NOW Magnesium Glycinate with BioPerine Review

Magnesium Glycinate with BioPerine® Veg Capsules from NOW is presented as a highly absorbable form of magnesium. The page explains that magnesium glycinate uses magnesium bound to the amino acid glycine, which facilitates intestinal absorption. The page describes magnesium as a mineral critical for energy production and metabolism, muscle contraction, nerve impulse transmission, and bone mineralization. It states that magnesium is a required cofactor for an estimated 300 enzymes, and that among the processes requiring magnesium are fat and protein production as well as glucose metabolism. The page also notes that magnesium status is important for regulation of calcium balance through its effects on the parathyroid gland. This product is enhanced with BioPerine®, a proprietary black pepper extract. Each serving provides 200 mg of elemental magnesium from magnesium bisglycinate (Albion™) along with 2.5 mg of black pepper fruit extract standardized to a minimum of 96% piperine. The suggested usage is to take 2 capsules 1 to 2 times daily with food. The product is listed under the Nervous System Support heading and is offered in 60 veg capsules (30 servings) and 180 veg capsules (90 servings). The capsules are made from hypromellose and the product is not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients, though it is produced in a GMP facility that processes other ingredients containing these allergens. The page states the product is made and quality tested in the USA with globally sourced ingredients, has Intertek GMP Supplement Certification, and is Non-GMO and Vegan. Natural color variation may occur. The page states that the product is for adults only, that pregnant or nursing persons, people taking medication, or those with a medical condition should consult a physician, and that it should be kept out of reach of children. It also notes the product should be stored in a cool, dry place after opening. The page carries the statement that these statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease.

Product Focus: Blood PressureAlso covers:HeartBrainMuscles
Tier ⓘ
Tier 2
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
83 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
97% of 15,777
Biohacker Mentions
7 of 10
Cost per month
$15

Study, Trial or Testing Result Summary

Members Only56 human studies · 25 improved

13 of these 56 human studies gave the ingredient by drip or inhaler, not by mouth.

56 human studies25 improved21 no effect24,918 people studied

Magnesium, taken at 400 mg a day in this product, has the strongest evidence here. A 2025 pooled analysis of 38 trials with 2709 people taking about 365 mg a day for about 12 weeks found the top blood pressure number fell by about 2.8 points and the bottom number by about 2.1 points. The largest drops were in people already on meds or low in magnesium, with no clear change in people with normal pressure [1]. A 2016 analysis of 34 trials found similar drops of about 2 points [2]. A review of 49 trials found benefit in uncontrolled high blood pressure but not in controlled or normal pressure [3]. Small trials in adults with metabolic syndrome taking 400 mg daily lowered blood pressure [4][5], but a 24 week trial in overweight adults found no change [6]. The 400 mg daily amount is above the recommended daily limit for supplements, so members can take less. Piperine, the black pepper extract, is at the studied 5 mg, but it has only been tested together with curcumin, which this product does not contain. So its own effect on blood pressure is unknown [7][8][9]. Animal and cell studies are never counted.

See all 56 studies →Hide the studies

Review Totals and Summary

Members Only15,777 reviews · 97% positive
15,777 reviews · IHerb 15,106 · Vitacost 597 · Walmart 42 · Swanson Vitamins 18 · EBay 4 · Fruitful Yield 1
97% positive2% neutral1% negative

Customers generally view NOW Magnesium Glycinate with BioPerine capsules very positively, with 93% of its approximately 15176 ratings across various stores being 4 or 5 stars. Buyers frequently praise its effectiveness for several health benefits and its gentle nature. **What it did for them** Many customers report significant improvements in sleep and relaxation. Reviewers describe it as an "Excellent sleep aids!!" that helps them "sleep like a baby" and "stay sleeping over night." Some find it helps keep the mind from racing and "Helps with anxiety." Beyond sleep, many users experience relief from muscle issues, with one noting it is "Really helping with my leg cramps." Others use it for muscle recovery after training or for joint muscle recovery after hard sessions. Some buyers report an overall improvement in health, with one stating their "overall health is 100% better." It's also credited with supporting a calmer nervous system, increasing energy and focus, and contributing to overall wellness. A few users mention it helps manage symptoms linked to conditions such as PCOS. The addition of BioPerine black pepper extract is often noted as making a noticeable difference compared to plain magnesium glycinate, with some buyers saying it enhances absorption. Users also appreciate waking up refreshed and without feeling groggy. **Complaints** While feedback is overwhelmingly positive, some critical points emerge. The primary concerns revolve around inactive ingredients; one reviewer objects to microcrystalline cellulose, which they say caused bloating, and silicon dioxide, expressing worry about its long-term effect on intestinal lining and gut bacteria. This reviewer wished they had checked the ingredients before buying. Another significant caution is that BioPerine, which is piperine, can interfere with the metabolism of certain medications processed by the liver enzyme CYP3A4, prompting advice for people on medication to consult a doctor first. A few customers express disappointment about the lack of a Certificate of Analysis (COA) for specific product lots, stating, "Disappointed there is no COA available." A very small number of users found the product ineffective for sleep, with one stating it "Does not put me to sleep." **Taste, smell, pill size, form** The capsules are consistently described as small and easy to swallow. Many reviewers highlight the product's gentleness on the stomach, reporting no burping, heartburn, bloating, or weird aftertaste, especially when taken with a light snack. Unlike some other forms of magnesium, customers note there is no laxative effect. The product is confirmed to be magnesium bisglycinate from Albion Minerals, which is praised as a top-tier, chelated ingredient form that is well-absorbed and gentle. **Value for money** Customers frequently praise the product's affordability, with comments like "Best price i could find" and "Outstanding product and price." Many consider NOW a "Reliable Brand" that offers "quality ingredients" and the amounts listed. The brand's trustworthiness for quality ingredients at a good price is a recurring theme. Packaging is described as reliable, the bottle size as generous, and shipping as fast. Many buyers express their intent to repurchase the product. **Who it seems to suit and who it did not** This magnesium glycinate product appears well-suited for individuals seeking support for sleep, relaxation, and muscle recovery, including relief from leg cramps and post-training soreness. It is also favored by those looking for a magnesium supplement that is gentle on the stomach and does not cause digestive upset. However, it may not be suitable for those with sensitivities to inactive ingredients like microcrystalline cellulose or silicon dioxide. Individuals taking medications, particularly those processed by the liver enzyme CYP3A4, should exercise caution and consult a healthcare professional due to the BioPerine content. A very small minority of users did not find it effective for sleep.

Biohacker Summary

Members Only7 of 10 recommend it
7 of 10 biohackers on our panel recommend it

Magnesium is the main ingredient here, and most of the panel recommends it or uses it, though a few stay neutral. The top reason is sleep, with several taking it before bed, and others point to blood pressure, muscle function, bone health, stress and brain function. On forms, four of them named threonate, mostly at 400 mg before bed, while one recommends glycinate at night and another also names glycinate. Doses people gave ranged from 300 mg before bed up to a daily minimum of 400 to 500 mg, and one aims for about a gram. Some pair it with electrolytes like sodium and potassium, and one links it with vitamins D3 and K2. Cautions: one panelist says the evidence that it reliably improves sleep is not strong or consistent, another says it does not fix waking in the night, and one warns that labels can overstate the real magnesium dose.

See all 10 biohackers →Hide the biohackers
  • Dr. Mark Hyman · Magnesium · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 21 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 14 Oct 2026 · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
    • 30 Sep 2026 · uses · YouTube ↗
      Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
    • 22 Sep 2026 · recommends · Instagram ↗
      Recommends correcting nutrient deficiencies with magnesium.
    • 16 Sep 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
    • 9 Sep 2026 · uses · YouTube ↗
      Has recommended Magnesium Breakthrough from Bio Optimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
    • 2 Sep 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advance 10 from Bio Optimizers, which contains 10 bioavailable forms of magnesium, as it plays a critical role in sleep recovery, stress regulation, and muscle function, and has become part of his evening routine, especially during periods of travel, training, and higher stress.
    • Date not recorded · Piperine · recommends · Website ↗
      Recommends consuming piperine, found in black pepper, with curcumin to make it easier for the body to absorb, enhancing its anti-inflammatory benefits.
  • Dave Asprey · Magnesium · neutral
    • 31 Oct 2026 · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 17 Oct 2026 · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 27 Sep 2026 · recommends · Podcast ↗
      Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
    • 7 Sep 2026 · uses · Instagram ↗
      Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
    • 3 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
    • 29 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
    • 15 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
    • 28 Jul 2026 · recommends · YouTube ↗
      Mentions magnesium glycinate as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
    • 19 Jul 2024 · Piperine · warns · YouTube ↗
      Warns that high doses of piperine, such as 20 or 30 milligrams, could raise inflammation in the gut and advises caution when combining supplements containing it.
    • 21 Jul 2021 · Piperine · neutral · YouTube ↗
      Explains that piperine, from black pepper, is included in the formulation to increase the absorption of multiple active ingredients in the gut.
  • Dr. Eric Berg · Magnesium · neutral
    • 30 Oct 2026 · neutral · Instagram ↗
      Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
    • 28 Oct 2026 · neutral · YouTube ↗
      Notes that magnesium could also be a factor in preventing muscle cramps.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
    • 25 Oct 2026 · recommends · X ↗
      Recommends increasing magnesium to restore balance and support healthy blood pressure.
    • 24 Oct 2026 · recommends · Instagram ↗
      Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
    • 24 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
    • 23 Oct 2026 · recommends · Instagram ↗
      Recommends taking magnesium 90 minutes to 2 hours before bedtime to support better sleep.
    • 23 Oct 2026 · recommends · YouTube ↗
      Suggests that magnesium glycinate can help support the missing 'break pads' on the nervous system, which contribute to constant pain.
    • 22 Oct 2026 · recommends · Podcast ↗
      Taking 400 mg of magnesium glycinate daily may also help support brain health during menopause.
    • 21 Oct 2026 · warns · YouTube ↗
      Warns against magnesium oxide because it is poorly absorbed, with only about 4% absorption, and can cause diarrhea, despite being commonly used in research and supplements due to its low cost.
    • 23 Aug 2021 · Piperine · neutral · YouTube ↗
      States that adding piperine, a phytonutrient from black pepper, at the same time as curcumin can increase curcumin absorption by 2000%.
    • 24 May 2020 · Piperine · neutral · Podcast ↗
      Identifies piperine as the main phytonutrient in black pepper that benefits health, but also notes that it can increase the bioavailability of toxic substances and prevent the liver from getting rid of toxins.
  • Ben Greenfield · Magnesium · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 22 Oct 2026 · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 3 Sep 2026 · recommends · YouTube ↗
      Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
    • 25 Aug 2026 · uses · Facebook ↗
      Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
    • 17 Aug 2026 · recommends · Facebook ↗
      Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
    • 15 Aug 2026 · warns · YouTube ↗
      Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
    • 8 Aug 2026 · recommends · YouTube ↗
      Recommends taking magnesium as a co-factor to increase vitamin D absorption.
    • 13 Jun 2026 · neutral · X ↗
      Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
    • 28 Jul 2020 · Piperine · warns · YouTube ↗
      Warns that piperine in pepper inhibits UDP-glucuronosyltransferase, a phase 2 detoxification enzyme.
    • 27 Feb 2020 · Piperine · warns · YouTube ↗
      Warns against supplementing curcumin with piperine, stating that it dangerously increases absorption by inhibiting UDP glucuronosyltransferase, leading to increased side effects.
    • 14 Mar 2019 · Piperine · warns · Podcast ↗
      States that piperine inhibits the body's natural detoxification process by inhibiting UDP glucuronosyltransferase and is added to curcumin supplements to increase curcumin absorption, but these molecules are not used in human biochemistry.
    • 14 Mar 2019 · Piperine · warns · YouTube ↗
      Ben Greenfield's guest explains that piperine, found in black pepper, inhibits the UDP-glucuronosyltransferase enzyme in the liver, which is crucial for detoxifying compounds by making them water-soluble for excretion.
  • Dr. Rhonda Patrick · Magnesium · neutral
    • 29 Oct 2026 · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 16 Oct 2026 · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 29 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium as an important nutrient component for testosterone.
    • 28 Sep 2026 · warns · YouTube ↗
      Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
    • 2 Sep 2026 · neutral · Facebook ↗
      States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
    • 10 Aug 2026 · neutral · Facebook ↗
      States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
    • 10 Aug 2026 · recommends · X ↗
      Recommends considering magnesium to improve mood.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
    • 29 Jun 2026 · neutral · Facebook ↗
      Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
    • 26 Jun 2026 · recommends · Facebook ↗
      Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
    • 25 Dec 2015 · Piperine · warns · YouTube ↗
      Warns that piperine should be avoided by people taking meds because it can extend the half-life of the drug, which could have unknown effects.
    • 11 Aug 2015 · Piperine · uses · YouTube ↗
      Consumes turmeric with ground pepper (piperine) to increase its bioavailability and absorption.
    • Date not recorded · Piperine · neutral · Website ↗
      Piperine from black pepper increases the bioavailability of curcumin.
    • Date not recorded · Piperine · uses · Website ↗
      Tim Ferriss consumes piperine (ground pepper) with turmeric to increase its bioavailability and absorption.
  • Thomas DeLauer · Magnesium · uses
    • 28 Oct 2026 · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 24 Oct 2026 · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 6 Oct 2026 · neutral · YouTube ↗
      Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
    • 1 Oct 2026 · recommends · YouTube ↗
      Recommends taking some magnesium glycinate tonight to help calm down and sleep.
    • 25 Sep 2026 · neutral · Facebook ↗
      Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
    • 18 Sep 2026 · neutral · Facebook ↗
      Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
    • 1 Sep 2026 · recommends · Instagram ↗
      Recommends Magnesium glycinate, stating that 200-400mg elemental helps with sleep as glycine cools the body and magnesium calms.
    • 29 Aug 2026 · neutral · Instagram ↗
      Notes that magnesium sits on the NMDA receptor and regulates excitatory transmission, in the context of feeling stressed.
    • 15 Jul 2026 · Piperine · recommends · YouTube ↗
      Recommends taking piperine with curcumin to increase its bioavailability, as curcumin gets metabolized before it can do anything without it.
    • 19 Dec 2025 · Piperine · recommends · YouTube ↗
      Recommends a piperine supplement to improve autophagy, citing a rodent study where piperine prevented neurotoxic effects and increased autophagy by inhibiting mTor X1.
    • 21 Jul 2022 · Piperine · neutral · YouTube ↗
      Discusses piperine's potential to improve resveratrol absorption by slowing its metabolism, citing a rodent study that showed a significant increase in serum resveratrol, but notes that this has not been successfully replicated in humans.
    • 16 Jan 2021 · Piperine · neutral · YouTube ↗
      Notes that piperine is included in a supplement to help with absorption.
  • Siim Land · Magnesium · recommends
    • 25 Oct 2026 · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Magnesium as one of 15 supplements backed by human studies.
    • 30 Sep 2026 · recommends · Instagram ↗
      States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
    • 30 Sep 2026 · neutral · X ↗
      Lists seafood and pumpkin seeds as sources of Magnesium.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks magnesium has some of the strongest evidence and is worth considering.
    • 17 Aug 2026 · recommends · YouTube ↗
      Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
    • 14 Aug 2026 · neutral · X ↗
      Notes that Boron reduces calcium/magnesium loss.
    • 10 Aug 2026 · recommends · YouTube ↗
      Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
    • 12 Jul 2025 · Piperine · warns · YouTube ↗
      Warns that piperine affects the metabolism of many drugs, and taking it shortly before certain medications could lead to a much higher concentration of the medication in the blood.
  • Andrew Huberman · Magnesium · neutral
    • 22 Oct 2026 · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 7 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 27 Jul 2026 · uses · YouTube ↗
      Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
    • 20 Jul 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 20 Jul 2026 · recommends · YouTube ↗
      Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
    • 13 Jul 2026 · uses · X ↗
      Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 12 Jul 2026 · uses · X ↗
      He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
    • 6 Jul 2026 · uses · X ↗
      Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 22 Jun 2026 · uses · X ↗
      Takes 400 mg of magnesium L-threonate before bed for sleep.
    • 18 Jun 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
  • Bryan Johnson · Magnesium · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 15 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 4 May 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 2 May 2026 · uses · X ↗
      He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 21 Apr 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 15 Apr 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 14 Apr 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 8 Apr 2026 · uses · X ↗
      Takes 400 mg of magnesium L-threonate before bed for sleep.
    • 7 Apr 2026 · uses · X ↗
      He takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 5 Apr 2026 · uses · X ↗
      Takes 400 mg of magnesium threonate before bed for sleep.
  • Peter Attia · Magnesium · neutral
    • 1 Jun 2026 · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 15 Sep 2025 · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
    • 6 Jul 2025 · recommends · YouTube ↗
      Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
    • 7 Jul 2024 · recommends · YouTube ↗
      Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
    • 1 Jul 2024 · uses · YouTube ↗
      Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
    • 20 May 2024 · uses · YouTube ↗
      Takes magnesium as a straightforward supplement.
    • 28 Feb 2024 · neutral · YouTube ↗
      Mentions that magnesium intake is often super low and impactful on testosterone levels.
    • 11 Dec 2023 · uses · Facebook ↗
      Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.

RAL Summary

Members OnlyTier 2 for Blood Pressure

Two large pooled analyses of placebo controlled trials show magnesium modestly lowers blood pressure, mainly in people with high blood pressure or low magnesium [1][2]. With 15777 reviews that are 97% positive, this meets tier 2.

Where the evidence disagrees: 21 of the 56 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system, Nervous system, Muscular system

Combine with: To further support heart health and blood pressure alongside Magnesium Glycinate, consider combining it with CoQ10, which is vital for cellular energy production in the heart and has been shown to support cardiovascular function. Omega-3 fatty acids (EPA and DHA) can also be beneficial due to their anti-inflammatory properties and ability to support healthy blood vessel function. Additionally, potassium can help balance sodium levels in the body, which is crucial for maintaining healthy blood pressure.

Possible side effects: The studies reported no major side effects. One reviewer blamed bloating on the filler ingredients, and piperine may change how the liver breaks down some medicines, so people on medication should check with a doctor.

Supplement Facts

Magnesium 200 mg · Bioperine 2.5 mg
Supplement Facts
Serving Size 2 Capsule(s)
Servings Per Container 90
Amount Per Serving% Daily Value
Magnesium200 mg
Bioperine2.5 mg†
† Daily Value not established.

Other ingredients: Hypromellose, Citric Acid, Ascorbyl Palmitate, Microcrystalline Cellulose, Silicon Dioxide.

Directions: Suggested usage: Take 2 capsules 1 to 2 times daily with food.

Barcode (UPC) 733739012876 · Label source: NIH label database · Report a label change

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Graded November 3, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.