NatureBell Vitamin K Complex (K1 + K2 as MK-4 & MK-7) 2,600mcg Per Serving, 300 Coconut Oil Softgels Review
Vitamin K Complex (K1 + K2 as MK-4 & MK-7) 2,600mcg Per Serving, 300 Coconut Oil Softgels from NatureBell is presented on this page as a complete vitamin K complex softgel. The product is described as a 3 in 1 full spectrum formula with K1 and K2 as MK4 and MK7, infused with coconut oil to help absorb vitamin K's fat-soluble nutrients. The bottle holds 300 coconut oil softgels, with a 2 softgel serving size. According to the page, each dose delivers 1,500mcg K1 as phytonadione, along with 1,000mcg K2 as menatetrenone (MK4) and 100mcg menaquinone (MK7) per dose. The page states that the bottle lasts up to a 150-day supply. The listing says the formula is easily digested and absorbed, and that it supports heart, joint, bone, and immune health, as well as calcium absorption in both men and women. NatureBell describes the product as a way to replenish natural vitamin K levels, explaining that combining all forms helps with overall nutrient uptake and minimizes waste. The page also says the product is an authentic non-GMO K vitamin supplement made with pure ingredients that are free of soy, dairy, gluten, preservatives, wheat, eggs, fish, and peanuts. It adds that all products are 3rd party lab tested for safety and potency. The page includes the standard disclaimer that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease. The price shown is $28.95 under a default title, and the cart subtotal matches that price. The page also offers a notify-by-email option for availability, and the product is marked as on sale. Related NatureBell products listed on the page include a K2 MK-7 and MK-4 capsule supplement, a D3 K2 softgel with coconut oil, and a higher-dose D3 K2 softgel, but these are separate products and are not part of this listing.
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Study, Trial or Testing Result Summary
Members Only100 human studies · 53 improved
Each serving gives 1,500 micrograms of vitamin K1 and 1,100 micrograms of vitamin K2 (as MK-4 and MK-7). Both are above the doses used in the studies. The strongest support is for vitamin K2. Pooled trials in women after menopause found it improved lower spine bone density [1][2]. The spine benefit showed up in women with osteoporosis but not in women without it [3]. Fewer fractures appeared only after one study was left out [1]. In a three year trial, 180 micrograms a day slowed bone loss in the spine and hip [4]. A one year trial found 90 micrograms a day reduced hip bone loss in women after menopause but not in men [5]. Vitamin K taken with vitamin D raised total bone density [6]. Vitamin K also raised markers of bone building [7]. Vitamin K1 is less certain. Trials found no change in bone density [8][9], though fewer women had fractures in one of them [9]. In pooled trials, vitamin K1 alone showed no clear gain [10]. Higher vitamin K1 from food was linked to fewer fractures in observational studies [11]. Animal and cell studies are never counted.
See all 100 studies →Hide the studies
- In six studies of 93,776 people, higher dietary vitamin K showed a trend toward fewer fractures that did not reach statistical significance, with benefit seen up to about 120 micrograms a day.Dietary Vitamin K Intake and Fracture Risk: A Systematic Review and Dose-Response Meta-Analysis on the Interplay with Vi…
- In five observational studies of 80,982 people, those with the highest dietary vitamin K intake had about 22% lower fracture risk than those with the lowest.Vitamin K intake and the risk of fractures: A meta-analysis.
- Across nine trials with 6853 postmenopausal women with osteoporosis, vitamin K2 raised lumbar and forearm bone density more than control, with more mild side effects but no serious ones linked to it.Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and…
- Across 19 trials with 6759 postmenopausal women, vitamin K2 improved spine bone density in women with osteoporosis but not those without, and fracture reduction was only significant after excluding one study.Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of…
- Across 16 trials of 6,425 postmenopausal women, vitamin K2 improved lower spine bone density and lowered undercarboxylated osteocalcin, with no overall fracture reduction unless one outlier study was excluded and no extra side effects.Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-anal…
- In 43 trials of 5,184 postmenopausal women, vitamin K gave the largest rise in a bone formation marker (bone alkaline phosphatase), and vitamin K with vitamin D most increased other bone formation markers.Effects of dietary supplements on bone turnover markers in women after menopause: a network meta-analysis.
- Across nine trials with 2570 postmenopausal women with osteoporosis, vitamin K2 improved most bone turnover markers, though bone density and fracture benefits were not measured.The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a…
- Across 10 randomized trials with 1346 people, vitamin K plus calcium raised lumbar spine bone density more than controls, but the vitamin K1 subgroup alone did not show a clear gain.The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled…
- In eight trials of 971 people, vitamin K combined with vitamin D increased total bone density and lowered undercarboxylated osteocalcin, with doses under 500 mcg per day working well.The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials…
- Pooling 13 trials lasting over 6 months, all but one showed vitamin K reduced bone loss, and the seven fracture trials, all using vitamin K2 in Japan, showed fewer vertebral, hip and other fractures.Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
- A pooled analysis of trials in middle-aged and older adults found vitamin K supplements raised lumbar spine bone density and improved bone protein carboxylation, but did not change other bone turnover markers.Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged a…
- A review of 13 trials found small studies showed little or modest bone density benefit, while there was some evidence of fewer vertebral fractures in postmenopausal women, and no evidence for men.Menatetrenone for the treatment of osteoporosis.
- In three small trials of 70 people with cystic fibrosis, it is very uncertain whether vitamin K changes bone density, though undercarboxylated osteocalcin fell.Vitamin K supplementation for cystic fibrosis.
- A review of Japanese trials reports vitamin K2 and K1 were linked to maintained or higher bone density and fewer fractures, though a larger trial with fractures as the main outcome is still needed.[Vitamin K2].
- In a review of seven trials of at least two years in postmenopausal women, high-dose vitamin K1 and K2 improved femoral neck bone strength indices and reduced clinical fractures despite little change in bone density.High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature.
- In five trials in postmenopausal women, vitamin K1 cut clinical fractures versus placebo in one good trial, while the K2 trials were poorly reported with mixed results and the larger one showed no reduced vertebral fractures.Vitamin K to prevent fractures in older women: systematic review and economic evaluation.
- This review looked at vitamin K levels, diet and supplements in relation to bone health, but the abstract says findings across studies were conflicting and unclear.Vitamin K and osteoporosis: Myth or reality?
- This review of ten studies on vitamin K for osteoporosis in postmenopausal women did not report clear results in its abstract, so the size of any benefit is not stated.The Anti-osteoporosis Effects of Vitamin K in Postmenopausal Women.
- A review of randomized trials in women found vitamin K2 results for bone density and fractures were promising, though study limitations mean confirmation is needed.Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled tria…
- In children on long-term a med treatment, vitamin K2 combined with alfacalcidol preserved bone density, but calcium with alfacalcidol prevented bone loss better than menatetrenone.Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review.
- In 452 men and women aged 60-80 who also took calcium and vitamin D, 500 micrograms a day of vitamin K1 for 3 years did not change bone density at the hip, spine or whole body compared with no vitamin K1.Effect of vitamin K supplementation on bone loss in elderly men and women.
- In 440 postmenopausal women with low bone density, 5 mg a day of vitamin K1 for 2 to 4 years did not change bone density compared with placebo, though fewer women had clinical fractures (9 versus 20), a small secondary finding.Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
- In 381 healthy postmenopausal women taking calcium and vitamin D, 45 mg a day of vitamin K2 (MK4) or 1 mg of vitamin K1 for 12 months lowered undercarboxylated osteocalcin but did not change bone turnover or bone density compared with placebo.Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in heal…
- In 379 healthy older adults, 500 mcg per day of phylloquinone for 3 years did not change inflammatory markers or bone density changes compared with no supplement.Vitamin K, circulating cytokines, and bone mineral density in older men and women.
- In 325 postmenopausal women, 45 mg per day of menatetrenone for 3 years increased bone mineral content and femoral neck width compared with placebo and kept hip bone strength unchanged, though overall bone density was not changed.Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women.
- In 311 middle-aged and older adults, 90 micrograms a day of vitamin K2 for one year reduced femoral neck bone loss in postmenopausal women compared with placebo, with no effect in men and no added benefit from calcium and vitamin D3.Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized C…
- In 244 healthy postmenopausal women, 180 mcg of MK-7 daily for 3 years slowed the age-related loss of bone mineral density in the lumbar spine and femoral neck compared with placebo.Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
- In 219 healthy young and older adults, 1000 mcg per day of phylloquinone for 2 weeks raised vitamin K levels about tenfold and lowered undercarboxylated osteocalcin, a vitamin K status marker, but did not change other bone turnover markers.Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elde…
- In 181 postmenopausal women aged 50 to 60, 1 mg per day of vitamin K1 added to minerals and vitamin D for 3 years reduced femoral neck bone loss compared with placebo, but did not change lumbar spine bone loss.Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.
- In a 12-month placebo-controlled trial of 148 postmenopausal women, 375 mcg of vitamin K2 (MK-7) daily cut undercarboxylated osteocalcin, a bone marker, by about 70% compared with a small change on placebo.Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women:…
- In 148 postmenopausal women with low bone density taking 375 mcg of vitamin K2 (menaquinone-7) daily for 12 months, the internal structure of tibia bone was preserved compared with placebo, while bone density showed no difference.Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postm…
- In a 3-year placebo-controlled trial of 142 postmenopausal women with low bone mass, 375 mcg daily of menaquinone-7 added to calcium and vitamin D raised carboxylated osteocalcin but did not change bone mineral density or bone structure compared with placebo.The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-ye…
- In 123 people on dialysis, 360 mcg of MK-7 daily for 2 years prevented lumbar spine bone loss compared with placebo but sped up bone loss in the distal radius, so the authors do not recommend it for bone protection.Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-control…
- In 122 postmenopausal women eating vitamin D enriched salmon twice weekly for 12 weeks, bone breakdown markers improved compared with a low vitamin D intake, though the amount of vitamin K was not stated.Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention…
- In a placebo-controlled trial of 120 adults, 100 mcg daily of menaquinone-7 for 12 weeks improved the activation of the bone protein osteocalcin compared with placebo, and a dose-finding trial suggested 100 mcg or more is needed.Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized C…
- Female endurance athletes who took vitamin K1 or placebo for two years lost similar amounts of hip bone density, and vitamin K did not prevent the bone loss.Factors affecting bone loss in female endurance athletes: a two-year follow-up study.
- In 110 healthy children and adults, MK-7 supplements improved vitamin K status most in people who were most deficient, and adults over 40 may benefit, though bone outcomes were not directly measured.Vitamin K status in healthy volunteers.
- In 105 postmenopausal women with osteoporosis taking meds, 1 mg of vitamin K1 daily for 18 months did not change bone density or bone turnover compared with placebo, though it had a small effect on some hip shape measures.Read the study on PubMed (37338608) →
- In a 1-year randomized double-blind trial of 94 lung and heart transplant recipients, 180 mcg daily of menaquinone-7 gave a favorable change in lumbar spine bone density compared with placebo, though the difference was borderline in the overall group.Dietary vitamin K2 supplement improves bone status after lung and heart transplantation.
- In 92 postmenopausal women with osteoporosis, 45 mg a day of menatetrenone for 2 years increased lumbar spine bone density more than calcium alone.Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopa…
- Adults with Crohn's disease who took 1000 micrograms of vitamin K1 daily with calcium and vitamin D for a year had no better bone turnover or bone density than those on placebo, apart from a small gain in forearm bone mass.Effect of phylloquinone (vitamin K1) supplementation for 12 months on the indices of vitamin K status and bone health in…
- In elderly hip fracture patients over 4 months, vitamin K1, calcium and vitamin D raised blood vitamin K1 levels but did not change bone turnover markers compared with usual care.Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial.
- In 68 people with type 2 diabetes and heart disease, 360 mcg of vitamin K2 daily for 6 months did not slow vertebral bone density loss compared with placebo.Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes melli…
- In 63 postmenopausal women with osteoporosis, 45 mg a day of menatetrenone with calcium for 48 weeks increased lumbar spine bone density more than placebo with calcium.Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia.
- In 60 adults with type 2 diabetes, 200 mcg per day of menaquinone-7 for 12 weeks did not change body composition, including bone mass, compared with placebo.The effect of menaquinone-7 supplementation on dp-ucMGP, PIVKAII, inflammatory markers, and body composition in type 2 d…
- In 55 healthy prepubertal children, 45 mcg per day of menaquinone-7 for eight weeks improved osteocalcin carboxylation compared with placebo.The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children.
- In 50 women with cirrhosis, vitamin K2 (menatetrenone) over 2 years prevented lumbar spine bone loss, with bone density rising 0.1% at 1 year and falling only 0.5% at 2 years while the control group lost 2.2% and 4.6%.Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver.
- In a 2-year placebo-controlled trial of 40 children with galactosemia, daily vitamin K1 with calcium and vitamin D3 raised lumbar spine bone mineral content, and this gain was seen only in the younger, prepubertal children.Effect of calcium, vitamins K1 and D3 on bone in galactosemia.
- In 40 healthy postmenopausal Japanese women taking 1.5 mg of menaquinone-4 daily for 4 weeks, osteocalcin activation improved compared with placebo, with the largest change at 2 weeks.Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
- In 40 hemodialysis patients with low parathyroid hormone, 45 mg per day of menatetrenone for one year improved bone remodeling markers compared with a control group.Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level.
- In 34 early postmenopausal women with low bone density taking 45 mg of vitamin K2 daily for 2 years, a marker of vitamin K status improved, but bone density results were not reported as a clear gain and there was no placebo comparison.Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women.
- In a 14-week placebo-controlled pilot of 33 postmenopausal women, a combination including 1000 mcg of vitamin K1 per day lowered serum osteocalcin, a bone turnover marker, by about 31% while placebo raised it by 19%.Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopa…
- Postmenopausal women who took 200 or 500 micrograms of vitamin K1 daily for six weeks improved their vitamin K levels, but their bone turnover markers did not change compared with placebo.Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal w…
- In a small trial of 29 children with leukemia, those given 100 mcg of vitamin K2 (menaquinone-7) with vitamin D3 during chemotherapy showed early bone-protective changes over about 6 months compared with children receiving chemotherapy alone.Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective…
- Postmenopausal women who ate 450 micrograms of vitamin K1 daily for a few weeks had a modest drop in a bone breakdown marker, but bone formation and mineral handling did not change.Dietary phylloquinone depletion and repletion in postmenopausal women: effects on bone and mineral metabolism.
- In 20 postmenopausal women with osteoporosis and wrist fractures, two weeks of vitamin K supplements corrected a defect in how bone protein osteocalcin was activated, and the benefit was still detectable four weeks later.Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation.
- In 20 patients starting a med treatment, 15 mg per day of menatetrenone for one year was linked to no significant bone density loss, while the group without it lost lumbar spine bone density.Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG).
- In a one-year randomized pilot of 16 a med-treated patients, adding vitamin K2 to risedronate gave no extra reduction in bone turnover markers beyond risedronate alone.Read the study on PubMed (20190467) →
- In 15 young adults in a crossover study, hydrogenated vitamin K (dihydrophylloquinone) at 200 mcg per day for 10 days was less absorbed than regular phylloquinone and had no measurable effect on markers of bone formation or breakdown.Effects of a hydrogenated form of vitamin K on bone formation and resorption.
- Elderly Chilean adults with thin hip bones who took a multi-nutrient supplement containing 60 micrograms of vitamin K daily for a year saw no change in bone density compared with the usual supplement, although their vitamin D rose and some bone turnover markers fell.Effect of a nutritional supplementation on bone health in Chilean elderly subjects with femoral osteoporosis.
- In a 6-month randomized trial of Indian premenopausal women aged 25 to 44, a daily protein beverage fortified with 55 mcg of vitamin K, plus calcium and vitamin D, lowered bone turnover markers compared with a non-fortified placebo drink.Randomised Controlled Trial of Nutritional Supplement on Bone Turnover Markers in Indian Premenopausal Women.
- Over 2 years, young Chinese women aged 20 to 35 who drank milk powder with 80 mcg of vitamin K1 and 1000 mg calcium did not gain more bone density than the control group, which received nothing.Milk supplementation and bone health in young adult chinese women.
- Elderly women with Parkinson's disease and low vitamin D who took 45 mg of vitamin K2 daily for a year had bone density in the hand that rose slightly, while untreated women lost bone, and fewer of the treated women broke a hip; this paper has been retracted.Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency.
- In 108 stroke patients with vitamin D and K deficiency, 45 mg of menatetrenone daily for 12 months raised bone density on the paralyzed side by 4.3% while untreated patients lost 4.7%.Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients.
- In 82 premenopausal women, adding 80 micrograms of vitamin K1 to calcium-fortified milk for 16 weeks improved vitamin K levels but did not reduce bone turnover more than milk alone.Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in pr…
- In 69 patients with osteopenia or osteoporosis having lumbar spine surgery, adding vitamin K2 to vitamin D3 and calcium for 6 months increased complete spinal fusion rates compared with the control group.Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative…
- In 60 people with autoimmune diseases taking meds and meds, menatetrenone raised bone formation markers during the first month, but bone density and fracture rates did not differ from those not taking it after about 1.5 years.Efficacy of Vitamin K2 for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases.
- In 21 women with anorexia nervosa followed for about 0.9 years, those taking menatetrenone lost less lumbar bone density (2.8%) than those not taking it (6.9%).Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa.
- In 20 people with kidney disease starting prednisolone, adding 45 mg a day of menatetrenone for 10 weeks prevented the spine bone density loss seen with prednisolone alone.Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chro…
- In 12 healthy young adults, 90 mcg of vitamin K2 (menaquinone-7) added to daily olive oil for 2 weeks increased the active form of bone protein and decreased the inactive form compared with baseline.Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation.
- In healthy volunteers, menaquinone-7 was absorbed well and fully activated osteocalcin, a bone protein, more completely than synthetic vitamin K1, but no bone density or fracture outcome was measured.Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.
- In healthy women given 1 mg of vitamin K daily, bone-related blood markers changed in some women, and in women who lost the most urinary calcium, calcium loss fell by about 30%; the abstract was truncated and the results are mixed.Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss.
- In postmenopausal women given dairy products with calcium, vitamin D and 100 mcg daily of vitamin K1 for 12 months, bone breakdown markers were lower and lumbar spine bone density rose more than in the control group.Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy pr…
- In an open-label 2-year study of 241 osteoporosis patients, those taking 45 mg of vitamin K2 daily had fewer new fractures and lost less spine bone density than the untreated control group.Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.
- In 109 postmenopausal women with osteoporosis, 45 mg of menatetrenone daily for 6 months raised active bone-building osteocalcin compared with calcium aspartate, but urinary bone-breakdown marker NTX also rose, so the effect on bone turnover was mixed.Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover …
- Postmenopausal women with osteoporotic fractures who took 5 mg of vitamin K2 daily cut their undercarboxylated osteocalcin, a marker of low vitamin K, by about three-quarters, and 45 mg gave no further gain.Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis.
- In 21 women aged 60 to 80, a low-vitamin K diet caused a drop in vitamin K status; adding 200 mcg per day of phylloquinone restored a liver protein to normal, but other vitamin K markers stayed low even at 450 mcg per day, suggesting the recommended intake of 90 mcg per day may not fully support bone protein activity.Dietary phylloquinone depletion and repletion in older women.
- In 20 children with thalassemia taking 50 mcg of menaquinone-7 plus calcitriol for 1 year, lumbar spine bone density and Z-score improved, though this was an uncontrolled pilot study.The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy.
- In 20 severely disabled children and adults with bone thinning, bone density rose after 4 months of oral vitamin K2 and stayed higher through 12 months, though there was no control group and the dose was not stated.[Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia].
- Patients with severe motor and intellectual disabilities who received vitamin K1 food-based therapy for three months had better vitamin K status, but bone formation and breakdown markers both rose, so the bone effect is unclear.Nutritional Therapy with Vitamin K1 Is Effective in the Improvement of Vitamin K Status and Bone Turnover Markers in Pat…
- In 15 healthy young men given menaquinone-4 in steps of 300, 600, 900 and 1500 mcg daily over 5 weeks, blood levels of活性 osteocalcin rose at 900 mcg daily or more, and the inactive form fell at 600 mcg daily or more.Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response st…
- In 8 female elite athletes, one month of 10 mg daily vitamin K raised bone-building markers by about 15-20% and lowered bone-breakdown markers by about 20-25%, with no placebo group for comparison.Improved bone metabolism in female elite athletes after vitamin K supplementation.
- Over about 14.5 years, older Australian women with the highest dietary vitamin K1 intake (99 mcg or more daily) had roughly a third lower risk of fracture-related hospitalization than those with the lowest intake.Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk: the Perth longitudin…
- In a large study of 583 men and 768 women in Framingham, higher blood vitamin K was linked to better heel ultrasound bone measures in men only, with no consistent link in women, and dietary vitamin K intake showed no association.Association of dietary and biochemical measures of vitamin K with quantitative ultrasound of the heel in men and women.
- In a Japanese cohort of 944 women followed for 3 years, eating more natto was linked to less bone loss, especially in postmenopausal women.Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-B…
- In 211 patients with chronic pancreatitis, vitamin K deficiency was the only factor linked to osteoporosis in men, with 32 percent of patients found to be vitamin K deficient.Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE …
- In 177 young Thai women, bone density was linked to cheese intake and fracture history, while the abstract reports no bone density link for vitamin K1 levels.Bone mineral density and bone turnover among young women in Chiang Mai, Thailand.
- In a case-control study of 99 people with Crohn's disease and 56 controls, low vitamin K intake was more common in Crohn's patients with metabolic bone disease, but this study did not test giving vitamin K.Risk factors for metabolic bone disease in Crohn's disease patients.
- In postmenopausal women, vitamin K lowered urinary calcium loss in a subgroup with high calcium loss, while long-term blood-thinning treatment that blocks vitamin K was linked to more calcium loss in young men than in untreated controls.Read the study on PubMed (8435316) →
- In 113 postmenopausal women, lower vitamin K status was linked to lower bone mass only in women who also had aortic calcification.Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study.
- In 97 Irish postmenopausal women, higher dietary vitamin K1 intake was linked to lower levels of undercarboxylated osteocalcin, a marker of poorer vitamin K status for bone.Phylloquinone (vitamin K1) intakes and serum undercarboxylated osteocalcin levels in Irish postmenopausal women.
- In a cross-sectional study of 36 vegans and 36 omnivores, vegans had lower bone ultrasound measurements than omnivores, while their vitamin K1 levels were higher.Vegan Diet and Bone Health-Results from the Cross-Sectional RBVD Study.
- In 70 people with inflammatory bowel disease, low vitamin K levels were linked to lower bone density, likely because the body absorbed too little vitamin K.High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease.
- In 18 healthy newborns, the active (carboxylated) form of bone protein osteocalcin rose sharply by day 5 of life after vitamin K was given, while the inactive form nearly disappeared; the dose was not stated and there was no control group.Shift of serum osteocalcin components between cord blood and blood at day 5 of life.
- In 16 Crohn's disease outpatients with a med-related bone loss, the vitamin K2 group showed no change in bone density after one year, while the alendronate group improved.Read the study on PubMed (19525577) →
- Patients with fractures had markedly depressed circulating vitamin K1 levels, and the time for these levels to return to normal appeared to depend on fracture severity.Circulating vitamin K levels in patients with fractures.
- People with osteoporosis who had spinal or hip fractures had significantly lower circulating vitamin K1 levels than age-matched controls.Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis.
- In 8 stable dialysis patients taking 45 mg of menatetrenone (vitamin K2) daily for 12 months, bone mineral density stayed at the same level, though some blood bone markers changed in mixed directions and there was no control group.Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients.
- In children with cystic fibrosis, higher vitamin K intake was linked to bone markers, suggesting possible bone health benefits, though the study details were limited.Vitamin K supplementation in cystic fibrosis.
- In Japanese patients with osteoporosis, vitamin K2 combined with EHDP worked better than either alone, while vitamin D3 plus vitamin K2 had little effect on spine bone density.[EHDP + vitamin D3 or vitamin K2].
Review Totals and Summary
Members Only1,380 reviews · 96% positive
The NatureBell website shows 3 ratings in total, and the themes below come from the written reviews that could be read on its page. Only one of those three reviews says anything real about the product, so what follows reflects one customer's experience rather than a broad pattern. Note that the total of 1380 ratings given for the product does not match what this single page shows, and I can only report on what was readable here. The star breakdown on the page is two five-star ratings and one three-star rating, with no four-, two- or one-star ratings. The two five-star ratings come from reviews that say nothing about the softgels, so they give no insight into what buyers like about the product. On the complaint side, the one useful review comes from a verified customer who had been taking another brand of K2 MK-4 with vitamin D (NOW). When that ran out, her husband ordered this NatureBell product. She reported feeling fewer positive effects than she had with the previous brand, even after doubling her dose and then going higher still. That comparison with another K2 product, and the question of whether a higher dose is needed to get a similar effect, is the main theme on the page. She was careful to be fair to the product, though. She noted that she was not taking the additional vitamin D that her previous product had included, and that she had been hydrating significantly less than before. In her view, those factors may have limited her results rather than any shortfall in the quality of this supplement. So her disappointment is tempered, and she does not say the product itself is poor. Regarding who it seems to suit, the page offers little to go on. The only buyer was someone already familiar with K2 MK-4 supplements who was switching brands, and the purchase was made by her husband on her behalf. There is a hint that people may want to pair K2 with vitamin D and keep up good hydration, but that is her own suggestion and not a finding about the softgels. Taste, size, form and value are not covered. Nothing in the readable reviews describes the coconut oil softgels' taste, how easy they are to swallow, the dosing instructions, the price, or the number of servings in the bottle. The other two reviews, from Kim and Ken, are not about this product at all. Both read like testimonials promoting an individual herbal healer for serious medical conditions, and they include contact details. They say nothing about the softgels, so they were set aside as irrelevant to the product. No reviews of other forms such as gummies, capsules or powder appeared on the page, so none had to be left out on that basis. In short, the readable feedback amounts to one verified customer who found the effects weaker than her previous K2 brand, while acknowledging that missing vitamin D and low hydration may have played a part.
Biohacker Summary
Members Only7 of 10 recommend it
Vitamin K is the main ingredient here, and all ten panelists spoke about it: four use it, three recommend it, and three stay neutral, with none saying they stopped. Those who take it mostly name vitamin K2 and give doses of 90 to 100 mcg in the morning for general health, longevity or keeping levels up, while one recommends a much larger 40 to 45 milligrams daily for osteoporosis. The main reasons given are bone strength and steering calcium into bones rather than arteries, plus arterial and joint health, and one says K1 is tied to easy bruising. Several advise pairing it with vitamin D, and one names the MK-7 form while another notes K2 breaks down into MK-4 and MK-7. The only caution came from one panelist, who warned that some multivitamins carry too much of another mineral, and food sources like leafy greens, natto, liver and grass-fed butter were also mentioned.
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Dr. Eric Berg · Vitamin K · recommends
- Discusses foods that contain Vitamin K2.
- Recommends taking 40 to 45 milligrams of vitamin K2 daily for osteoporosis, citing a study from Japan with great results.
- Mentions that easy bruising can result from a lack of vitamin K1.
- Mentions that grass-fed liver has vitamin K2.
- Recommends getting plenty of vitamin K2 to support joint and metabolic health.
- Recommends vitamin K2 to keep calcium in control and protect against calcium buildup in joints and arteries, which is important for osteoarthritis.
- States that butter is loaded with vitamin K2, which is essential for making teeth strong and keeping calcium out of soft tissues like arteries.
- Recommends Vitamin K2 for arthritis, stating it removes calcium buildup and calcification from joints, decreases inflammation in cartilage, and helps remodel or rebuild cartilage.
- Recommends taking 100 mcg of vitamin K2 when supplementing with 6000–10,000 IU of vitamin D3 daily, as it works closely with vitamin D and higher vitamin D intake can increase the need for it.
- Recommends taking vitamin K2 as a co-factor whenever taking vitamin D3.
Bryan Johnson · Vitamin K · uses
- Takes 90 mcg of Vitamin K2 in the morning for general health.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- He takes 100 mcg of Vitamin K2 in the morning for general health.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- Takes 90 mcg of Vitamin K2 in the morning.
- Takes 100 mcg of Vitamin K2 in the morning.
- Takes 100 mcg of Vitamin K2 in the morning.
- Takes 90 mcg of Vitamin K2 in the morning for longevity.
- Takes 100 mcg of Vitamin K2 in the morning.
- He takes 100 mcg of Vitamin K2 in the morning.
Ben Greenfield · Vitamin K · neutral
- Discusses vitamin K2, specifically the menaquinone forms, as crucial for arterial health and notes that it breaks down into MK-4 and MK-7.
- Explains that gut bacteria liberate K from the diet or make the K needed, and that poor absorption of vitamin K due to bacterial imbalances is linked to heart disease.
- Recommends taking vitamin K complex as a co-factor to increase vitamin D absorption.
- Lists vitamin D3 and K2 for the immune system as a recommended intervention on the True Age test.
- Recommends adequate intake of vitamin K for bone strength.
- Takes 90 mcg of Vitamin K2 in the morning.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- He takes 100 mcg of Vitamin K2 in the morning for general health.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- Takes 90 mcg of Vitamin K2 in the morning.
Siim Land · Vitamin K · neutral
- Notes that Vitamin K2 helps activate proteins involved in bone mineralization and calcium regulation.
- Mentions that prunes contain vitamin K, which is a factor in their ability to help with bone density.
- Recommends Vitamin K2 for bone health and calcium metabolism, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Vitamin K2 as one of 15 supplements backed by human studies.
- Lists leafy greens as a source of Vitamin K1.
- Thinks vitamin K2 has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends pairing magnesium with vitamin K2, as it ensures that calcium mobilized by active vitamin D ends up in bones and teeth rather than arterial walls.
- He takes 100 mcg of Vitamin K2 in the morning for general health.
- Takes 90 mcg of Vitamin K2 in the morning for general health.
Dave Asprey · Vitamin K · recommends
- Recommends taking vitamin K2 with vitamin D to keep calcium in the bones, and suggests kids also take it for stronger bones.
- Recommends Vitamin K2, stating it supports healthy calcium metabolism.
- Recommends adding vitamin K2 to vitamin D supplementation.
- Mentions that natto is a good source of vitamin K2, which is probably its primary benefit.
- Dave Asprey discusses the overlooked link between the microbiome and vitamin K2 production, and its role in bone density.
- Realized that you have to have K2, and that's why vitamin D exists, for the right ratios of all the fat solubles.
- Has done their best to teach people to always take vitamin K2 with vitamin D3, as it is a critical ingredient for avoiding cardiovascular disease and is affordable and powerful.
- Natto also has a substantial dose of vitamin K2, which is hard to get in food.
- Recommends vitamin K2, stating it activates proteins that help move calcium into bones and teeth and reduces calcium deposition in soft tissue like arteries, and suggests getting it from foods like grass-fed dairy and egg yolks or a targeted supplement.
- Introduces vitamin K2 as important for directing calcium once it is in circulation.
Dr. Rhonda Patrick · Vitamin K · neutral
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Mentions that kale delivers vitamin K, a micronutrient many diets fall short on.
- Rhonda takes 100 mcg of Vitamin K2 (MK-7) daily for general health.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Rhonda includes Vitamin K2 in her supplement routine.
- Takes Vitamin K2 at night.
- Notes additional gaps in vitamin K.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Warns that over 50% of people aren't getting enough vitamin K, increasing their risk of arterial calcification and bone mineral density losses, and that chronic deficiency allows calcium to accumulate in arteries, contributing to atherosclerosis over time and increasing cardiovascular disease risk.
Andrew Huberman · Vitamin K · uses
- Takes 90 mcg of Vitamin K2 in the morning for longevity.
- Takes 90 mcg of Vitamin K2 in the morning.
- He takes 90 mcg of Vitamin K2 in the morning for overall health.
- Takes 100 mcg of Vitamin K2 in the morning.
- Takes 90 mcg of Vitamin K2 in the morning for general health.
- Takes 100 mcg of Vitamin K2 every day for longevity.
- He takes 90 mcg of Vitamin K2 every morning.
- He takes 100 mcg of Vitamin K2 in the morning for general health.
- He takes 100 mcg of Vitamin K2 in the morning.
- Notes that many people are deficient in fat-soluble vitamins, particularly vitamin K2.
Dr. Mark Hyman · Vitamin K · uses
- Takes 100 mcg of Vitamin K2 in the morning for general health.
- Takes 100 mcg of Vitamin K2 in the morning.
- Takes 90 mcg of Vitamin K2 in the morning for overall health.
- States that green leafy vegetables are great sources of vitamin K.
- Lists Vitamin K as important for bone health.
- Takes 90 mcg of Vitamin K2 in the morning.
- Takes 100 mcg of Vitamin K2 in the morning.
- Takes 90 mcg of Vitamin K2 in the morning for general health.
- Mentions Vitamin K as one of the things given to newborn babies in the first couple of days, alongside Hepatitis B and RSV vaccines, without taking a specific stance on its use.
- Explains that vitamin K1 is very important for blood coagulation, as the body triages it to essential functions to prevent acute death.
Thomas DeLauer · Vitamin K · recommends
- Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
- Notes that grass-fed butter provides more Vitamin K2, which plays a role in directing calcium towards bones instead of arteries, contributing to bone health.
- Advises checking multivitamins because many contain 100, 200, or 300% of the daily value of selenium, which can contribute to excessive intake.
- Recommends Vitamin K2 for bone density, stating it must be taken with D3.
- Recommends taking a multivitamin to ensure adequate intake of important cofactors like B vitamins, magnesium, iron, and zinc, which are essential for the signaling system to be operational.
- Recommends a multivitamin stack, specifically Fyhealth, for those who are fasting, as it helps ensure adequate nutrition when calorie and food intake are reduced.
- Warns against synthetic multivitamins, arguing that they are an attempt to be smarter than nature by combining isolated nutrients in proportions not found naturally, and that a whole food approach is superior.
- Vitamin K2 makes sure calcium ends up in your bones instead of your arteries.
- Recommends Thi Health's multi-stage multivitamin, which is broken into AM and PM stacks and uses micro encapsulation beads for delayed absorption, ensuring compounds like magnesium and calcium don't compete.
- Recommends consuming vitamin K2 through good quality egg yolks or fermented foods, as it helps direct calcium toward bones and away from arteries, completing the synergy with vitamin D.
Peter Attia · Vitamin K · uses
- Takes 100 mcg of Vitamin K2 in the morning to maintain levels.
RAL Summary
Members OnlyTier 2 for Bone Health
Tier 2 holds because pooled trials of vitamin K2 in thousands of women after menopause show better spine bone density [1][2], and 96% of 1,380 reviews are positive. The vitamin K1 evidence the rules cited is weaker: its largest analysis looked at diet rather than supplements, and K1 alone showed no clear gain in pooled trials [10], so the grade rests on the vitamin K2 and overall vitamin K findings.
Where the evidence disagrees: 25 of the 100 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skeletal system
Combine with: Vitamin K works best for bone health alongside other nutrients that supply and direct calcium. Vitamin D3 (1,000-5,000 IU, based on blood levels) improves calcium absorption and drives production of osteocalcin, the vitamin K-dependent protein that binds calcium into bone. Calcium (from food or a citrate or microcrystalline hydroxyapatite supplement) supplies the building material, and magnesium (glycinate or citrate, 200-400 mg) supports vitamin D activation and bone mineral structure. Collagen peptides or type I collagen add to the bone matrix, and boron, zinc, and vitamin C support bone formation. Take the softgels with a fat-containing meal to improve absorption. People on a med or other meds should avoid vitamin K supplements unless their doctor approves and monitors them, since vitamin K directly counteracts these drugs.
Possible side effects: One pooled analysis found more mild side effects with vitamin K2 but no serious ones, and others found no extra side effects compared with placebo. No side effects were mentioned in the readable review.
Supplement Facts
Vitamin K 2600 mcg · Vitamin K1 1500 mcg · Vitamin K2 1000 mcg
| Vitamin K | 2,600 mcg | |
| Vitamin K1 | 1,500 mcg | |
| Vitamin K2 | 1,000 mcg | |
| Vitamin K2 | 100 mcg |
Other ingredients: Coconut oil, natural carob, softgel (gelatin, vegetable glycerin, purified water).
Label source: Reverseagelab · Report a label change
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Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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