Solaray Magnesium Glycinate Review

Solaray Magnesium Glycinate 350 mg is presented as a formula designed for optimum bioavailability and gentle digestion. The page describes it as an award-winning supplement that supports healthy muscles, bones, relaxation, and a healthy heart. It is produced in the company's GMP facility certified by NSF and tested to meet strict guidelines on potency, purity, and contaminants. Each serving is 4 VegCaps and delivers 350 mg of magnesium from magnesium bisglycinate, made through the company's in-house chelation process using only magnesium, glycine, heat, and water. The formula also includes BioPerine black pepper extract, which the page says helps with gentle digestion. The product is listed as Voted Best Single Mineral supplement in the Vitamin Retailer 2025 Vity Awards and is described as TESTED by SuppCo, with anonymous purchase and independent testing in ISO 17025 accredited labs to verify label claims. The page lists testing for heavy metals, contaminants, microorganisms, identity, purity, and potency, and notes that most contaminants, heavy metals, and microbes are tested to ensure no more than 3 ppm. The manufacturing facility is in Ogden, Utah, where the company says it sources and triple-tests raw materials, makes most products in-house, and runs an ISO-accredited lab. The page explains that chelation combines magnesium with glycine, and that the company believes it is the only U.S. supplement finished product manufacturer with its own in-house proprietary chelation process, which it says allows control and testing of inputs and outputs. Suggested use is 4 VegCaps daily with a meal or glass of water, stored in a cool, dry place. The FAQ notes it can be taken at any time of day, split between morning and bedtime, with or without food. The page also says it is a popular choice for supporting healthy bones and muscles and for help finding rest and relaxation, and that statements have not been evaluated by the FDA and the product is not intended to diagnose, treat, cure, or prevent any disease. Solaray has made supplements since 1973 and states that what people put in their bodies should be proven, not promised.

Product Focus: Thyroid HealthAlso graded for:Occasional Heartburn: Fast Relief · T4Also covers:HormonesBrainMuscles and joints
Tier ⓘ
Tier 4 · Rank 4
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 4 within Tier 4 for Thyroid Health; 36 of 58 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
61 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
99% of 8,911
Biohacker Mentions
8 of 10
Cost per month
$32

Study, Trial or Testing Result Summary

Members Only12 human studies · 5 improved
12 human studies5 improved7 no effect570,280 people studied

The evidence for magnesium and thyroid health is mixed. This product gives 350 mg of magnesium a day, above the 250 mg used in one trial. A large pooled review of 35 trials in people with an underactive thyroid found that adding zinc, magnesium and vitamin A to meds raised free thyroxine, but magnesium was not tested on its own [1]. A 10-week trial in 86 adults with an underactive thyroid found the same three-nutrient combination raised free thyroxine and lowered an inflammation marker, with no change in thyroid-stimulating hormone [2]. A small 4-week study found magnesium alone raised active thyroid hormone in athletes and inactive people [3]. Magnesium before thyroid surgery did not clearly change calcium levels [4], and diet magnesium was not linked to thyroid cancer risk [5]. Magnesium taken with a thyroid hormone tablet cut its absorption, so take them hours apart [6]. The black pepper extract is present at 5 mg, and its studied dose is unclear. The only human study used a multi-herb blend and reported no thyroid result [7], while animal studies disagree on whether piperine raises or lowers thyroid hormone [8][9]. Animal and cell studies are never counted.

See all 12 studies →Hide the studies

Review Totals and Summary

Members Only8,911 reviews · 99% positive
8,911 reviews · Amazon 8,614 · Solaray 297
99% positive0% neutral1% negative

Across the stores, Solaray Magnesium Glycinate has garnered 8911 ratings, and the following themes emerge from the written reviews that could be read on their pages. Customers frequently praise the effectiveness of these magnesium glycinate capsules, particularly for their impact on sleep and relaxation. Several users report significant improvements in their ability to sleep properly, with some noting they had struggled with sleep before starting the supplement. One verified buyer described it as "very effective" for evening use, stating that it surpassed other brands of magnesium glycinate she had tried. Beyond sleep, the product is also credited with aiding recovery. The brand itself, Solaray, enjoys a high level of trust among its users, who consistently commend its quality and reliability. Customers express general satisfaction with Solaray supplements, often describing them as good quality and dependable. Service and delivery also receive positive mentions, with one reviewer noting prompt shipping. An AI-generated summary of customer feedback on one page further highlights the product's effectiveness in supporting muscle, bone, and relaxation health, emphasizing optimal absorption and gentle digestion. It also notes the flexible dosing and describes the capsules as a popular choice for those seeking a dependable magnesium supplement. The primary criticism mentioned by reviewers concerns the pill count. Users note that the recommended serving of four VegCaps per day can feel like a substantial number of pills to take daily, with one customer expressing a wish for fewer pills to achieve the daily value. Overall, these Solaray Magnesium Glycinate capsules appear to be well-suited for individuals seeking support for sleep, relaxation, and recovery. They are also favored by those who prioritize a trusted brand known for reliable quality, optimal absorption, and gentle digestion. The product is seen as a dependable option for general magnesium supplementation, particularly for those looking to support muscle and bone health. While the written comments are few in number, they consistently point to high satisfaction, with the main caveat being the daily pill volume.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

Most of the panel recommends or uses magnesium, and sleep is the main reason, with several also citing blood pressure, stress, muscle recovery, bone health and mood. Forms vary: two panelists specifically recommend glycinate, while several others take or favor threonate, often 400 mg before bed, and others use blended or electrolyte products. Doses mentioned include 300 mg before bed, 400 to 600 mg a day as a general need, and 300 to 500 mg a day as a minimum for bone health, and some suggest timing it 90 minutes to 2 hours before bed or taking it in the evening. One panelist cautions that labels can mislead by listing the whole compound weight instead of the actual magnesium, and says the evidence that it reliably improves sleep is not yet strong or consistent, though it may modestly lower blood pressure.

See all 10 biohackers →Hide the biohackers
  • Dr. Rhonda Patrick · Magnesium · recommends
    • 8 Nov 2026 · recommends · Instagram ↗
      Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
    • 6 Nov 2026 · neutral · Instagram ↗
      Mentions that getting too little magnesium may play a role in declining testosterone levels.
    • 3 Nov 2026 · recommends · X ↗
      Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
    • 1 Nov 2026 · neutral · YouTube ↗
      Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
    • 31 Oct 2026 · neutral · YouTube ↗
      Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
    • 29 Oct 2026 · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 16 Oct 2026 · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 29 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium as an important nutrient component for testosterone.
    • 28 Sep 2026 · warns · YouTube ↗
      Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
    • 2 Sep 2026 · neutral · Facebook ↗
      States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
    • 25 Dec 2015 · Black Pepper · recommends · YouTube ↗
      Adds black pepper to her turmeric tea because the piperine in it stops enzymes in the liver from clearing out polyphenols, thus extending their half-life.
  • Dr. Eric Berg · Magnesium · recommends
    • 7 Nov 2026 · recommends · Facebook ↗
      Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
    • 7 Nov 2026 · neutral · Instagram ↗
      Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
    • 6 Nov 2026 · recommends · Podcast ↗
      Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
    • 6 Nov 2026 · neutral · Instagram ↗
      Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
    • 6 Nov 2026 · recommends · YouTube ↗
      States that magnesium is a cofactor that allows B1 to work more efficiently.
    • 4 Nov 2026 · recommends · YouTube ↗
      States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
    • 1 Nov 2026 · neutral · YouTube ↗
      Magnesium is involved in 300 to 600 enzyme reactions, acts as a biological brake pedal, is the master controller over calcium, and is involved in making ATP, the energy currency of the body. It takes energy to go to sleep, and magnesium is required for relaxation and good sleep. Magnesium also helps balance cortisol levels and calm you.
    • 1 Nov 2026 · Black Pepper · recommends · Facebook ↗
      Dr. Eric Berg recommends pairing black pepper with turmeric to improve curcumin absorption.
    • 30 Oct 2026 · neutral · Instagram ↗
      Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
    • 28 Oct 2026 · neutral · YouTube ↗
      Notes that magnesium could also be a factor in preventing muscle cramps.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
    • 17 Oct 2026 · Black Pepper · neutral · Instagram ↗
      Notes that black pepper aids in the absorption of Curcumin.
    • 16 Oct 2026 · Black Pepper · recommends · Instagram ↗
      Dr. Eric Berg recommends adding black pepper to eggs to support satiety, antioxidant potential, cardiovascular, and liver health.
    • 20 Aug 2026 · Black Pepper · recommends · Facebook ↗
      Recommends adding black pepper to food, especially when consuming turmeric, to increase absorption.
  • Thomas DeLauer · Magnesium · recommends
    • 5 Nov 2026 · recommends · YouTube ↗
      Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
    • 4 Nov 2026 · neutral · YouTube ↗
      Mentions that magnesium glycinate also helps a lot with sleep.
    • 2 Nov 2026 · neutral · YouTube ↗
      Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
    • 28 Oct 2026 · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 24 Oct 2026 · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 6 Oct 2026 · neutral · YouTube ↗
      Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
    • 1 Oct 2026 · recommends · YouTube ↗
      Recommends taking some magnesium glycinate tonight to help calm down and sleep.
    • 25 Sep 2026 · neutral · Facebook ↗
      Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
    • 15 Jul 2026 · Black Pepper · recommends · YouTube ↗
      Recommends taking black pepper with curcumin to increase its bioavailability, as curcumin gets metabolized before it can do anything without it.
    • 10 Jun 2026 · Black Pepper · recommends · YouTube ↗
      Recommends mixing curcumin with black pepper (piperine) for general inflammation, as piperine inhibits the breakdown of curcumin, increasing its bioavailability by up to 2,000%.
    • 14 Mar 2026 · Black Pepper · recommends · Facebook ↗
      Recommends black pepper with turmeric because its piperine blocks liver clearance, allowing curcumin to absorb and shut down inflammatory response.
    • 4 Mar 2026 · Black Pepper · neutral · Facebook ↗
      Black pepper makes curcumin actually absorb.
  • Andrew Huberman · Magnesium · recommends
    • 4 Nov 2026 · recommends · Instagram ↗
      Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
    • 22 Oct 2026 · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 7 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 27 Jul 2026 · uses · YouTube ↗
      Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
    • 20 Jul 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 20 Jul 2026 · recommends · YouTube ↗
      Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
    • 13 Jul 2026 · uses · X ↗
      Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 12 Jul 2026 · uses · X ↗
      He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
    • 6 Jul 2026 · uses · X ↗
      Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 22 Jun 2026 · uses · X ↗
      Takes 400 mg of magnesium L-threonate before bed for sleep.
    • 25 Dec 2025 · Black Pepper · warns · YouTube ↗
      Recommends avoiding bioavailable curcuminoids like black pepper extract if someone's DHT is already low or if they have somewhat insensitive androgen receptors.
    • 11 Apr 2022 · Black Pepper · warns · YouTube ↗
      States that black pepper extract, also known as BioPerine, is a 5-alpha-reductase inhibitor.
    • Date not recorded · Black Pepper · warns · Website ↗
      Huberman states he avoids black pepper fruit extract (Bioperine) like the plague because it is a 5-alpha reductase inhibitor and affects liver cytochrome, which he believes caused his negative experience with turmeric.
  • Dr. Mark Hyman · Magnesium · recommends
    • 4 Nov 2026 · recommends · YouTube ↗
      Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
    • 1 Nov 2026 · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 29 Oct 2026 · neutral · YouTube ↗
      Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
    • 21 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 14 Oct 2026 · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
    • 30 Sep 2026 · uses · YouTube ↗
      Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
    • 22 Sep 2026 · recommends · Instagram ↗
      Recommends correcting nutrient deficiencies with magnesium.
    • 16 Sep 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
    • 27 Aug 2026 · Black Pepper · recommends · Instagram ↗
      Recommends seasoning turmeric with black pepper to help the body absorb more nutrients.
    • 27 May 2026 · Black Pepper · neutral · YouTube ↗
      Notes that black pepper, along with gentle heat, improves the absorption of curcumin in Paleovalley's turmeric complex.
    • 29 Nov 2024 · Black Pepper · recommends · YouTube ↗
      Recommends taking curcumin with black pepper, specifically piperine, because it increases the absorption of curcumin.
    • 2 Jan 2023 · Black Pepper · uses · YouTube ↗
      Uses black pepper with turmeric to activate curcumin.
  • Dave Asprey · Magnesium · uses
    • 3 Nov 2026 · uses · Instagram ↗
      Looks at magnesium alongside protein to keep muscle for the long run.
    • 3 Nov 2026 · recommends · YouTube ↗
      Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
    • 31 Oct 2026 · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 17 Oct 2026 · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 27 Sep 2026 · recommends · Podcast ↗
      Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
    • 7 Sep 2026 · uses · Instagram ↗
      Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
    • 3 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
    • 29 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
    • 5 Feb 2026 · Black Pepper · stopped · YouTube ↗
      Dave Asprey used to research black pepper extract but changed his mind about its use after a discussion with Christian DPO, who highlighted its downsides.
    • 31 Aug 2023 · Black Pepper · warns · YouTube ↗
      Dave Asprey states that black pepper is higher in aflatoxin and oxalate, neither of which is good for dogs.
    • 30 Apr 2020 · Black Pepper · warns · YouTube ↗
      Dave Asprey warns against curcumin that comes with black pepper extract because studies show it pokes holes in the gut, allowing bacterial toxins to enter and cause inflammation, which is counterproductive to stopping inflammation.
    • Date not recorded · Black Pepper · warns · Website ↗
      Recommends skipping black pepper when seasoning meals to avoid oxalates.
  • Ben Greenfield · Magnesium · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 22 Oct 2026 · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 3 Sep 2026 · recommends · YouTube ↗
      Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
    • 25 Aug 2026 · uses · Facebook ↗
      Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
    • 17 Aug 2026 · recommends · Facebook ↗
      Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
    • 15 Aug 2026 · warns · YouTube ↗
      Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
    • 8 Aug 2026 · recommends · YouTube ↗
      Recommends taking magnesium as a co-factor to increase vitamin D absorption.
    • 13 Jun 2026 · neutral · X ↗
      Notes a new study indicating that magnesium is a core dietary antioxidant closely associated with a reduced risk of accelerated biological aging.
    • 23 May 2026 · Black Pepper · warns · YouTube ↗
      Advises watching out for black pepper, as it is eliminated in core AIP and many people are surprisingly sensitive to it.
    • 25 Dec 2025 · Black Pepper · recommends · YouTube ↗
      Recommends combining black pepper with Triphala and Himalayan pink salt as a powder to brush with, as it is astringent, drives up inflammation and infection in the gums, is refreshing, and prevents plaque.
    • 26 Oct 2025 · Black Pepper · uses · Facebook ↗
      Rubbed the beef with black pepper before searing.
    • 16 Mar 2024 · Black Pepper · neutral · Podcast ↗
      Mentions black pepper as something that can help with quelling tobacco/nicotine addiction.
  • Siim Land · Magnesium · recommends
    • 25 Oct 2026 · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Magnesium as one of 15 supplements backed by human studies.
    • 30 Sep 2026 · recommends · Instagram ↗
      States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
    • 30 Sep 2026 · neutral · X ↗
      Lists seafood and pumpkin seeds as sources of Magnesium.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks magnesium has some of the strongest evidence and is worth considering.
    • 17 Aug 2026 · recommends · YouTube ↗
      Recommends taking magnesium, specifically glycinate and threonate forms, 1 to 2 hours before bed for sleep benefits, noting that glycinate promotes relaxation and threonate crosses the blood-brain barrier for sleep quality and cognitive function.
    • 14 Aug 2026 · neutral · X ↗
      Notes that Boron reduces calcium/magnesium loss.
    • 10 Aug 2026 · recommends · YouTube ↗
      Notes that magnesium is important for activating thiamine into its more biologically active form, and a magnesium deficiency can impair blood sugar regulation even with adequate thiamine intake.
    • 5 Aug 2018 · Black Pepper · neutral · YouTube ↗
      Lists black pepper as an herb or spice that is high in oxalates.
    • 1 Jun 2018 · Black Pepper · uses · YouTube ↗
      Adds black pepper to his autophagy-boosting cocktail to promote bioavailability and slow down digestion.
  • Bryan Johnson · Magnesium · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 15 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 4 May 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 2 May 2026 · uses · X ↗
      He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 21 Apr 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 15 Apr 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 14 Apr 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 8 Apr 2026 · uses · X ↗
      Takes 400 mg of magnesium L-threonate before bed for sleep.
    • 7 Apr 2026 · uses · X ↗
      He takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 5 Apr 2026 · uses · X ↗
      Takes 400 mg of magnesium threonate before bed for sleep.
    • 16 Oct 2025 · Black Pepper · uses · YouTube ↗
      Adds black pepper to turmeric because a compound in pepper called piperine boosts the power of turmeric by slowing the breakdown of curcumin in the gut and liver, making its antioxidant, anti-inflammatory, and metabolic benefits last longer.
  • Peter Attia · Magnesium · neutral
    • 1 Jun 2026 · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 15 Sep 2025 · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
    • 6 Jul 2025 · recommends · YouTube ↗
      Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
    • 7 Jul 2024 · recommends · YouTube ↗
      Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede the metabolism of vitamin D because magnesium is a cofactor in its enzymatic conversion.
    • 1 Jul 2024 · uses · YouTube ↗
      Takes a hardline view that most people do not have adequate or optimal levels of magnesium, and suboptimal levels will impede vitamin D metabolism because magnesium is a co-factor in the enzymatic conversion of vitamin D.
    • 20 May 2024 · uses · YouTube ↗
      Takes magnesium as a straightforward supplement.
    • 28 Feb 2024 · neutral · YouTube ↗
      Mentions that magnesium intake is often super low and impactful on testosterone levels.
    • 11 Dec 2023 · uses · Facebook ↗
      Discusses the important roles of magnesium in the body, how to determine if one might be deficient, the prevalence of magnesium deficiency, and its potential cognitive benefits.

RAL Summary

Members OnlyTier 4 for Thyroid Health

The tier 2 grade rests on a pooled review and a trial that gave magnesium only combined with zinc and vitamin A, so they do not show magnesium alone works for the thyroid, and five of eight human studies found no effect. So it is graded Tier 4, lower than the rules alone gave.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 7 of the 12 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Endocrine system, Nervous system, Musculoskeletal system

Combine with: To further support thyroid health alongside Magnesium Glycinate, consider supplementing with Selenium, which is crucial for the conversion of T4 to T3 and protects the thyroid from oxidative stress. Iodine is another fundamental nutrient, as it is a building block for thyroid hormones. Zinc plays a role in thyroid hormone synthesis and TSH production. Vitamin D is important for immune modulation and overall thyroid function, while B vitamins, particularly B12, can address common deficiencies and support energy metabolism. Additionally, adaptogens like Ashwagandha can help balance thyroid hormones and manage stress, which often impacts thyroid function.

Possible side effects: Magnesium can reduce absorption of thyroid hormone tablets if taken at the same time. Some reviewers note the four-capsule daily serving is a lot of pills.

Supplement Facts

Magnesium 350 mg · BioPerine® Black Pepper Extract 5 mg
Supplement Facts
Serving Size 4 VegCaps
Servings Per Container 30
Amount Per Serving% Daily Value
Calories10
Magnesium (from Magnesium Bisglycinate)350 mg83%
BioPerine® Black Pepper Extract (Piper nigrum) (fruit)5 mg†
† Daily Value not established.

Other ingredients: Vegetable Cellulose Capsule, Magnesium Stearate, Cellulose and Silica.

Directions: Use only as directed. Take 4 VegCaps daily with a meal or glass of water. Store in a cool, dry place.

Label source: Solaray · Report a label change

Show entire label
The Solaray Magnesium Glycinate label
Magnesium Glycinate

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Our articles on this subject

Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.