RepHresh Pro-B Review
The repHresh Pro-B™ Vaginal Probiotic Supplement is presented on its product page as a daily oral probiotic intended to balance yeast and bacteria and help maintain vaginal health. The page headline reads Balance Vaginal Yeast & Bacteria to Maintain Feminine Health. The product is described as a daily capsule containing clinically tested lactobacillus strains, intended to help the user feel fresh and confident. The page lists four key claims. It states the product is clinically tested to balance yeast and bacteria. It states the product contains 5 billion beneficial bacteria per serving. It instructs users to take just one capsule per day orally. It states the formula is vegan, non-GMO and gluten free. The page explains that lactobacillus, yeast and other bacteria are naturally present in the body, and that optimum vaginal health depends on a healthy balance of these elements. It says Pro-B contains clinically tested lactobacillus strains that have been shown to help balance yeast and bacteria, and that it is designed to help maintain vaginal flora in a normal range. A frequently asked questions section names two specific strains found in Pro-B, L. rhamnosus GR-1 and L. reuteri RC-14, and says clinical studies have shown they help maintain vaginal flora. The page says the product was formulated by doctors at the Canadian Research and Development Centre for Probiotics. It states that clinical studies show the product starts to work within 7 days. The page clarifies that Pro-B is not intended to treat yeast infections, and that users with symptoms such as itching or persistent odor should consult a doctor. The page also compares Pro-B with repHresh Odor Eliminating Vaginal Gel. The gel is described as balancing pH and is inserted directly into the vagina, while Pro-B is described as a probiotic taken orally to support beneficial bacteria. The page advises consulting the package insert for full instructions for use.
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
Finding the lowest prices at the stores now. This takes a few seconds.
Study, Trial or Testing Result Summary
Members Only21 human studies · 11 improved
This product contains a probiotic blend listed in the store as L. rhamnosus GR-1 and L. reuteri RC-14, but the label does not give the amounts, so the dose cannot be compared with any study. None of the studies we have tested these two strains. A large review pooling 39 studies of women around and after menopause found probiotics in general eased overall menopause symptoms, hot flashes, mood symptoms and vaginal dryness, but not body or sexual symptoms, and many of those studies had quality concerns [1]. A trial of a heat-treated Lactobacillus gasseri product helped 75% of women with menopause symptoms compared with 55% on placebo [2]. A daily Lactobacillus acidophilus capsule improved sexual function and menopause quality of life over 8 weeks [3]. Lactobacillus paragasseri improved premenstrual mood in younger women [4]. Probiotics combined with isoflavones reduced hot flushes in two trials [5][6], but the isoflavones may explain much of that effect. Because these results come from different strains, they cannot be assumed to apply to this product. Animal and cell studies are never counted.
See all 21 studies →Hide the studies
- Across 39 studies of 3187 perimenopausal and postmenopausal women, probiotics reduced overall menopausal, hot flash, psychological and vaginal dryness symptoms versus placebo, though not somatic or sexual symptoms, and the studies had a high risk of bias.Investigating the effects of probiotics during the menopause transition: A systematic review & meta-analysis.
- Across nine studies of 751 postmenopausal women, vaginal Lactobacillus appeared to help prevent recurrent cystitis in non-randomized studies, but randomized trials were mixed or negative and evidence for other urinary and vaginal symptoms was limited.Effect of Lactobacillus-based probiotics on genitourinary syndrome of menopause in post-menopausal women: A systematic r…
- In 286 early postmenopausal women taking a probiotic and prebiotic blend for 12 months, bone loss in the spine was not significantly reduced overall, though loss was lower at the hip in women with a BMI of 30 or more.A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy of the synbiotic medical food, SB…
- In 130 postmenopausal women over 12 months, isoflavones plus Lactobacillus sporogenes reduced menopausal symptom severity and frequency versus calcium plus vitamin D, with no differences in endometrium, breast density or liver safety.Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in post-menopausal women.
- In 80 women aged 40-60 over six menstrual cycles, L. gasseri CP2305 gave greater relief of total, hot flash and psychological menopausal symptoms than placebo, with 30 of 40 (75%) improving versus 22 of 40 (55%) on placebo.Effects of Lactobacillus gasseri CP2305 on Mild Menopausal Symptoms in Middle-Aged Women.
- In 80 healthy women aged 25-40 over three menstrual cycles, L. paragasseri OLL2809 improved premenstrual arousal and activity scores and lowered premenstrual irritability versus placebo.Lactobacillus paragasseri OLL2809 Improves Premenstrual Psychological Symptoms in Healthy Women: A Randomized, Double-Bl…
- In 78 postmenopausal women with low bone density over 12 months, red clover isoflavones with probiotics reduced bone loss, lowered a bone breakdown marker and shifted estrogen metabolites favorably versus placebo.Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopeni…
- In 72 postmenopausal women over 48 weeks, a daily probiotic did not change hip bone density, fracture risk or bone turnover markers compared with placebo.Using probiotic supplementation to support bone health in postmenopausal women: a randomized, double-blind, parallel, pl…
- In 66 postmenopausal women, eating 100 g of probiotic yogurt daily for 6 weeks lowered anxiety, stress and menopause quality-of-life scores compared with ordinary yogurt, but depression and sleep quality did not differ.The effect of probiotics on mood and sleep quality in postmenopausal women: A triple-blind randomized controlled trial.
- In 64 premenopausal and menopausal women with sexual dysfunction, one daily Lactobacillus acidophilus capsule (3 billion CFU) for 8 weeks gave higher sexual function scores and better menopause quality of life than placebo.The effect of probiotic supplementation on sexual function in premenopausal and menopausal women: a randomized controlle…
- In 62 perimenopausal women with hot flushes, a red clover isoflavone (34 mg/day) and probiotic combination for 12 weeks reduced hot flush frequency and intensity more than placebo.Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.
- In 48 perimenopausal and postmenopausal women on a standardized diet, a multispecies probiotic for 5 weeks raised follicle-stimulating hormone from baseline, but the placebo group showed a similar rise and body mass fell in both groups.Effects of probiotics supplementation on the hormone and body mass index in perimenopausal and postmenopausal women usin…
- In 47 postmenopausal women taking 150 mg isoflavones for 16 weeks, adding a probiotic blend did not produce significant links between gut bacteria and equol production.Correlation between equol production and intestinal microbiota after treatment with isoflavone, isoflavone plus probioti…
- In a randomized crossover study of 40 postmenopausal women (breast cancer survivors and controls), 6 weeks of a probiotic added to soy or milk protein did not change the urinary 2-hydroxyestrone to 16alpha-hydroxyestrone ratio.The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol producti…
- In a placebo-controlled pilot of 22 postmenopausal breast cancer patients on chemotherapy, taking Lactobacillus capsules twice daily for 2 weeks improved vaginal bacterial balance in 7 of 11 women, compared with 4 of 11 on placebo.Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer durin…
- In an exploratory double-blind placebo-controlled trial, peri- and postmenopausal women taking a probiotic formula containing L. brevis KABP052 kept higher serum estradiol and estrone levels after 12 weeks, while levels fell in the placebo group.Supplementation with a Probiotic Formula Having β-Glucuronidase Activity Modulates Serum Estrogen Levels in Healthy Peri…
- In a 10-week randomized trial of women with primary dysmenorrhea, probiotics reduced premenstrual and menstrual distress but had no notable effect on pain, inflammation, or hormone levels.Impact of Probiotic Supplementation and High-Intensity Interval Training on Primary Dysmenorrhea: A Double-Blind, Random…
- In 54 postmenopausal women given 100 mL daily of fermented soy-honey milk for 90 days, blood osteocalcin fell only in the group that received the Lactobacillus plantarum version, while the other groups showed no such change.Effect of Fermented Soymilk-Honey from Different Probiotics on Osteocalcin Level in Menopausal Women.
- In 36 premenopausal women taking a soy formula with about 120 mg of isoflavones daily for one month, the estrogen metabolite ratios did not change, and adding Lactobacillus GG reduced isoflavone excretion by about 40% without changing those ratios.Soy isoflavone intake and estrogen excretion patterns in young women: effect of probiotic administration.
- In a survey of 2044 women aged 40 to 65 taking a soy extract with a probiotic for 6 months, women and their gynecologists reported improved menopausal symptoms and sexual function, but there was no control group.Women's perception of the efficacy of a soy extract with probiotic: the M3 study.
- In 96 perimenopausal and postmenopausal women, lower vaginal Lactobacillus levels were linked to more genitourinary menopause symptoms, and a vaginal Lactobacillus capsule briefly relieved genital symptoms and improved sexual life.Associations of vaginal microbiota with the onset, severity, and type of symptoms of genitourinary syndrome of menopause…
Review Totals and Summary
Members Only8,413 reviews · 78% positive
Across the stores that sell it, RepHresh Pro-B carries about 5,529 ratings, and the feedback is largely positive. Buyers mostly describe a daily capsule that helps with vaginal pH balance and recurring problems, with price the main complaint. **What buyers say it did for them:** The most common theme is steadier pH balance and fewer recurring problems. One reviewer who had BV twice in a year says it is "working for me" and that they wanted to avoid meds. They also report help with moisture, especially after menstruation. Another reports monthly UTIs that stopped: "I haven't had one since I've been on this!!!" A third says "I do feel like it has helped balance out the Ph." One reviewer says a fishy odor disappeared. Others offer short praise such as "Works well" and "These supplements save my life!" Several note they had tried other brands without success before this one. Store summaries mention taking it daily for roughly three to six months. **What they complain about:** Cost is the main complaint. A three-month user says "I just wish it wasn't so expensive" and may try cheaper products. One buyer gave 1 star over delivery, not effectiveness: five boxes arrived with an October 2021 expiry date after being ordered in July. The reviewer felt it was unacceptable to receive nearly expired stock. That is a single report about shipping, and it says nothing about how the capsules perform. **Taste, smell, pill size or form:** The reviews say little about this. The only related comment is the one about odor disappearing, which concerns the user's own scent, not the capsule. One reviewer mentions taking one tablet per day as directed. Another says they use the capsules together with the brand's vaginal gel. Nothing in the reviews describes capsule size or any aftertaste. This summary covers the capsules only, and any reviews of other forms were left out. **Value for money:** Buyers who are happy with the results still find it pricey. The 3-month user says they know of other products "that offer the same qualities" for less, though they plan to keep using this one for now. The reviewer who reordered a second time seemed to find it worth buying again after the results. The buyer who ordered five boxes for a five-month course shows some people commit to it long term, which makes checking expiry dates on delivery worthwhile. **Who it seems to suit and who it did not:** It seems to suit women looking for a daily probiotic to support pH balance and cut down on recurrent BV, yeast problems or UTIs, especially those who want to avoid repeated meds. It also appeals to people who want to pair it with the brand's gel. Those who did not do well with it are hard to identify, as the reviews are nearly all positive and short, with little detail on dosing or timing. The one unhappy buyer was dissatisfied with the shipment, not the product. Anyone on a tight budget may want to compare prices before committing to a months-long course.
Biohacker Summary
Members Only8 of 10 recommend it
Six of the ten panelists spoke about probiotics, the main ingredient here, and the panel leans positive, though several comments were neutral notes about other products. Most of the supportive voices point to one synbiotic, a probiotic and prebiotic in a single capsule, which they take for gut health, less bloating and gas, better regularity, and in one case clearer skin within about 4 days. One panelist suggests taking it a couple of hours apart from fermented foods, another uses strains chosen from a gut test, and another cites links between gut bacteria and mood. One panelist cautions that some strains lower histamine while others can make it worse, so strain choice matters, and another notes that some blends contain strains that do not produce histamine. No doses were given, and nobody said they stopped taking a probiotic.
See all 6 biohackers →Hide the biohackers
Thomas DeLauer · Probiotic Blend · recommends
- Recommends Seed probiotic, stating it's the only probiotic he would ever recommend due to its scientific approach and multi-stage delivery system.
- Highly recommends Seed Daily Synbiotic, a prebiotic and probiotic, to capitalize on the beneficial effects of fermented foods and improve gut health, suggesting it be taken a couple of hours apart from fermented foods.
- Uses Seed DS-01 Synbiotic, a prebiotic and probiotic, and noticed a difference in skin clarity, smoothness, and overall well-being within about 4 days of taking it.
- Recommends Seed's synbiotic, a combination of prebiotic and probiotic, for gut inflammation, stating it's the only probiotic he's ever recommended and personally felt a difference from.
- Recommends Seed Synbiotic as the only probiotic he has ever recommended, noting it contains both a prebiotic and probiotic in one capsule to help the body utilize glucose better by supporting a healthy microbiome.
- States they don't take any other probiotics besides Seed, believing others are garbage, and has noticed a huge difference in their joints, mental clarity, and gut health within about two weeks.
- Uses Seed probiotics, stating they are the only ones he knows that publish studies based on their own research and have a unique capsule-in-capsule technology. He has noticed a huge difference in his joints, mental clarity, and gut health within about 2 weeks.
- Mentions that probiotic strains are included in RX Sugar Fiber Pro and are effective at helping the GLP-1 response.
- Is a huge fan of Seed Daily Synbiotic and says it's the only probiotic he personally uses, appreciating their transparency in publishing clinical trials, even when results aren't in their favor, and their multi-stage delivery system.
- Recommends Seed Daily Synbiotic, a prebiotic and probiotic in one, especially when changing diet or acclimating to a new diet style, and offers a discount code.
- Recommends Seed's daily symbiotic, which is a prebiotic and probiotic in one capsule, as a great tool to use in conjunction with honey to shift and alter the microbiome rapidly.
- Is a huge fan of Seed Daily Symbiotic and states it's the only probiotic he personally uses, appreciating their transparency in publishing clinical trials, even when results aren't in their favor.
- Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for good digestive health and notes the brand's commitment to microbiome research.
- Recommends Seed Daily Synbiotic, a prebiotic and probiotic in one capsule with multi-stage delivery, for improving gut health and the microbiome.
Dr. Mark Hyman · Probiotic Blend · uses
- Continues to recommend and take Seed's DS-01 Daily Synbiotic, highlighting its 24 unique probiotic strains, capsule-in-capsule technology, and clinical evidence for reducing bloating, alleviating gas, and improving regularity.
- Has reviewed countless probiotics and states that Seed's DS-01 Daily Synbiotic stands out as the number one digestive health probiotic, formulated with 24 clinically studied strains to support gut and whole body health.
- Notes that some probiotic strains can help reduce histamine, but warns that others may make it worse, emphasizing the importance of guidance to choose strains that lower histamine.
- Gave a good general probiotic blend to a patient to improve gut health.
- Uses a product containing 24 probiotic strains that are not commonly found in food, yogurt, or beverages, to support gut health.
Ben Greenfield · Probiotic Blend · neutral
- Notes that IM8health includes a full probiotic blend for the gut.
- Recommends Pendulum's new probiotic strain or series of strains, which simulate the feeling of fullness similar to injectable meds, as an effective way to suppress hunger.
- Recommends Seed's Daily Synbiotic for those who want to add a probiotic + prebiotic to their daily routine, noting that gut health affects whole-body health.
- Will be using certain probiotic strains that specifically address the probiotics they are deficient in, as recommended by their gut test.
- Uses probiotic blends APO-808™ and APO-19™ as part of Dr. John Lieurance's Travel Hacking Kit, which are designed to assist in gut health by placing probiotics in the lower intestine.
Dave Asprey · Probiotic Strains · neutral
- Confirms that all probiotic strains in Omni-Biotic do not produce histamine, which is significant for people with histamine sensitivity, long COVID, or mast cell activation syndrome.
Andrew Huberman · Probiotic Strains · neutral
- Notes that AG1's latest formula upgrade includes several clinically studied probiotic strains shown to support digestive health, immune system health, improve bowel regularity, and reduce bloating.
Dr. Eric Berg · Probiotic Strains · recommends
- Research shows that intestinal flora composition is closely linked with anxiety and depressive disorders and may improve by introducing beneficial probiotic strains to the gut.
RAL Summary
Members OnlyTier 4 for Hormone Balance for Women
The study support behind the tier comes from other probiotic strains (Lactobacillus gasseri, acidophilus, paragasseri and isoflavone combinations), not the L. rhamnosus GR-1 and L. reuteri RC-14 strains in this product, so it has no direct study support for this goal. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
- Probiotic strains: amount hidden in a blend
Where the evidence disagrees: 7 of the 21 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Reproductive system, Immune system, Urinary system
Combine with: For its true purpose of vaginal and urogenital health, Pro-B pairs well with D-mannose or cranberry proanthocyanidins for urinary tract support, vitamin D3 and zinc for mucosal immune function, and a prebiotic fiber such as inulin or partially hydrolyzed guar gum to nourish beneficial lactobacilli. Boric acid or other topical measures should only be used under clinician guidance. If the user still wants genuine cellular and DNA repair support, they should use separate products such as NAD+ precursors (nicotinamide riboside or NMN), trans-resveratrol, quercetin, CoQ10 or ubiquinol, and omega-3 fatty acids, after consulting a healthcare provider.
Possible side effects: No major side effects reported.
Supplement Facts
Pro-B Feminine Probiotic Strains 0
| Pro-B Feminine Probiotic Strains | 0 | † |
Other ingredients: Anhydrous Dextrose, Gelatin, Potato Starch, Microcrystalline Cellulose, Magnesium Stearate, Titanium Dioxide.
Directions: Directions: Take orally. One (1) capsule daily. Best used within 90 days of opening and before date on bottom of carton.
Barcode (UPC) 366715833303 · Label source: NIH label database · Report a label change
Show entire label
More hormone balance for women products
Members OnlyThe highest ranked for the same goal
Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataTermsDo Not Sell or Share My Personal InformationCookie settings