DNA Dynamic Nutritional Associates Dynagesic Review
Dynagesic is a dietary supplement from DNA Dynamic Nutritional Associates, listed in the Dietary Supplement Label Database with DSLD ID 337276. The product is sold as a capsule, with net contents of 60 capsules and a market status of On Market. The label was entered into the database on 22 August 2025, and the source is listed as NIH, August 2025. The product classification is Other Combinations, with a dietary claim listed as All Other. The intended target group is adults aged 18 to 50 years, and the product is listed as sugar free. The supplement facts show a serving size of 1 capsule, with 60 servings per container. Each serving provides 200 mg of magnesium as magnesium oxide, which is 47 percent of the daily value, plus a 225 mg proprietary blend that includes white willow extract, DL-phenylalanine and methylsulfonylmethane. The label lists hypromellose, water and rice flour as other ingredients. The FDA statement of identity is dietary supplement. The label states that the product contains no sugar, soy, preservatives, artificial coloring or flavoring. Suggested use is 1 capsule up to 2 times per day or as directed by a health care professional. The product is manufactured for DNA Laboratories, Inc. in Chelan, WA. The page notes that makers change their formulas and that each label is shown as printed on the bottle, with no grades, rankings or advice.
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Study, Trial or Testing Result Summary
Members Only18 human studies · 16 improved
6 of these 18 human studies gave magnesium by injection, not by mouth.
Each daily serving gives 400 milligrams of magnesium as magnesium oxide, well above the 80 milligrams that helped in one study. Most of the magnesium research for joints tested injections, not pills. A pooled analysis of 8 trials found that a magnesium injection into the joint after keyhole surgery lowered pain compared with placebo [1]. Adding magnesium to numbing injections cut pain and painkiller use after knee surgery [2][3]. Knee injections of dextrose, ozone and magnesium eased arthritis pain more than a med injections [4]. These results do not show what magnesium taken by mouth does. The pill studies tested mixed products, not magnesium alone. A calcium, vitamin D and mineral tablet with 80 milligrams of magnesium a day eased back and joint pain in women over 12 months [5]. A blend of algae, seawater magnesium and pine bark improved knee pain and walking over 12 weeks [6]. White willow, phenylalanine and methylsulfonylmethane sit in a proprietary blend with undisclosed amounts, and no study findings were given for them. Animal and cell studies are never counted.
See all 18 studies →Hide the studies
- In 6 observational studies of 15,715 people, higher blood magnesium was linked to lower knee osteoarthritis risk, but higher dietary magnesium intake was not, though it was linked to fewer fractures in people with knee osteoarthritis.The relationship between magnesium and osteoarthritis of knee: A MOOSE guided systematic review and meta-analysis.
- In a pooled analysis of 8 randomized trials and 8 experimental studies, a single magnesium injection into the joint after keyhole surgery lowered pain scores compared with placebo and boosted the pain relief of bupivacaine without more side effects.Analgesic effect and safety of single-dose intra-articular magnesium after arthroscopic surgery: a systematic review and…
- A review of 36 articles on hip or knee replacement found that pre-surgery meds, including magnesium among many others, reduced short-term pain after surgery without severe side effects, but magnesium was not assessed separately.Preventive analgesia in hip or knee arthroplasty: a systematic review.
- In 180 people with moderate-to-severe knee osteoarthritis, three knee injections of dextrose, ozone and magnesium given 3 weeks apart reduced pain more than a med injections at 24 weeks.Prolozone M Therapy's Analgesic Efficacy for Managing Moderate-to-Severe Knee Osteoarthritis: A Randomized, Double-Blind…
- In 134 people with rheumatoid arthritis, choline magnesium trisalicylate for 7 weeks reduced symptoms about as well as a med, with a greater reduction in swollen joints.Read the study on PubMed (7361026) →
- In 80 people having knee replacement, a magnesium and ropivacaine injection into the joint during surgery lowered morphine use and pain in the first 24 hours and sped early recovery compared with saline (this paper was retracted).Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following tot…
- In 80 people having knee replacement, a magnesium and ropivacaine injection into the joint during surgery lowered morphine use and pain in the first 24 hours and sped early recovery compared with saline.Efficacy and safety of an intra-operative intra-articular magnesium/ropivacaine injection for pain control following tot…
- In 75 adults having knee arthroscopy, adding 1.5 g magnesium sulfate to a bupivacaine joint injection reduced morphine use and pain at 24 hours compared with bupivacaine alone.Intra-articular infiltration of bupivacaine in arthroscopic knee surgery: Dexamethasone versus magnesium sulfate as adju…
- In 61 people after partial knee replacement, a cocktail containing magnesium sulphate and sodium bicarbonate gave longer pain relief, less meds and better early knee recovery than the conventional cocktail.Magnesium sulphate and sodium bicarbonate as additives for periarticular local infiltration analgesia improve pain manag…
- In 60 people having knee replacement, adding 250 mg magnesium sulfate to a levobupivacaine injection around the knee prolonged pain relief and reduced painkiller use in the early days after surgery.Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period…
- In 40 people with active rheumatoid arthritis, 3 g daily of magnesium dithiosalicylate for 3 months eased stiffness, tender joints and pain about like a med, but 8 people dropped out from serious side effects.Read the study on PubMed (6996929) →
- In 30 adults with mild knee osteoarthritis, a 12-week daily algae, seawater magnesium and pine bark supplement improved pain, walking function and cut meds use by about 72% compared with glucosamine.Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, …
- Across three randomized trials in rheumatoid arthritis, choline magnesium trisalicylate improved joint pain, swelling and morning stiffness similarly or better than a med, with fewer stomach side effects.Efficacy and safety of a non-acetylated salicylate, choline magnesium trisalicylate, in the treatment of rheumatoid arth…
- In 8 adults with hemophilia-related joint damage, choline magnesium trisalicylate gave greater relief of joint pain and stiffness than placebo in 3 of the 8 patients, with no consistent effect on bleeding.Read the study on PubMed (7072708) →
- In people with rheumatoid arthritis, seven weeks of choline magnesium trisalicylate reduced joint symptoms as well as a med, cut swollen joints more, and caused fewer side effects.Clinical comparative evaluation of choline magnesium trisalicylate and acetylsalicylic acid in rheumatoid arthritis.
- In 334 postmenopausal women with low bone density, two tablets a day of a calcium, vitamin D and mineral product containing 40 mg magnesium per tablet for 12 months relieved back and joint pain, compared with calcium alone or no treatment.[Vitrum osteomag in prevention of osteoporosis in postmenopausal women: results of the comparative open multicenter tria…
- In an uncontrolled treatment series of 80 people with soft tissue calcifications, about 75 percent were cured after local magnesium sulfate injections for 2 to 20 weeks followed by oral magnesium lactate for 4 to 6 months, with calcifications disappearing or greatly reduced and no side effects reported.Treatment of soft tissue calcifications with magnesium.
- In 392 people with knee osteoarthritis followed for two years, higher dietary magnesium intake was linked to fewer joint symptoms, better quality of life, and fewer depressive symptoms.Associations of Dietary Macroelements with Knee Joint Structures, Symptoms, Quality of Life, and Comorbid Conditions in …
Review Totals and Summary
Members OnlyWhat buyers say
Overall, buyers are warm about the seller, Naturally Botanicals, but the reviews say very little about Dynagesic capsules themselves. Most praise the service and shipping, and a few mention results from products that may not be this one. **What buyers say it did for them:** Only one review speaks directly of relief, and it is not clear it refers to these capsules. That buyer wrote, in Spanish, "el alivio es de inmediato" (the relief is immediate). Another reviewer says a new product added for seasonal allergies "worked rea..." (the text is cut off), but it is not named as Dynagesic. A third says they love "the results" and calls them "Real results!!", again without naming a product. No review describes what Dynagesic did, how well it worked, or how quickly. Treat these comments as general impressions only. **What they complain about:** The complaints are about the seller, not the capsules. One buyer was "Very unhappy," citing "No answers" and "Too many issues at Naturally Botanicals." Another found the service good but delivery slow, and advised ordering "at least 2 weeks" before you need it. No review reports side effects, a failure to work, or a quality problem with the capsules. **Taste, smell, pill size or form:** The reviews say nothing about these. Reviews of other forms of the product, if any appear on the store pages, were left out. The reviews I read give no detail on capsule size, swallowing ease, or smell. **Value for money:** Price is not discussed. One reviewer mentions that two items were reshipped "with no extra c..." (the text is cut off, presumably no extra charge), which speaks to the seller's fairness rather than the product's price. **Who it seems to suit and who it did not:** The reviews do not say who the capsules suit. The feedback comes mainly from long-term customers of the seller, such as one who has "been a customer over 10 years" and another who has used the seller's flower essences for about 20 years. They seem happy with the range of products, the customer service and reliable ordering. People who need a product quickly may be less satisfied, given the comment on delivery time. Someone who had a poor purchase experience also felt let down. Nothing in the reviews points to a type of person who got no benefit from the capsules. **Bottom line:** If you are weighing this purchase, the reviews are a better guide to the seller than to the product. Most describe friendly, helpful service and dependable shipping, though one calls delivery slow and one is very unhappy. For evidence about how Dynagesic capsules work, you would need to look elsewhere.
Biohacker Summary
Members Only8 of 10 recommend it
Magnesium is the main ingredient, and most of the panel recommends it or uses it, with all ten speaking about it. Sleep is the most common reason, followed by blood pressure, muscle function, bone health, stress, brain function and replacing electrolytes. Forms named include glycinate, threonate (the choice of several, with 400 mg before bed given by three of them) and electrolyte drinks, and other doses given range from 300 mg to about a gram a day. Some pair it with vitamin D3 and K2 or with sodium and potassium. Cautions came from one panelist who said labels can overstate the real magnesium dose, and who also said the evidence that it reliably improves sleep is inconsistent, while another said it does not fix waking during the night.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
- Has recommended Magnesium Breakthrough from Bio Optimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends Magnesium Breakthrough Advance 10 from Bio Optimizers, which contains 10 bioavailable forms of magnesium, as it plays a critical role in sleep recovery, stress regulation, and muscle function, and has become part of his evening routine, especially during periods of travel, training, and higher stress.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
- Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
- Mentions magnesium glycinate as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Recommends taking magnesium 90 minutes to 2 hours before bedtime to support better sleep.
- Suggests that magnesium glycinate can help support the missing 'break pads' on the nervous system, which contribute to constant pain.
- Taking 400 mg of magnesium glycinate daily may also help support brain health during menopause.
- Warns against magnesium oxide because it is poorly absorbed, with only about 4% absorption, and can cause diarrhea, despite being commonly used in research and supplements due to its low cost.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
- Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
- Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
- Recommends Magnesium glycinate, stating that 200-400mg elemental helps with sleep as glycine cools the body and magnesium calms.
- Notes that magnesium sits on the NMDA receptor and regulates excitatory transmission, in the context of feeling stressed.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
- Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.
RAL Summary
Members OnlyTier 4 for Joints and Mobility
The review summary describes feedback about the seller, Naturally Botanicals, and its other products such as flower essences, not about Dynagesic capsules. Its reviews are set aside, so it is graded on its studies alone. Human studies support Magnesium (16 of 18 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).
- Emerging: not enough evidence to rank higher yet.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system
Combine with: For joint and discomfort support, consider pairing with omega-3 fish oil (EPA/DHA), curcumin with piperine, glucosamine and chondroitin, collagen peptides (type II), and magnesium glycinate for muscle relaxation. If blood pressure is the actual concern, use a separate heart-targeted stack such as magnesium, potassium-rich foods, CoQ10, and omega-3s, and check with a healthcare provider first, especially if taking meds or meds.
Possible side effects: No major side effects reported. The injection studies found no extra side effects when magnesium was added.
Supplement Facts
Magnesium 200 mg · Proprietary Blend 225 mg
| Magnesium | 200 mg | |
| Proprietary Blend | 225 mg | † |
Other ingredients: Hypromellose, Water, Rice Flour.
Directions: Directions: 1 capsule up to 2 times per day or as directed by a health care professional.
Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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