Nature's Bounty Magnesium Softgels, 400 mg - 75 ct | CVS Review
Nature's Bounty High Potency Magnesium provides 100% of the daily recommended value for this important mineral in just one softgel. The page describes magnesium as essential for supporting bone health, and says it plays an important role in maintaining bone mineralization. It also states that magnesium is a component in over 200 enzymes in the body and is involved in muscle contractions, nerve impulses, energy metabolism and protein formation. The listing shows 75 count, 0.1 lbs, Item # 175248, and notes that the item is part of CVS's Test to be Trusted Program, with program details linked on the CVS site. Listed product claims are that it helps maintain healthy bones, supports muscle health, is involved in protein formation, and offers one rapid release liquid softgel per day. The page carries the standard notice that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The page shows the item as out of stock, with no price, ingredients list, or written customer reviews displayed in the scraped text. The product is sold under the Nature's Bounty brand, and the page links to related ingredients and reviews pages for the same product.
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Study, Trial or Testing Result Summary
Members Only32 human studies · 26 improved
No study given here tested magnesium oxide on its own, or in a softgel, for heartburn. The research is on antacid mixtures that contain magnesium alongside other ingredients. In pregnant women, a review of nine small trials found treatments that included a magnesium and aluminium antacid with simethicone gave complete heartburn relief more often than placebo, though the evidence was limited [1]. A two week magnesium and aluminium gel improved heartburn frequency in 88% of pregnant women, about the same as an alginate product [2]. For speed, a calcium and magnesium antacid raised stomach pH within about 6 minutes versus about 240 minutes on placebo [3], and a magnesium antacid gel acted within the first 5 minutes [4]. A month of a mixture with simethicone, charcoal and magnesium oxide eased indigestion and burning more than placebo [5]. However, an aluminium and magnesium antacid did not relieve indigestion better than placebo in another trial [6]. This product gives 400 mg of magnesium, above the studied 350 mg and above the daily recommended limit, so members can take less. Animal and cell studies are never counted.
See all 32 studies →Hide the studies
- In a review of nine small trials in pregnant women, drug treatments including a magnesium-aluminium antacid with simethicone gave complete heartburn relief more often than placebo or no treatment, though evidence was limited.Interventions for heartburn in pregnancy.
- A review of nutrition trials in children with cerebral palsy found magnesium helped constipation but did not assess heartburn relief.Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review.
- In 276 adults with indigestion, one month of a simethicone, charcoal and magnesium oxide combination lowered overall symptoms and epigastric burning more than placebo.Efficacy of a simethicone, activated charcoal and magnesium oxide combination (Carbosymag®) in functional dyspepsia: res…
- In 100 pregnant women with heartburn, a magnesium-aluminium antacid gel for two weeks worked about as well as an alginate-based product, with 88% improving in heartburn frequency versus 80%.Efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnanc…
- In 97 patients with gastritis, esophagitis or upper abdominal complaints, a magnesium and aluminium hydroxide antacid with smectite beat an aluminium hydroxide antacid on pain relief, speed of effect and heartburn over four weeks.[Antacid therapy of upper abdominal symptoms. Double-blind study on the effect and tolerance of 2 antacids in gastritis …
- In 90 people with acid reflux disease, adding magnesium-containing mineral water to standard treatment for a month improved indigestion and pain more than standard treatment alone.Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease.
- In 89 people with nonulcer indigestion, four weeks of an aluminum-magnesium antacid did not relieve symptoms compared with placebo.Antacids reduce Campylobacter pylori colonization without healing the gastritis in patients with nonulcer dyspepsia and …
- In 89 people with reflux not helped by standard drugs, a regimen including magnesium aluminum carbonate gave the best improvement in heartburn sensation compared with a herbal decoction.Efficacy evaluation and exploratory analysis of influencing factors of Banxia Houpu Decoction in the treatment of refrac…
- In 80 children with reflux, 8 weeks of domperidone plus magnesium and aluminum hydroxide fully cleared symptoms in 16 of 20 children, versus 7 of 20 on placebo.Domperidone plus magnesium hydroxide and aluminum hydroxide: a valid therapy in children with gastroesophageal reflux. A…
- In 72 infants with regurgitation, two weeks of magnesium alginate lowered reflux symptom scores about as well as thickened formula, at slightly lower cost.Magnesium Alginate in Gastro-Esophageal Reflux: A Randomized Multicenter Cross-Over Study in Infants.
- In 64 infants with reflux, magnesium alginate plus simethicone reduced symptom scores more than thickened formula or reassurance alone over up to 2 months.Effect of magnesium alginate plus simethicone on gastroesophageal reflux in infants.
- In 50 adults with throat reflux, 2 months of magnesium alginate suspension reduced symptoms and signs about as much as a med 20 mg daily.Read the study on PubMed (35032204) →
- In 44 people with reflux, 23 percent reported good relief on a magnesium-aluminium antacid gel over two 15-day periods, compared with 84 percent on Liquid Gaviscon.A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium--alumin…
- In 37 people with chronic dyspepsia, an aluminium-magnesium antacid plus antispasmodic tablet relieved heartburn earlier and more than aluminium hydroxide alone over 4 weeks.A comparison of an antacid plus antispasmodic combination and aluminium hydroxide in dyspepsia.
- In 30 patients with stomach or duodenal ulcers, antacids containing 1.6 g magnesium hydroxide and 1.6 g aluminium hydroxide daily relieved heartburn and pain, but less than when triletide was added.Controlled clinical assessment of the efficacy and tolerance of triletide versus antacids in patients with gastric and d…
- In 24 healthy volunteers, a single dose of Riopan Gel (800 mg magaldrate) or Rennie tablets raised stomach pH for a short time compared with no drug, with Riopan acting faster in the first 5 minutes.Comparison of two antacid preparations on intragastric acidity--a two-centre open randomised cross-over placebo-controll…
- In 20 adults with chronic cough, the antacid Maalox reduced cough-like efforts triggered by deep lung emptying within minutes, while placebo did not, though this study measured cough rather than heartburn.Effect of an anti-reflux medical device in the control of deflation cough: A placebo-controlled comparative study with a…
- In 16 healthy fasting adults, a single 1360 mg dose of the calcium-magnesium antacid Rennie raised stomach acid pH above 3 within about 6 minutes, compared with about 240 minutes with placebo.Comparison of the effect of the antacid Rennie versus low-dose H2-receptor antagonists (ranitidine, famotidine) on intra…
- In 15 patients with reflux-related eye symptoms, a month of magnesium alginate eye drops and tablets brought tear film measures back to normal values.Ocular Surface Disease as Extraesophageal Gastroesophageal Reflux Disease Manifestation: A Specific Therapeutic Strategy…
- In people with reflux oesophagitis over 10 weeks, Gastrocote reduced heartburn days from baseline, though acid exposure was no lower than with cimetidine and the combination with cimetidine worked best.Combined cimetidine-alginate antacid therapy versus single agent treatment for reflux oesophagitis: results of prospecti…
- A single 1.5 gram dose of the aluminium-magnesium antacid almagate was effective for reflux damage to the food pipe in a double-blind crossover trial, with both tested formulations performing equally.Effectiveness of almagate in gastroesophageal reflux disease: a post-hoc analysis of a randomized cross-over double-blin…
- In infants under one year with reflux, giving a small formula feeding before a standard magnesium-aluminum antacid dose improved how well the antacid buffered stomach acid.Antacid and formula effects on gastric acidity in infants with gastroesophageal reflux.
- In 169 people with heartburn, the aluminum-magnesium antacid almagate was effective, and most patients were symptom free by the end of a 2-week open trial with no control group.Treatment of gastric pyrosis with almagate in patients with and without endoscopically demonstrable duodenal ulcer. A mu…
- In 61 adults with fatty liver disease and stomach or bowel symptoms, drinking 400 mL of a magnesium-containing mineral water daily for six months improved lower bowel symptoms, which worsened after stopping; the study had no placebo group and did not test heartburn directly.The use of bicarbonate-sulphate-calcium-magnesium and sodium-low drinkable water improves functional gastrointestinal sy…
- In 60 elderly patients with reflux, an alginate product (Geviskon) relieved heartburn, regurgitation, cough and sore throat more completely and faster than an aluminum-magnesium antacid over 7 days.[Using gaviscon preparation for relief of esophageal, extraesophageal syndromes and functional dyspepsia in elderly pati…
- In 49 healthy adults, a combined esomeprazole and magnesium hydroxide tablet raised stomach pH to 4 faster than enteric-coated esomeprazole alone over seven days of dosing.Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to th…
- In a large cohort of about 356,000 people, harder tap water was linked to lower risk of some digestive conditions such as dyspepsia, but moderately hard water was linked to higher risk of reflux disease and peptic ulcer.Water hardness and digestive diseases: a large-scale population-based prospective cohort study.
- In 100 outpatients with throat reflux, two months of magnesium alginate significantly reduced voice problems, swallowing trouble and cough on a visual scale, with no side effects reported.Magnesium alginate in patients with laryngopharyngeal reflux.
- In 15 children with reflux treated with magnesium and aluminium hydroxide for eight weeks, 12 were cured and 3 improved, and acid reflux measured on pH monitoring was significantly reduced.[Magnesium hydroxide and aluminum hydroxide in the treatment of gastroesophageal reflux].
- Drinking a magnesium-rich sulphate mineral water was linked to fewer symptoms and better heart measures in people with mild gastroesophageal reflux and heart-related symptoms.[Magnesium-containing mineral waters in the treatment of patients with cardial manifestations of gastroesophageal reflux…
- In a lab and small test in normal people, acidic stomach contents helped an alginate and magnesium antacid mixture form a protective floating barrier against reflux, while plain water did not.Use of 111In-labeled alginate to study the pH dependence of alginic acid anti-esophageal reflux barrier.
- A 1994 Ukrainian report describes an antacid containing alginic acid and magnesium, used with antisecretory drugs for dyspepsia and reflux, that forms a protective floating layer in the stomach, but the abstract gives no patient numbers or outcome figures.[The use of 3rd-generation antacid preparations for the treatment of patients with nonulcerous dyspepsia and peptic ulce…
Review Totals and Summary
Members Only9,619 reviews · 77% positive
Nature's Bounty Magnesium Softgels, 400 mg, has garnered approximately 9552 ratings across various stores, with a strong majority of 73% giving it 4 or 5 stars. Overall, customers generally find this magnesium supplement effective and a good value, though some common points of feedback emerge regarding its size and occasional quality concerns. **What it did for buyers** Many users report positive effects from taking these softgels. They are frequently praised for aiding in "muscle relaxation and mild constipation," and for helping to alleviate muscle cramping. Customers have noted feeling "more energetic and less achy," with some describing the product as "effective at stopping or lessening muscle cramps." One store summary also highlighted that it gives users "the boost they need." **Complaints** While many are satisfied, some customers did not experience significant benefits, with one reviewer stating, "haven't noticed a significant difference in my energy or sleep." A notable concern revolves around product quality and packaging. There have been reports of softgels arriving in poor condition, with descriptions like "looked like they either melted or were just crushed." In rare instances, a softgel might burst, leading to "oil. It will go rancid," which is a quality control issue. **Taste, Smell, Pill Size, and Form** This product comes in rapid-release softgel form, which many users prefer for better absorption compared to standard tablets or pills. Most find the softgels "so easy to swallow," and generally report "no stomach upset or bad aftertaste." However, a consistent theme is the size of the softgels; they are often described as "pretty large soft gels" or "larger than other brands," with one reviewer noting they are "about an inch long." While many still find them easy to swallow, this size can be a drawback for some. This summary focuses exclusively on the softgel form, excluding feedback on other product forms like gummies or capsules. **Value for Money** For many, the Nature's Bounty Magnesium Softgels offer good value. Some customers feel they are "worth the little extra money" due to their effectiveness and superior absorption. Reviewers frequently call it a "great value for the money" and an "effective product." While one reviewer considered it an "okay supplement for the price," another cautioned against wasting money due to quality issues. **Who it seems to suit and who it did not** The softgels appear to be well-suited for individuals seeking relief from muscle cramps, muscle relaxation, or mild constipation. Older adults, in particular, have found them beneficial. Those looking for an energy boost or better absorption than traditional pills also seem to benefit. However, the large size of the softgels might pose a challenge for "people with swallowing problems." It may also not be the ideal choice for those who have not seen significant changes in energy or sleep with other magnesium brands.
Biohacker Summary
Members Only8 of 10 recommend it
Most of the panel recommends or uses magnesium, and sleep is the most common reason, with others citing blood pressure, stress, muscle recovery, bone health and brain function. Preferred forms are glycinate and threonate, and several take about 400 mg of threonate before bed, while others suggest 300 mg of glycinate or taking it 90 minutes to 2 hours before sleep. Some pair it with electrolyte drinks that contain sodium and potassium, and one suggests it alongside zinc. One panelist warns that labels can make the dose look larger than it is, since the listed compound weight may be far more than the actual magnesium, and says the evidence that it improves sleep is not yet consistent. Two others stayed neutral and mainly reviewed the evidence.
See all 10 biohackers →Hide the biohackers
Dr. Rhonda Patrick · Magnesium · recommends
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
Dr. Eric Berg · Magnesium · recommends
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
- Magnesium is involved in 300 to 600 enzyme reactions, acts as a biological brake pedal, is the master controller over calcium, and is involved in making ATP, the energy currency of the body. It takes energy to go to sleep, and magnesium is required for relaxation and good sleep. Magnesium also helps balance cortisol levels and calm you.
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
Thomas DeLauer · Magnesium · recommends
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
Andrew Huberman · Magnesium · recommends
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
Dr. Mark Hyman · Magnesium · recommends
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
Dave Asprey · Magnesium · uses
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
- Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.
RAL Summary
Members OnlyTier 4 for Occasional Heartburn: Fast Relief
The tier 2 grade rests on studies of antacid mixtures, mostly magnesium with aluminium, calcium, simethicone or charcoal, none of which tested magnesium oxide alone in a swallowed softgel for fast heartburn relief. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 5 of the 32 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: Magnesium works synergistically with several other nutrients. Vitamin D3 is crucial as magnesium is required for its activation and utilization, supporting bone health and immune function. Vitamin B6 can enhance magnesium absorption and cellular uptake, further aiding nerve function and energy metabolism. Zinc is another beneficial addition, as it participates in numerous enzymatic reactions alongside magnesium, supporting immune health and overall cellular processes.
Possible side effects: Reviewers mostly report no stomach upset or aftertaste, though some note it eases mild constipation and some received melted, crushed or burst softgels. The softgels are large, which may be hard for people with swallowing problems.
Supplement Facts
Magnesium 400 mg
| Calories | 10 | |
| Calories from Fat | 5 | |
| Total Fat | 0.5 g | 1% |
| Saturated Fat | 0.5 g | 3% |
| Magnesium (as Magnesium Oxide) | 400 mg | 100% |
Other ingredients: Medium Chain Triglycerides, Gelatin, Vegetable Glycerin. Contains <2% of: Natural Caramel Color, Soy Lecithin, Yellow Beeswax.
Directions: For adults, take one (1) softgel daily, preferably with a meal.
Label source: Naturesbounty · Report a label change
Sizes and barcodes: Magnesium Softgels, 400 mg - 75 ct | CVS, UPC 0 74312 59408 3 (on market)
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Our articles on this subject
- Magnesium Glycinate vs Citrate: What the Studies ShowArticle · Oct 30, 2026
- Magnesium Glycinate vs Threonate: Which Form Is Right for You?Article · Nov 6, 2026
Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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