California Gold Nutrition Defender 4 Review

California Gold Nutrition Defender 4 is a supplement with vitamins and minerals sold as 180 veggie capsules. The product page lists its overview as California Gold Nutrition Defender 4, with Vitamins C and D, Zinc, and Selenium, with immune system support. It is formulated without gluten, GMOs, or soy, is produced in a 3rd party audited cGMP registered (certified) facility, and is suitable for vegetarians. The page states that Defender 4 is formulated with a combination of four clinically-studied vitamins and minerals to help promote a healthy immune system. The product is listed as first available 04/2025, with a shipping weight of 0.43 lb, product code CGN-02546, UPC 898220025466, and package quantity of 180 count. Dimensions are 5.3 x 2.8 x 2.8 in. The suggested use is to take 1 capsule daily, with food, and the page advises use as directed by a qualified healthcare professional. The supplement facts list a serving size of 1 capsule and 180 servings per container. Vitamin C (as Ascorbic Acid) provides 500 mg, 556% Daily Value. Vitamin D (as D3, Cholecalciferol) provides 25 mcg (1,000 IU), 125% DV. Zinc (as Zinc Picolinate) provides 10 mg, 91% DV. Selenium (as L-Selenomethionine) provides 50 mcg, 91% DV. Other ingredients are modified cellulose (hypromellose veggie capsule), microcrystalline cellulose, magnesium stearate, and silicon dioxide (silica). The page states the product is not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten, and is produced in an FDA-registered, third-party audited, cGMP-compliant facility that may process other products containing these allergens. It is manufactured and quality tested in USA with globally sourced ingredients. Key info lists certifications as halal, gluten-free, and soy-free, and quality standards as GMP. Warnings advise keeping out of reach of children and consulting a healthcare professional if pregnant or lactating, chronically ill, elderly, under 18, taking meds such as meds, or with a diagnosed medical condition. The seal should be intact, and the product should be stored in a cool, dry place away from heat, light, and moisture.

Tier ⓘ
Tier 3 · Rank 11
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 11 within Tier 3 for Immune Health; 39 of 87 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
77 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
98% of 205,744
Biohacker Mentions
10 of 10
Cost per month
$5 at 2 servings

Study, Trial or Testing Result Summary

Members Only152 human studies · 59 improved

3 of these 152 human studies gave the ingredient by drip or injection, not by mouth.

152 human studies59 improved50 no effect86,453 people studied

Vitamin C at this full dose has modest support. Across 29 trials, colds were not less common in the general public, but they were about 8% shorter in adults and 14% shorter in children, and about half as common in marathon runners, skiers and soldiers [1]. Another pooled analysis found a 4% lower risk of respiratory infections and 9% shorter symptoms [2]. A review of eight reviews concluded vitamin C does not prevent colds [3]. Zinc at a full dose did not prevent colds, but colds were about 2.4 days shorter when it was used as treatment [4]. Vitamin D reaches the studied dose only at two capsules a day. Its results are mixed. A pooled analysis found about 12% lower odds of respiratory infection, mostly in very deficient people [5]. Large trials found no benefit, including 15,804 older adults taking 2,000 international units daily [6] and 2,157 adults aged 70 or older [7]. Selenium at a full dose did not substantially change antibodies or white blood cells in healthy people. The only benefit was higher natural killer cell activity, and those results were inconsistent [8]. Animal and cell studies are never counted.

See all 152 studies →Hide the studies

Review Totals and Summary

Members Only205,744 reviews · 98% positive
205,744 reviews · IHerb 188,001 · EBay 17,457 · Vitacost 286
98% positive1% neutral1% negative

California Gold Nutrition Defender 4 enjoys an overwhelmingly positive reception from customers, with 100% of star-rated reviews giving it 4 or 5 stars across approximately 205,744 ratings. Buyers consistently express satisfaction with this supplement. **What it did for them** Customers primarily highlight the product's effectiveness in supporting their immune system and overall daily wellness. Many consider it a comprehensive solution for their vitamin needs, noting that it "contains all 4 essential vit to boost immune." Reviewers frequently describe it as a "good immune booster" and state that it "performs exactly as expected," contributing to their general health and efficiency. Some users find it to be "all I need for my daily vitamins." **What they complain about** Based on the provided customer feedback, there are no complaints regarding the product's performance, quality, or any other aspect. All reviews were positive, indicating a high level of satisfaction among buyers. **Taste or smell or pill size or form** Customers generally find the product convenient to use. The pill size is often described as manageable, with one reviewer noting the "size is good." The overall experience of taking the supplement is positive, with comments like "It is easy to use." Additionally, the product's presentation is appreciated, as some mention that the "packaging was well done." **Value for money** While not explicitly detailing price points, the consistent positive feedback and intent to repurchase strongly suggest customers perceive good value. Many buyers express high satisfaction with the "Very good quality" of the product and the brand itself. The sentiment of "I would definitely consider purchasing it again" and strong recommendations from repeat buyers imply that the benefits outweigh the cost for them. **Who it seems to suit and who it did not** This supplement appears well-suited for individuals looking for a daily vitamin regimen that specifically targets immune support. It appeals to those who appreciate a product that is "easy to use" and offers "good quality." Given the entirely positive feedback, there is no indication from these reviews as to who the product might not suit.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

The panel has no single main ingredient for this product, since every ingredient is a smaller ingredient here, so the paragraph covers the four that came up most. Vitamin D drew the most attention: nearly all ten panelists mentioned it, and most recommend it or take it themselves. They cite immune health, mood, muscle, sperm health and general health or longevity, and one takes 5000 IU in the morning, while another says it is not worth taking unless you are deficient. Zinc was recommended by about half the panel for testosterone, sperm health, immunity and mood, with doses of 15 milligrams for longevity and 30 milligrams for sperm health when preparing for IVF, and one uses a gut-lining form called zinc carnosine. Vitamin C was recommended or used by a few for detox, inflammation and skin, and selenium was a smaller ingredient in this product that three panelists mentioned for thyroid and glutathione support. Pairings named were vitamin K2 with vitamin D, and one panelist advises taking vitamin D on days apart from liver, with no one saying they stopped.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin D · warns
    • 2 Nov 2026 · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 31 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
    • 25 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
    • 24 Oct 2026 · neutral · YouTube ↗
      States that a lack of vitamin D can potentially cause achy bones or crashing mood.
    • 24 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
    • 24 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends Vitamin C as a cofactor, especially for collagen.
    • 23 Oct 2026 · recommends · YouTube ↗
      States that vitamin D is intimately involved in the immune system and recommends taking at least 10,000 IUs each day.
    • 23 Oct 2026 · Zinc · recommends · YouTube ↗
      Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
  • Dave Asprey · Vitamin D · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 9 Oct 2026 · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Zinc · uses · YouTube ↗
      Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
    • 3 Sep 2026 · recommends · YouTube ↗
      States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
    • 3 Sep 2026 · Zinc · recommends · YouTube ↗
      Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
    • 3 Sep 2026 · Selenium · recommends · YouTube ↗
      Emphasizes the importance of having enough selenium before trying advanced longevity strategies like peptides.
    • 1 Sep 2026 · Zinc · recommends · YouTube ↗
      Suggests that zinc has better safety and protective data than meds for reducing cardio respiratory risk.
    • 29 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
    • 20 Aug 2026 · Selenium · warns · YouTube ↗
      Warns that too much selenium increases cancer risk, becomes a toxin, and gets sequestered in tumors.
  • Siim Land · Vitamin D · recommends
    • 31 Oct 2026 · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 24 Oct 2026 · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 30 Sep 2026 · Vitamin C · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks vitamin D has some of the strongest evidence and is worth considering.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
    • 6 Sep 2026 · Vitamin C · neutral · X ↗
      Notes that Vitamin C is one of several supplements with human evidence.
    • 26 Aug 2026 · recommends · Instagram ↗
      Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
    • 23 Aug 2026 · neutral · X ↗
      Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
    • 17 Aug 2026 · recommends · X ↗
      Recommends taking Vitamin D in the morning or at lunch with fat.
    • 14 Aug 2026 · neutral · X ↗
      Notes that Boron improves vitamin D.
    • 5 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
  • Andrew Huberman · Zinc · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Zinc carnosine to support and improve the lining of your gut.
    • 26 Oct 2026 · uses · YouTube ↗
      Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 19 Oct 2026 · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 12 Oct 2026 · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 28 Sep 2026 · uses · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
    • 21 Sep 2026 · uses · YouTube ↗
      States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 14 Sep 2026 · uses · YouTube ↗
      Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
    • 31 Aug 2026 · uses · YouTube ↗
      AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
    • 24 Aug 2026 · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
    • 17 Aug 2026 · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 7 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 20 Jul 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · Vitamin D · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
  • Ben Greenfield · Zinc · warns
    • 29 Oct 2026 · warns · YouTube ↗
      Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Selenium · recommends · YouTube ↗
      Recommends taking sufficient selenium to ensure free T3 levels are right, which is important for the reverse calcium transport system.
    • 10 Oct 2026 · recommends · YouTube ↗
      Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
    • 24 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 19 Sep 2026 · recommends · YouTube ↗
      Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
    • 19 Sep 2026 · neutral · Podcast ↗
      He mentions zinc as a supplement with real human data behind it for male fertility.
    • 8 Sep 2026 · neutral · X ↗
      Zinc may support both testosterone and sperm count.
    • 25 Aug 2026 · Vitamin C · neutral · X ↗
      Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
    • 20 Aug 2026 · Vitamin D · uses · YouTube ↗
      Has been taking Vitamin D3 K2 for over a decade.
  • Dr. Mark Hyman · Vitamin D · recommends
    • 26 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 8 Oct 2026 · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
    • 7 Oct 2026 · Vitamin C · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
    • 7 Oct 2026 · Zinc · uses · YouTube ↗
      Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
    • 6 Oct 2026 · Vitamin C · neutral · X ↗
      Mentions that what they do when a cold comes on is not just vitamin C.
    • 5 Oct 2026 · neutral · Podcast ↗
      Mentions vitamin D as a key nutrient for supporting immune function.
    • 5 Oct 2026 · recommends · YouTube ↗
      States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
    • 5 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
  • Thomas DeLauer · Vitamin C · recommends
    • 26 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Zinc · uses · YouTube ↗
      Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 8 Oct 2026 · Zinc · recommends · Facebook ↗
      Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 8 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · Vitamin D · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
    • 4 Oct 2026 · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 4 Oct 2026 · Selenium · recommends · YouTube ↗
      Recommends adding selenium to the diet, found in Brazil nuts (two or three a day), eggs, shellfish, and mushrooms, as the glutathione recycling process is very selenium dependent and it helps protect against feroptosis.
    • 3 Oct 2026 · Zinc · neutral · YouTube ↗
      Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 29 Sep 2026 · Vitamin D · uses · YouTube ↗
      Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
  • Bryan Johnson · Vitamin D · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 3 Jul 2026 · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 4 May 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 14 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 14 Apr 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning.
    • 8 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 7 Apr 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 2 Apr 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 3 Feb 2025 · Vitamin C · neutral · YouTube ↗
      Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
  • Dr. Rhonda Patrick · Vitamin D · neutral
    • 5 Oct 2026 · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 29 Sep 2026 · Zinc · recommends · YouTube ↗
      Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 28 Sep 2026 · Zinc · recommends · YouTube ↗
      Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
    • 24 Sep 2026 · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 21 Aug 2026 · Zinc · neutral · Instagram ↗
      Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
    • 22 Jul 2026 · neutral · YouTube ↗
      Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
    • 26 Jun 2026 · recommends · Facebook ↗
      Recommends Vitamin D, explaining that it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity.
    • 15 Jun 2026 · neutral · Instagram ↗
      Combining omega-3s with vitamin D and exercise has an additive effect, translating to ~3 months of slowed biological aging.
    • 11 Jun 2026 · neutral · Facebook ↗
      The effect got stronger when omega-3 was combined with vitamin D and resistance training, with the full stack delaying phenotypic aging by about 3.8 months.
  • Peter Attia · Vitamin D · uses
    • 4 Jan 2026 · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 4 Jan 2026 · Zinc · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 16 Nov 2025 · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 16 Nov 2025 · Selenium · neutral · YouTube ↗
      Notes that several studies show patients taking selenium can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 6 Aug 2025 · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 3 Aug 2025 · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 10 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 6 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
    • 3 Jul 2025 · Vitamin C · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 29 Jun 2025 · Vitamin C · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
    • 8 Jun 2025 · recommends · YouTube ↗
      Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
    • 17 Mar 2025 · neutral · Instagram ↗
      Discusses evaluating vitamin D, understanding deficiency, and optimal levels.

RAL Summary

Members OnlyTier 3 for Immune Health

The tier rests on a misreading of the vitamin D evidence: 19 of 52 studies improved and 21 showed no effect, and the largest trials found no benefit, so it is not a clear improvement. So it is graded Tier 3, lower than the rules alone gave.

Take 2 servings a day (2 capsules) to match the dose that worked in the studies.

Where the evidence disagrees: 50 of the 152 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Immune system, Respiratory system

Combine with: To further enhance immune system support, consider combining this product with probiotics to bolster gut health, which is intrinsically linked to immune function. Additionally, elderberry extract can provide further antiviral and immune-modulating benefits, especially during seasonal challenges. Quercetin, a powerful flavonoid, can also be a valuable addition due to its antioxidant and anti-inflammatory properties, working synergistically with Vitamin C to support immune cell function.

Possible side effects: Zinc caused more mild side effects in cold trials. Selenium side effects were similar to placebo in thyroid trials.

Supplement Facts

Vitamin C 500 mg · Vitamin D 25 mcg · Zinc 10 mg
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 60
Amount Per Serving% Daily Value
Vitamin C (as Ascorbic Acid)500 mg556%
Vitamin D (as D3, Cholecalciferol)25 mcg125%
Zinc (as Zinc Picolinate)10 mg91%
Selenium (as L-Selenomethionine)50 mcg91%

Other ingredients: Modified Cellulose (Hypromellose Veggie Capsule), Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide (Silica). Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in an FDA-registered, third-party audited, cGMP-compliant facility that may process other products that contain these allergens or ingredients. Manufactured and quality tested in USA with globally sourced ingredients.

Directions: Take 1 capsule daily, with food. Best when taken as directed by a qualified healthcare professional.

Barcode (UPC) 898220025466 · Label source: Vitacost · Report a label change

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Graded October 24, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.