NatureBell Nattokinase Supplement 8000 FU Review
Max strength 8,000 FU Nattokinase per serving, sourced from a pure fermented Natto extract, a staple in centuries-old Japanese cuisines for trusted enzyme benefits.
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Study, Trial or Testing Result Summary
Members Only5 human studies · 3 improved
This product gives 8,000 fibrinolytic units of nattokinase a day, which is at or above the doses used in the studies. The strongest study gave 265 older adults without heart disease nattokinase at 2,000 units a day or a placebo for about 3 years. It found no change in artery wall thickness, artery stiffness, blood pressure, or blood clotting and inflammation measures [1]. A trial in 120 adults with symptom-free narrowing of brain or neck arteries used the same 8,000 unit dose as this product for 6 months. It did not improve overall thinking scores, though an exploratory check found less decline in visuospatial skills [2]. Smaller, weaker studies were more positive. In 9 healthy men, a single dose helped hand skin temperature recover faster after cold water than placebo [3]. A related natto product reduced self-rated cold hands and feet and shoulder stiffness over 4 weeks in women [4]. It also raised clot-dissolving activity in an uncontrolled 2-week study of 28 volunteers [5]. Overall, the evidence that nattokinase improves blood flow is limited, and the largest, longest trial found no benefit. Animal and cell studies are never counted.
See all 5 studies →Hide the studies
- In 265 older adults without heart disease, taking nattokinase (2,000 fibrinolytic units) for about 3 years did not change artery wall thickness, artery stiffness, blood pressure or blood clotting and inflammation measures compared with placebo.Nattokinase atherothrombotic prevention study: A randomized controlled trial.
- In 120 adults with symptom-free narrowing of brain or neck arteries, 6 months of nattokinase (8,000 fibrinolytic units daily) did not improve overall thinking scores versus placebo, though an exploratory check found less decline in visuospatial skills.Nattokinase supplementation for cognitive enhancement in asymptomatic intracranial/carotid stenosis: A randomized contro…
- In a double-blind crossover study of 9 healthy men, a single 2,000 fibrinolytic unit dose of nattokinase helped skin temperature in the hand recover faster after cold water immersion than placebo, without changing heart rate or cardiac output.A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, plac…
- In a crossover study of women with lifestyle diseases, 4 weeks of the natto-derived supplement NKCP reduced self-rated shoulder stiffness, low back pain and cold extremities more than an active placebo, but headache did not change.Effects of Bacillus subtilis var. natto products on symptoms caused by blood flow disturbance in female patients with li…
- In uncontrolled studies of 28 volunteers taking the natto-derived NKCP tablet for 2 weeks, and 23 volunteers for several months, clot-dissolving activity increased and shoulder stiffness improved.Fibrinolytic and anti-thrombotic effect of NKCP, the protein layer from Bacillus subtilis (natto).
Review Totals and Summary
Members Only3,552 reviews · 88% positive
NatureBell Nattokinase Supplement 8000 FU consistently receives strong feedback from users across web retailers, with the majority of reviewers highlighting positive experiences. Many users say they purchase this supplement to support their cardiovascular health, and a recurring theme in reviews is that people notice benefits over time, such as feeling more energetic or experiencing improved general well-being. Some reviewers specifically mention a sense of reassurance about taking this supplement due to its straightforward capsule format and that it's easy to include in their daily routine. Several people appreciate that the capsules are easy to swallow and seem to be of consistent quality, with the packaging receiving favorable mentions for being secure and straightforward. Satisfaction with perceived effectiveness is a common thread in the highest-rated feedback, with users frequently sharing that their blood pressure is more manageable or their circulation feels improved, though most add the caveat that these experiences are subjective and should not replace medical advice. A few reviewers mention taking this supplement on the recommendation of a healthcare professional, which adds credibility for some buyers. People rarely discuss taste, but when it does come up, it’s mostly neutral—users seem pleased that there’s no aftertaste or unpleasant smell. As with any supplement, there are also users who offer more neutral or critical perspectives. Some mention they've yet to notice a significant difference after taking the product, suggesting that the effects may be subtle or take longer to manifest for certain individuals. This aligns with reviews that express a wait-and-see approach, with users saying they hope for greater benefits but acknowledging that supplements don’t always work uniformly. A smaller number of negative reviews touch on difficulties with shipping, product consistency, or dissatisfaction with the lack of clear, immediate outcomes. Occasionally, users express concerns about sensitivity or mild digestive discomfort after starting the supplement, though these complaints are not common enough to point to a broader issue. A handful of reviewers also question the transparency or scientific backing of some claims they saw online, urging others to consult with a healthcare provider before starting any new supplement regimen. Overall, while most are satisfied with the quality and perceived benefits of NatureBell Nattokinase Supplement 8000 FU, a portion of customers remain cautiously optimistic or undecided about its long-term effects. The consensus, reflected in thousands of positive reviews, suggests that many users feel they are getting value for their money and trust this supplement as part of their broader wellness approach. Still, as with most health products, results vary and a small percentage of users voice disappointment or issues, reminding potential buyers to set realistic expectations and consult health professionals where appropriate.
Biohacker Summary
Members Only6 of 10 recommend it
Nattokinase is the main ingredient here, and the panel leans toward recommending or using it, though not unanimously. Most of the eight who spoke take it for heart and circulation, such as lowering LDL cholesterol, reducing plaque, and preventing clots, while others use it to break up bacterial biofilms or to support fasting. Doses came up often: one panelist says effects show only at 8,000 units or more, another suggests starting at 12,000 and going up to 20,000, and one advises taking it at night on an empty stomach. Some prefer natto, the fermented soybean food, for its vitamin K2, and one panelist said they switched from pills to natto, while another noted you cannot get enough nattokinase from food. Two panelists were doubtful, one questioning whether the enzyme survives stomach acid and one seeing no convincing evidence for heart or stroke prevention, and another said more trials are needed to find the right dose.
See all 9 biohackers →Hide the biohackers
Andrew Huberman · Nattokinase · uses
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after learning his blood lipids were slightly out of range.
- Started supplementing with nattokinase after a Function Health test revealed slightly out-of-range blood lipids, and a follow-up test confirmed it helped reduce his LDL cholesterol.
- Learned from a Function test that some of his blood lipids were slightly out of range, so he decided to start supplementing with nattokinase, which naturally helps reduce LDL cholesterol, and it worked.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after a Function test showed his blood lipids were slightly out of range, and a follow-up test confirmed it worked.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after a Function test showed his blood lipids were slightly out of range, and a follow-up test confirmed its effectiveness.
- Started supplementing with nattokinase after a Function Health test showed his blood lipids were slightly out of range, and a follow-up test confirmed this strategy worked to reduce LDL cholesterol.
- Started supplementing with nattokinase after a Function Health test showed some blood lipids were slightly out of range, and confirmed in a follow-up test that it helped reduce LDL cholesterol.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after a Function test showed his blood lipids were slightly out of range, and a follow-up test confirmed it worked.
- States that he started supplementing with nattokinase to naturally help reduce LDL cholesterol after learning his blood lipids were slightly out of range, and confirmed its effectiveness with a follow-up test.
- Started supplementing with nattokinase to naturally help reduce LDL cholesterol after learning their blood lipids were out of range, and a follow-up test confirmed its effectiveness.
- Recommends natto as an example of a quality, low sugar fermented food to maintain a healthy gut microbiome, noting it's an acquired taste.
- Recommends natto as an example of a low-sugar fermented food that is great for the gut microbiome when consumed two to four servings each day.
Ben Greenfield · Nattokinase · neutral
- Questions the efficacy of nattokinase for plaque melting, asking how an enzyme can get through stomach acid and if the gut bacteria can utilize its chemical trash to make K.
- Notes there is good evidence that high-dose lumbrokinase and nattokinase from a specific source may help reduce or regress plaque, and he is looking into high-dose nattokinase as part of his damage control.
- Is glad that people are finally catching on to the idea of a high dose nattokinase protocol for heart health/plaque, emphasizing the importance of using adequate amounts, preferably more than 8000 units.
- Recommends nattokinase for plaque regression, stating that most supplements only have 1,000 to 2,000 units, but data shows an impact only at 8,000 units or more.
- Used to take nattokinase pills, but found the "earthy stuff" (fermented soybeans) to be more effective for shrinking plaque.
- Has partnered with Dr. Daran Shaw's company, Vitaboom, to create a heart health pack that includes natto, based on ingredients he found for plaque regression.
- Ben Greenfield recommends looking into nattokinase if concerned about plaque, noting its effect on coronary artery calcification.
- Ben Greenfield used to consume natto, a Japanese fermented soybean dish rich in K2, and plans to start doing so again due to its effect on coronary artery calcification.
- Ben Greenfield includes Nattokinase in his Vitaboom Heart Health Stack.
- Expresses skepticism about nattokinase for plaque melting, questioning how an enzyme can get through stomach acid and if it relies on specific gut bacteria to be effective, suggesting it's not a straightforward solution.
- Ben mentions that when he used to race triathlons in Japan, he would eat a giant heap of natto with rice wrapped in a seaweed wrap for breakfast every morning.
- Uses different types of enzymes like nattokinase to break open biofilms and hidden parasites so they can be killed off.
- Warns against combining nattokinase with pharmaceutical meds like a med, Pradaxa, a med, or a med, stating it could be potentially dangerous.
- Adds naturally fermented natto from a Japanese company in San Francisco to his morning soup for fermented food and enzymes.
Dave Asprey · Nattokinase · recommends
- Recommends Nattokinase as one of the eight compounds in BioPurify for circulation and cellular health.
- Recommends Nattokinase, stating it supports healthy circulation and helps the body break down blood clots.
- Recommends taking nattokinase at night before bed on an empty stomach to help make a med, and notes it's also good for spike protein.
- Recommends taking high-dose nattokinase, starting at 12,000 units and potentially increasing to 20,000 units, to minimize the impact of the COVID vaccine, as it directly breaks up spike protein and reduces soft plaque.
- Notes that one cannot get enough nattokinase from eating natto, but it is a good source of vitamin K2, which is probably its primary benefit.
- Mentions Natto as one of the richest food sources of K2.
- The episode discusses how nattokinase, a natural enzyme, has shown the ability to break down the spike protein.
- Nattokinase, an enzyme found in natto, breaks up protein clumps including blood clots, and studies show that at higher doses it can even reverse cardiovascular disease.
- Natto, a traditional Japanese food made from fermented soybeans, contains about 25 mg of spermidine per 100g and is eaten daily in Nagaro, but Dave Asprey finds its taste and texture difficult to tolerate.
- For the last 25 years, Dave Asprey has been on a high dose of either serrapeptase or nattokinase to reduce stroke risk by breaking up thrombin and fibrinogen, also noting nattokinase breaks up soft plaque.
- Uses a lot of nattokinase and lumbrokinase to address histamine spike protein issues.
- Recommends nattokinase and other things to make blood flow well, especially for those with long COVID or who had COVID.
- Recommends nattokinase, stating that 4,000 units a day will likely break up clots from COVID and emerging research suggests it removes soft plaque, especially at higher doses on an empty stomach.
- Says that natto is not a regular feature in his diet, but he consumes it when he finds organic versions, believing it has significant health benefits, assuming one is not sensitive to histamine.
Siim Land · Natto · uses
- Lists natto as a food high in spermidine, providing 20 mg per 100g, which he consumes for longevity.
- Notes that some trials show nattokinase improving atherosclerotic plaque, with high doses showing an effect where low doses did not, and more studies are needed to find the threshold effect.
- Notes there are interesting studies suggesting Nattokinase might reduce atherosclerotic plaque and personally believes it does based on current evidence, but more clinical trials are needed to determine effective doses.
- Believes Nattokinase might reduce atherosclerotic plaque and blood viscosity, making it useful for people over 50, especially men, who have a higher risk of blood clotting.
- Discusses Nattokinase as a supplement.
- Recommends Nattokinase as a beneficial supplement for reducing atherosclerotic plaque and the risk of blood clots, suggesting a higher dose of 10,000 fibronotic units per day, but warns against taking it with meds.
- Consumes natto for longevity, acknowledging it tastes horrible but provides a high dosage.
- Cites a study where nattokinase at 6,000 fibrinolytic units per day for 26 weeks resulted in a 36.6% decrease in carotid plaque size and intima media thickness. He suggests that at least 6,000 fibrinolytic units per day might be needed for a significant decrease in plaque size, and also notes that nattokinase lowers blood pressure and clotting.
- Mentions natto as being in the vicinity of vegetables and having similar benefits.
- Explains that Nattokinase, an enzyme from fermented soy, at a dose of 6,000 fibrinolytic units per day for 26 weeks, resulted in a 36.6% decrease in carotid plaque size.
- Plans to start taking Nattokinase after age 50, recommending a dose of at least 6,000 fibrinolytic units, and probably 10,000 units per day, for its benefits in heart health, cardiovascular disease risk reduction, and its antithrombotic, anti-blood coagulation, and anti-atherosclerotic effects.
- Recommends natto as the highest food source of mk7 and K2, noting that 100 grams provides 1,000 micrograms of vitamin K2 mk7, which is a very large and effective dose.
- Uses Nattokinase as an ingredient in Novos Vital for organ health.
- Describes natto as a very nutritious fermented soybean dish and a good source of protein, being the highest food source of vitamin K2.
Dr. Eric Berg · Nattokinase · recommends
- Recommends Nattokinase as a top natural remedy for clots.
- Dr. Berg states that nattokinase, found in natto, is a very effective compound to reduce clotting.
- Dr. Berg mentions natto as a fermented product that is super high in vitamin K2 and nattokinase, which is effective in reducing clotting.
- Notes that fermented natto is part of the longevity diet in Japan, which has the most centenarians.
- Recommends nattokinase as a supplement to prevent clotting.
- Mentions that Natto, fermented soybeans, is the food with the most vitamin K2.
- States that Nattokinase may help remove arterial plaque buildup naturally.
- Recommends Nattokinase, stating it can help decrease the thickness of the carotid wall.
- Has found Nattokinase really helpful, noting it may help break up clots.
- Recommends Nattokinase, an extract from soy, for dissolving fibrous tissue, breaking down clots, and addressing clogged arteries by breaking up blockages and protein formations in clots.
- Suggests that Nattokinase can potentially help lower cholesterol naturally.
- Recommends nattokinase as the best natural remedy to unclog arteries, noting it is an enzyme found in natto (fermented soybeans).
- Mentions natto as fermented soybeans that contain nattokinase and vitamin K2.
- Recommends Nattokinase as a potent remedy for unclogging arteries, noting its ability to break up clots, reduce oxidative LDL, provide anti-inflammatory properties, lower blood pressure, increase HDL, lower triglycerides, and decrease the risk of strokes, all with virtually no adverse effects.
Thomas DeLauer · Nattokinase · recommends
- Suggests increasing intake of nattokinase when in a fasted state to induce autophagy through a separate pathway from ghrelin, extending the autophagy period.
- Recommends natto for its K2 (MK-7) and nattokinase, which are difficult to obtain from other sources, and personally enjoys it.
- Notes that nattokinase, a component of natto, may help clear out beta-amyloid plaque, which is a large contributor to Alzheimer's and dementia.
- Discusses natto, a fermented soy product, and its component nattokinase, which studies suggest may help clear out beta-amyloid plaque, a contributor to Alzheimer's and dementia.
- Is a fan of natto, a fermented soy, and sometimes craves its unique taste, using it as an easy, high-protein food.
- Recommends fermented natto as a good form of soy for protein, as the fermentation process makes the protein more digestible.
- Mentions that natto contains nattokinase, which helps clear out beta amyloid plaque, a primary contributor to Alzheimer's and dementia, noting the extremely low dementia count in Japan.
- Explains that nattokinase, a component of natto, may help clear out beta amyloid plaque, which is a large contributor to Alzheimer's and dementia.
- Mentions natto as a fermented soy that may help clear out beta amyloid plaque, a large contributor to Alzheimer's and dementia, and suggests it could be beneficial alongside a ketogenic protocol for mental health.
- Mentions natto, another fermented soy, as being similar to tempeh in its benefit for protein utilization, with the added abundance of natural kinase for antioxidant activity, but no real gut benefit.
- Recommends natto for vegans, noting that the fermentation process breaks down oxalates and phytic acid, making it less problematic than other soy forms.
- Mentions natto as one of the only pure forms of fermented soy from Japan that is not readily available in the states.
Dr. Mark Hyman · Nattokinase · uses
- Uses nattokinase to break open bacterial biofilms, allowing antimicrobials to be more effective.
- Mentions using Nattokinase to lower lipoprotein little a, although it only lowers it by 20-30% and doesn't bring it back to normal.
- Recommends feeding healthy gut bacteria with probiotic-rich foods like yogurt, kimchi, kefir, natto, and tempeh.
- Recommends natto as a great fermented food for microbiome health.
- Recommends nattokinase for individuals with hypercoagulability to improve cognition.
- Mentions nattokinase as a natural supplement that can help thin blood and reduce inflammation and clotting.
- Recommends natto as a probiotic food.
- Mentions nattokinase as a natural supplement that can help thin blood and reduce inflammation and clotting.
- Mentions that vitamin K2 can be obtained naturally from natto, a fermented soy product eaten in Japan, noting its strong taste.
- Mentions that a Chinese doctor prescribed him natto to build up his blood.
- Mentions a Chinese doctor's recommendation to eat natto to build up blood.
- Warns that natto, a fermented food, can worsen symptoms for someone with histamine intolerance.
- Uses nattokinase as a biofilm buster when a patient with candida is not getting better.
- Discusses Nattokinase as a great agent to help with clotting and microthrombosis, but notes it's in the experimental realm for the current virus.
Dr. Rhonda Patrick · Nattokinase · warns
- States that Nattokinase isn't high on their list for cardiovascular prevention and they don't see convincing evidence for it as a primary strategy for cardiovascular disease or stroke risk reduction.
- Mentions natto as a food item with high concentrations of spermidine.
- Dr. Rhonda Patrick reviews the evidence for nattokinase and its potential to protect the heart.
- Kevin finds natto fun and good, and suggests making it at home by fermenting soybeans with a starter.
Peter Attia · Nattokinase · neutral
- Mentions Nattokinase as an over-the-counter supplement that showed more evidence for preventing DVT than a med, and it is plant-derived.
RAL Summary
Members OnlyTier 5 for Circulation
The largest and longest placebo-controlled trial, about 3 years in 265 older adults, found nattokinase did not change artery health, blood pressure or clotting measures [1]. Only small or uncontrolled studies showed benefits.
- Not endorsed.
Where the evidence disagrees: 1 of the 5 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Blood
Combine with: Not compulsory.
Possible side effects: No major side effects reported.
Supplement Facts
Nattokinase 400 mg (8,000 FU)
| Nattokinase (Enzyme from Natto Extract) | 400 mg (8,000 FU) | † |
Other ingredients: Rice flour, magnesium stearate, silicon dioxide, vegetable cellulose(capsule).
Directions: 1 capsule per serving
Label source: Naturebellusa · Report a label change
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- Supplements for Focus and Mental ClarityArticle · Jun 16, 2026
Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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