and Selenium Supplementation on Body Composition and Thyroid Function in Individuals with Overweight…
- A review of studies on trace elements and thyroid disease found few supplementation trials, but zinc supplementation lowered a marker of oxidative damage (malondialdehyde) in people with underactive thyroid.The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases.
- In 25,871 older adults taking 2000 IU of vitamin D daily for a median of 5.3 years, autoimmune diseases (including autoimmune thyroid disease, not reported separately) were 22% less frequent than with placebo.Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled tri…
- In 404 South African children aged 5 to 14 with low vitamin A and iodine, a 200,000 IU vitamin A dose given at the start and at 3 months over 6 months lowered thyroid-stimulating hormone, thyroglobulin and thyroid size when given without iodine, compared with placebo.Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and redu…
- In 278 adults with Graves' disease taking 2800 IU of vitamin D daily for up to 3 years, vitamin D did not improve remission; failure was 42% with vitamin D versus 32% with placebo.Effect of Vitamin D Supplementation on Graves' Disease: The DAGMAR Trial.
- In 164 people with cirrhosis given vitamin D for one year, thyroid-stimulating hormone and free T4 did not change compared with placebo, though vitamin D levels rose.Effect of Vitamin D Supplementation on Vitamin D Level and Bone Mineral Density in Patients With Cirrhosis: A Randomized…
- In 148 people having thyroid cancer surgery with neck dissection, calcium plus vitamin D cut symptomatic low calcium to 2.0% from 26.0% with no supplements.Prevention of postoperative hypocalcemia with routine oral calcium and vitamin D supplements in patients with differenti…
- In 140 older adults with sarcopenia, adding vitamin D to heat therapy and resistance exercise lowered inflammatory markers and raised thyroid hormone levels more than exercise and heat therapy alone.The effects of vitamin D combined with thermotherapy and resistance exercise on inflammatory factors, thyroid hormones a…
- In 138 Moroccan children with goiter and low vitamin A using iodized salt, 200,000 IU of vitamin A at start and 5 months over 10 months reduced thyroglobulin, thyroid-stimulating hormone and goiter rate compared with placebo.The effects of vitamin A deficiency and vitamin A supplementation on thyroid function in goitrous children.
- In 102 people with autoimmune thyroiditis, 500 mg of vitamin C daily for 3 months lowered thyroid antibody levels within the group, but there was no significant difference compared with placebo, and thyroid stimulating hormone did not change.Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyr…
- In 86 adults with underactive thyroid, 25,000 IU vitamin A twice weekly with zinc and magnesium for 10 weeks raised free thyroxine and lowered an inflammation marker compared with placebo, with no change in thyroid-stimulating hormone.Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stre…
- In 84 women, 25,000 IU of vitamin A daily for 4 months lowered thyroid-stimulating hormone in both obese and non-obese women and raised T3, while total T4 fell.The effect of vitamin A supplementation on thyroid function in premenopausal women.
- In 80 postmenopausal women with or without type 2 diabetes, 6 weeks of hormone therapy with vitamin C and E did not significantly change free thyroxine or triiodothyronine levels.Effects of hormone replacement therapy with vitamin C and E supplementation on plasma thyroid hormone levels in postmeno…
- In 75 adults with type 2 diabetes given 1000 IU of vitamin D daily in a yogurt drink for 12 weeks, thyroid antibodies and thyroid-stimulating hormone fell only when calcium was added, while vitamin D alone raised resting metabolic rate without changing thyroid measures.Daily intake of yogurt drink fortified either with vitamin D alone or in combination with added calcium causes a thyroid…
- In 68 overweight or obese women with underactive thyroid, 12 weeks of zinc alone or with selenium raised some thyroid hormones (free T3, and free T4 with lower TSH when combined with selenium), but there were no significant differences between groups for most measures.Effects of Zinc and Selenium Supplementation on Thyroid Function in Overweight and Obese Hypothyroid Female Patients: A …
- In 68 hemodialysis patients given 600 mcg daily of N-acetyl-cysteine, with or without selenium, for 12 weeks, reverse T3 fell compared with placebo, but free T3, free T4 and thyroid stimulating hormone did not differ between groups.Effects of Selenium and/or N-Acetyl-Cysteine Supplementation on Nonthyroidal Illness Syndrome in Hemodialysis Patients: …
- In 67 heart attack patients given N-acetylcysteine or placebo for 48 hours, N-acetylcysteine prevented the drop in T3 and lowered reverse T3, while free T4 and thyroid stimulating hormone were unchanged, and oxidative balance improved.N-acetylcysteine administration prevents nonthyroidal illness syndrome in patients with acute myocardial infarction: a r…
- In 62 very low birth weight infants, adding trace elements to fortified human milk raised zinc intake, but zinc deficiency was rare and the abstract reports no thyroid result.Nutrition of very low birth weight infants fed human milk with or without supplemental trace elements: a randomized cont…
- In 57 people with Graves' disease on methimazole, an antioxidant mix with beta-carotene, vitamins C and E and selenium over 60 days helped them reach normal thyroid function faster than the drug alone.Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and…
- In 57 people with Hashimoto's thyroiditis who followed an anti-inflammatory diet, 1320 mg a day of curcumin for 12 weeks lowered thyroid antibody levels more than placebo, but thyroid hormone differences between groups were not significant after adjustment.The Combined Effects of an Anti-Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in …
- In 55 people with Graves' disease taking methimazole, adding an antioxidant mix (vitamins C and E, beta-carotene and selenium) for 60 days helped them reach normal thyroid function faster than methimazole alone.The effect of antioxidant supplementation on superoxide dismutase activity, Cu and Zn levels, and total antioxidant stat…
- In 44 women with mildly underactive thyroid, 50,000 IU of vitamin D weekly for 12 weeks lowered thyroid-stimulating hormone and total cholesterol compared with placebo, while other thyroid hormones did not differ.Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical …
- In 43 adults with obesity given 600 mg of N-acetylcysteine daily for 8 weeks, a thyroid-related gene (DIO3) was less active in belly fat than with placebo, but other thyroid genes and blood thyroid hormone levels did not significantly change.Effects of N-acetylcysteine on the expressions of UCP1 and factors related to thyroid function in visceral adipose tissu…
- In 42 women with Hashimoto's thyroiditis, 50,000 IU of vitamin D weekly for 3 months reduced thyroglobulin antibody and thyroid-stimulating hormone versus baseline, but the drop in thyroid peroxidase antibody was not significant versus placebo and T3 and T4 did not change.Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, …
- In 42 newly diagnosed Graves' disease patients, adding selenium and vitamin D to standard antithyroid medicine for about 270 days lowered thyroid hormone levels faster and improved quality of life compared with medicine alone.Add-On Effect of Selenium and Vitamin D Combined Supplementation in Early Control of Graves' Disease Hyperthyroidism Dur…
- In 41 men with moderately high cholesterol, 7.2 g per day of aged garlic extract for 6 months lowered cholesterol and blood pressure; thyroid function was monitored but the abstract reports no thyroid effect.A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract an…
- In 40 people, a hydration drink that also contained vitamin C caused no meaningful change in safety or thyroid hormone measures compared with placebo over 4 weeks, though one thyroid hormone showed a statistically significant main effect.Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverag…
- In women with Hashimoto's thyroiditis taking a med, weekly vitamin D (50,000 IU cholecalciferol) for 3 months raised vitamin D levels, and inflammatory markers fell in both the vitamin D and placebo groups, so the drop was not shown to be due to vitamin D.Read the study on PubMed (36243929) →
- In 40 children with autoimmune thyroid disease, 12 weeks of 25 mg daily elemental zinc did not change thyroid antibodies, thyroid tests or oxidative stress, but children given zinc needed no increase in a med dose, while the standard-therapy group did.Effect of daily zinc supplementation for 12 weeks on serum thyroid auto-antibody levels in children and adolescents with…
- In people with hyperthyroidism and high blood calcium, adding 800 to 1,200 IU daily of vitamin D3 to standard treatment lowered thyroid hormone and thyroid antibody levels more than the antithyroid drug methimazole alone.Prevalence of hyperthyroidism with hypercalcemia in Xindu district and the efficacy of vitamin D3 treatment in these pat…
- In women with Hashimoto's thyroiditis, weekly vitamin D (50,000 IU cholecalciferol) for 3 months lowered the Th17/Tr1 immune cell ratio, but most other immune cell levels did not change compared with placebo.Effects of vitamin D supplements on frequency of CD4+ T-cell subsets in women with Hashimoto's thyroiditis: a double-bli…
- In 34 people with benign thyroid nodules, a combined spirulina, curcumin and Boswellia supplement over 12 weeks shrank nodules more than placebo (about 0.61 vs 0.18 square cm), though curcumin's effect alone cannot be separated.Treatment for benign thyroid nodules with a combination of natural extracts.
- In 31 critically ill trauma patients given selenium for 5 days, adding 13 mg zinc (with vitamin E) produced no additional change in thyroid hormones beyond selenium alone.Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial.
- In 28 overweight or obese adults on a calorie-restricted diet, 8 weeks of 25 mg daily zinc gluconate plus selenium did not change thyroid function compared with placebo.The Effects of Zinc and Selenium Co-Supplementation on Resting Metabolic Rate, Thyroid Function, Physical Fitness, and F…
- In 25 infants with congenital hypothyroidism, mild high blood calcium during thyroxine treatment was linked to vitamin D supplementation.Hypercalcemia in infants with congenital hypothyroidism and its relation to vitamin D and thyroid hormones.
- In 12 underactive thyroid patients needing high-dose a med, 1 g vitamin C daily for 16 weeks improved symptom scores and lowered thyroid stimulating hormone more than placebo after adjustment, but the very small size and baseline imbalances limit conclusions.Read the study on PubMed (41210509) →
- In a single-dose study of 12 healthy adults, a zinc-bound form of liothyronine (50 mcg) produced a lower but longer-lasting rise in blood T3 than standard liothyronine, with no tested health outcome.Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and C…
- In seven competitive cyclists, 22 mg of zinc daily for 30 days did not change thyroid hormone levels, although insulin rose later on.Plasma zinc, copper, and serum thyroid hormones and insulin levels after zinc supplementation followed by placebo in com…
- In a placebo-controlled trial of schoolchildren in India, a daily micronutrient-fortified drink for 14 months significantly changed thyroid-stimulating hormone compared with placebo, alongside improvements in vitamin D and other nutrients; this was a multi-nutrient product, so the vitamin D effect cannot be isolated.Effect of micronutrient supplement on health and nutritional status of schoolchildren: biochemical status.
- In hypothyroid newborns, giving vitamin D during the first 3 months of thyroxine treatment raised the rate of high blood calcium to 70%, compared with 21% in those not given vitamin D.[Prophylaxis of vitamin D deficiency in hypothyroidism in the newborn infant].
- In people with newly diagnosed Graves' disease taking anti-meds, nine months of 2,800 IU daily vitamin D reduced muscle strength gains and quality-of-life improvement compared with placebo.Effects of Supplemental Vitamin D on Muscle Performance and Quality of Life in Graves' Disease: A Randomized Clinical Tr…
- In 110 people with Down's syndrome given zinc for about a year, thyroxine was lower and thyroid-stimulating hormone higher than before treatment, so thyroid function did not improve.Thyroid function and plasma immunoglobulins in subjects with Down's syndrome (DS) during ontogenesis and zinc therapy.
- In 53 patients with mild underactive thyroid and 45 healthy people, vitamin C infused into the forearm artery normalized blood vessel dilation in patients but not in healthy people, suggesting oxidative stress from inflammation impairs vessel function; this was a short-term vessel test, not a supplement trial.Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis.
- In children with Down syndrome, zinc sulfate supplements restored plasma zinc, TSH and reverse T3 levels that had been abnormal, though the study duration was not stated.Modulation of the neuroendocrine system and immune functions by zinc supplementation in children with Down's syndrome.
- In 47 women with Hashimoto's thyroiditis and low vitamin D, 4000 IU daily for 6 months lowered thyroid antibody levels, with a larger drop in women also taking selenomethionine, and thyroid hormone levels did not change.Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto's thyroid…
- In 12 women with an underactive thyroid, a single 100,000 IU dose of vitamin D3 raised blood vitamin D less than in healthy women, and thyroid hormone replacement raised vitamin D levels; the study did not measure thyroid health improvement.Effect of vitamin D3 loading and thyroid hormone replacement therapy on the decreased serum 25-hydroxyvitamin D level in…
- In 34 women with Hashimoto's thyroiditis on a med and normal vitamin D, 2000 IU daily of vitamin D for 6 months reduced thyroid antibody levels compared with women not taking vitamin D.Read the study on PubMed (28073128) →
- In 18 overweight adults on a controlled diet for 7 days in a crossover design, elderberry juice raised blood thyroxine and thyroid stimulating hormone compared with placebo, with no change in thyroglobulin; in mice, elderberry powder did not significantly change thyroxine.A Preliminary Analysis of the Influence of Elderberry Juice Consumption on Thyroid Metabolism in Mice and Humans Fed Hig…
- In a small study of 11 iron-depleted women, ascorbic acid supplementation had no significant effect on their responses to cold exposure, which included changes in thyroid hormone levels.Thermogenesis and thermoregulatory function of iron-deficient women without anemia.
- In healthy young and elderly people, 10 days of vitamin A (retinol, 50,000 IU a day) did not significantly change thyroid-stimulating hormone levels compared with placebo.Effects of vitamin A administration on serum thyrotropin concentrations in healthy human subjects.
- In Down syndrome children with low blood zinc, zinc sulfate supplementation for 6 months lowered TSH from about 4.0 to 2.6 mIU/mL, bringing it to levels similar to children with normal zinc.Zinc sulfate supplementation improves thyroid function in hypozincemic Down children.
- In 186 vitamin D deficient people with Hashimoto's thyroiditis on Crete, taking 1200 to 4000 IU of vitamin D3 daily for four months lowered anti-thyroid peroxidase antibodies by 20.3% in an uncontrolled study; the drops in thyroglobulin antibodies and TSH were not significant.Is vitamin D related to pathogenesis and treatment of Hashimoto's thyroiditis?
- In 34 older adults over 6 months, a fruit, vegetable and berry powder that raised blood vitamin C was well tolerated and caused no thyroid-related safety problems, though a marker of protein damage fell before adjustment for baseline differences.Effects of a Commercial Fruit, Vegetable and Berry Juice Powder Concentrate on Metabolic Safety and Cardiovascular Healt…
- In 31 patients with underactive thyroid and gastritis, 500 mg vitamin C taken with a med for 2 months lowered thyroid stimulating hormone in all patients, normalized it in 55%, and raised thyroid hormone levels.Read the study on PubMed (24601693) →
- In a 3-month uncontrolled pilot of 15 adults with type 2 diabetes, powdered leaves of the Eugenia punicifolia plant, which contains quercetin compounds, were linked to lower TSH (a thyroid hormone), lower C-reactive protein and lower blood pressure, though there was no control group and the quercetin dose was not given.Eugenia punicifolia (Kunth) DC. as an adjuvant treatment for type-2 diabetes mellitus: a non-controlled, pilot study.
- In 10 sedentary young men, 4 weeks of oral zinc sulfate supplements prevented the drop in thyroid hormone levels that followed bicycle exercise, though zinc did not raise thyroid hormones at rest beyond the pre-supplement values.Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with ora…
- In 9 people with an underactive thyroid, about 4 months of thyroxine replacement cleared fats from the blood faster after a meal containing vitamin A and lowered LDL cholesterol, though this study did not test vitamin A as a supplement.Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism.
- In a non-randomized study of thyroid and parathyroid surgery patients with low vitamin D, weekly 50,000 IU vitamin D2 for 8 to 12 weeks raised vitamin D levels in most patients, but thyroid health itself was not measured.Vitamin D deficiency: a simple algorithm employing weekly administration of 50,000 IU of vitamin D.
- In hypothyroid people taking a med, 15 days of Meriva curcumin supplementation did not change thyroid function tests compared with before supplementation, so the curcumin did not interfere with thyroid replacement.Read the study on PubMed (30070343) →
- In a large cohort of over 566,000 adults followed for years, dietary beta-carotene intake was not clearly associated with thyroid cancer risk.The association between selenium and other micronutrients and thyroid cancer incidence in the NIH-AARP Diet and Health S…
- In 8,828 pregnant women, adequate vitamin D in early pregnancy was linked to higher free thyroxine and free triiodothyronine, and sufficient first-trimester with deficient second-trimester vitamin D was linked to lower thyroid-stimulating hormone.Associations between Dynamic Vitamin D Level and Thyroid Function during Pregnancy.
- In a survey of 5,878 US adults, higher vitamin C intake was linked to lower total thyroxine levels, with curved patterns for other thyroid hormone measures, so the effect on thyroid function is unclear.Association between vitamin C intake and thyroid function among U.S. adults: a population-based study.
- In 5,230 health-check adults, people with Hashimoto's thyroiditis had lower vitamin D levels than those without it, and lower vitamin D went with higher TSH and lower thyroid hormone levels; this association does not show cause.Correlation Between Hashimoto's Thyroiditis-Related Thyroid Hormone Levels and 25-Hydroxyvitamin D.
- In a large US national survey of 2,732 adults, dietary vitamin C intake was not significantly associated with risk of Hashimoto's thyroiditis, though higher omega-3 fat intake was linked to lower risk.Investigating the associations between dietary nutrient intake and risk of Hashimoto's thyroiditis: a cross-sectional st…
- In about 2,000 women in China, higher intake of garlic and onions was linked to a lower risk of thyroid nodules, though this observational link does not prove cause.Thyroid nodularity and chromosome aberrations among women in areas of high background radiation in China.
- Vitamin D deficiency was more common in people with Hashimoto's and non-autoimmune hypothyroidism than in healthy controls in a study of 1,138 people in Iran.Vitamin D deficiency in non-autoimmune hypothyroidism: a case-control study.
- In 933 German patients with autoimmune thyroiditis, those whose vitamin D rose to 75 nmol/l or above over about two years saw their thyroid antibody levels fall by 25%, compared with a 9% fall in patients whose vitamin D stayed low; this was not a randomized trial.Vitamin D Status and Thyroid Autoantibodies in Autoimmune Thyroiditis.
- Among 461 people with Hashimoto's thyroiditis and 176 healthy controls, vitamin D levels did not differ overall between the groups, though slightly lower levels were seen in people with overt hypothyroidism.Vitamin D and Hashimoto's Thyroiditis: Observations from CROHT Biobank.
- In 608 people newly diagnosed with papillary thyroid cancer, urinary zinc levels were not reported as linked to tumor aggressiveness; men had higher zinc than women.Associations between essential microelements exposure and the aggressive clinicopathologic characteristics of papillary …
- In a cross-sectional study of 401 men, 301 infertile and 100 controls, infertile men had lower vitamin D levels, and men with azoospermia also had higher thyroid stimulating hormone than the other groups, suggesting abnormal thyroid function; no supplement was given.25-Hydroxy cholecalciferol, anti-Müllerian hormone, and thyroid profiles among infertile men.
- In 387 middle-aged and older adults, red blood cell zinc was only weakly and negatively related to total T4 thyroid hormone levels.Basal metabolic rate and thyroid hormones of late-middle-aged and older human subjects: the ZENITH study.
- In 300 euthyroid people, low vitamin D was associated with a higher chance of thyroid autoimmunity, though this was a cross-sectional association and not a supplementation test.Latent autoimmune thyroid disease.
- In 256 surgical patients, vitamin D levels and deficiency rates were similar whether or not they had lymphocytic (Hashimoto's) thyroiditis, so no link was found.Is Vitamin D Deficiency Associated with Chronic Lymphocytic Thyroiditis?
- In 252 pregnant women with an underactive thyroid, having enough vitamin D during pregnancy was linked to better thyroid function up to a year after giving birth.Vitamin D categories and postpartum thyroid function in women with hypothyroidism.
- In a questionnaire survey of 232 Polish people with hypothyroidism, vitamin C was among the supplements commonly taken, but the survey did not measure whether it improved thyroid health.Dietary supplements in hypothyroidism.
- In 200 Iranian adults, a healthy dietary pattern that included garlic, along with vegetables and fruit, was linked to lower odds of an underactive thyroid, though garlic was not studied on its own.Associations between empirically derived dietary patterns and oxidative stress and inflammation in adults with primary h…
- In 190 people, those with autoimmune thyroid disease had more vitamin D deficiency than healthy controls, and low levels were linked to thyroid antibodies and abnormal thyroid tests; this was a cross-sectional study and cannot show cause.Vitamin D and autoimmune thyroid diseases.
- Women with chronic hair shedding had vitamin D and thyroid test levels similar to healthy controls.A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitami…
- In 78 people with subclinical hypothyroidism and 75 healthy controls in Iraq, vitamin D levels were not linked to thyroid peroxidase antibody levels or thyroid peroxidase gene variants. No supplement was given.Thyroid Peroxidase and its Gene Variants as Diagnostic Markers in Subclinical Hypothyroidism: Evidence from a Duhok Case…
- In a retrospective review of 130 people having thyroid surgery, serum zinc levels did not differ significantly between those with papillary thyroid cancer and those with benign disease; copper was higher in the cancer group.Copper as ancillary diagnostic tool in preoperative evaluation of possible papillary thyroid carcinoma in patients with …
- Women with Hashimoto's thyroiditis had vitamin D levels similar to healthy women, though vitamin D correlated with some metabolic measures.Assessment of Vitamin Concentrations in Patients with Hashimoto's Thyroiditis and Their Relationships with Thyroid Funct…
- A dietary survey of 103 schoolchildren in Adygea found insufficient intake of iodine, zinc, vitamin A and beta-carotene, and the authors concluded that low vitamin A and zinc intake may contribute to iodine deficiency and thyroid problems, but no supplement was tested.[Assessment of the structure and quality of nutrition as a factor that influences thyroid functional activity].
- In a cross-sectional study of 92 women with Hashimoto's thyroiditis, higher dietary vitamin C intake was weakly linked to lower thyroid antibody levels (r = -0.22, p = 0.05), but this was one of several correlations and does not show cause and effect.Parallel investigation of oxidative stress and nutritional profile in women with Hashimoto's thyroiditis.
- In 67 adults with an overactive or underactive thyroid, blood zinc levels showed no clear link to thyroid activity.Free amino acids, copper, iron and zinc composition in sera of patients with thyrometabolic diseases.
- In 31 children with congenital hypothyroidism on long-term thyroid hormone treatment, vitamin D levels were higher than in 29 healthy children, and bone breakdown was not increased.Congenital Hypothyroidism and Bone Remodeling Cycle.
- Vitamin D deficiency was common in both people with and without autoimmune thyroid disease, with no statistically significant difference between groups.Vitamin D deficiency in thyroid autoimmune diseases.
- In a study of 50 people, serum zinc was lower in thyroid cancer patients than in controls both before and after surgery, while zinc was higher in thyroid tissue; this study did not give zinc and so does not show an effect of zinc on thyroid health.Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients.
- In a retrospective review of 45 Chinese adults admitted with thyrotoxic periodic paralysis, about one quarter had normal red blood cell zinc levels; this was not a zinc supplement study.Thyrotoxic periodic paralysis in a Chinese population.
- In a case series of 22 surgical patients with low vitamin C or thiamin and raised TSH, two patients died from scurvy, and no vitamin C treatment effect on thyroid function was studied.Hypothyroidism Complicated by Vitamin C and Thiamin Deficiency in Surgical Patients.
- In 20 adults with acquired hypothyroidism, vitamin D metabolites and calcium-phosphorus measures were normal, and bone changes were linked to slowed bone activity; no vitamin D was given.[Bone effects of hypothyroidism in adults. Apropos of 20 cases].
- In a small clinic case series of 16 people, many with autism or Hashimoto's thyroiditis, quercetin supplements produced clinical differences in only two patients, and the study did not report doses or a control group.Importance of Using Epigenetic Nutrition and Supplements Based on Nutrigenetic Tests in Personalized Medicine.
- In patients with both diabetes and thyroid disorders, marked vitamin D3 deficiency was reported alongside disturbed blood sugar and mineral metabolism; the study does not give a clear sample size.[Mineral metabolism and metabolic markers in patients with concomitant endocrine disorders and vitamin D3 deficiency].
- Women with Hashimoto's thyroiditis had vitamin D levels similar to or higher than healthy controls, and no women with the condition were vitamin D deficient, so Hashimoto's was not linked to more deficiency.HASHIMOTO THYROIDITIS NOT ASSOCIATED WITH VITAMIN D DEFICIENCY.
- In people with type 2 diabetes, correcting vitamin D deficiency did not change thyrotropin (TSH) levels, which were only slightly higher in those with deficiency.Vitamin D and thyrotropin in type 2 diabetic patients.
- This study tested a zinc measurement kit and found red blood cell zinc was lower in Graves' disease than in silent thyroiditis, helping tell the two apart; it did not test any supplement.Measurement of red blood cell zinc concentration with Zn-test kit: discrimination between hyperthyroid Graves' disease a…
- In a 1977 study, people with overactive thyroid excreted more zinc in urine than healthy people, and the extra loss tracked with how severe the thyroid-driven metabolic response was; no supplement was tested.Zinc metabolism and thyroid status.
- In 49 people with an underactive thyroid, 1,25-hydroxyvitamin D3 did not change TSH in those not on meds, but significantly raised basal TSH in those taking a med.[TSH secretion stimulated by thyroliberin in patients with hypothyroidism receiving 1,25-hydroxyvitamin D3].
- Five infants aged 8 to 11 months developed yellow skin from eating large amounts of carotene-rich foods, and their thyroid function tests were normal; stopping those foods cleared the yellow color, and the authors described the condition as benign.Benign carotenemia in children.
- This study compared ways of adding lab tests, including vitamin D and thyroid hormone tests, to diagnose deficiency and thyroid disorders. It did not test any vitamin D supplement's effect on thyroid health.Reflex and reflective testing: efficiency and effectiveness of adding on laboratory tests.
- In male rabbits fed garlic extract at 100 mg per kg of diet for 8 weeks, thyroid hormone levels rose along with liver antioxidant activity and semen quality; this was an animal study.Amelioration of sperm fertilizability, thyroid activity, oxidative stress, and inflammatory cytokines in rabbit bucks tr…
- In rats with methimazole-induced underactive thyroid, quercetin at 10 or 25 mg per kg daily for 8 weeks reduced oxidative stress markers in the liver, kidney, and blood.Effects of quercetin on oxidative stress biomarkers in methimazole - induced hypothyroid rats.
- In rats with thyroxine-induced high thyroid hormone levels, a seaweed extract containing quercetin among other compounds lowered thyroid hormones and inflammatory markers, but the abstract does not isolate quercetin's effect.The possible role of the seaweed Ulva fasciata on ameliorating hyperthyroidism-associated heart inflammations in a rat m…
- In male rats given a food pigment that harmed the seminal vesicles, aged garlic extract at 2 ml per kg did not change thyroid hormone levels but reduced tissue damage and oxidative stress; this was an animal study.Impact of titanium dioxide on androgen receptors, seminal vesicles and thyroid hormones of male rats: possible protectiv…
- In rats given a fish oil and garlic supplement for 12 months, thyroid function stayed within normal range compared with placebo, while triglycerides and LDL cholesterol were lowered; this was an animal study.Acute and chronic toxicity study of fish oil and garlic combination.
- In rats exposed to 3.5 GHz radiofrequency radiation for 30 days, quercetin at 20 mg per kg showed trends toward reversing thyroid hormone and oxidative stress changes, but most effects were not statistically significant.Protective effects of quercetin against 3.5 GHz RF radiation-induced thyroid dysfunction and oxidative stress in rats.
- In rats exposed to a fluorinated industrial chemical, quercetin given daily for 4 weeks eased heart muscle damage, but the abstract does not report a thyroid benefit from quercetin.Structural and molecular changes in the rat myocardium following perfluoroctane sulfonate (PFOS) exposure are mitigated …
- In rats made hyperthyroid with thyroxine, garlic bulb extract at 500 mg per kg per day lowered elevated thyroid hormones and blood glucose, with effects comparable to a standard antithyroid drug; this was an animal study.Mitigation of thyroxine-induced hyperglycaemia by two plant extracts.
- In diabetic rats given a garlic-derived compound for 45 days, blood glucose and HbA1c fell, thyroid hormone and TSH levels and antioxidant levels rose; this was an animal study.Antidiabetic effect of S-allylcysteine: effect on thyroid hormone and circulatory antioxidant system in experimental dia…
- In male rats given different garlic preparations for one month, thyroid hormones rose in some groups, while testosterone fell in all garlic groups; this was an animal study.Effect of Different Garlic Preparations on Testosterone, Thyroid Hormones, and Some Serum Trace Elements in Rats.
- In male rats exposed to a weedkiller, garlic extract at 10 mg per kg, alone or with silymarin, restored thyroid hormone balance, improved liver enzymes, and reduced oxidative damage; this was an animal study, not a human trial.A combination of silymarin and garlic extract enhances thyroid hormone activation and body metabolism in orally intoxica…
- In male rats fed cholesterol and garlic oil for 12 weeks, garlic did not change circulating thyroid hormone levels or thyroid radioiodine uptake, though it controlled cholesterol-induced high lipids; this was an animal study.Hypolipidemic effect of garlic and thyroid function.
- In rats, quercetin treatment for 14 days lowered thyroid-related gene activity and reduced radioactive iodine uptake by the thyroid, suggesting it can disrupt thyroid function and calls for caution with supplements.The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function.
- In rats with methimazole-induced underactive thyroid, quercetin at 10 or 25 mg per kg daily for 60 days reversed the rise in lipid peroxidation and the fall in antioxidant enzymes in platelets and reduced platelet clumping.Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
- In rats with thyroxine-induced high thyroid hormone levels, quercetin given daily for 14 days at doses of 5 to 100 mg per kg lowered thyroid hormones and oxidative stress and restored antioxidant levels, with the liver protected via a cellular antioxidant pathway.Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway.
- In male rats given cyclophosphamide, quercetin given every other day for 7 days raised serum thyroid hormone levels and reduced oxidative stress and inflammation in the liver and kidney; this was an animal study, not a human trial.Cyclophosphamide instigated hepatic-renal oxidative/inflammatory stress aggravates immunosuppressive indoleamine 2,3-dio…
- In iodine-deficient pregnant rats, quercetin at 150 mg per kg daily throughout pregnancy, combined with beta-sitosterol, improved brain development and tissue structure in their pups.β-Sitosterol & quercetin enhances brain development in iodine deficient rat models.
Review Totals and Summary
Members Only14 reviews · 100% positive
Direct customer feedback on this product was sparse in what I could access. Most retailer listings showed no reviews, and some Walmart listings showed only seller ratings. The reactions I found fall into a few themes. The clearest comes from a shopper on the Village Green Apothecary site, who said the product works for what they need and thanked the store for stocking it. They noted it is "almost impossible to find anywhere nowadays." That points to a loyal repeat-buyer base and to frustration with availability. That comment sits in a store-wide testimonial widget, though, so I can't confirm it was written about this exact product. Beyond that, the useful signal comes from feedback on Bluebonnet's other caplet products on iHerb, which is only indirect evidence. Customers there consistently praise the brand's clean, allergen-free ingredient lists and its glass bottles. They also like the brand's kosher certification and its reasonable price for the dose. Reviewers describe feeling the benefits, for example better sleep or fewer cramps with the mineral products, and they appreciate that the products don't upset the stomach. The recurring complaint is caplet size. Some reviewers of the calcium-magnesium-potassium caplets found them too large to swallow comfortably. That is relevant here because this formula needs two caplets per serving and packs many ingredients. Other complaints on related products are about potency or form choices, such as wanting a lower dose, and about a few people noticing no benefit or getting headaches. For this immune formula, I'd expect similar themes, but I haven't confirmed them with reviews of this product. Likely positives are the broad herbal and nutrient range and the clean label. Likely negatives are the price per serving, at about $0.58 to $1.95 depending on retailer, the two-caplet dose, and uneven stock. Anyone who needs real customer feedback should read the reviews on the Amazon listing directly.
Biohacker Summary
Members Only9 of 10 recommend it
Zinc gets a mostly favorable view from the panel: three of the ten recommend it, four say they use it, and the rest are neutral or cautious. People take it for immune support, wound and tissue healing, gut lining support (as zinc carnosine), hormone support, and longevity, and one also mentions possible help with sleep. The only dose given as a daily habit is 15 mg in the morning, while one panelist describes a much larger short course taken for one week before surgery and two weeks after to help wound healing, and that one carries a warning. Pairings include vitamin C, which zinc is said to help the body absorb, and magnesium, and one panelist uses zinc in a sunscreen rather than as a supplement. Vitamin D is a smaller ingredient in this product and is widely praised by the panel, often taken in the morning or with fat.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Zinc · recommends
- Recommends zinc as a trace mineral, noting that modern farming practices deplete it from the soil, leading to low levels in crops.
- Lists Vitamin D as an ingredient found in sardines.
- Mentions that the body relies on healthy fats to absorb essential vitamins like A, D, E, and K, which help support skin health, moisture, and normal cell function.
- Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
- Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Notes that white spots on nails point to zinc deficiency, which is usually depleted by eating sugar and refined carbs.
- States that zinc greatly supports natural killer cells.
- Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- Suggests that increasing vitamin D3 may help address the underlying problem of bruxism.
- Recommends garlic, explaining that crushing it releases allicin, which activates fat burning in the liver and significantly reduces liver enzymes.
Dr. Rhonda Patrick · Zinc · neutral
- Mentions that getting too little zinc may play a role in declining testosterone levels, and that zinc helps the body make testosterone.
- Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
- States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
- Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Rhonda's current diet includes a homemade salad dressing made with avocado, garlic, apple cider vinegar, and olive oil.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
Andrew Huberman · Zinc · neutral
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- Makes it a point to ingest a 600 milligram capsule of garlic anytime they take Alpha-GPC to offset potential increases in TMAO.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- He suggests taking 600 milligrams of garlic, which contains allicin, to inhibit TMAO production, especially when taking Alpha GPC regularly, and notes that garlic capsules are inexpensive and don't cause bad breath.
Ben Greenfield · Zinc · warns
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- Advises patients to stop turmeric before surgery because it can act as a med or antiplatelet agent.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
- Mentions vitamin C as part of a bare-minimum protocol.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Mentions Astragalus as one of the Chinese herbs used, noting its potential in decreasing the rate at which telomeres shorten.
- Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
- He mentions zinc as a supplement with real human data behind it for male fertility.
- Zinc may support both testosterone and sperm count.
Dr. Mark Hyman · Zinc · neutral
- Explains that zinc is important for the body's repair crew, helping to heal damaged tissue, and a deficiency can lead to cuts and wounds taking longer to heal.
- Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
- Included turmeric in their chicken dish as an anti-inflammatory power couple with ginger.
- Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Recommends garlic as a fibrous food to heal the gut.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
Thomas DeLauer · Zinc · uses
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Recommends quercetin from food sources like capers and red onions, stating it inhibits the xanthine oxidase enzyme that produces uric acid.
- Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recently started taking turmeric for their joints, specifically for knee issues, as it helps support recovery, especially after a workout.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Mentions that Dose Daily contains turmeric, which contributes to its positive impact on liver enzyme levels.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
Dave Asprey · Zinc · uses
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Recommends taking vitamin C for better skin health.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends Bromelain, stating it supports healthy circulation.
- Likes garlic but notices their brain feels less sharp when they eat a lot of it, even tracking the effect with EEG, and advises using it strategically, especially if it affects cognition.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- Host Dave Asprey separates what the human data actually supports regarding raw garlic, modest blood pressure and cholesterol effects, real antimicrobial properties, and a genuine bleeding-risk caution for anyone on meds, from the unproven parasite-cleanse and brain fog claims driving the trend online.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
Siim Land · Zinc · recommends
- States that deficiencies in nutrients such as zinc can impair normal immune regulation.
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Recommends Aged garlic extract for blood pressure and cholesterol, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Aged garlic extract as one of 15 supplements backed by human studies.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Mentions quercetin as a phytochemical that has been shown to stimulate GLP-1 expression directly, and also increase glucose uptake and insulin sensitivity.
- Lists liver and carrots as sources of Vitamin A.
- Says garlic is an old food with health benefits, especially good for lipids and the immune system.
- Says garlic has benefits for the immune system and the cold, and advises crushing or chopping it and letting it sit for 10 minutes before heating or eating it to preserve its health benefits.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
Bryan Johnson · Zinc · uses
- Takes 15 mg of Zinc in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Uses garlic as part of their breakfast.
- Eats garlic for breakfast.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 15 mg of Zinc in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
Peter Attia · Zinc · recommends
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Peter Attia's brand, AVIA Skincare, incorporates Ayurvedic wisdom, including turmeric and other Eastern botanicals, for anti-inflammatory care.
RAL Summary
Members OnlyTier 4 for Thyroid Health
Human studies give some support to zinc, vitamin C and vitamin D at the doses in this product, but the results are mixed [1][6][8]. With only 24 reviews, the product cannot rank higher than emerging.
Take 2 servings a day (4 caplets) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 61 of the 127 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Immune system
Combine with: Bluebonnet Targeted Choice Wellness Support is a thyroid-oriented formula, though the label ingredient list was not itemized here, so this assumes a typical thyroid-support profile (iodine/tyrosine, selenium, zinc, and possibly ashwagandha or other botanicals). To complement it, consider additional selenium (selenomethionine, 100-200 mcg total daily) for T4-to-T3 conversion and antioxidant protection, zinc (15-30 mg) with copper balance, and vitamin D3 with K2, since low vitamin D is common in thyroid disorders. Iron (only if ferritin is low) and B12 support energy and are often depleted in hypothyroidism. Magnesium glycinate aids relaxation and sleep, and omega-3 fish oil supports inflammatory balance. Avoid excess iodine or kelp on top of this product, especially with autoimmune thyroiditis (Hashimoto's or Graves'). Separate calcium, iron, and magnesium from meds by at least 4 hours, and biotin can interfere with thyroid lab tests, so pause it before testing. Consult a healthcare provider if on meds.
Possible side effects: In the studies, vitamin D given to newborns with an underactive thyroid raised the risk of high blood calcium, and one large survey linked high vitamin C from food to a higher thyroid cancer risk. No written reviews of this product were read.
Supplement Facts
Vitamin A 563 mcg · Vitamin C 500 mg · Vitamin D3 25 mcg
| Vitamin A | 563 mcg | |
| Vitamin C | 500 mg | |
| Vitamin D3 | 25 mcg | |
| Zinc | 15 mg | |
| Andrographis leaf extract | 300 mg | † |
| fresh Garlic bulb extract | 300 mg | † |
| N-Acetyl-Cysteine | 200 mg | † |
| Turmeric root extract | 150 mg | † |
| Astragalus root extract | 100 mg | † |
| Elderberry fruit extract | 100 mg | † |
| Olive leaf extract | 100 mg | † |
| Quercetin | 100 mg | † |
| Echinacea root extract | 75 mg | † |
| Bromelain | 25 mg | † |
| Stinging Nettle leaf extract | 25 mg | † |
Other ingredients: Vegetable Cellulose, Vegetable Magnesium Stearate, Stearic Acid, Vegetable Glaze.
Directions: Directions: As a dietary supplement, take two caplets once daily, preferably with a meal or as directed by a healthcare practitioner.
Barcode (UPC) 743715020023 · Label source: NIH label database · Report a label change
Other sizes and barcodes: 30 Caplet(s), UPC 7 43715 02000 9 (on market)
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- What Supplements and Vitamins Should Not Be Taken TogetherArticle · Sep 7, 2026
- Supplement Redundancy: How to Find the Ingredients You Are Taking Twice, and Why It MattersArticle · Oct 13, 2026
Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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