Nutricost Calcium D-Glucarate Review

Nutricost Calcium D-Glucarate is a dietary supplement featuring calcium D-glucarate, a compound derived from D-glucaric acid. D-glucaric acid is a natural substance found in various fruits and vegetables such as oranges, apples, broccoli, and cabbage, and is also produced in small amounts within the human body. This supplement is designed to support the body's natural detoxification processes and promote healthy hormone balance. Each serving of Nutricost Calcium D-Glucarate provides 500mg of calcium D-glucarate and 60mg of calcium, delivered in an easy-to-take "Veggie" capsule. The product is Non-GMO, Gluten-Free, Vegetarian Friendly, and manufactured in a GMP Compliant, FDA Registered Facility. The primary mechanism of action for calcium D-glucarate revolves around its role in enhancing the body's glucuronidation pathway, a crucial component of Phase II liver detoxification. During glucuronidation, the liver conjugates (binds) various endogenous and exogenous substances, including a med hormones like estrogen, environmental toxins, carcinogens, and metabolic waste products, to glucuronic acid. This conjugation process renders these compounds water-soluble, allowing them to be safely excreted from the body via bile and urine. However, an enzyme called beta-glucuronidase, produced by gut bacteria and found in various tissues, can deconjugate these glucuronide-bound substances in the intestines. This deconjugation effectively "un-binds" the toxins and hormones, allowing them to be reabsorbed back into the bloodstream, thereby increasing the body's toxic load and potentially leading to hormonal imbalances. Calcium D-glucarate, upon ingestion, is metabolized into D-glucaro-1,4-lactone, its most active metabolite. This metabolite acts as a potent inhibitor of the beta-glucuronidase enzyme. By inhibiting beta-glucuronidase, calcium D-glucarate ensures that the compounds conjugated during Phase II detoxification remain bound to glucuronic acid, preventing their reabsorption and facilitating their efficient elimination from the body. This action is particularly beneficial for managing estrogen levels, as it helps the body safely remove excess estrogen and its metabolites, contributing to hormonal equilibrium. Beyond hormone regulation, calcium D-glucarate also supports overall detoxification, reduces the burden of environmental toxins, and has been suggested to support healthy lipid metabolism and cholesterol levels.