Natural Vitality Calm Magnesium Citrate Liquid Review
Natural Vitality Calm Magnesium Citrate Liquid is a supplement designed to help manage stress, release tension, and promote a sense of calm through a bioavailable form of magnesium.
Product Focus: Regularity: Fast ReliefAlso covers:Digestion
Tier ⓘ
Tier 3
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
60 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
70% of 2,237
Biohacker Mentions
6 of 10
Cost per month
$8
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- TargetLowest$19.99 a bottle$5.31/moBuy at Target (opens in a new tab)
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Study, Trial or Testing Result Summary
Members Only35 human studies · 23 improved
35 human studies23 improved9 no effect4,329 people studied
This product gives 325 milligrams of magnesium a day, which is below the 800 milligrams that worked in studies, so the results below may not apply at this dose. Studies mostly used magnesium oxide, magnesium sulfate or magnesium-rich mineral water, not the citrate form in this product. A pooled analysis of 8 trials with 787 adults found that 68 percent responded to magnesium oxide versus 19 percent on control, with about 3.7 more bowel movements per week and softer stools [1]. In a trial of 90 adults, magnesium oxide daily for 4 weeks improved symptoms in 68.3 percent versus 11.7 percent on placebo [2]. Drinking magnesium-rich mineral water helped 50 percent of 226 adults versus 29 percent on low-mineral water, with relief in about 6 to 7 days [3]. In 244 women, it reduced constipation in 37.5 percent versus 21.1 percent [4]. In 100 children with cerebral palsy, magnesium sulfate for a month worked in 68 percent versus 9.5 percent on placebo [5]. Children with chronic constipation also had more bowel movements on magnesium oxide over 4 weeks [6]. These results took days to weeks, not immediate relief. Animal and cell studies are never counted.
See all 35 studies →Hide the studies
- In a pooled analysis of 8 trials (787 adults with chronic constipation, 2 trials of magnesium oxide), 68% responded to magnesium oxide versus 19% on control, with about 3.7 more bowel movements per week and softer stools.The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-anal…
- In a review of constipation treatments in palliative care, small low-quality controlled studies including one of magnesium hydroxide found no significant differences in effect or side effects.[Is the pharmacological treatment of constipation in palliative care evidence based? : a systematic literature review].
- A review of 41 trials lasting at least 4 weeks found moderate evidence supporting magnesium salts for chronic constipation, with stronger evidence for polyethylene glycol and senna.Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review.
- In a review of 15 trials in children with cerebral palsy, two trials found that probiotics, prebiotics, synbiotics or magnesium helped constipation, but the evidence was weak with high risk of bias.Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review.
- A review of 41 trials of over-the-counter constipation treatments of at least 4 weeks found moderate evidence supporting magnesium oxide, with stronger evidence for polyethylene glycol and senna.Evidence-based treatment recommendations for OTC management of chronic constipation.
- In a review of 20 trials in cancer patients taking meds, one cohort study showed magnesium oxide helped prevent a med-induced constipation compared with no laxative, but one trial found naldemedine worked better than magnesium oxide.Read the study on PubMed (38452708) →
- In 244 women with functional constipation, drinking 1 L daily of magnesium sulfate-rich mineral water for 4 weeks reduced constipation in 37.5% by week 2 versus 21.1% on low-mineral water, and cut rescue medication use.Efficacy and safety of a magnesium sulfate-rich natural mineral water for patients with functional constipation.
- In 226 adults with functional constipation, drinking 1 L daily of magnesium- and sulphate-rich mineral water for 14 days gave a response in 50% versus 29% on low-mineral water, with response in about 6.4 days versus 7.3 days.Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation.
- In 128 hospital patients with partial adhesive small-bowel obstruction, adding oral magnesium oxide with a probiotic and simethicone to standard care led to successful treatment without surgery in 91% versus 76% and a shorter hospital stay (1.0 vs 4.2 days).Nonsurgical management of partial adhesive small-bowel obstruction with oral therapy: a randomized controlled trial.
- In 106 adults with functional constipation, drinking 500 mL a day of magnesium sulphate-rich mineral water for 6 weeks improved bowel movement frequency, stool consistency and constipation symptoms compared with placebo water.Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: a double-blind, random…
- In 102 adults having heart bypass surgery, taking 800 mg of magnesium oxide daily by mouth from admission until discharge led to less constipation, nausea, vomiting and irregular heartbeat than in the control group.Oral magnesium supplementation reduces the incidence of gastrointestinal complications following cardiac surgery: a rand…
- In 100 adults with functional constipation, 1 liter a day of sulfate-rich mineral water increased weekly bowel movements more than tap water after 3 weeks, but the difference was not significant after 6 weeks.Effects of Sulfate-Rich Mineral Water on Functional Constipation: A Double-Blind, Randomized, Placebo-Controlled Study.
- In 100 children with cerebral palsy and chronic constipation, oral magnesium sulfate for 1 month improved constipation score, stool frequency and consistency versus placebo, with effective treatment in 68% versus 9.5%.Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a random…
- In a placebo-controlled trial of 90 adults with chronic constipation, 1.5 g of magnesium oxide daily for 28 days improved overall symptoms in 68.3% of users, compared with 11.7% on placebo, and increased bowel movements.Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
- In 84 children with chronic constipation, magnesium oxide alone for four weeks produced at least three bowel movements a week in 67.5% of children, and adding cisapride raised this to 90.9%.Use of cisapride with magnesium oxide in chronic pediatric constipation.
- In a placebo-controlled trial of 83 patients with advanced cancer taking meds, magnesium-L-threonate capsules over 90 days reduced the increase in a med dose needed and the authors state it significantly relieved a med-induced constipation.Read the study on PubMed (36703238) →
- In 74 patients recovering from liver surgery, postoperative magnesium hydroxide laxative led to first bowel movement at a median of 4 days versus 5 days in controls.Randomized clinical trial of laxatives and oral nutritional supplements within an enhanced recovery after surgery protoc…
- In 64 elderly long-stay patients with constipation, about 25 ml of magnesium hydroxide daily gave more frequent bowel movements and more normal stools than a bulk laxative over 4 weeks.Constipation in elderly long-stay patients: its treatment by magnesium hydroxide and bulk-laxative.
- In a placebo-controlled trial of 60 children with functional constipation, all groups improved in bowel movement frequency over 4 weeks, including groups without magnesium oxide, while magnesium oxide significantly softened stools and altered gut bacteria.Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and…
- After open colon surgery, magnesium oxide at 1 g twice daily did not speed the return of bowel function compared with placebo.Effect of the laxative magnesium oxide on gastrointestinal functional recovery in fast-track colonic resection: a double…
- In 45 children under 10 with chronic constipation, magnesium oxide taken for 4 weeks gave more bowel movements, more treatment success and less hard stool than placebo, with results similar to a probiotic.Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation.
- In healthy adults without constipation, drinking 1 litre of magnesium-rich mineral water daily for 2 weeks softened stool and increased bowel movements compared with soft water.Magnesium-Rich Mineral Water Improves Stool Consistency and Bowel Habits in Healthy Subjects: A Randomized Controlled Tr…
- In children with chronic functional constipation followed for 6 months, magnesium hydroxide worked about as well as polyethylene glycol, though more children refused the taste of magnesium hydroxide.Comparison of the effectiveness of polyethylene glycol 4000 without electrolytes and magnesium hydroxide in the treatmen…
- In 15 children with a surgically corrected anorectal malformation and constipation, magnesium hydroxide, senna and polyethylene glycol each taken for three-week periods did not differ significantly in clearing stool from the bowel, with magnesium hydroxide clearing it in about 47%.Sennosides vs magnesium hydroxide vs polyethylene glycol as a treatment for constipation in anorectal malformation: a ra…
- In 10 healthy volunteers, high-dose magnesium-aluminum antacids increased stool frequency and weight and made stools looser, which is the opposite of what someone with constipation wants.Effects of high dose antacids on bowel motility.
- In six adults over 55 with normal bowel habits, magnesium hydroxide at 1,200 to 3,600 mg per day increased bowel movements and stool water compared with placebo in a crossover trial, with the effect growing at higher doses.Magnesium hydroxide: new insights into the mechanism of its laxative effect and the potential involvement of prostagland…
- In 100 adults with duodenal ulcer taking magnesium hydroxide-based antacids for 20 days, constipation was affected more often than with the control preparation, though the study focused mainly on ulcer pain and healing.[Clinical trial of the Bulgarian preparations, flatugel and almagel-neo in duodenal ulcer].
- In constipated elderly hospital patients, magnesium hydroxide and a bulk laxative produced no significant differences in blood lipids, minerals or vitamins A and E, though low magnesium occurred less often with magnesium hydroxide.Comparison of the effects of magnesium hydroxide and a bulk laxative on lipids, carbohydrates, vitamins A and E, and min…
- In 6 people with an ileostomy, oral magnesium chloride over 3 days increased daily output, and in 5 people without a stomach, magnesium chloride increased stool weight while magnesium hydroxide did not.Effects of Mg++ and Ca++ on water absorption from rodent and human intestine.
- In 8 healthy young adults, a magnesium sulphate laxative sped up movement through the intestine and increased stool weight compared with placebo.The osmotic laxative magnesium sulphate activates the ileal brake.
- In a review of 768 children given enemas in an emergency department, the pink lady enema, which contains magnesium citrate, produced stool output no different from sodium phosphate or soap suds enemas.A Comparison of the Efficacy of Enema Solutions in Pediatric Emergency Department Patients.
- In 619 cancer patients starting oral meds, constipation occurred in 34% of those given laxatives including magnesium oxide versus 55% of those given none.Read the study on PubMed (22156893) →
- In a real-life observational study of 196 infants with digestive problems, a formula high in magnesium (also containing prebiotics and a probiotic) given for two weeks reduced constipation from 18.8% to 6.5% within three days, though magnesium's effect cannot be separated from the other ingredients.An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders.
- In patients taking stomach acid-reducing drugs, magnesium oxide was less effective at controlling constipation, so higher doses were needed than in patients taking it alone.Interaction of magnesium oxide with gastric acid secretion inhibitors in clinical pharmacotherapy.
- In a 1974 study using a radio-transmitting capsule to measure bowel acidity, magnesium sulphate had little effect on acidity in the colon, though it raised acidity in the rectum; this physiology study did not measure constipation relief.Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device.
Review Totals and Summary
Members Only2,237 reviews · 70% positive
2,237 reviews · Target 1,204 · Walgreens 664 · Naturalvitality 369
70% positive25% neutral5% negative
Natural Vitality Calm Magnesium Citrate Liquid has built a notable presence across popular retailers like Target, Walgreens, and the brand’s own site, with thousands of user reviews reflecting a generally positive impression. Most reviewers highlight its effectiveness in helping to support relaxation and ease the symptoms of stress or tension. Many users share that they notice feeling calmer after taking the product consistently, and some specifically mention it aiding with sleep or alleviating muscle cramps. Several reviewers appreciate the ease of use of the liquid format, saying it’s a convenient addition to their routine, and a number of people like mixing it with water or juice as part of their wind-down ritual. Taste is a recurring topic: while some enjoy the fruity or citrus flavors and find them pleasant, others find certain flavors to be a bit too sweet or, on occasion, have a slightly artificial aftertaste. It appears that, overall, the taste is acceptable to most but not a universal hit. Notably, a significant portion of the reviews—reflecting a neutral sentiment—point out that while the product works as described, it doesn’t produce dramatic effects, and individual results can vary. Some people observed a mild benefit but weren’t sure if it was worth continuing in the long run, while others simply didn’t notice much difference, indicating that expectations may shape satisfaction quite a bit. Negative feedback is relatively rare but does come up. The most common complaints relate to digestive issues, such as stomach upset or diarrhea, which some people experienced even at the recommended amount. A handful of users mention packaging leaks or difficulty closing the bottle tightly, which slightly detracted from the overall experience. A few reviewers were disappointed by the cost compared to perceived results. Overall, Natural Vitality Calm Magnesium Citrate Liquid is generally well-regarded for its calming support and straightforward use, with the majority of users satisfied or pleasantly surprised by their experience. There's a fair share of moderate or neutral voices who think it’s fine but not exceptional, and a much smaller group found it didn’t meet their needs or came with mild side effects. The consensus, shaped from thousands of opinions, suggests that for most people seeking a gentle and accessible way to supplement magnesium and promote calm, this product is a solid choice—though not without minor drawbacks or limitations for some.
Biohacker Summary
Members Only6 of 10 recommend it
6 of 10 biohackers on our panel recommend it
Most of the panel recommends or uses magnesium, often taking it for sleep, but also for overall health, brain function, relaxation, and blood pressure. Several panelists prefer specific forms such as magnesium glycinate or magnesium threonate, with some taking 300 to 400 milligrams before bed for sleep. Other panelists aim for 400 to 600 milligrams daily for general health or bone health, with one aiming for up to a gram. Magnesium is sometimes paired with vitamin D or zinc, or included in electrolyte drinks with sodium and potassium. One panelist warns that some magnesium supplement labels can be misleading about the actual elemental magnesium content, specifically mentioning magnesium citrate, and another warns against magnesium oxide due to poor absorption.
See all 10 biohackers →Hide the biohackers
Dr. Rhonda Patrick · Magnesium · recommends
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
Dr. Eric Berg · Magnesium · recommends
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
- Magnesium is involved in 300 to 600 enzyme reactions, acts as a biological brake pedal, is the master controller over calcium, and is involved in making ATP, the energy currency of the body. It takes energy to go to sleep, and magnesium is required for relaxation and good sleep. Magnesium also helps balance cortisol levels and calm you.
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
Thomas DeLauer · Magnesium · recommends
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
Andrew Huberman · Magnesium · recommends
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
Dr. Mark Hyman · Magnesium · recommends
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
Dave Asprey · Magnesium · uses
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
- Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.
RAL Summary
Members OnlyTier 3 for Regularity: Fast Relief
This product is in the reviews tier because 70 percent of its 2237 reviews are positive, but it is not recommended because its 325 milligram dose of magnesium is below the 800 milligrams that relieved constipation in studies [1].
- Magnesium: below the dose that worked in studies
Where the evidence disagrees: 9 of the 35 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Not compulsory. Best taken on an empty stomach or with a light meal.
Possible side effects: No major side effects reported.
Supplement Facts
Magnesium 325 mg
Supplement Facts
Serving Size Approx. 2 Teaspoons (4 g)
Servings Per Container About 113
Amount Per Serving% Daily Value
| Magnesium (as Ionic Magnesium Citrate, Ionic Magnesium Glycinate [when mixed with water]) | 325 mg | 77% |
Other ingredients: Ingredients: Natural Vitality MAXCALM® is a highly absorbable proprietary formulation of pH-balanced Magnesium Citrate (Acreated from Citric Acid and Magnesium Carbonate) and Magnesium Glycinate in ionic form, Organic Flavor, Organic Stevia (leaf) Extract.
Directions: HOW TO USE: Scoop. Fizz. Sip. For fastest prep, pour approximately 2 teaspoons (4 g) of powder into your favorite glass or mug, add 2-3 oz of hot water, and let it do its fizzy thing. Stir until dissolved, then top off with warm or cold water. Prefer it quick? Just add MAXCALM® to a bottle of cold water and shake it up on the go.
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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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