NOW Magnesium Glycinate with BioPerine Review
Magnesium Glycinate with BioPerine® Veg Capsules from NOW is presented as a highly absorbable form of magnesium. The page explains that magnesium glycinate uses magnesium bound to the amino acid glycine, which facilitates intestinal absorption. The page describes magnesium as a mineral critical for energy production and metabolism, muscle contraction, nerve impulse transmission, and bone mineralization. It states that magnesium is a required cofactor for an estimated 300 enzymes, and that among the processes requiring magnesium are fat and protein production as well as glucose metabolism. The page also notes that magnesium status is important for regulation of calcium balance through its effects on the parathyroid gland. This product is enhanced with BioPerine®, a proprietary black pepper extract. Each serving provides 200 mg of elemental magnesium from magnesium bisglycinate (Albion™) along with 2.5 mg of black pepper fruit extract standardized to a minimum of 96% piperine. The suggested usage is to take 2 capsules 1 to 2 times daily with food. The product is listed under the Nervous System Support heading and is offered in 60 veg capsules (30 servings) and 180 veg capsules (90 servings). The capsules are made from hypromellose and the product is not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients, though it is produced in a GMP facility that processes other ingredients containing these allergens. The page states the product is made and quality tested in the USA with globally sourced ingredients, has Intertek GMP Supplement Certification, and is Non-GMO and Vegan. Natural color variation may occur. The page states that the product is for adults only, that pregnant or nursing persons, people taking medication, or those with a medical condition should consult a physician, and that it should be kept out of reach of children. It also notes the product should be stored in a cool, dry place after opening. The page carries the statement that these statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease.
Study, Trial or Testing Result Summary
Members Only56 human studies · 25 improved
13 of these 56 human studies gave the ingredient by drip or inhaler, not by mouth.
Magnesium, taken at 400 mg a day in this product, has the strongest evidence here. A 2025 pooled analysis of 38 trials with 2709 people taking about 365 mg a day for about 12 weeks found the top blood pressure number fell by about 2.8 points and the bottom number by about 2.1 points. The largest drops were in people already on meds or low in magnesium, with no clear change in people with normal pressure [1]. A 2016 analysis of 34 trials found similar drops of about 2 points [2]. A review of 49 trials found benefit in uncontrolled high blood pressure but not in controlled or normal pressure [3]. Small trials in adults with metabolic syndrome taking 400 mg daily lowered blood pressure [4][5], but a 24 week trial in overweight adults found no change [6]. The 400 mg daily amount is above the recommended daily limit for supplements, so members can take less. Piperine, the black pepper extract, is at the studied 5 mg, but it has only been tested together with curcumin, which this product does not contain. So its own effect on blood pressure is unknown [7][8][9]. Animal and cell studies are never counted.
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- In 38 randomized trials of 2709 people taking a median 365 mg of elemental magnesium daily for a median 12 weeks, systolic blood pressure fell 2.81 mm Hg and diastolic 2.05 mm Hg versus placebo, with larger drops in people on meds or with low magnesium and no significant change in people with normal blood pressure.Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- In 34 placebo-controlled trials of 2028 adults taking a median 368 mg of magnesium daily for about 3 months, systolic blood pressure fell 2.00 mm Hg and diastolic 1.78 mm Hg versus placebo.Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Tr…
- In 23 randomized trials of 1345 people with type 2 diabetes, magnesium supplements were linked to lower diastolic blood pressure, but the abstract gives no figures for blood pressure, dose or duration.Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 D…
- In four studies of 1334 children with infantile epileptic spasms, adding magnesium sulfate to hormone therapy (ACTH) cut the rate of high blood pressure as a side effect compared with the hormone alone, though the studies were not about blood pressure in healthy people or treating it.Efficacy and tolerability of magnesium sulfate in children with infantile epileptic spasms syndrome: A systematic review…
- Across 15 trials of 855 adults with prediabetes or type 2 diabetes, curcumin or turmeric lowered systolic blood pressure by about 2.7 mmHg versus control but did not significantly change diastolic pressure; curcumin with piperine above 1 g a day also lowered systolic pressure.Antihypertensive Effects of Curcumin/Turmeric Supplementation in Prediabetes and Diabetes: A Systematic Review and Meta-…
- This broad review of pre-eclampsia and high blood pressure in pregnancy lists magnesium supplementation among many treatments, but the abstract gives no results for magnesium.Pre-eclampsia, eclampsia, and hypertension.
- A review of double-blind trials lasting at least four weeks found magnesium supplements can help treat metabolic syndrome in people with low magnesium, with no specific blood pressure numbers given.Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials.
- Across 49 trials, oral magnesium of at least 240 mg daily lowered blood pressure in people with uncontrolled hypertension on medication and over 600 mg daily was needed in untreated hypertension, while people with controlled blood pressure or normal blood pressure saw no change.Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials.
- In 10141 women with pre-eclampsia, magnesium sulphate cut the risk of eclampsia seizures by 58% versus placebo (0.8% vs 1.9%), though 24% reported side effects versus 5% on placebo; blood pressure itself was not reported as an outcome.Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-c…
- In 816 children with severe asthma in the emergency department, nebulized magnesium sulfate added to albuterol did not change systolic blood pressure or reduce hospitalization compared with placebo.Effect of Nebulized Magnesium vs Placebo Added to Albuterol on Hospitalization Among Children With Refractory Acute Asth…
- In a single-blinded controlled study of 430 adults, a magnesium-rich diet averaging about 1,142 mg a day for 12 weeks lowered total cholesterol, bad cholesterol and triglycerides by about 10% each, compared with a usual diet; blood pressure was not reported.Can dietary magnesium modulate lipoprotein metabolism?
- Over 10 years, 400 high-risk adults assigned to a magnesium-rich diet (about 1142 mg daily) had fewer heart complications and lower total and sudden death rates than those on their usual diet (about 418 mg daily).Effect of dietary magnesium supplementation in the prevention of coronary heart disease and sudden cardiac death.
- In 200 healthy first-time pregnant women, daily magnesium did not change the rise in blood pressure compared with placebo.Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study.
- In 194 pregnant women with preeclampsia treated for two weeks, adding a multivitamin to magnesium sulfate lowered blood pressure no more than magnesium sulfate alone.Effects of multivitamin combined with magnesium sulfate versus magnesium sulfate alone on hemodynamics, coagulation, and…
- In 182 women with severe preeclampsia, giving magnesium sulfate for 12 hours after delivery was as effective as 24 hours, with blood pressure similar in both groups.A comparison between the two methods of magnesium sulfate administration for duration of 12 versus 24 h after delivery i…
- In 164 overweight or slightly obese adults, 450 mg of magnesium daily as citrate, oxide or sulfate for 24 weeks did not change blood pressure or artery stiffness compared with placebo.Effects of Magnesium Citrate, Magnesium Oxide, and Magnesium Sulfate Supplementation on Arterial Stiffness: A Randomized…
- In 150 pregnant women with chronic hypertension, a treatment plan that included magnesium orotate, along with other measures, reduced hypertension symptoms and supported a favorable pregnancy course.[Magnesium orotate in treatment of chronic hypertension in pregnant women].
- In 110 overweight pregnant women, a resveratrol and magnesium hydroxide complex with inositols for up to 60 days did not change systolic or diastolic blood pressure across groups, though lipid and glucose levels improved.Can trans resveratrol plus d-chiro-inositol and myo-inositol improve maternal metabolic profile in overweight pregnant p…
- In 97 patients having bypass surgery, adding magnesium sulfate to heart-protecting cardioplegia fluid every 25 minutes protected the heart about as well as the standard every-15-minute method, with no difference in heart damage markers.The efficacy and safety of extending the ischemic time with a modified cardioplegic technique for coronary artery surger…
- In 95 overweight adults, 360 mg of magnesium glycinate three times daily with vitamin D for 12 weeks raised vitamin D levels more than vitamin D alone, and lowered systolic blood pressure only in those whose baseline systolic pressure was above 132 mmHg.The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pre…
- In 88 patients having adrenal tumor surgery, magnesium sulfate infusion given before surgery cut the time blood pressure and heart rate stayed outside target ranges from 8.3% to 4.3% compared with placebo, with a lower peak systolic pressure.Efficacy and Safety of Preemptive Magnesium Sulfate Infusion during Pheochromocytoma and Paraganglioma Resection: A Rand…
- In 80 patients with organophosphorus poisoning, adding intravenous magnesium sulfate lowered diastolic blood pressure at 0 and 2 hours and lowered heart rate for up to 24 hours compared with saline, but systolic blood pressure did not differ.Therapeutic Effect of Adding Magnesium Sulfate in Treatment of Organophosphorus Poisoning.
- In 80 overweight adults with borderline high fasting glucose, 8 weeks of phytosomal curcumin with piperine improved blood pressure compared with the start of the study, but the abstract reports only insulin, triglycerides, liver and cortisol measures as better than placebo.Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty li…
- In 75 pregnant women with pregnancy-related hypertension, magnesium sulfate (20-25 g daily) served as the comparison group, and ligustrazine lowered mean arterial pressure more than magnesium sulfate did.[Treatment of hypertension syndrome of pregnancy with ligustrazine].
- In 72 people with type 2 diabetes and high triglycerides, 12 weeks of curcuminoids plus piperine did not change blood pressure compared with placebo, though triglycerides and fasting glucose fell.The effect of curcumin-piperine supplementation on lipid profile, glycemic index, inflammation, and blood pressure in pa…
- In 68 patients preparing for colonoscopy, a magnesium citrate drink taken before a lavage solution did not produce significant changes in heart rate or blood pressure compared with lavage alone or with bisacodyl.The effect of stimulant laxatives and polyethylene glycol-electrolyte lavage solution for colonoscopy preparation on ser…
- In 66 stroke patients in rehabilitation (56 finished), 12 weeks of curcumin with piperine lowered systolic and diastolic blood pressure more than placebo, along with lower inflammation, cholesterol and triglycerides.The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients wit…
- In 60 adults with moderate-to-high fatty liver, 12 weeks of curcumin with piperine lowered systolic blood pressure more than placebo, along with waist size, cholesterol, blood sugar and liver enzymes.Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized,…
- In 59 women treated for premature labor, bolus fenoterol caused fewer side effects, including blood pressure and heart rate effects, than continuous fenoterol, while the magnesium sulfate given in each arm was not the variable being tested.[Comparative study of maternal side effects of various forms of intravenous therapy with fenoterol in premature labor].
- In 54 people with irregular heartbeats, a micronutrient combination for 6 weeks lowered fasting insulin and reduced heart muscle mass, with some signs of better heart filling, compared with placebo; blood pressure was not reported.Dietary intervention with a specific micronutrient combination for the treatment of patients with cardiac arrhythmias: t…
- In 27 adults with metabolic syndrome, 400 mg of oral magnesium daily for 12 weeks significantly lowered systolic blood pressure from about 135 to 126 mmHg and diastolic from about 84 to 79 mmHg, and also lowered interleukin-6, compared with a control group that took no magnesium.Positive effects of magnesium supplementation in metabolic syndrome.
- In 50 newborns with birth asphyxia, magnesium sulfate infusion did not change blood pressure compared with saline placebo over the first 48 hours, although neurological outcomes at discharge were better.Short-term outcome of magnesium sulfate infusion in perinatal asphyxia.
- In a randomized, double-blind trial of 50 heart bypass patients, magnesium sulfate given for 5 days after surgery reduced atrial fibrillation (irregular heartbeat) to 4% of patients compared with 20% on placebo.Atrial fibrillation after coronary artery bypass surgery: predictors and the role of MgSO4 replacement.
- In a randomized, placebo-controlled trial of 48 women with mild preeclampsia after 34 weeks, magnesium sulfate lowered blood flow resistance in the baby's umbilical artery but did not change it in the baby's middle cerebral artery.Randomized controlled study comparing effect of magnesium sulfate with placebo on fetal umbilical artery and middle cere…
- In 45 patients with brain bleeding from a ruptured aneurysm, two weeks of intravenous magnesium sulfate shortened vasospasm but did not significantly improve outcomes or reduce cardiac and lung complications compared with saline.Intravenous magnesium sulfate to improve outcome after aneurysmal subarachnoid hemorrhage: interim report from a pilot s…
- In 40 women with polycystic ovary syndrome, 250 mg of magnesium oxide daily for 2 months did not change blood pressure compared with placebo, although insulin resistance and some cholesterol measures improved.The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profiles in Women with Polycystic Ovary Synd…
- In 40 adults with acute asthma, inhaled magnesium sulfate was compared with inhaled salbutamol; blood pressure was recorded, but the abstract reports no blood pressure result, and salbutamol worked better for asthma.Inhalation therapy with magnesium sulfate and salbutamol sulfate in bronchial asthma.
- In a pilot trial of 28 newborns with severe lung blood vessel constriction, nebulized magnesium sulfate over 24 hours gave a larger fall in the oxygenation index and a slightly higher average blood pressure than intravenous magnesium.Nebulized Magnesium Sulfate for Treatment of Persistent Pulmonary Hypertension of Newborn: A Pilot Randomized Controlled…
- In 25 newborns with persistent pulmonary hypertension, intravenous magnesium sulfate did not produce a different response rate than inhaled nitric oxide, though infants who switched to nitric oxide after magnesium failed did better.Inhaled nitric oxide and intravenous magnesium sulphate for the treatment of persistent pulmonary hypertension of the ne…
- In 24 adults with metabolic syndrome and normal magnesium levels, 400 mg of magnesium citrate daily for 12 weeks lowered systolic and diastolic blood pressure and HbA1c compared with placebo.Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome…
- In 23 healthy adults, a single dose of resveratrol with 20 mg piperine did not change blood pressure compared with placebo, although it increased brain blood flow.Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance…
- In 22 hemodialysis patients, using a low-magnesium dialysis bath did not significantly change QT dispersion, a measure of heart rhythm risk, compared with a normal-magnesium bath.The effect of different dialysate magnesium concentrations on QTc dispersion in hemodialysis patients.
- In 20 dialysis patients, a higher magnesium dialysate concentration did not change intradialytic blood pressure or heart stunning compared with a lower concentration over 2-week periods.High magnesium dialysate does not improve intradialytic hemodynamics or abrogate myocardial stunning.
- In 14 people after a brain bleed, a 5 gram intravenous magnesium bolus slightly lowered average blood pressure compared with saline but did not change blood flow speed in the brain.Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.
- In children with critical hand, foot and mouth disease, magnesium sulfate added to routine treatment lowered systolic blood pressure and heart rate more than routine treatment alone.The clinical value of aquaporin-4 in children with hand, foot, and mouth disease and the effect of magnesium sulfate on …
- In 69 pregnant women with high blood pressure, pretreatment with magnesium sulphate before tracheal intubation prevented the rise in blood pressure seen with lignocaine, and only 1 of 24 magnesium-treated women had a systolic pressure above 180 mm Hg afterward, compared with 6 of 24 given alfentanil and 6 of 21 given lignocaine.Attenuation of the pressor response to tracheal intubation in hypertensive proteinuric pregnant patients by lignocaine, …
- In an open, non-randomized study of 62 pregnant women with high blood pressure, a combined regimen that included magnesium orotate along with meds delayed pregnancy complications compared with a control group, but the magnesium effect cannot be separated from the other treatments and blood pressure itself was not reported as a separate result.[Basic and metabolic therapy of hypertensive disease in pregnant women].
- In nine young healthy people, magnesium infused into the arm improved blood vessel widening in response to methacholine, but overall blood pressure was not significantly changed.Magnesium infusion improves endothelium-dependent vasodilation in the human forearm.
- In an observational study of 1,160 patients with heart rhythm disorders, at least 300 mg of oral magnesium per day for at least 6 weeks gave good to very good results in 82% of patients, and high blood pressure also improved.[High-dosage oral magnesium therapy in arrhythmias. Results of an observational study in 1.160 patients with arrhythmia]…
- In a 1986 survey of 976 coloured adults in Cape Town, hypertensive people had lower dietary magnesium intake than normotensive people, but this survey did not test magnesium supplements.Hypertension in the coloured population of the Cape Peninsula.
- In 100 women with severe preeclampsia, a 6 g intravenous dose of magnesium sulfate lowered maternal systolic blood pressure from about 173 to 157 and diastolic from about 110 to 102 within 20 minutes, and also lowered heart rate.The effect of loading dose of magnesium sulfate on uterine, umbilical, and fetal middle cerebral arteries Doppler in wom…
- In 60 adults with joint or back pain, a one-month course of a supplement containing piperine alongside physical therapy did not change blood pressure, including in patients who also had high blood pressure.[Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evalua…
- In 10 hypertensive late-pregnancy women, a 4 g intravenous infusion of magnesium sulfate mildly lowered blood pressure and reduced peripheral resistance while increasing stroke volume and cardiac output.[The value of magnesium sulfate in intensive care of severe toxemias of pregnancy (author's transl)].
- In 8 women with severe gestational proteinuric hypertension, a magnesium sulphate infusion significantly lowered blood pressure, with the largest drop in diastolic pressure in those whose serum magnesium rose most.The effect of magnesium sulphate infusion on circulating catecholamine levels in severe gestational proteinuric hyperten…
- In 22 patients on long-term meds for high blood pressure or heart failure, 10 mmol of magnesium chloride per day for four months lowered systolic and diastolic pressure by about 13 mm Hg on average.Role of magnesium in the management of hypertension.
- In a nonrandomized study of 7 premature newborns with persistent pulmonary hypertension, intravenous magnesium sulfate led to clinical improvement in 6 infants, with no significant side effects, though blood pressure results were not separately reported.Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates.
Review Totals and Summary
Members Only15,777 reviews · 97% positive
Customers generally view NOW Magnesium Glycinate with BioPerine capsules very positively, with 93% of its approximately 15176 ratings across various stores being 4 or 5 stars. Buyers frequently praise its effectiveness for several health benefits and its gentle nature. **What it did for them** Many customers report significant improvements in sleep and relaxation. Reviewers describe it as an "Excellent sleep aids!!" that helps them "sleep like a baby" and "stay sleeping over night." Some find it helps keep the mind from racing and "Helps with anxiety." Beyond sleep, many users experience relief from muscle issues, with one noting it is "Really helping with my leg cramps." Others use it for muscle recovery after training or for joint muscle recovery after hard sessions. Some buyers report an overall improvement in health, with one stating their "overall health is 100% better." It's also credited with supporting a calmer nervous system, increasing energy and focus, and contributing to overall wellness. A few users mention it helps manage symptoms linked to conditions such as PCOS. The addition of BioPerine black pepper extract is often noted as making a noticeable difference compared to plain magnesium glycinate, with some buyers saying it enhances absorption. Users also appreciate waking up refreshed and without feeling groggy. **Complaints** While feedback is overwhelmingly positive, some critical points emerge. The primary concerns revolve around inactive ingredients; one reviewer objects to microcrystalline cellulose, which they say caused bloating, and silicon dioxide, expressing worry about its long-term effect on intestinal lining and gut bacteria. This reviewer wished they had checked the ingredients before buying. Another significant caution is that BioPerine, which is piperine, can interfere with the metabolism of certain medications processed by the liver enzyme CYP3A4, prompting advice for people on medication to consult a doctor first. A few customers express disappointment about the lack of a Certificate of Analysis (COA) for specific product lots, stating, "Disappointed there is no COA available." A very small number of users found the product ineffective for sleep, with one stating it "Does not put me to sleep." **Taste, smell, pill size, form** The capsules are consistently described as small and easy to swallow. Many reviewers highlight the product's gentleness on the stomach, reporting no burping, heartburn, bloating, or weird aftertaste, especially when taken with a light snack. Unlike some other forms of magnesium, customers note there is no laxative effect. The product is confirmed to be magnesium bisglycinate from Albion Minerals, which is praised as a top-tier, chelated ingredient form that is well-absorbed and gentle. **Value for money** Customers frequently praise the product's affordability, with comments like "Best price i could find" and "Outstanding product and price." Many consider NOW a "Reliable Brand" that offers "quality ingredients" and the amounts listed. The brand's trustworthiness for quality ingredients at a good price is a recurring theme. Packaging is described as reliable, the bottle size as generous, and shipping as fast. Many buyers express their intent to repurchase the product. **Who it seems to suit and who it did not** This magnesium glycinate product appears well-suited for individuals seeking support for sleep, relaxation, and muscle recovery, including relief from leg cramps and post-training soreness. It is also favored by those looking for a magnesium supplement that is gentle on the stomach and does not cause digestive upset. However, it may not be suitable for those with sensitivities to inactive ingredients like microcrystalline cellulose or silicon dioxide. Individuals taking medications, particularly those processed by the liver enzyme CYP3A4, should exercise caution and consult a healthcare professional due to the BioPerine content. A very small minority of users did not find it effective for sleep.
Biohacker Summary
Members Only7 of 10 recommend it
Magnesium is the main ingredient here, and most of the panel recommends it or uses it, though a few stay neutral. The top reason is sleep, with several taking it before bed, and others point to blood pressure, muscle function, bone health, stress and brain function. On forms, four of them named threonate, mostly at 400 mg before bed, while one recommends glycinate at night and another also names glycinate. Doses people gave ranged from 300 mg before bed up to a daily minimum of 400 to 500 mg, and one aims for about a gram. Some pair it with electrolytes like sodium and potassium, and one links it with vitamins D3 and K2. Cautions: one panelist says the evidence that it reliably improves sleep is not strong or consistent, another says it does not fix waking in the night, and one warns that labels can overstate the real magnesium dose.
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Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
- Has recommended Magnesium Breakthrough from Bio Optimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Recommends Magnesium Breakthrough Advance 10 from Bio Optimizers, which contains 10 bioavailable forms of magnesium, as it plays a critical role in sleep recovery, stress regulation, and muscle function, and has become part of his evening routine, especially during periods of travel, training, and higher stress.
- Recommends consuming piperine, found in black pepper, with curcumin to make it easier for the body to absorb, enhancing its anti-inflammatory benefits.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
- Dave Asprey recommends adding 300 or 400 mg of magnesium glycinate before bed to improve deep sleep quality, support growth hormone release, and burn visceral fat while asleep.
- Mentions magnesium glycinate as one of the extensively researched ingredients in Kill Switch that helps with natural sleep.
- Warns that high doses of piperine, such as 20 or 30 milligrams, could raise inflammation in the gut and advises caution when combining supplements containing it.
- Explains that piperine, from black pepper, is included in the formulation to increase the absorption of multiple active ingredients in the gut.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Recommends taking magnesium 90 minutes to 2 hours before bedtime to support better sleep.
- Suggests that magnesium glycinate can help support the missing 'break pads' on the nervous system, which contribute to constant pain.
- Taking 400 mg of magnesium glycinate daily may also help support brain health during menopause.
- Warns against magnesium oxide because it is poorly absorbed, with only about 4% absorption, and can cause diarrhea, despite being commonly used in research and supplements due to its low cost.
- States that adding piperine, a phytonutrient from black pepper, at the same time as curcumin can increase curcumin absorption by 2000%.
- Identifies piperine as the main phytonutrient in black pepper that benefits health, but also notes that it can increase the bioavailability of toxic substances and prevent the liver from getting rid of toxins.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
- Warns that piperine in pepper inhibits UDP-glucuronosyltransferase, a phase 2 detoxification enzyme.
- Warns against supplementing curcumin with piperine, stating that it dangerously increases absorption by inhibiting UDP glucuronosyltransferase, leading to increased side effects.
- States that piperine inhibits the body's natural detoxification process by inhibiting UDP glucuronosyltransferase and is added to curcumin supplements to increase curcumin absorption, but these molecules are not used in human biochemistry.
- Ben Greenfield's guest explains that piperine, found in black pepper, inhibits the UDP-glucuronosyltransferase enzyme in the liver, which is crucial for detoxifying compounds by making them water-soluble for excretion.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
- Recommends Magnesium, stating it is a cofactor for over 300 biological processes, including DNA repair, energy production, and sleep regulation.
- Warns that piperine should be avoided by people taking meds because it can extend the half-life of the drug, which could have unknown effects.
- Consumes turmeric with ground pepper (piperine) to increase its bioavailability and absorption.
- Piperine from black pepper increases the bioavailability of curcumin.
- Tim Ferriss consumes piperine (ground pepper) with turmeric to increase its bioavailability and absorption.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
- Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
- Recommends Magnesium glycinate, stating that 200-400mg elemental helps with sleep as glycine cools the body and magnesium calms.
- Notes that magnesium sits on the NMDA receptor and regulates excitatory transmission, in the context of feeling stressed.
- Recommends taking piperine with curcumin to increase its bioavailability, as curcumin gets metabolized before it can do anything without it.
- Recommends a piperine supplement to improve autophagy, citing a rodent study where piperine prevented neurotoxic effects and increased autophagy by inhibiting mTor X1.
- Discusses piperine's potential to improve resveratrol absorption by slowing its metabolism, citing a rodent study that showed a significant increase in serum resveratrol, but notes that this has not been successfully replicated in humans.
- Notes that piperine is included in a supplement to help with absorption.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
- Warns that piperine affects the metabolism of many drugs, and taking it shortly before certain medications could lead to a much higher concentration of the medication in the blood.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
- Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
- Takes magnesium as a straightforward supplement.
- Mentions that magnesium intake is often super low and impactful on testosterone levels.
- Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.
RAL Summary
Members OnlyTier 2 for Blood Pressure
Two large pooled analyses of placebo controlled trials show magnesium modestly lowers blood pressure, mainly in people with high blood pressure or low magnesium [1][2]. With 15777 reviews that are 97% positive, this meets tier 2.
Where the evidence disagrees: 21 of the 56 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Nervous system, Muscular system
Combine with: To further support heart health and blood pressure alongside Magnesium Glycinate, consider combining it with CoQ10, which is vital for cellular energy production in the heart and has been shown to support cardiovascular function. Omega-3 fatty acids (EPA and DHA) can also be beneficial due to their anti-inflammatory properties and ability to support healthy blood vessel function. Additionally, potassium can help balance sodium levels in the body, which is crucial for maintaining healthy blood pressure.
Possible side effects: The studies reported no major side effects. One reviewer blamed bloating on the filler ingredients, and piperine may change how the liver breaks down some medicines, so people on medication should check with a doctor.
Supplement Facts
Magnesium 200 mg · Bioperine 2.5 mg
| Magnesium | 200 mg | |
| Bioperine | 2.5 mg | † |
Other ingredients: Hypromellose, Citric Acid, Ascorbyl Palmitate, Microcrystalline Cellulose, Silicon Dioxide.
Directions: Suggested usage: Take 2 capsules 1 to 2 times daily with food.
Barcode (UPC) 733739012876 · Label source: NIH label database · Report a label change
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Where to Buy
NOW · iHerb · Walmart
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Our articles on this subject
- How to Lower Diastolic Blood Pressure for LongevityArticle · Sep 17, 2026
- Magnesium Glycinate vs Citrate: What the Studies ShowArticle · Oct 30, 2026
Graded November 3, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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