Nature Made Vision Based on the AREDS 2 Formula Review
Product Focus: Sexual Health for WomenAlso covers:Eyes
Tier ⓘ
Tier 4 · Rank 1
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 1 within Tier 4 for Sexual Health for Women; 3 of 4 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only10 human studies · 2 improved
10 human studies2 improved4 no effect669 people studied
This is an eye health formula, and none of its ingredients has been shown on its own to improve sexual function in women. Vitamin E taken by mouth has the most research, and it does not look promising. In 93 women after menopause, daily vitamin E for 8 weeks eased hot flashes but did not change sexual function scores compared with placebo [1]. In a small older trial, a high daily dose made no difference in arousal or behavior compared with placebo [2]. A vitamin E vaginal suppository improved sexual function about as much as estrogen cream, but that was a different form and there was no placebo group [3]. Benefits seen with vitamin E combined with saffron or ginseng were credited to those herbs [4][5]. The only vitamin C study mixed it with several other ingredients and did not report the dose, so it cannot show that vitamin C helped [6]. Zinc has been studied only in male rats [7]. Blood copper levels were not linked to sexual function in pregnant teenagers [8]. Lutein and zeaxanthin have not been studied for this goal. No reviews were available. Animal and cell studies are never counted.
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- In 93 postmenopausal women, 200 IU of vitamin E daily for 8 weeks reduced hot flashes but did not change sexual function scores compared with placebo.The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple bl…
- In 62 women with sexual dysfunction who finished the trial, a daily supplement of 100 IU vitamin E plus ginseng for 6 weeks improved desire and satisfaction more than placebo, but not total sexual function score.Vitamin E and ginseng supplementation to enhance female sexual function: a randomized, double-blind, placebo-controlled,…
- In 52 postmenopausal women, a vitamin E vaginal suppository for 12 weeks improved sexual function scores about as much as vaginal estrogen cream, with no significant difference between the two and no placebo group.Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial.
- In 50 reproductive-age women with recurrent urinary tract infections, a once-daily combination of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine and vitamin C taken for 3 months (in a crossover trial lasting 6 months) gave higher sexual function scores than the control group at 3 months, though the vitamin C dose was not stated and its effect cannot be separated from the other ingredients.Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary…
- In 50 women with sexual dysfunction, adding saffron to 50 mg of vitamin E daily for 8 weeks improved sexual function more than vitamin E alone, so this shows the saffron combination's benefit rather than that of vitamin E itself.Effect of vitamin E with and without saffron on the sexual function in women of reproductive age with sexual dysfunction…
- In 35 people, 1000 IU of vitamin E daily for 28 days made no difference in sexual arousal or behavior compared with placebo.Effect of vitamin E on human sexual functioning.
- In a cross-sectional study of 200 pregnant teenagers in Iran, blood copper levels were not significantly linked to sexual function; the only copper association found was a higher level in those with depression.Serum Levels of Vitamin D, Calcium, Magnesium, and Copper, and their Relations with Mental Health and Sexual Function in…
- In a pilot study of 78 reproductive-age women with autoimmune thyroiditis taking selenomethionine for six months, sexual function improved significantly only in those with adequate vitamin E intake.Vitamin E Intake Modulates the Effect of Selenomethionine on Sexual Function and Depressive Symptoms in Reproductive-Age…
- In a retrospective review of 49 women with vulva itching, oral and topical vitamin E with physical therapy reduced itching, pain, and depression, but the abstract does not report the sexual function result.Effects of vitamin E and physical therapy in alleviating the symptoms of vulva pruritus: A review of 49 cases.
- In a pilot study of young women with Hashimoto's disease taking vitamin D for six months, sexual function improved most in those with adequate vitamin E intake, with limited changes in low intake and no change in high intake.Influence of Vitamin E Intake on Sexual Function and Depressive Symptoms in Young Women with Euthyroid Autoimmune Thyroi…
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
This product has no single main ingredient in the panel's statements, so the paragraph covers the ingredients that came up, all of which are smaller ingredients in this product. Vitamin C drew the most support: six of the ten recommend or use it, mainly for collagen, skin, joints, immunity and detox, and several suggest taking it with collagen, with one giving 500 mg to 1 g in a surgery setting and another pairing it with zinc. Zinc was also widely backed, with six panelists recommending or using it for testosterone, gut lining, mood, immunity, wound healing and sleep, with doses of 15 mg a day in one case and 30 mg in others, and zinc carnosine named as the gut form. The cautions were that too much zinc can lead to low copper, and one panelist stopped using a vitamin C serum over its smell and noted that supplement doses did not protect against cataract. Copper, vitamin E and zeaxanthin got only brief, mostly neutral mentions, with one panelist taking 2 mg of copper daily and another saying zeaxanthin may slow advanced macular degeneration in high-risk people.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Zinc · recommends
- Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
- Recommends Vitamin C as a cofactor, especially for collagen.
- Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Notes that birth control pills deplete the body of zinc, which is needed for the brain to make serotonin.
- Added zinc to his creatine product because a deficiency in zinc might make creatine not work as well.
- Mentions that grass-fed liver is loaded with zinc.
- Recommends zinc to enhance testosterone.
- Added copper to his creatine product because a deficiency in copper might make creatine not work as well.
- Mentions that grass-fed liver is loaded with copper.
- Mentions that grass-fed liver has vitamin E.
Andrew Huberman · Zinc · uses
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- Takes a multivitamin every day for longevity.
- Takes a multivitamin every day for longevity.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
Ben Greenfield · Copper · neutral
- Mentions that overshooting zinc can lead to a copper deficiency, highlighting the interplay between these elements.
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Mentions vitamin C as part of a bare-minimum protocol.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
- He mentions zinc as a supplement with real human data behind it for male fertility.
- Zinc may support both testosterone and sperm count.
- Says Formula IQ CopperIQ Serum has stayed in their routine to close out summer strong.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Warns that he was taking so much zinc without realizing it because it was in five different things he was taking, and he couldn't pinpoint the problem.
- Recommends supplementing with zinc if deficient, as multiple trials show significant symptom reduction of tinnitus in zinc-deficient individuals.
Siim Land · Vitamin C · recommends
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Mentions that copper is a mineral necessary for making collagen.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Notes that Vitamin C is one of several supplements with human evidence.
- Notes that Lutein is one of several supplements with human evidence.
- Supplementing lutein and zeaxanthin 5-20 mg/day improves macular pigment optical density (MPOD), a marker of eye health, in people with healthy eyes.
- Supplementing lutein and zeaxanthin 5-20 mg/day improves macular pigment optical density (MPOD), a marker of eye health, in people with healthy eyes.
- States that deficiencies in nutrients such as zinc can impair normal immune regulation.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Notes that oral vitamin E and C supplementation has been noted to increase the dose of UVB radiation from the sun needed to cause redness of the skin, suggesting increased resilience against sun damage. He also mentions a trial where a combination of slow-release vitamin C and vitamin E decreased the progression of carotid atherosclerosis in men.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
Thomas DeLauer · Vitamin C · recommends
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Compares zinc content, noting salmon has under 1mg while oysters have 74mg per 100g, a 70x difference.
- Recommends keeping zinc levels topped off because it is a critical cofactor for over 300 enzymes and is important for immune cells, testosterone, and wound healing.
- Recommends 15 mg of supplemental zinc if oysters are not realistic, but emphasizes that food source zinc is better as it comes with natural cofactors like copper and selenium.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
- Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
- Mentions a causal link found between vitamin E and waking up in the middle of the night.
Dave Asprey · Vitamin C · recommends
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
- Emphasizes the importance of having enough copper before trying advanced longevity strategies like peptides.
- Suggests that zinc has better safety and protective data than meds for reducing cardio respiratory risk.
- Recommends Vitamin E as one of the most important supplements for overall health.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Includes vitamin K2 as a critical ingredient in Vitamin DAKE, stating that the body needs the right fat soluble vitamins for thousands of reactions.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Dave Asprey mentions that he will discuss copper in the episode.
Dr. Mark Hyman · Vitamin C · recommends
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Recommends ensuring adequate zinc intake on a regular basis for immune support, noting some data on zinc lozenges for early cold.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends correcting nutrient deficiencies with zinc.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Recommends nutrient-dense foods rich in zinc, such as pumpkin seeds and oysters, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Used zinc as part of a protocol to rebuild the gut microbiome and heal the gut of a nine-year-old girl with severe behavioral issues.
- Notes that patients who were very malnourished had extremely low vitamin E.
Dr. Rhonda Patrick · Zinc · recommends
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Zeaxanthin may be among the most evidence-backed carotenoids for longevity. It accumulates in the brain, where higher levels are associated with greater crystallized intelligence, and supplementation can improve some measures of cognitive function. Evidence also suggests it may slow progression to advanced macular degeneration in high-risk individuals.
- Lutein may be among the most evidence-backed carotenoids for longevity. It accumulates in the brain, where higher levels are associated with greater crystallized intelligence, and supplementation can improve some measures of cognitive function. Evidence also suggests it may slow progression to advanced macular degeneration in high-risk individuals.
- Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
- Consumes lutein through kale, noting its accumulation in the retina and brain for visual and cognitive function, and that avocado increases its absorption.
- Notes that lutein, a carotenoid found in kale, builds up in the retina and brain, helping to protect against macular degeneration and is linked to faster cognitive processing and better fluid intelligence.
- Zeaxanthin may improve cognition, even in younger adults. It accumulates in the retina, where it helps neutralize light-driven oxidative damage linked to macular degeneration risk, and also accumulates in the brain, where higher blood levels are associated with better fluid and crystallized intelligence.
- Lutein may improve cognition, even in younger adults. It accumulates in the retina, where it helps neutralize light-driven oxidative damage linked to macular degeneration risk, and also accumulates in the brain, where higher blood levels are associated with better fluid and crystallized intelligence.
- Recommends nutrients like zinc for men to prioritize sperm mitochondrial health.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
Bryan Johnson · Zinc · uses
- Takes 15 mg of Zinc in the morning for longevity.
- Takes 15 mg of Zinc in the morning.
- Takes 15 mg of Zinc in the morning for longevity.
- Takes 2 mg of Copper in the morning for longevity.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Bryan Johnson's baseline measurements showed low zinc, which was easy to fix by adjusting her protocol and supplements.
- Takes 250 milligrams of Vitamin C.
- Stopped taking lutein because it caused his skin to turn a little yellow after taking 20 milligrams a day for about a year.
- Recommends adequate Zinc for hair health, noting it is in the Blueprint stack.
- Bryan uses a copper pillowcase as part of his curated sleep environment.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
- Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
- He uses Vitamin C, typically in a serum, in the morning for skin health.
Peter Attia · Zinc · recommends
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
- Mentions that there is mixed, weak evidence suggesting lutein and zeaxanthin might be protective for cataract, as they are also antioxidants.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Notes that there are some downsides to Vitamin E, including cardiovascular longitudinal risk and prostate cancer, and that discussions are needed with patients, especially those with diabetes or cirrhosis, due to studies indicating increased all-cause mortality depending on the dose.
- Explains that for Wilson's syndrome, which can lead to liver failure, the treatment given to children is zinc, which is inexpensive and effective in outcompeting copper to prevent overload.
- Peter Attia, involved in the American Urological Association Peyronie's guidelines, stated that vitamin E is not indicated for Peyronie's disease and should not be given.
- Uses a new irrigant called ZinC and Gent because they are very worried about prosthetic infection.
- States that American Urological Association guidelines advise against giving vitamin E for Peyronie's disease as it is not indicated.
- Discusses the AREDS formula, which includes C, E, beta-carotene, zinc, and copper, and later lutein and zeaxanthin instead of beta-carotene. Studies showed it could delay or reduce the conversion of mild to severe macular degeneration but had no effect on severe disease or preventing it in healthy individuals.
RAL Summary
Members OnlyTier 4 for Sexual Health for Women
The evidence is thin. Placebo-controlled trials of vitamin E taken by mouth found no effect, the one positive vitamin E result used a vaginal suppository, and the other ingredients have no useful human studies for this goal [1][3].
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 4 of the 10 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Reproductive system, Eyes
Possible side effects: No major side effects reported. Members should note that the daily zinc amount studied is above the recommended daily limit, so they can take less.
Supplement Facts
Vitamin C 250 mg · Vitamin E 90 mg · Zinc 40 mg
Supplement Facts
Serving Size 1 Softgel
Servings Per Container 60
Amount Per Serving% Daily Value
| Calories | 5 | |
| Total Fat | 0.5 g | |
| Total Carbohydrate | 1 g | |
| Vitamin C | 250 mg | |
| Vitamin E | 90 mg | |
| Zinc | 40 mg | |
| Copper | 1 mg | |
| Lutein | 5 mg | † |
| Zeaxanthin | 1 mg | † |
† Daily Value not established.
Other ingredients: Ascorbic Acid, dl-Alpha Tocopheryl Acetate, Soybean Oil, Gelatin, Glycerin, Zinc Oxide, Corn Oil, Lecithin, Lutein, Colors Added (Including Carmine), Yellow Beeswax, Cupric Oxide, Zeaxanthin.
Directions: SUGGESTED USE: Adults, take 1 softgel twice daily with water and a meal. Take 1 in the morning and 1 in the evening. Store tightly closed, in a cool, dry place, out of reach of children. Do not use if seal under cap is broken or missing.
Barcode (UPC) 031604043001 · Label source: Naturemade · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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