Seven Seas Cod Liver Oil with Omega 3 Review
Product Focus: Kidney HealthAlso covers:Digestion
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Tier 4 · Rank 1
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 1 within Tier 4 for Kidney Health; 3 of 8 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
42 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
90% of 5,276
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0 of 10
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Study, Trial or Testing Result Summary
Members Only92 human studies · 26 improved
3 of these 92 human studies gave omega-3 fatty acids by drip, not by mouth.
92 human studies26 improved45 no effect617,069 people studied
The omega-3 amount in this cod liver oil is not stated on the label, so it cannot be compared with the doses studied. Research on omega-3 and the kidneys is mixed. A trial in 415 adults with type 2 diabetes found 3 grams daily for 14 months improved kidney filtering compared with placebo [1]. A trial in 2,344 heart attack survivors found 400 milligrams daily over 40 months slightly slowed the decline in kidney filtering [2]. A two-year trial in 106 people with an immune kidney disease found fish oil slowed kidney loss. A review of 80 trials in that same kidney disease found small benefits compared with placebo or no treatment, but not compared with standard care [3]. Other large studies found no benefit. A trial of 8,179 adults taking 4 grams daily saw no change in kidney filtering [4]. A five-year trial of 1,312 adults with diabetes taking 1 gram daily found no difference from placebo and more stomach and gut bleeding [5]. A review of 46 trials in diabetes found no significant kidney effect [6]. Reviews in dialysis and transplant patients mostly found no benefit. Animal and cell studies are never counted.
See all 92 studies →Hide the studies
- Across 20 trials with 63,030 people, omega-3 supplements did not clearly reduce overall heart events or death; end-stage kidney disease was a planned secondary outcome but no kidney result is given in the summary.Omega 3 Fatty acids and cardiovascular outcomes: systematic review and meta-analysis.
- In 5,768 kidney transplant patients across 15 trials, fish oil was not among the treatments ranked as reducing kidney transplant failure, and it ranked low for raising good cholesterol.Management of blood lipids in post-kidney transplant patients: a systematic review and network meta-analysis.
- In 46 trials of 4,991 people with type 2 diabetes, omega-3 fatty acids improved cholesterol, blood sugar (HbA1c) and a marker of inflammation but had no significant effect on kidney function.The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis.
- Across 80 trials of 4856 people with IgA kidney disease, fish oil showed small kidney function benefits compared with placebo or no treatment, but these benefits were no longer seen compared with standard care.Non-immunosuppressive treatment for IgA nephropathy.
- In a review of 15 trials in 2230 dialysis patients, two trials of fish oil did not significantly improve how long dialysis access fistulas or grafts stayed open compared with placebo.Medical Adjuvant Treatment to Improve the Patency of Arteriovenous Fistulae and Grafts: A Systematic Review and Meta-ana…
- In 16 trials of 1,020 organ transplant recipients, omega-3 supplements had inconsistent and mostly non-significant effects on filtration rate and creatinine clearance, though blood pressure and cholesterol improved.Omega-3 fatty acid supplementation in solid organ transplant recipients: A systematic review and meta-analysis of random…
- In 833 dialysis patients across five trials, omega-3 made little or no difference to keeping dialysis access open for people with fistulas, and results were very uncertain for those with grafts; mild stomach side effects were more common.Omega-3 fatty acids for dialysis vascular access outcomes in patients with chronic kidney disease.
- In 11 trials of 810 people, omega-3 raised blood levels of precursors of inflammation-resolving molecules, including in people with chronic kidney disease, but kidney outcomes were not measured.Omega-3 fatty acids, specialized pro-resolving mediators, and depression: A mechanistic meta-analysis of precursors and …
- In 487 people with chronic kidney disease across 12 trials, omega-3 supplements did not significantly lower blood markers of inflammation compared with placebo.Effects of Omega-3 Fatty Acids on Markers of Inflammation in Patients With Chronic Kidney Disease: A Controversial Issue…
- In nine studies with 347 people with kidney-related conditions, omega-3 supplements had no statistically significant effect on protein in the urine.Role of omega-3 fatty acids in reducing proteinuria: A systematic review and meta-analysis.
- In 344 people with diabetes across ten trials, omega-3 lowered urine protein in type 2 diabetes, especially with 24 weeks or more of use, while kidney filtering rate rose but not significantly.The effects of omega-3 fatty acids on diabetic nephropathy: A meta-analysis of randomized controlled trials.
- In 239 adults with IgA kidney disease across five trials, omega-3 did not significantly reduce urine protein or improve kidney filtering, but two trials showed lower risk of creatinine rise and end-stage kidney disease.ω-3 fatty acids therapy for IgA nephropathy: a meta-analysis of randomized controlled trials.
- In thirteen placebo-controlled trials in people with chronic kidney disease, omega-3 lowered total cholesterol, triglycerides and an oxidative stress marker and raised antioxidant enzymes, with no effect on blood pressure, LDL or HDL.Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chron…
- A review of 112 trials found mixed effects of omega-3 on inflammation markers, and there was too little data to judge the effect in people with kidney disease.The effect of omega-3 fatty acids on biomarkers of inflammation: a rapid evidence assessment of the literature.
- In 53 studies of dialysis patients, blood omega-3 levels were lower than in healthy adults and higher omega-3 levels were linked to lower risk of sudden cardiac death, but the link with death from any cause was unclear.Blood Fatty Acid Status and Clinical Outcomes in Dialysis Patients: A Systematic Review.
- In 13 lupus studies, fish oil omega-3 improved disease activity scores but did not improve kidney measures such as serum creatinine or 24-hour urine protein.The effect of Omega-3 fatty acid supplementation in systemic lupus erythematosus patients: A systematic review.
- In 8179 a med-treated adults with heart disease or diabetes and high triglycerides, 4 g daily of icosapent ethyl did not change kidney filtration rate compared with placebo, though it lowered heart events across all kidney function levels.Benefits of Icosapent Ethyl Across the Range of Kidney Function in Patients With Established Cardiovascular Disease or D…
- In 2,344 adults with a past heart attack, 400 mg daily of EPA and DHA over 40 months slowed the decline in kidney filtration rate by about 2 ml/min per 1.73 m2 compared with placebo, a small benefit.Effect of omega-3 fatty acids on kidney function after myocardial infarction: the Alpha Omega Trial.
- In 1312 adults with type 2 diabetes taking 1 gram per day of omega-3 fatty acids for 5 years, kidney filtration decline was no different from placebo, and the trial found more gastrointestinal bleeding with omega-3.Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Random…
- In 536 people having dialysis access surgery, 4 grams daily of fish oil for three months reduced fistula interventions compared with placebo, but did not change fistula usability or patency.Read the study on PubMed (30913208) →
- In 415 adults with type 2 diabetes, 3 grams daily of marine omega-3 for 14 months improved estimated kidney filtration compared with placebo.Marine n-3 fatty acids protect against renal function deterioration in diabetic patients by modulating lipoproteins and …
- In 336 heart attack survivors with reduced kidney function, about 41 months of omega-3 margarine did not lower the blood hormone FGF23 compared with placebo margarine, and FGF23 rose over time in all groups.Effect of Omega-3 Fatty Acid Supplementation on Plasma Fibroblast Growth Factor 23 Levels in Post-Myocardial Infarction …
- In 206 hemodialysis patients with heart disease given omega-3 or olive oil for 3 months, triglycerides fell more with omega-3 but other cholesterol measures did not change.The effect of n-3 fatty acids on lipids and lipoproteins in patients treated with chronic haemodialysis: a randomized pl…
- In 201 adults with stage 5 kidney disease and new dialysis grafts, 4 g of fish oil daily for 12 months did not significantly cut the main graft problem rate (48% vs 62%) but reduced graft failure, clotting, interventions and systolic blood pressure.Effect of fish oil supplementation on graft patency and cardiovascular events among patients with new synthetic arteriov…
- In 161 hemodialysis patients with end-stage kidney disease, 1.7 g of omega-3 daily for 3 months lowered triglycerides but did not change small dense LDL cholesterol particles.The Effect of n-3 Fatty Acids on Small Dense Low-Density Lipoproteins in Patients With End-Stage Renal Disease: A Random…
- In a randomized trial of 132 kidney transplant recipients, 2.6 g per day of marine omega-3 fatty acids for 44 weeks did not improve quality of life compared with olive oil.Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant.
- In 130 patients with chronic kidney disease undergoing coronary angiography, omega-3 fatty acids given around the contrast dye procedure did not reduce the rate of contrast-induced kidney injury compared with N-acetylcysteine.Could Omega 3 fatty acids reduce the risk of contrast-induced nephropathy in patients undergoing coronary angiography? A…
- In 128 critically ill COVID-19 patients, 14 days of omega-3 fortified feeding formula was linked to lower blood urea nitrogen, creatinine and potassium and a higher one-month survival rate compared with the control formula.The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with …
- In a placebo-controlled trial of 120 people on dialysis, 3 grams of omega-3 daily for 2 months did not change body weight, fat mass, muscle, or visceral fat compared with placebo, except a near-significant trend in visceral fat.Effect of omega-3 fatty acids supplementation on muscle mass, fat mass, and visceral fat of hemodialysis patients; A ran…
- In 112 people on dialysis, 3 g of omega-3 daily for 2 months did not reduce itching compared with a placebo oil.Effectiveness of omega-3 fatty acid supplementation for pruritus in patients undergoing hemodialysis.
- In 107 older adults at risk of muscle loss, 24 weeks of leucine-enriched protein with fish oil raised kidney filtration rate and lowered cystatin c versus control, but the same changes occurred with protein alone so the fish oil's own kidney effect is unclear.Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle…
- In 106 adults with IgA nephropathy and persistent protein in urine, 12 grams of fish oil daily for two years slowed loss of kidney function compared with olive oil placebo, with 3 of 55 fish oil patients versus 14 of 51 placebo patients having a 50 percent or greater rise in serum creatinine.A controlled trial of fish oil in IgA nephropathy. Mayo Nephrology Collaborative Group.
- In 100 people with chronic kidney disease, 3,666 mg of omega-3 daily for 3 months did not significantly reduce urine albumin (19 of 50 vs 13 of 50 had a 20% drop) but improved artery stiffness and triglycerides.A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of an Omega-3 Fatty Acid Supplement in Patients With Predi…
- In 97 adults with type 2 diabetes, 4 g a day of fish oil for 12 weeks lowered blood creatinine by 4.5 micromol/l compared with olive oil, a sign of better kidney function, though blood vessel function did not improve.Fish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with …
- In 96 people with IgA nephropathy, 4 grams per day of omega-3 fatty acids for 2 years did not slow kidney decline compared with placebo or a med.Read the study on PubMed (17699247) →
- In 93 people on hemodialysis for kidney failure, 12 weeks of 2.4 grams a day of omega-3 capsules, compared with paraffin oil placebo, did not change kidney disease markers but significantly lowered inflammation markers such as C-reactive protein and interleukin-6.Oral supplementation with omega-3 fatty acids and inflammation markers in patients with chronic kidney disease in hemodi…
- In 90 kidney transplant recipients, starting 9 or 18 grams a day of fish oil after 16 weeks did not change kidney filtration or blood flow compared with corn oil placebo over 26 weeks, though blood pressure fell modestly.Delayed omega-3 fatty acid supplements in renal transplantation. A double-blind, placebo-controlled study.
- In 86 kidney transplant recipients, 6 g of fish oil daily for 3 months did not change rejection rate, kidney function or graft survival compared with soy oil, though triglycerides fell more.Dietary fish oil does not influence acute rejection rate and graft survival after renal transplantation: a randomized pl…
- In 85 people with chronic kidney disease, 4 grams per day of n-3 fatty acids for 8 weeks raised levels of pro-resolving inflammation-clearing molecules in the blood, though kidney function itself was not measured.A randomized controlled trial of the effects of n-3 fatty acids on resolvins in chronic kidney disease.
- In 85 people with chronic kidney disease, 4 g of omega-3 daily for 8 weeks raised anti-inflammatory resolution molecules and lowered a blood inflammation marker (myeloperoxidase) when taken alone, but did not change neutrophil LTB4 or 5-HETE.The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation res…
- In a post hoc analysis of 85 a med-treated adults with stage 3 kidney disease and high triglycerides, 4 grams daily of icosapent ethyl for 12 weeks lowered inflammation and oxidized LDL markers compared with placebo, without changing kidney filtration or creatinine.Read the study on PubMed (31306043) →
- In a re-analysis of 73 high-risk people with IgA kidney disease given 4 g or 8 g of omega-3 for 2 years, body size and blood omega-3 levels were not linked to changes in kidney function, protein in urine, or kidney failure, so benefit did not depend on dose by body size.Is body size a biomarker for optimizing dosing of omega-3 polyunsaturated fatty acids in the treatment of patients with …
- In 73 people with moderate kidney disease, 4 grams daily of omega-3 for 8 weeks slowed the rise of the inflammation marker interleukin-18 compared with placebo, with no effect on other inflammation markers.The Effects of OMEGA-3 Fatty Acid Supplementation Upon Interleukin-12 and Interleukin-18 in Chronic Kidney Disease Patie…
- In a randomized trial of 70 teenagers with type 1 diabetes and early kidney disease, taking 1 gram of omega-3 daily for 6 months lowered protein in the urine and a kidney injury marker compared with placebo, and also reduced carotid artery thickening.Omega-3 fatty acids supplementation improves early-stage diabetic nephropathy and subclinical atherosclerosis in pediatr…
- In 66 kidney transplant recipients on cyclosporine, 6 g of fish oil daily for a year gave higher kidney filtration (53 vs 40), lower blood pressure and fewer rejection episodes than coconut oil, but graft survival was not significantly better.Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants.
- In 60 adults on hemodialysis, taking omega-3 capsules along with standard care for six months raised blood levels of fetuin-A and osteoprotegerin, proteins that help block vascular calcification, compared with standard care alone.Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patient…
- In a pilot trial of 60 children with kidney infection, omega-3 fatty acids given for three days with meds reduced kidney scarring when both kidneys were combined, but not when each kidney was assessed separately, so the result is preliminary.Protective Effects of Omega-3 Fatty Acids Supplementation Against Renal Parenchymal Scarring in Children with Acute Pyel…
- In a randomized trial of 59 adults with type 2 diabetes, 180 days of fish oil changed urine metabolites compared with corn oil, and some changes correlated with lower blood urea nitrogen, a kidney-related marker, though direct kidney function was not reported as improved.Changes of urine metabolites in response to n-3 fatty acid supplements and their correlation with metabolic risk factors…
- In 56 people with chronic kidney disease, 2.4 g a day of omega-3 for 8 weeks shifted inflammatory molecules from white blood cells favorably, but kidney function and protein in urine did not improve versus olive oil.The effect of n-3 polyunsaturated fatty acids on leukotriene B₄ and leukotriene B₅ production from stimulated neutrophil…
- In 50 kidney transplant patients taking cyclosporin, 6 g daily of fish oil for 3 months did not significantly improve kidney function or reduce rejection compared with coconut oil.Dietary fish oil in renal transplant recipients treated with cyclosporin-A: no beneficial effects shown.
- In 47 older adults with chronic kidney disease stages 3 to 5, a 6% low-protein formula containing omega-3 fats plus diet counseling for 3 months improved grip strength and walking speed and raised omega-3 intake compared with counseling alone, but it did not change nutritional status or body composition.Effects of a low-protein nutritional formula with dietary counseling in older adults with chronic kidney disease stages …
- In 46 people with chronic kidney failure, 2.4 grams per day of omega-3 for 8 weeks produced a non-significant drop in C-reactive protein compared with olive oil, with no difference between groups.The effect of n-3 fatty acids on C-reactive protein levels in patients with chronic renal failure.
- In 45 hypertensive heart transplant recipients, 3.4 grams of omega-3 daily for one year prevented the rise in creatinine and fall in filtration seen with placebo.Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipien…
- In 44 dialysis patients, a single intravenous dose of 4.1 g omega-3 fatty acids raised omega-3 levels in the blood for a short time, but this did not measure kidney health outcomes.Effect of intravenous omega-3 fatty acid infusion and hemodialysis on fatty acid composition of free fatty acids and pho…
- In 42 adults on long-term home intravenous feeding, a fish-oil-containing lipid for 8 weeks did not change kidney function compared with the standard lipid.Efficacy of a long-term home parenteral nutrition regimen containing fish oil-derived n-3 polyunsaturated fatty acids: a…
- In 41 adults with polycystic kidney disease, 2.4 grams daily of EPA for two years did not slow the decline in kidney function or change kidney volume compared with control.The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD.
- In 40 people with severe acute pancreatitis, fish oil in intravenous feeding for 5 days lowered inflammation and shortened the days needing kidney dialysis support.Omega-3 fatty acids-supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disea…
- In 40 people with chronic kidney failure and high blood fats, 2.1 grams per day of fish oil for 90 days lowered triglycerides by about half and reduced markers of oxidative stress compared with controls.Effects of omega-3 polyunsaturated fatty-acid supplementation on redox status in chronic renal failure patients with dys…
- In a crossover trial of 40 hemodialysis patients, 3 g per day of omega-3 capsules for 4 weeks significantly reduced itching compared with placebo.Pruritus-reducing effects of omega-3 fatty acids in hemodialysis patients: A cross-over randomized clinical trial.
- In a placebo-controlled pilot of 38 people on dialysis, 12 weeks of 2.9 grams a day of fish oil reduced inflammatory signals from immune cells (RANTES and MCP-1), though blood inflammation markers did not change significantly.Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients.
- In 32 adults with IgA kidney disease, 6 grams daily of a high omega-3 fish oil for six months slightly lowered kidney filtration compared with corn oil, which showed no change.Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: a prospective, double-blind, randomized study.
- In 31 people with non-dialysis chronic kidney disease, 2.4 grams per day of fish oil for 8 weeks lowered the inflammatory marker IL-1β compared with placebo, but did not change IL-6 or TNF-α.The effects of fish oil supplementation on markers of inflammation in chronic kidney disease patients.
- In a double-blind crossover trial of 26 people with lupus kidney inflammation, one year of 15 grams a day of fish oil versus olive oil placebo did not improve kidney function or reduce disease activity, though it lowered blood triglycerides.Fish oil in lupus nephritis: clinical findings and methodological implications.
- In 22 kidney transplant recipients, 6 g a day of fish oil for 6 months lowered cholesterol but blunted the drop in an oxidative stress marker seen after transplant in the placebo group.Effect of omega-3 fatty acids on plasma level of 8-isoprostane in kidney transplant patients.
- In 12 people with advanced chronic kidney disease, 1.8 or 3.6 grams a day of fish oil for 10 weeks gave different effects; the lower dose reduced some inflammation-related genes in fat tissue, while the higher dose improved blood fats. Kidney outcomes were not reported.Differential dose effect of fish oil on inflammation and adipose tissue gene expression in chronic kidney disease patien…
- In dialysis patients, 1.56 grams per day of fish oil for 6 months did not lower lipoprotein(a) compared with corn oil.Effect of over-the-counter fish-oil administration on plasma Lp(a) levels in an end-stage renal disease population.
- In an open-label randomized trial of healthy adults, 0.5 grams of plant-based omega-3 daily for 16 weeks raised omega-3 levels in the blood, with no adverse effects on kidney function.Effects of a plant-based fatty acid supplement and a powdered fruit, vegetable and berry juice concentrate on omega-3-in…
- In adults on hemodialysis, 3 grams of omega-3 daily for two months did not lower inflammation markers CRP or IL-6 compared with placebo capsules.Modulation of Inflammatory Indices by Omega-3 Fatty Acids Supplementation in Hemodialysis: A Clinical Trial Approach.
- In 60 kidney transplant recipients, 6 months of an omega-3-rich diet lowered inflammation markers and cut protein in the urine by about 50%, but kidney filtration rate did not change.Effects of a diet rich in N-3 polyunsaturated fatty acids on systemic inflammation in renal transplant recipients.
- In a randomized crossover trial of 36 adults with high triglycerides and heart disease, fish oil ethyl esters were less effective than pemafibrate at lowering triglycerides, and the abstract does not report any kidney outcome results for the fish oil period.Crossover Trial of Pemafibrate and Omega-3-Acid Ethyl Esters for Hypertriglyceridemia in Patients with Cardiovascular Di…
- In a double-blind crossover trial of 26 adults with lupus kidney disease, fish oil supplementation did not significantly change protein in the urine, kidney filtration, or disease activity, though it did change blood lipids.Omega-3 fatty acid supplementation in clinical and experimental lupus nephritis.
- In 20 people with psoriasis taking the immune drug cyclosporin, adding 6 grams a day of fish oil for 3 months led to a smaller drop in kidney filtration (8.7% versus 18.0%) and kept kidney blood flow stable, while cyclosporin alone reduced it.Does fish oil protect renal function in cyclosporin-treated psoriasis patients?
- In 17 people with cirrhosis and fluid in the belly, 12 grams of fish oil per day for 1 month did not improve kidney function in those with kidney failure and lowered blood pressure in both groups.Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration.
- In 12 kidney transplant patients taking low-dose cyclosporin A, 12 weeks of fish oil at 6 grams a day did not change kidney filtration or blood flow, either at baseline or after cyclosporin A.Fish oil and cyclosporin A-induced renal hypoperfusion in kidney-transplanted patients.
- In 10 people with chronic glomerular kidney disease, 6 weeks of omega-3 fish oil ethyl esters at 7.7 grams a day lowered triglycerides and total cholesterol and prolonged bleeding time; the abstract shown does not report the protein-in-urine result.n-3 fatty acids reduce proteinuria in patients with chronic glomerular disease.
- In 8 people with chronic glomerular kidney disease, 6-week courses of omega-3 fish oil at 7.7 grams a day lowered protein in the urine from 2.9 to 2.1 grams a day in the high-dose group, though it did not change lipoprotein(a) levels.Omega-3 fatty acid supplementation and lipoprotein(a) concentrations in patients with chronic glomerular diseases.
- In people with calcium oxalate kidney stones, a 30-day fish oil diet lowered urinary calcium and oxalate and normalized a red blood cell transport abnormality.Anomalous phospholipid n-6 polyunsaturated fatty acid composition in idiopathic calcium nephrolithiasis.
- In 73 people with IgA kidney disease, high-dose and low-dose omega-3 for at least two years slowed kidney function loss about equally.A randomized trial of high-dose compared with low-dose omega-3 fatty acids in severe IgA nephropathy.
- In 27 people on dialysis taking 1000 mg of fish oil daily for 3 months, itching, skin dryness and the inflammation marker IL-6 improved, but the study had no control group.Omega-3 Fatty Acids Improve Chronic Kidney Disease-Associated Pruritus and Inflammation.
- In 15 patients with IgA nephropathy, fish oil supplementation raised omega-3 levels and was accompanied by less protein in the urine and better kidney filtration.Essential fatty acid deficiency profiles in idiopathic immunoglobulin A nephropathy.
- In over 400,000 UK adults, regular fish oil use was linked to a 10% lower chance of developing chronic kidney disease over about 12 years.Habitual Fish Oil Supplementation and Incident Chronic Kidney Disease in the UK Biobank.
- In over 80,000 people, higher blood levels of omega-3 and other polyunsaturated fats were linked to a lower risk of developing chronic kidney disease over about 12 years.Plasma Levels of Polyunsaturated Fatty Acids and Adverse Kidney Outcomes.
- In a pooled analysis of 19 cohorts with about 25,570 people followed for around 11 years, higher blood levels of seafood omega-3 fats were linked to a lower risk of developing chronic kidney disease, while plant omega-3 fats showed no link.Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts.
- In 627 kidney transplant recipients, higher dietary intake of marine omega-3s (median about 102 mg a day of EPA plus DHA) was linked to lower risk of death from any cause over about 5 years, with the strongest links in older and non-smoking patients.Intake of Marine-Derived Omega-3 Polyunsaturated Fatty Acids and Mortality in Renal Transplant Recipients.
- In a retrospective study of 278 pregnant women, omega-3 supplementation for about 5 weeks did not change liver or kidney function compared with controls.Effects of omega-3 fatty acids supplementation on lipids and pregnancy outcomes in pregnant women.
- In 198 kidney transplant recipients compared with 48 controls, fatty acid levels were abnormal, and higher omega-3 levels were linked to less inflammation.Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients.
- Kidney transplant patients had lower blood levels of omega-3 and other beneficial fatty acids than people with chronic kidney disease or healthy controls, and no supplement was tested.Disorders of Serum Polyunsaturated Fatty Acids in Renal Transplant Patients.
- In 134 stomach cancer surgery patients, a formula containing omega-3 and other nutrients was linked to fewer complications, including acute kidney failure, than standard feeding, but this was a retrospective comparison.[Effectiveness of immunonutrition in the perioperative nutritional management of gastric cancer].
- In 56 people with kidney disease, the balance of omega-6 to omega-3 fats was linked to FGF23 and MCP1 levels, and this link changed as kidney function declined.MCP1 Could Mediate FGF23 and Omega 6/Omega 3 Correlation Inversion in CKD.
- In a comparison of 33 people on dialysis with 22 matched controls, dialysis patients had lower blood levels of omega-3 fats, and lower omega-3 levels were linked with less body fat.Disorders of serum omega-3 fatty acid composition in dialyzed patients, and their associations with fat mass.
- In 54 kidney transplant patients, higher omega-3 fatty acid levels in red blood cells were linked to fewer rejection episodes, though this was an association study rather than a controlled trial.Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant…
- In 24 kidney transplant patients with high cholesterol, adding 1 gram of fish oil to low-dose pravastatin further improved blood fats, while kidney function and cyclosporine levels did not change.Combined treatment with low-dose pravastatin and fish oil in post-renal transplantation dislipidemia.
Review Totals and Summary
Members Only5,276 reviews · 90% positive
5,276 reviews · Amazon 5,276
90% positive6% neutral4% negative
Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Most of the panel backs omega-3 fatty acids: four of the ten have a latest position of recommends, and the rest are neutral, with none speaking against it. They take it for brain function, lowering inflammation, heart health and triglycerides, skin, fertility and sperm health, and slowing aging. Many prefer getting it from oily fish such as salmon, sardines and mackerel, while others use fish oil or cod liver oil, and one advises taking it with a fat-containing meal for better absorption. Doses range from 1 gram a day up to 2 to 4 grams of combined EPA and DHA, 1 to 3 grams for fertility, and one panelist warns that many people underdose because standard capsules hold little EPA and DHA. As a caution, one panelist says the research on omega-3s is not strong for reducing hard heart disease outcomes, and some pair it with vitamin D and strength training.
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Dr. Mark Hyman · Omega-3 Fatty Acids · neutral
- Explains why omega-3s are important for brain, mood, and healthy aging.
- Eats Zetopia's Atlantic salmon for Omega-3s and Vitamin D, especially in winter, noting that one serving provides as much EPA and DHA as two standard fish oil capsules.
- Mentions omega-3 fats as existing biomarkers that play a role in mental health, which Function Health includes in their measurements.
- Mentions that omega-3s are anti-inflammatory and helpful.
- Tries to supplement with omega-3s for psoriasis and considers them the one clearly clinically effective skin nutrient for skin, hair, and nails.
- Emphasizes the importance of focusing on omega-3s, noting that a national crisis of omega-3 deficiency exists and that low omega-3 levels are a significant problem, more so than omega-6s.
- Consumes omega-3 fats through salmon at dinner.
- Notes that omega-3s are important nutrients for brain performance and aging, and that many people have gaps in these nutrients.
- Recommends omega-3 fats from wild fish, seafood, and certain nuts and seeds to fight inflammation.
- Mentions omega-3 fats as something that might be helpful for gut repair.
Dr. Eric Berg · Omega-3 Fatty Acids · neutral
- Notes that one can of sardines contains 900 mg of omega-3s (EPA and DHA).
- Recommends Omega-3s from fish oil or cod liver oil to improve the omega-6 to omega-3 ratio, which should be around 2:1 or 1:1 but is often 10:1 or 20:1 for most people.
- Suggests that taking cod liver oil can help with flaky skin around the nose or forehead, which usually means too much omega-6 fat relative to omega-3 fat.
- Recommends fatty fish like salmon, sardines, and mackerel, which are high in omega-3 fatty acids (EPA and DHA) that reduce liver inflammation and prevent scarring.
- Recommends wild-caught salmon as a healthy food to eat every day, noting it contains about 2000 mg of omega-3s in just 3 ounces.
- Recommends wild salmon as it is rich in omega-3 fatty acids, which help reduce inflammation and support brain health and cognitive function, especially important as one ages.
- Recommends DHA, an omega-3 fatty acid, as a natural remedy that, along with sweet wormwood, can trigger iron into an explosion to hit cancer.
- Dr. Eric Berg mentions that sardines are packed with omega-3 fatty acids, which support brain health and metabolism.
- Mentions that wild salmon, specifically half a fillet, has 970 mg of potassium, zero carbohydrates, a good amount of magnesium, and is loaded with omega-3 fatty acids.
- Discusses what would happen if one consumed omega-3 fatty acids every day for 30 days, highlighting their benefits for brain health, heart health, and various conditions like dry eyes, dermatitis, and high blood pressure, as well as supporting calcium absorption and promoting better sleep.
Thomas DeLauer · Omega-3 Fatty Acids · recommends
- Recommends eating more omega-3s to turn over cell membranes more quickly.
- Recommends fish oil supplements as an omega-3 source for gut health, as they help reduce inflammatory signaling while tissue repairs.
- Recommends high-dose omega-3s, specifically 2 to four grams of combined EPA and DHA daily, to lower hepatic fat output and improve chylomicron clearance, which helps with non-fasting triglycerides.
- Recommends omega-3s, specifically 4 grams a day, to boost the muscle building response by making muscle cell membranes work better for the mTor switch to fire, and specifically mentions Pury for their clean, third-party tested omega-3s.
- Recommends consuming more omega-3s to help balance the mitochondrial membrane, as it will absorb more omega-3s instead of omega-6s.
- Recommends consuming more omega-3s to drive down inflammation.
- Recommends omega-3s, stating that a meta-analysis found 1,000 mg significantly reduced liver fat by shutting down inflammatory signals that promote fat storage, and advises looking for a triglycerol form for better absorption and to avoid oxidation.
- Recommends fatty fish like salmon and sardines, aiming for two to three servings per week, especially around a workout, because their omega-3s, particularly DHA, increase BDNF expression.
- Considers omega-3s a fundamental for brain protection, recommending both dietary sources and supplementation for EPA and DHA, as they produce pro-resolving mediators to limit inflammation.
- Recommends timing omega-3 intake around workouts because they directly help build and keep muscle by making muscle more responsive to growth signals and fighting anabolic resistance as one ages.
Dr. Rhonda Patrick · Omega-3 Fatty Acids · neutral
- Notes that Omega-3s (EPA and DHA) are important for neuronal membranes, brain function, and resolving inflammation, and higher levels are associated with lower dementia risk.
- Highlights omega-3 fatty acids as important for cell membranes, neurons, supporting brain cells, the blood-brain barrier, and regulating inflammation, which can contribute to memory problems.
- Mentions that EPA is an omega-3 examined in mortality analysis and found primarily in seafood.
- States that Omega-3 fatty acids are very important for sperm health.
- Omega-3s may help slow biological aging, with added benefits when combined with vitamin D and strength training. In a 3-year randomized trial of healthy, mostly active older adults, omega-3 alone slowed several DNA-based aging clocks.
- Recommends regular intake of omega-3 rich seafood and supplementation with omega-3 fatty acids if it's appropriate for one's lifestyle, as they are beneficial for the heart by resolving inflammation and preserving membrane fluidity.
- Notes that a 100 mg per day increase in omega-3 fatty acids was associated with lowering the risk of Alzheimer's disease and cognitive decline by 10%, and that it takes about two grams a day to get to a high omega-3 index if one has a low index.
- Practical habits to help keep chronic inflammation in check include getting enough omega-3s.
- States that Omega-3s, specifically EPA and DHA, may be the most potent naturally occurring dietary compounds for reducing inflammation, and that about 2 g/day of combined EPA and DHA can raise a low omega-3 index.
- Recommends fatty fish as a source of healthy fats for muscle gain.
Andrew Huberman · Omega-3 Fatty Acids · recommends
- Mentions that AG1 is giving away a free bottle of omega-3 co-enzyme Q10 with the first subscription to AG1 Pro.
- AG1 is giving away a free bottle of omega-3 coenzyme Q10 with your first subscription.
- Mentions that AG1 is giving away a free bottle of Omega-3 co-enzyme Q10 with the first subscription to AG1 Pro.
- Discusses Omega-3 Fatty Acids and EPA.
- Mentions that AG1 is offering a free bottle of Omega-3 co-enzyme Q10 with a first subscription to AG1 Pro.
- Recommends a free bottle of Omega-3 co-enzyme Q10 with the first AG1 Pro subscription.
- Mentions Omega-3s in the context of the microbiome and processed foods.
- Recommends Omega-3 co-enzyme Q10, which is offered as a free bottle with the first AG1 Pro subscription.
- States that getting 1 to 3 grams of EPA essential fatty acid per day can improve mood and cognitive function, supporting focus and concentration.
- Discusses Omega-3 Fatty Acids.
Siim Land · Omega-3 Fatty Acids · recommends
- Recommends taking omega-3s, including EPA and DHA, with a fat-containing meal to increase absorption.
- Increased his omega-3 intake to achieve a higher omega-3 index, which is associated with greater insulin sensitivity and better metabolic health markers.
- Increased his omega-3 index to 9.5% and notes that omega-3s have strong evidence for reducing elevated triglycerides.
- Mentions that EPA and DHA Omega-3s support heart and brain function and can lower triglycerides, with a higher omega-3 index associated with lower heart disease, Alzheimer's and mortality risk.
- Recommends Omega-3s for triglycerides and cardiovascular health, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends choosing an omega-3 supplement from a brand that uses independent third-party testing and publishes a recent certificate of analysis, verifying EPA and DHA amounts, and testing for heavy metals, contaminants, and oxidation markers.
- Lists Omega-3s as one of 15 supplements backed by human studies.
- Explains that omega-3s can alter mitochondrial membranes and have broader cardiometabolic effects, making mitochondria more responsive to cellular signaling and oxidative stress from exercise, but they don't increase maximal mitochondrial respiration.
- Notes that 75% of people aren't meeting the daily recommendation for omega-3s and that Japanese people eat 2-3x more omega-3s per day than Americans or Europeans, which reflects in their higher omega-3 index.
- Thinks omega-3s have some of the strongest evidence and are worth considering.
Dave Asprey · Omega-3 Fatty Acids · recommends
- Suggests that omega-3s may help slow aging and support cellular repair.
- Recommends omega-3s, noting that 1 gram a day slowed epigenetic aging by up to 4 months in a randomized trial of people over 70.
- Dave Asprey recommends Omega-3, citing a randomized trial showing 1g a day slowed epigenetic aging in older adults, but warns that most people underdose due to low EPA and DHA content in standard capsules.
- A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, a med, pitavastatin, and ketamine.
- Recommends getting nutrients like omega-3s from real food or Vision 101 for eyesight.
- Recommends adding omega-3 fats to improve how neurons absorb and use nutrients like vitamin C.
- States that Fatty15 supports cells better than omega-3s or fish oil, but he uses both.
- Notes that Inuit people consumed very high levels of omega-3s, specifically EPA and DHA, which contributed to their health on a whale blubber diet.
- Lists Omega-3s as a nutrient that forms the structure and different parts of the brain.
- Uses both C15 and omega-3s, noting that C15 supports cells better than omega-3s or fish oil with three times more benefits.
Ben Greenfield · Omega-3 Fatty Acids · neutral
- Notes that omega-3s have solid research behind them for fertility.
- Recommends omega-3 fatty acids, specifically EPA and DHA, at 1 to 3 grams per day for better sperm morphology and motility, noting that sperm membranes are rich in polyunsaturated fatty acids.
- Recommends getting Omega-3 from oily fish such as sardines, anchovies, mackerel, herring, and salmon with skin.
- Discusses why fatty fish or fish oil may matter more than plant-based omega-3s if seed oils are in one's diet.
- Says that omega-3 fatty acids are a great way to feed the system and help with stress.
- Recommends testing for and replenishing omega-3 fatty acids if levels are low, as they can affect the ability to maintain or preserve muscle, especially for those on GLP-1s.
- Recommends including EPA from fatty fish or fish oil in one's diet, especially if seed oils are present in the diet.
- Notes that B vitamins and Omega-3s work as a pair to support the brain, but not independently.
- Notes that the DO-Health study showed omega-3 had good effects, and it's a supplement people commonly take.
- Mentions that omega-3, vitamin D, and exercise all had good effects in the DO-Health study.
Peter Attia · Omega-3 Fatty Acids · neutral
- Peter and Michael explore the benefits of omega-3 fatty acids for cardiovascular trials and the challenge of delivering DHA to the brain.
- Mentions that some trials showing a benefit to PUFA were confounded by the inclusion of omega-3s, and argues that the literature on omega-3s is not super strong for decreasing hard cardiovascular disease endpoints.
- Took big doses of omega-3 postpartum to help maintain when she wasn't sitting down to eat full meals.
- Mentions consuming fatty fish, specifically sardines, as part of their diet, noting their high fat and protein content.
- Peter discusses how omega-3s from fish oil impact inflammation, heart health, and brain function, as well as the strengths and limitations of current research.
- Mentions the importance of DHA omega-3 fatty acids for neuronal membranes, which are concentrated in synapses and crucial for communication between neurons.
- Highlights the importance of DHA omega-3 fatty acids for neuronal membranes and communication between neurons, as they are concentrated in synapses.
- Discusses the mfsd2a transporter, which is specific to DHA in phospholipid form, and its role in blood-brain barrier integrity, noting that animal studies show disruption of this transporter causes significant breakdown of the blood-brain barrier and loss of omega-3 in the brain.
- States that there is a very strong clinical impression that high doses of omega-3s help with dry eye, primarily from an anti-inflammatory standpoint.
- Recommends omega-3 fatty acids, specifically DHA and EPA, for brain protection, especially for individuals with the APOE4 gene, stating that they require higher doses.
RAL Summary
Members OnlyTier 4 for Kidney Health
The tier 5 grade does not fit because several controlled trials found kidney benefits while others found none, so the studies disagree rather than showing omega-3 does not work. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 45 of the 92 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Kidneys and urinary system, Heart and blood vessels, Digestive system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: One five-year trial found more stomach and gut bleeding with omega-3 than with placebo. No other side effects were reported in the information given.
Supplement Facts
Vitamin A 4000 IU · Vitamin D 400 IU · Vitamin E 10 IU
Supplement Facts
Serving Size 1 Teaspoon(s)
Servings Per Container 45
Amount Per Serving% Daily Value
| Calories | 84 | |
| Total Fat | 9 g | |
| Cholesterol | 46 mg | |
| Vitamin A | 4,000 IU | |
| Vitamin D | 400 IU | |
| Vitamin E | 10 IU | |
| Cod Liver Oil | 9.2 g | † |
| Vitamin A | 2,000 IU | |
| Vitamin D | 200 IU | |
| Vitamin E | 5 IU | |
| Cod Liver Oil | 4.6 g | † |
† Daily Value not established.
Other ingredients: Cod Liver Oil.
Label source: NIH label database · Report a label change
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Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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