Kyolic Formula 103 Review
Kyolic Aged Garlic Extract - Immune Formula 103 is a capsule supplement from Wakunaga of America Company that the page describes as combining vitamin C, astragalus and mushrooms. The product description states that Kyolic Aged Garlic Extract begins with 100% organically grown garlic bulbs. The bulbs are then aged in a unique extraction process that the page says eliminates odor and creates beneficial compounds found only in Kyolic. The page says this combination of vitamins, mushrooms and herbs helps to support healthy immune function. The label lists each serving as two capsules, with 100 servings per bottle, and the product is sold as a 200 capsule bottle. Each serving provides 105 mg of vitamin C as calcium ascorbate, which the page lists as 175 percent daily value. The formula also includes 440 mg of aged garlic extract powder from the bulb, 150 mg of premium mushroom complex made from shiitake, maitake, poria cocos, reishi and agaricus, 100 mg of astragalus extract from the root, 100 mg of oregano extract from the leaf, and 80 mg of olive leaf extract standardized to 18 percent oleuropein. The other ingredients are gelatin and magnesium stearate from a vegetable source. The page states the product is preservative free and free of artificial sweeteners, flavors and colors. The directions say to take two capsules with a meal twice daily. The warning asks that the product be kept out of reach of children. The specifications list the form as capsules, the product weight as 6 oz, and the item number as WA-1010 with 1125054. The allergen section marks the product as egg free, fish free, milk free, peanut free, shellfish free, soy free, tree nut free and wheat free, and specialty diet notes include corn free, dairy free, salt free, starch free, sugar free and yeast free. The page also shows a nutritionist verified badge updated January 15, 2026, from the Vitamin Shoppe wellness team. The page lists a price of 28.99 dollars, which equals about 0.28 dollars per serving in the page's own calculation.
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Study, Trial or Testing Result Summary
Members Only110 human studies · 76 improved
28 of these 110 human studies gave the ingredient by drip or injection, not by mouth.
This product itself was tested in 3 human studies.
The main ingredient, aged garlic extract, has the strongest support for blood flow. A review of 12 trials in 553 people with high blood pressure found garlic lowered the top number by about 8 points and the bottom by about 5.5, and aged garlic extract made arteries less stiff [1]. In 49 people with uncontrolled high blood pressure, Kyolic aged garlic extract lowered blood pressure and artery stiffness versus placebo [2]. A year of aged garlic extract raised skin blood flow in people at raised heart risk [3], and 400 mg daily reduced artery stiffness in obese adults [4]. These trials tested garlic alone, often at 1.2 grams, more than the 880 mg in two servings here. Olive leaf is at a studied dose but results are mixed: one trial lowered blood pressure [5], another found no benefit over placebo [6]. Vitamin C helped vessel widening at 500 mg [7], but this product gives 210 mg, below that dose, and a large review found no overall effect on artery stiffness [8]. Astragalus studies mostly used injections or herb mixes [9]. Oregano was only tested as a skin application of its main compound [10]. The mushroom complex has no human studies. Animal and cell studies are never counted.
See all 110 studies →Hide the studies
- In 21 trials with 2,055 people with hypertensive heart disease, adding Chinese herbal formulas (Astragalus was one of five common herbs) to standard medicine lowered blood pressure and improved heart pumping and structure more than standard medicine alone.Potential preventive effects of selected traditional Chinese medicine as adjuvant therapy on hypertensive heart disease …
- In seven controlled trials with 872 patients having heart artery procedures or bypass surgery, vitamin C given by vein lowered peak troponin by about 43% and peak CK-MB by about 14% and reduced oxidative stress markers.Vitamin C may reduce troponin and CKMB levels after PCI and CABG: a meta-analysis.
- Across 12 trials of 553 people with high blood pressure, garlic supplements lowered top blood pressure by about 8.3 mmHg and bottom blood pressure by about 5.5 mmHg, and Kyolic aged garlic extract also lowered arterial stiffness.Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta…
- In six studies of 160 people with sleep apnea, antioxidant treatments including vitamin C improved blood vessel dilation by about 2.16 percentage points and reduced oxidative stress, but vitamin C was not analyzed separately.Antioxidant therapies for obstructive sleep apnea: A systematic review and meta-analysis.
- A review of 10 systematic reviews covering 6409 people found contrasting results for vitamin C on blood vessel function, with no overall effect on arterial stiffness and only limited benefit in some subgroups.Limited evidence for a beneficial effect of vitamin C supplementation on biomarkers of cardiovascular diseases: an umbre…
- In eight trials with 1185 patients, vitamin C given by vein before a heart artery procedure reduced heart injury markers, oxidative stress and inflammation, while improvements in heart pumping function were inconclusive.Vitamin C for Cardiac Protection during Percutaneous Coronary Intervention: A Systematic Review of Randomized Controlled…
- A review of randomized trials in people with diabetes or metabolic syndrome found vitamin C, mostly 1,000 mg daily for 4 weeks to 12 months, lowered cholesterol and inflammation and was consistent with better endothelial function and blood flow.Vitamin C intake potentially lowers total cholesterol to improve endothelial function in diabetic patients at increased …
- A review of Ayurvedic herbs for high cholesterol found more than half of garlic trials reported effectiveness, but it did not directly measure blood flow.Ayurvedic and collateral herbal treatments for hyperlipidemia: a systematic review of randomized controlled trials and q…
- A review of ten randomized trials found inconsistent effects of garlic on blood vessel function, with possible benefit in people who have heart disease risk factors.The effect of garlic on vascular function: A systematic review of randomized clinical trials.
- A broad review of herbal treatments for heart disease listed garlic among herbs with promising cardiovascular benefits, but gave no garlic-specific results and called for larger trials.A Systematic Review of Herbal Interventions for the Management of Cardiovascular Diseases.
- In 122 people at raised heart risk, 2400 mg of aged garlic extract daily for one year increased skin blood flow more than placebo (about 103% versus 79% change).Aged garlic extract preserves cutaneous microcirculation in patients with increased risk for cardiovascular diseases: A …
- In 96 people with prehypertension, two garlic extract capsules daily for eight weeks lowered blood pressure, improved cholesterol and raised nitric oxide levels compared with placebo.Randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure,…
- In 96 healthy adults, 8 weeks of a grapefruit, bitter orange and olive leaf extract blend improved blood vessel dilation, blood pressure, cholesterol, oxidative stress and inflammation markers compared with placebo.Effect of a Combination of Citrus Flavones and Flavanones and Olive Polyphenols for the Reduction of Cardiovascular Dise…
- In 92 obese people, 400 mg of garlic extract daily for 3 months reduced arterial stiffness, inflammation and LDL cholesterol, while the placebo group did not change.Garlic extract favorably modifies markers of endothelial function in obese patients -randomized double blind placebo-con…
- In 90 overweight smokers, 2.1 g of garlic powder daily for 3 months had no significant effect on inflammation, endothelial function or cholesterol compared with placebo.Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects.
- In 88 adults with uncontrolled high blood pressure, 1.2 g of aged garlic extract daily for 12 weeks lowered systolic blood pressure by 5 mmHg more than placebo, with central blood flow measures tending to improve.The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives:…
- In 84 people with liver cirrhosis and portal hypertension, Salvia plus Astragalus for up to 3 months narrowed the portal and splenic veins and sped up blood flow in them more than usual care alone, and improved liver scarring markers.[Influence of Salvia miltiorrhizae and Astragalus membranaceus on hemodynamics and liver fibrosis indexes in liver cirrh…
- In 83 people with congestive heart failure, a daily Astragalus injection for 2 weeks improved heart function and pumping measures more than the nitroglycerin comparison, with 78.6% responding after 1 month and fewer heart events during follow-up.[Study on effect of Astragalus injection in treating congestive heart failure].
- In 80 burn patients, Astragalus saponin for up to 21 days lowered blood markers of blood vessel lining injury and inflammation compared with burn patients not given it.[Effect of Astragalus saponin on vascular endothelial cell and its function in burn patients].
- In 75 middle-aged recreational endurance athletes, 12 weeks of Kyolic aged garlic extract (1.2 g or 2.4 g daily) improved arterial flexibility, aerobic fitness and recovery time compared with placebo.Kyolic aged garlic extract improves aerobic fitness in middle‑aged recreational endurance athletes: A randomized double‑…
- In 75 healthy middle-aged adults with normal cholesterol, garlic powder tablets for 12 weeks did not change blood pressure, arterial stiffness or blood fats compared with placebo.Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidae…
- In 46 people with high cholesterol, a single 2 g dose of ascorbic acid lengthened the duration of forearm reactive blood flow after two hours versus placebo but did not raise peak flow.Effect of ascorbic acid on forearm reactive hyperaemia in patients with hypercholesterolaemia.
- In 70 healthy young adults exposed to simulated night train noise, vitamin C improved blood vessel dilation in women but not in men.Acute Exposure to Simulated Nocturnal Train Noise Leads to Impaired Sleep Quality and Endothelial Dysfunction in Young H…
- In 65 firefighters, aged garlic extract (1,200 mg) plus coenzyme Q10 daily for one year reduced artery stiffness by 1.21 m/s and improved blood vessel function compared with placebo.Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH ra…
- In 60 people having kidney stone shock wave treatment, a Chinese herb mix including Astragalus kept nitric oxide, endothelin-1, inflammation and oxidative stress markers from rising as much as in controls and reduced kidney tubule damage.The protective effects of the traditional Chinese herbs against renal damage induced by extracorporeal shock wave lithot…
- In 60 men with pre-high blood pressure, 6 weeks of olive leaf extract lowered blood pressure, cholesterol and triglycerides versus control, but other markers of blood vessel function were not affected.Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised contr…
- In a placebo-controlled trial of 57 adults with slightly elevated blood pressure, aged garlic extract for 12 weeks significantly lowered blood pressure, especially diastolic, and improved arterial elasticity by 21.6% compared with the start.Effects of aged garlic extract on arterial elasticity in a placebo-controlled clinical trial using EndoPAT™ technology.
- In 56 adults with high systolic blood pressure, 440 mg daily of olive extract for 8 weeks lowered blood pressure no more than placebo did.Evaluation of the effect of olive extracts on blood pressure and cardiovascular health markers in adults: Findings from …
- In 52 adults with cardiometabolic risk factors, encapsulated purple garlic oil taken for 5 weeks improved small blood vessel function, lowered a blood inflammation marker and reduced the number of metabolic syndrome components compared with placebo.Effect of Encapsulated Purple Garlic Oil on Microvascular Function and the Components of Metabolic Syndrome: A Randomize…
- In 49 people with uncontrolled high blood pressure, 1.2 g of Kyolic aged garlic extract daily for 12 weeks lowered blood pressure by about 10 (top) and 5.4 (bottom) mmHg versus placebo and reduced arterial stiffness.The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: T…
- In 46 people with coronary artery disease, 500 mg of vitamin C daily for 30 days improved blood vessel widening in the arm artery (about 8.6% to 9.0% vs unchanged with placebo), and a single 2 g dose also helped.Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disea…
- In 42 people with kidney disease, a one-time vitamin C infusion produced only a non-significant trend toward better artery dilation in the placebo group; the trial's main test was a different drug (rilonacept), not vitamin C.IL-1 Inhibition and Vascular Function in CKD.
- In 40 adults with moderately high cholesterol, 8 weeks of a combined supplement containing olive improved cholesterol and blood vessel reactivity (+6.73% vs -1.4%) compared with placebo.Effect of combined lipid-lowering and antioxidant nutraceutical on plasma lipids, endothelial function, and estimated ca…
- In 39 people with high blood pressure, 500 mg of vitamin C daily for one month did not improve blood vessel widening compared with placebo.Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension.
- In 39 people with heart failure, 4 grams of vitamin C daily for 4 weeks improved a blood vessel measure but worsened muscle energy handling during exercise.Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure.
- A single intravenous vitamin C infusion lowered elevated blood flow in the brain in people with Fabry disease and in healthy controls, though the placebo group responded more slowly.Ascorbate decreases Fabry cerebral hyperperfusion suggesting a reactive oxygen species abnormality: an arterial spin tag…
- In 26 healthy men and 8 men with peripheral artery disease, vitamin C infused into the arm during reperfusion after ischemia prevented the loss of blood vessel widening seen with placebo.Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion.
- In 31 people with leg artery disease, vitamin C given before maximal walking prevented the drop in artery widening and the rise in oxidative stress seen after exercise in those given saline.Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication.
- In 30 adults with type 2 diabetes, 500 mg of vitamin C daily for 4 weeks lowered blood pressure and reduced arterial stiffness, while placebo had no effect.Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes.
- In 30 overweight adults with high cholesterol, 500 mg of vitamin C taken daily with vitamin E for 6 weeks did not significantly improve blood vessel widening compared with placebo.Oats, antioxidants and endothelial function in overweight, dyslipidemic adults.
- In 30 heart surgery patients on heart-lung bypass, one intravenous vitamin C dose given during rewarming reduced a rise in reactive oxygen molecules and improved red blood cell flexibility compared with placebo.Vitamin C supplementation attenuates oxidative stress and improves erythrocyte deformability in cardiac surgery with car…
- In 29 salt-resistant adults on a high-salt diet for 7 days, local infusion of ascorbic acid restored skin blood vessel dilation that the high-salt diet had reduced.Apocynin and Tempol ameliorate dietary sodium-induced declines in cutaneous microvascular function in salt-resistant hum…
- In 26 adults with type 2 diabetes, 1200 mg of aged garlic extract daily for 4 weeks did not significantly improve endothelial function, inflammation, oxidative stress or insulin resistance compared with placebo.The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance …
- A single intravenous 1,000 mg dose of vitamin C improved arm blood vessel widening in people with type 1 diabetes and in regular smokers, compared with saline, in a study of 24 people where uric acid was the main test.Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers.
- In 24 people having open heart surgery, Astragalus injection, especially combined with ligustrazine, lowered heart injury enzymes and oxidative stress markers and improved nitric oxide activity compared with no treatment.[Clinical study of Astragalus injection plus ligustrazine in protecting myocardial ischemia reperfusion injury].
- In a double-blind trial of 21 obese children aged 8 to 12, 500 mg of vitamin C daily for 45 days lowered mean blood pressure and restored forearm blood vessel dilation during mental stress, while placebo did not.Vitamin C restores blood pressure and vasodilator response during mental stress in obese children.
- In 20 women with systemic sclerosis, 900 mg of dried garlic powder daily for 7 days reduced platelet and red blood cell clumping, but did not change vasomotor function.[Does garlic influence rheologic properties and blood flow in progressive systemic sclerosis?].
- In 19 healthy adults, a single 2 g oral dose of vitamin C shortened the blood vessel dysfunction caused by smoking one cigarette, recovering to baseline levels faster than placebo.Oral administration of ascorbic acid attenuates endothelial dysfunction after short-term cigarette smoking.
- In 19 patients on meds, 4 ml of aged garlic extract daily for 1 year slowed the growth of coronary artery calcium compared with placebo.Read the study on PubMed (15475033) →
- In 18 people with metabolic syndrome, a single 1 g intravenous vitamin C infusion improved artery widening compared with placebo and counteracted the rise in an oxidative stress marker.Oxidative stress-mediated arterial dysfunction in patients with metabolic syndrome: Effect of ascorbic acid.
- In 18 trained young men, a single 900 mg dose of powdered garlic taken before exercise did not change blood vessel dilation or clot-breakdown markers compared with placebo, though maximal oxygen uptake was slightly higher.The effects of acute garlic supplementation on the fibrinolytic and vasoreactive response to exercise.
- In 17 people with resistant high blood pressure and high cholesterol, 500 mg of vitamin C daily for 8 weeks did not change blood pressure, cholesterol or artery widening compared with placebo, while a med did.Read the study on PubMed (15609886) →
- In 16 healthy women, taking a lutein complex containing 500 mg of vitamin C daily for three weeks increased blood flow in the retina of the eye and lowered diastolic blood pressure compared with placebo, though the effects cannot be attributed to vitamin C alone because it was combined with other ingredients.Lutein Complex Supplementation Increases Ocular Blood Flow Biomarkers in Healthy Subjects.
- In 15 men with coronary artery disease, two weeks of aged garlic extract improved the widening of the brachial artery in response to blood flow compared with placebo, which suggests better blood vessel function.Aged garlic extract improves endothelial function in men with coronary artery disease.
- In 14 overweight men, a single 3 g intravenous ascorbic acid infusion reduced oxidative damage and vascular remodeling markers during mental stress compared with placebo.Ascorbic acid inhibits vascular remodeling induced by mental stress in overweight/obese men.
- In 13 kidney transplant recipients, a single 2,000 mg oral dose of vitamin C improved the widening of blood vessels in the arm after blood flow was increased, compared with placebo, measured 2 hours after dosing.Vitamin C improves endothelial dysfunction in renal allograft recipients.
- In 12 healthy young adults, intra-arterial vitamin C during a single session of forearm exercise in high oxygen blocked the drop in forearm blood flow only in the subgroup most affected by high oxygen, and had no effect in the other subgroups.Effect of vitamin C on hyperoxia-induced vasoconstriction in exercising skeletal muscle.
- In 11 men sitting for 3 hours, taking 1 g plus 500 mg of vitamin C prevented the usual decline in artery flow-mediated dilation seen when sitting without it.Antioxidant vitamin C prevents decline in endothelial function during sitting.
- In a crossover study of 10 healthy adults, 2 g of oral vitamin C did not prevent the drop in endothelial-dependent blood vessel dilation caused by methionine-induced raised homocysteine.The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia.
- In 8 people with high blood pressure, vitamin C infused directly into an artery improved blood vessel widening, and 2 months of a med also improved it.Read the study on PubMed (12164090) →
- In 8 male smokers, 1 g of vitamin C daily for about 5 weeks did not improve blood vessel widening or clot-dissolving activity compared with placebo.Vitamin C has no effect on endothelium-dependent vasomotion and acute endogenous fibrinolysis in healthy smokers.
- Vitamin C applied to the skin after UV exposure, alone or combined with vitamin E and melatonin, did not significantly reduce sunburn redness or change skin blood flow.Effect of topical antioxidants on UV-induced erythema formation when administered after exposure.
- In healthy men, a single 2 g oral dose of vitamin C reduced arterial stiffness and clotting-cell aggregation compared with placebo, which showed no change.Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.
- In a double-blind trial in people with heart failure, vitamin C lowered circulating apoptotic microparticles (signs of blood vessel cell death) compared with placebo, which had no effect.Vitamin C inhibits endothelial cell apoptosis in congestive heart failure.
- In people with heart failure from blocked heart arteries, infused vitamin C was tested alone and with L-arginine on nervous system control of blood vessels, but the abstract does not clearly report the effect of vitamin C alone.Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic car…
- In a randomized, double-blind crossover study of healthy men, a single 2 g intravenous dose of vitamin C given before a two-hour high-blood-sugar challenge prevented the rise in arterial stiffness and pulse wave reflection seen with placebo.Protective effects of ascorbic acid on arterial hemodynamics during acute hyperglycemia.
- A single 2 gram oral dose of vitamin C made skin blood vessels constrict more strongly to cold, which reduced skin blood flow.Oral vitamin C enhances the adrenergic vasoconstrictor response to local cooling in human skin.
- In healthy volunteers, a single 900 mg dose of garlic powder increased capillary blood flow in the skin by 55% after 5 hours compared with placebo, which caused no change.Influence of garlic powder on cutaneous microcirculation. A randomized placebo-controlled double-blind cross-over study …
- In adults with coronary artery disease, garlic powder taken twice daily for 3 months improved blood vessel dilation compared with placebo, though the difference in a blood inflammation marker was not statistically significant.Effects of garlic on brachial endothelial function and capacity of plasma to mediate cholesterol efflux in patients with…
- In healthy adults, a single dose of fermented garlic extract containing nitrite increased blood flow in the brain and body surface compared with placebo, with blood pressure and artery speed also changing within 30 to 60 minutes.Effects of Fermented Garlic Extract Containing Nitric Oxide Metabolites on Blood Flow in Healthy Participants: A Randomi…
- In adults with grade I hypertension taking meds, 12 weeks of a low-dose aged black garlic extract lowered blood pressure more than placebo, raised blood nitric oxide, and lowered uric acid, with no change in endothelial function.Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive …
- In 75 men with coronary artery disease, vitamin C infused into the forearm artery raised baseline forearm blood flow and acetylcholine-stimulated flow in those with high inflammation (CRP) but not those with low CRP.C-reactive protein levels determine systemic nitric oxide bioavailability in patients with coronary artery disease.
- In 62 adults, eating 4 cloves of black garlic (12 g) daily for 12 weeks lowered some artery-lining adhesion molecules in people with high cholesterol and in healthy people, but one molecule rose in healthy people, and there was no placebo group.Effect of Black Garlic Consumption on Endothelial Function and Lipid Profile: A Before-and-After Study in Hypercholester…
- In 46 people with coronary artery disease, a single 2 g dose of vitamin C improved blood vessel dilation within 2 hours in those with poor baseline function (2.0% to 9.7%), while placebo had no effect.Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.
- In 39 lean, obese, and metabolic syndrome adults, an acute infusion of ascorbic acid did not change how quickly or how much blood vessels widened during arm exercise.Exercise-mediated vasodilation in human obesity and metabolic syndrome: effect of acute ascorbic acid infusion.
- In 23 healthy young men, intra-arterial vitamin C reversed the angiotensin II-related weakening of endothelium-dependent forearm blood vessel dilation, while vitamin C alone did not change it.Vitamin C improves attenuated angiotensin II-induced endothelium-dependent vasodilation in human forearm vessels.
- In 11 people with high cholesterol and 12 healthy controls, vitamin C infused directly into the arm improved blood vessel widening in response to methacholine in the people with high cholesterol, with no change in controls.Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia.
- In 10 people with type 2 diabetes, vitamin C infused into the arm artery improved the widening of forearm blood vessels in response to methacholine, while it had no effect in 10 non-diabetic controls.Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
- In 10 chronic smokers, vitamin C infused into the arm artery markedly improved the widening of forearm blood vessels in response to acetylcholine, while it had no effect in 10 non-smoking controls.Antioxidant vitamin C improves endothelial dysfunction in chronic smokers.
- In 20 young adults, a one-minute skin application of 10% carvacrol widened forearm blood vessels by about 40% of maximum for 90 minutes, and this effect was reduced by blocking nitric oxide, COX enzymes, or potassium channels; this was a small mechanistic study on skin blood vessels, not a heart outcome.Brief topical application of TRPV3 channel agonist carvacrol mediates skin vasodilation via NOS, COX, and K+ channel pat…
- In 11 smokers, vitamin C restored heart muscle blood flow reserve that was reduced compared with 8 non-smokers, while it had no effect in the non-smokers.Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function.
- In 11 people with postural tachycardia syndrome and 8 healthy controls, ascorbate given through the skin and through a vein increased blood flow in the skin and limbs and raised cardiac output by about 40% after infusion.Ascorbate improves circulation in postural tachycardia syndrome.
- In 8 adults with Down's syndrome, who had weaker blood vessel function than 9 controls of similar age, vitamin C gave only a slight improvement in endothelium-dependent blood vessel widening that was not statistically significant; the dose and duration are not stated in the abstract.Endothelial cell function in patients with Down's syndrome.
- In 15 overweight or obese men, a 3 gram intravenous vitamin C infusion increased blood vessel dilation 60 minutes after a mental stress task, although it did not change the response at 30 minutes.Mental stress induces endothelial dysfunction by AT1R-mediated redox imbalance in overweight/obese men.
- In 14 patients with essential hypertension, an infusion of vitamin C into the arm improved blood vessel widening in response to acetylcholine, while healthy controls showed no change.Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.
- In healthy people, an infused antioxidant (vitamin C) fully restored the artery widening that high insulin had impaired over a 4-hour clamp, while vitamin C alone did not change artery widening in saline controls.Insulin causes endothelial dysfunction in humans: sites and mechanisms.
- In healthy people made temporarily hyperglycemic, vitamin C infused into the arm artery restored the blood vessel widening response to methacholine that hyperglycemia had reduced.Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans.
- In healthy men, infusing vitamin C into the forearm prevented angiotensin II from weakening the blood vessel dilation caused by a nitrate drug.Angiotensin II attenuates the vasodilating effect of a nitric oxide donor, glyceryl trinitrate: roles of superoxide and …
- In people with metabolic syndrome during high insulin levels, vitamin C improved the blood vessel dilation response to acetylcholine, though adding the drug infliximab did not further improve it.Tumor necrosis factor-alpha antagonism improves vasodilation during hyperinsulinemia in metabolic syndrome.
- In a placebo-controlled crossover pilot study of healthy adults, 6 weeks of aged garlic extract pretreatment reduced the damage a methionine challenge caused to blood vessel dilation in both large arteries and small vessels.Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro- and microcirculation.
- In a study of 20 adults with essential hypertension and 20 normotensive controls, 250 mg of garlic pearls daily for 2 months lowered blood pressure moderately and reduced markers of oxidative DNA damage, nitric oxide and lipid peroxidation in the hypertensive group.Garlic supplementation prevents oxidative DNA damage in essential hypertension.
- In 12 hypertensive adults taking Vascanox HP, which combines nitrate with garlic-derived S-allylcysteine, systolic blood pressure fell by about 11 mmHg over 4 weeks in an open-label study without a placebo group.Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitr…
- In an open-label study of 9 adolescents with type 1 diabetes, six weeks of combined vitamin C and vitamin E did not change endothelial function or related blood markers.Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus.
- In a small preliminary study of pre-hypertensive and hypertensive volunteers taking 1600 mg of olive leaf extract daily, blood pressure and blood nitric oxide improved, and LDL resistance to oxidation increased.[HYPOTENSIVE EFFECT OF AN EXTRACT OF BIOACTIVE COMPOUNDS OF OLIVE LEAVES: PRELIMINARY CLINICAL STUDY].
- In 281 people with coronary artery disease followed for about 4.5 years, poor blood vessel widening predicted later heart events, and vitamin C raised widening more in those who had events.Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease.
- In 58 healthy men, a single vitamin C infusion improved artery widening only in middle-aged and older men with low testosterone, and had no effect in young men or older men with higher testosterone.Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone.
- In a feasibility study of 35 adults with hypertension, a single dose of fermented garlic extract lowered blood pressure and improved radial artery pulse wave measures within 15 to 25 minutes, but these effects were no longer present after 2 weeks of use.Effect of fermented garlic extract containing nitric oxide on radial artery pulse waves in hypertension patients: a feas…
- In 45 young adults (lean, obese, or with metabolic syndrome), vitamin C infused into the forearm artery increased blood flow responses to vessel-dilating drugs across all groups, with no control group on placebo.Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress.
- In 14 young and 14 older adults, a short vitamin C infusion raised forearm blood flow about 34% during continuous exercise in older adults only, and did not change the quick blood flow response to single muscle contractions in either group.Endothelium-dependent vasodilatation and exercise hyperaemia in ageing humans: impact of acute ascorbic acid administrat…
- In 11 young habitual hookah smokers, a single vitamin C infusion raised blood vessel dilation at baseline and prevented the drop in dilation caused by 30 minutes of e-hookah vaping.Ascorbic Acid Prevents Vascular Endothelial Dysfunction Induced by Electronic Hookah (Waterpipe) Vaping.
- In 10 healthy young adults, adding vitamin C to acetylcholine during 4-6 days at 4300 meters altitude raised the blood flow response in the forearm by about 20%, partly restoring the response that altitude had reduced by about 30%.GLOBAL REACH 2018: intra-arterial vitamin C improves endothelial-dependent vasodilatory function in humans at high altit…
- In 10 healthy volunteers, a single 600 mg dose of dried garlic extract increased blood flow in the skin for up to 2 hours.Acute effect of a dried ethanol-water extract of garlic on the microhaemovascular system of the skin.
- In 10 healthy volunteers taking a supplement combination that included black garlic for 4 weeks, endothelial function improved, with arterial stiffness reduced in all participants.Oral nutraceutical intervention to improve endothelial function: Evidence from in vitro and pilot clinical studies.
- A review of epidemiologic and trial research found that vitamin C may slightly improve blood vessel function and blood fats in some groups, especially those with low vitamin C levels, but there is little support for supplementing to reduce heart disease risk.Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies.
- In healthy people given Astragalus, systolic and diastolic blood pressure fell within 4 hours and returned to baseline by 24 hours, alongside temporary immune and cytokine changes.Characterization of the Physiological Response following In Vivo Administration of Astragalus membranaceus.
- Mostly animal work found an olive compound combination protected the heart and blood vessels, and a small clinical study in people with coronary artery disease reported better heart, blood vessel and endothelial function after four weeks.Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary e…
- In rats given a toxic dose of a med, carvacrol at 10 mg per kg body weight daily for one week improved kidney blood flow and lowered kidney oxidative damage and cell death compared with a med alone.Read the study on PubMed (35020122) →
- In rats with sepsis-induced heart and aorta injury, carvacrol at 25 to 100 mg per kg body weight daily for about two weeks restored antioxidant enzyme levels and reduced oxidative stress and nitric oxide in heart and aortic tissue compared with untreated septic rats.Zataria multiflora and its constituent, carvacrol, counteract sepsis-induced aortic and cardiac toxicity in rat: Involve…
- In hypertensive rats, carvacrol at 50 to 100 mg per kg body weight daily for four weeks improved the function of endothelial progenitor cells, which help repair blood vessel lining, and reduced vascular oxidative stress and cell aging compared with vehicle.Carvacrol Improves Vascular Function in Hypertensive Animals by Modulating Endothelial Progenitor Cells.
- In an animal study of rats with chemically induced high blood pressure, a combination of roselle and olive extracts given for 4 weeks lowered blood pressure in a dose-dependent way and reduced oxidative stress; this was not tested in people.Antihypertensive Effects of Roselle-Olive Combination in L-NAME-Induced Hypertensive Rats.
Review Totals and Summary
Members Only131 reviews · 97% positive
Buyers rate Kyolic Formula 103 capsules very highly, with about 130 ratings across the stores. Most are from long-term users who take it for immune support. The few complaints concern allicin content, one filler ingredient and the vitamin C source, and a single serious allergic reaction. **What buyers say it did for them:** Most describe steady immune support over many years. One says "Have used them for over 10 years!" and another credits it with staying healthy through two flu seasons without a flu shot. One reviewer thinks it "Seemed to speed up the healing" of shingles. A Vitacost buyer reports getting sick less often, and a PureFormulas reviewer mentions fewer sinus infections. Others are still judging: one has used it for only a month, and another is waiting to see whether it prevents colds. These are personal impressions, not proof. **What they complain about:** Complaints are few. One 3-star reviewer says it "doesn't contain the amount of Allicin in the Supplement facts." A Vitacost reviewer calls the quality good apart from one filler and dislikes the vitamin C source, wishing it were food-based. The one 1-star review reports a severe reaction in the reviewer's husband, with facial swelling, hives and digestive trouble. The reviewer blames the astragalus in the formula, because a separate astragalus product caused the same reaction. **Taste, smell and form:** This is the most repeated praise. Buyers like the lack of garlic taste or odor: "No garlic odor. No colds." One says "I hardly notice it," and another notes "no aftertaste like may happen with other garlic products." A reviewer who struggles with strong-tasting pills says these go down easily. Another mentions no stomach ache. Pill size is not criticized, and a Blue Sky Vitamin buyer calls the capsules easy to swallow and odorless. **Value for money:** Opinion on price is positive. One buyer says "I think the price is very fair for the quality," and another says this is "same product sold in health food stores for more." A Piping Rock reviewer says they could not find this much product for the money elsewhere. A Vitacost buyer chose it over a pricier brand, believing the ingredients were the same. **Who it seems to suit:** It suits people who want a garlic-based immune supplement without the smell or aftertaste, and those who value a trusted brand. Several say it combines what they need, so "no need to take the individual products." Repeat buyers are common, and many take it daily or through the winter. One reviewer uses it for heart and general health, and another for candida support. It did not suit the one person who reacted badly, and it may disappoint anyone who cares about the allicin amount or filler ingredients. Buyers sensitive to astragalus should note that complaint. Reviews of other forms of this product, such as gummies or powder, were left out; this summary covers the capsules only.
Biohacker Summary
Members Only10 of 10 recommend it
Garlic is the main ingredient, and most of the panel leans positive: five of the ten recommend it and three more use it, while one warns and one says he does not eat it. Panelists take it for gut health, blood pressure and cholesterol, with one favoring aged garlic extract backed by human trials, and one using a 600 milligram capsule whenever he takes Alpha-GPC. Others eat it as food, paired with avocado or in a dressing, or at breakfast. The caution comes from one panelist who says eating a lot of garlic left his brain feeling less sharp, and who notes a bleeding risk for anyone on meds, so he advises using it strategically. Vitamin C and oregano are smaller ingredients in this product, and vitamin C draws mostly positive comments, mainly for collagen and immune support.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Garlic · recommends
- Recommends garlic, explaining that crushing it releases allicin, which activates fat burning in the liver and significantly reduces liver enzymes.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Garlic supports detoxification, contains allicin, is antimicrobial, supports a healthy heart, supports healthy blood pressure, may have anticancer benefits, supports healthy gut microbes, and is a potent anti-inflammatory.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- Dr. Eric Berg recommends adding garlic to eggs to support satiety, antioxidant potential, cardiovascular, and liver health.
- Recommends mixing one drop of garlic with five drops of povidone iodine for a wart and skin tag remedy, suggesting to crush the garlic.
- Recommends garlic for its chelation abilities and its ability to turn up the body's detoxification genes.
- Recommends putting some garlic on skin tags to help them go away quickly.
- Recommends chewing one clove of garlic every single day, noting that it has a unique compound called allicin which is highly antimicrobial and can cause the liver to detoxify poisons, get rid of pathogens, increase nitric oxide, decrease blood pressure, and act as a med.
Dr. Mark Hyman · Garlic · recommends
- Recommends garlic as a fibrous food to heal the gut.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Eats a lot of garlic and includes it in his chicken soup and a special drink because it is an antimicrobial and antiviral.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Puts astragalus, a Japanese herb, into his chicken soup because it has a huge effect on the immune system and improves immune response.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Recommends vitamin C for immune system support and modulation.
- Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
- Notes that crushing garlic and letting it rest for 10 minutes before cooking activates an enzyme that significantly increases its cancer-fighting and heart-protective compounds.
Siim Land · Garlic · recommends
- Recommends Aged garlic extract for blood pressure and cholesterol, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Lists Aged garlic extract as one of 15 supplements backed by human studies.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Says garlic is an old food with health benefits, especially good for lipids and the immune system.
- Says garlic has benefits for the immune system and the cold, and advises crushing or chopping it and letting it sit for 10 minutes before heating or eating it to preserve its health benefits.
- Notes that Vitamin C is one of several supplements with human evidence.
- Mentions aged garlic extract as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
Andrew Huberman · Garlic · uses
- Makes it a point to ingest a 600 milligram capsule of garlic anytime they take Alpha-GPC to offset potential increases in TMAO.
- He suggests taking 600 milligrams of garlic, which contains allicin, to inhibit TMAO production, especially when taking Alpha GPC regularly, and notes that garlic capsules are inexpensive and don't cause bad breath.
- Takes a multivitamin every day for longevity.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
- Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
- Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
- Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
- States that AG1 is the highest quality and most complete foundational nutritional supplement available, containing vitamins, minerals, probiotics, prebiotics, and adaptogens, and that he has been taking it daily since 2012, often twice a day, to bolster his energy, immune system, and gut microbiome.
- Huberman mentions that vitamin C seems to help with the absorption or utilization of collagen protein.
- Mentions that if one takes Alpha GPC, they would have to take 600 milligrams of garlic to offset the increase in TMAO, if one believes TMAO matters. He prefers to just eat garlic anyway.
- Agrees with a dermatologist's recommendation to ingest garlic because it contains sulfur, which is key for collagen synthesis and repair.
Thomas DeLauer · Garlic · recommends
- Recommends using garlic along with avocado in the same meal to feed the same microbes and compound the positive effects on gut health.
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Notes that garlic's allicin converts to hydrogen sulfide, which relaxes vessel walls.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Includes garlic in their homemade mineral broth, noting its detoxifying properties as part of a detoxification protocol.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
- Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
- Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
- Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
- Garlic is recommended for its inulin content.
Dave Asprey · Garlic · warns
- Likes garlic but notices their brain feels less sharp when they eat a lot of it, even tracking the effect with EEG, and advises using it strategically, especially if it affects cognition.
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Host Dave Asprey separates what the human data actually supports regarding raw garlic, modest blood pressure and cholesterol effects, real antimicrobial properties, and a genuine bleeding-risk caution for anyone on meds, from the unproven parasite-cleanse and brain fog claims driving the trend online.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
- Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
- Recommends adding oregano to oil halfway through cooking to provide additional antioxidants and protect the oil, or when using butter at the end for flavor.
- Recommends Vitamin C as the real biological fix for deep focus issues, explaining how the brain hoards it at levels 100 times higher than blood and how to bypass the blood-brain barrier.
- States that Ensure is like SlimFast but worse, and that its ingredients, including synthetic vitamins, guar gum, maltodextrin, high fructose corn syrup, and seed oils, are disgusting and should not be given to sick or well people.
- States that oregano regulates gut bacteria.
Dr. Rhonda Patrick · Garlic · uses
- Rhonda's current diet includes a homemade salad dressing made with avocado, garlic, apple cider vinegar, and olive oil.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
- Rhonda's current supplement routine includes Vitamin C.
- Suggests that if someone is an 'immuno-ager,' they might want to take garlic to help with their immune system.
- Used a concoction of garlic and grapefruit seed extract, applied both topically and orally, to successfully treat MRSA after meds failed.
- Rhonda Patrick points out that garlic is very high in sulfur-containing compounds like beta-mercaptans.
Bryan Johnson · Garlic · uses
- Uses garlic as part of their breakfast.
- Uses oregano as part of their breakfast.
- Eats garlic for breakfast.
- Eats oregano for breakfast.
- Uses garlic, noting it has been shown to lower blood pressure and help the immune system.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Includes one odor-free garlic pill in his Blueprint stack.
- Adds one peeled clove of garlic to his Super Veggie for heart and immune health.
- Takes 250 milligrams of Vitamin C.
- Includes garlic in his Super Veggie meal, which he eats at 7 AM.
- Takes garlic for liver enzymes and cholesterol management, and also eats it daily as part of his super veggie.
- Includes garlic in his daily 'Super Veggie' breakfast for its nutrient density.
- Uses chopped garlic in his Super Veggies.
Ben Greenfield · Garlic · recommends
- Recommends root spices like garlic for use on the AIP diet.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Mentions vitamin C as part of a bare-minimum protocol.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Mentions Astragalus as one of the Chinese herbs used, noting its potential in decreasing the rate at which telomeres shorten.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Vitamin C for skin repair post-tattoo.
- Does not agree that ascorbic acid is vitamin C, comparing it to calling chaff wheat, and notes that it is made from genetically modified cornstarch or corn syrup byproducts using solvents.
- Oregano was mentioned in a study as a biofilm disruptor that can improve microbial access and affect outcomes in SIBO and methane-dominant cases.
- Warns against ascorbic acid, stating that it does not cure scurvy and that the world has been led astray by the deception around it versus the whole food vitamin C complex.
- Warns against taking 1,000 mg of vitamin C immediately after a workout for individuals under 50, as it can dull the body's natural adaptation signal.
- Warns that using high-dose antioxidants like vitamin C directly before or after a hyperbaric session is not a great idea, as it could impair some of the effects by reducing reactive oxygen species.
- Warns that taking a whole bunch of antioxidants like vitamin C after a workout can suppress the body's inflammatory response, which is necessary for benefits like mitochondrial proliferation and satellite cell generation for new muscle.
- Stuffs the trout with herbs like oregano.
Peter Attia · Garlic · uses
- States that he does not eat garlic.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
- Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
- Expresses skepticism about 'panacea treatments' for cancer, specifically mentioning a 'twenty thousand dollars of vitamin C' treatment, implying it's an example of something he's 'squirrely' about due to cost and unproven claims.
- Asks if vitamin C matters for immune function, suggesting a need for a definitive study.
- Warns against the "total nonsense" of taking excessive amounts of vitamin C, especially in specific forms like liposomal vitamin C, for immunity, stating that it is idiotic and potentially dangerous to think it will offer immunity.
- Would love to see more research done on mega dose intravenous vitamin C for viral infections, noting some interesting but not followed-through research from the 1960s.
RAL Summary
Members OnlyTier 2 for Circulation
Tier 2 fits: several placebo-controlled human trials and a review show aged garlic extract, the main ingredient, lowers blood pressure and artery stiffness [1][2], and 94% of 141 reviews are positive.
Take 2 servings a day (4 capsules) to match the dose that worked in the studies.
This product itself was tested in 3 human studies.
Where the evidence disagrees: 16 of the 110 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Immune system
Combine with: Aged garlic extract with S-allyl cysteine has clinical support for modestly improving arterial elasticity, endothelial function, and reducing arterial stiffness and plaque progression, which aligns with healthy blood flow. Synergistic options include omega-3 fish oil (EPA/DHA) for endothelial function and triglyceride support, CoQ10 (ubiquinol) for mitochondrial and vascular energy, magnesium for vascular smooth muscle relaxation, and vitamin K2 (MK-7) to help direct calcium away from arteries. L-citrulline or L-arginine can boost nitric oxide production for vasodilation, and beet root or nitrate-rich extracts add further nitric oxide support. Because garlic can have mild antiplatelet effects, consult a physician before combining with meds, high-dose fish oil, or ahead of surgery.
Possible side effects: The studies listed report no major side effects. One reviewer reported a severe allergic reaction in her husband with facial swelling, hives and digestive trouble, which she blamed on the astragalus.
Supplement Facts
Vitamin C 105 mg · Aged Garlic Bulb Extract, Powder 440 mg · Premium Mushroom Complex 150 mg
| Vitamin C | 105 mg | |
| Aged Garlic Bulb Extract, Powder | 440 mg | † |
| Premium Mushroom Complex | 150 mg | † |
| Astragalus Root Extract | 100 mg | † |
| Oregano Leaf Extract | 100 mg | † |
| Olive Leaf Extract | 80 mg | † |
Other ingredients: Gelatin, Magnesium Stearate.
Directions: Suggested Use: Take two capsules with a meal twice daily.
Barcode (UPC) 023542103411 · Label source: NIH label database · Report a label change
Other sizes and barcodes: 200 Capsule(s), UPC 0 23542 10342 8 (not checked yet); 200 Capsule(s), UPC 0 23542 10342 8 (not checked yet)
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- Supplements for Focus and Mental ClarityArticle · Jun 16, 2026
Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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