Spring Valley D3 Supplement 1000 IU Review
Spring Valley Vitamin D3 25 mcg (1,000 IU) Vitamin Supplement is presented as a way to get the Vitamin D you need every day. The page describes D3 as a potent and active form of Vitamin D, essential for calcium absorption, bone health, immune health and healthy teeth. It notes the body can produce D3 when skin is exposed to sunlight, but that it may be difficult to get an adequate amount from the sun alone. The softgels are described as gluten, lactose and preservative free, with no artificial colors or flavors. The listing says Spring Valley supports family health and holistic wellbeing with an affordable range of products inspired by nature. Adults should take one Vitamin D3 25 mcg softgel daily, preferably with a meal. Bullet points state it is a reliable source of Vitamin D as D3 Cholecalciferol and a daily immune support supplement, and that Vitamin D3 contributes to proper calcium absorption and supports healthy bones and teeth. The bottle contains 450 softgels, listed as over 14 months (450 days) of supply. Package dimensions are 4.5 x 2.5 x 2.5 inches, 4.8 ounces. The page notes that statements have not been evaluated by the FDA and that the product is not intended to diagnose, treat, cure or prevent any disease.
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Study, Trial or Testing Result Summary
Members Only52 human studies · 19 improved
Vitamin D for immune support has mixed study results. At two softgels a day, members get 2,000 international units, the dose used in several trials. A 2019 pooled analysis of 25 trials with 11,321 people found vitamin D lowered the odds of a sudden respiratory infection by about 12 percent, with the most benefit in very deficient people taking daily or weekly doses [1]. A 2021 update found a much smaller benefit: about 3 percent lower risk and slightly shorter symptoms [2]. Large placebo-controlled trials did not find a benefit. In 15,804 older adults, 2,000 international units daily for one year did not lower upper respiratory infections [3]. In 2,157 adults aged 70 or older, the same daily dose for three years did not reduce infections [4]. In 8,851 schoolchildren given weekly vitamin D for three years, tuberculosis and respiratory infections were not reduced [5]. In 408 adults with asthma, 28 weeks of vitamin D did not reduce how often or how badly they caught colds [6]. Overall, any benefit seems small and may be limited to people who are very low in vitamin D. Animal and cell studies are never counted.
See all 52 studies →Hide the studies
- Across 25 trials with 11,321 people of all ages, vitamin D supplements lowered the odds of a sudden respiratory infection by about 12%, with the biggest benefit in very deficient people and those taking daily or weekly doses rather than large single doses.Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis.
- Across nine studies of 2,367 people, vitamin D deficiency was not overall linked to the immune response to flu vaccination, though protection rates for two strains were lower in deficient people.Does Vitamin D Deficiency Affect the Immunogenic Responses to Influenza Vaccination? A Systematic Review and Meta-Analys…
- Pooled randomized trials in adults found vitamin D supplements slightly reduced the risk of acute respiratory infections (3% lower) and shortened symptom duration by about 6%.Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic revie…
- Across 22 supplementation studies in people with multiple sclerosis, vitamin D3 did not clearly reduce relapses or disability overall, but high doses did lower the yearly relapse rate while low doses did not.Vitamin D status, supplementation, and multiple sclerosis: a systematic review and meta-analysis.
- A review of 20 trials in healthy adults (8 on vitamin D) found micronutrients other than vitamin C, including vitamin D, may not prevent colds or reduce symptom severity.Zinc Supplementation Reduces Common Cold Duration among Healthy Adults: A Systematic Review of Randomized Controlled Tri…
- A review of 9 reviews found low vitamin D levels linked to higher risk of COVID-19 infection, but trials are still needed to confirm whether supplements help with severity or death.The role of vitamin D in prevention OF COVID-19 and its severity: an umbrella review.
- A review of the literature suggests vitamin D plays a role in innate immunity and that supplementation may help prevent or treat COVID-19, though this is a hypothesis.Vitamin D in SARS-CoV-2 infection.
- In a review of 14 diet trials in people with lupus, vitamin D was linked to better inflammation markers in most studies but not to better disease activity scores.Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention.
- A review of 28 systematic reviews on diet and lupus looked at vitamin D among other nutrients but the abstract gives no clear result for vitamin D, and no specific dietary recommendations were established.The Interconnection Between Systemic Lupus Erythematosus and Diet: Unmet Needs, Available Evidence, and Guidance-A Patie…
- A guideline review of evidence made a conditional recommendation against vitamin D supplements for preventing eczema in children.Guidelines of care for the primary prevention of atopic dermatitis and awareness of comorbid conditions in pediatric ato…
- In 15,804 older adults, 2,000 IU of vitamin D3 daily did not significantly lower the risk of upper respiratory infection at 1 year compared with placebo.Effect of Daily Vitamin D Supplementation on Risk of Upper Respiratory Infection in Older Adults: A Randomized Controlle…
- In 8,851 schoolchildren in Mongolia, 14,000 IU of vitamin D3 weekly for 3 years did not lower tuberculosis infection (3.6% vs 3.3% with placebo), tuberculosis disease, or respiratory infection.Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.
- In 2157 adults aged 70 or older, 2000 IU of vitamin D3 daily for 3 years did not significantly reduce infection rates or improve blood pressure, physical performance, cognition, or fractures compared with placebo.Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clin…
- In 881 pregnant women, 4,400 IU daily of vitamin D started at 10-18 weeks of pregnancy did not lower preeclampsia compared with 400 IU (8.08% vs 8.33%), though women with higher vitamin D blood levels had lower risk.Early pregnancy vitamin D status and risk of preeclampsia.
- In 597 Chinese infants revaccinated against tuberculosis, 3 months of daily vitamin A plus 500 IU vitamin D raised positive skin test response to 96.1% versus 89.7% in the control group.Enhancement of vitamin A combined vitamin D supplementation on immune response to Bacille Calmette-Guérin vaccine revacc…
- In 408 adults with mild to moderate asthma, vitamin D for 28 weeks did not reduce cold severity or frequency compared with placebo, and African American participants had more colds on vitamin D.Vitamin D Supplementation and the Risk of Colds in Patients with Asthma.
- In 275 adults with early COVID-19 given a 10-day multi-drug and supplement combination including vitamin D3, with or without famotidine, the treatment was safe and well tolerated, but there was no placebo group and the effect of vitamin D alone was not tested.Read the study on PubMed (41693032) →
- In 254 older adults with COVID-19, a single high dose of 400,000 IU vitamin D3 lowered deaths at 14 days compared with 50,000 IU (6% vs 11%), but the benefit was gone by 28 days.High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, ope…
- In 247 high school students, 2000 IU of vitamin D3 daily for 2 months did not lower overall influenza A (13.5% vs 12.1% on placebo), though a post hoc look showed fewer cases in the first month only.Effects of vitamin D supplements on influenza A illness during the 2009 H1N1 pandemic: a randomized controlled trial.
- In 245 breastfeeding mothers given 600 IU vitamin D2 plus 1800 IU vitamin A daily for 2 months, infant fever, respiratory infection, diarrhoea and eczema were not lower than with placebo; the effect of vitamin D alone cannot be separated.Impact of Maternal Daily Oral Low-Dose Vitamin A Supplementation on the Mother-Infant Pair: A Randomised Placebo-Control…
- In 228 health care workers, vitamin D2 raised blood vitamin D levels but did not change COVID-19 infection rates (50.5% vs 52.4%), symptoms, or inflammation markers compared with no treatment.Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19.
- In 120 children with acute Kawasaki disease, adding vitamin D to standard treatment brought fever down faster (27 vs 50 hours) and lowered inflammatory markers compared with standard treatment alone.Read the study on PubMed (40996174) →
- In 112 women with repeated implantation failure, vitamin D alone gave a 17.8% pregnancy rate versus 10.7% for control, and only the combination with vaginal probiotics (46.4%) significantly changed immune markers.The effect of vitamin D supplementation and vaginal probiotics on fertility in women with recurrent implantation failure…
- In 91 adults with cystic fibrosis given a large vitamin D3 dose during a lung flare-up then every other week for a year, there was no difference from placebo in time to next flare-up or death, lung function, or an infection-fighting protein.Vitamin D for the Immune System in Cystic Fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled c…
- In 91 health care workers given 5000 or 2000 IU of vitamin D3 daily for 3 months, vitamin D intake was not linked to lower COVID-19 illness, though the higher dose group had only asymptomatic cases.Vitamin D Intake May Reduce SARS-CoV-2 Infection Morbidity in Health Care Workers.
- In 87 lung transplant recipients, 100,000 IU of vitamin D monthly for 2 years did not change chronic lung rejection, inflammation or other outcomes compared with placebo.High-dose vitamin D after lung transplantation: A randomized trial.
- In 82 adolescent swimmers, 12 weeks of vitamin D3 versus placebo did not change thymus activity markers, and these were not linked to respiratory infection severity or duration.Thymus Activity, Vitamin D, and Respiratory Infections in Adolescent Swimmers.
- In 53 people with multiple sclerosis, 48 weeks of vitamin D3 did not change immune cell CD25 or IL2RA gene activity compared with placebo, though some CD25 measures fell only in the placebo group.Vitamin D3 supplementation and the IL-2/IL-2R pathway in multiple sclerosis: Attenuation of progressive disturbances?
- In 40 adults with active rheumatoid arthritis, adding vitamin D to standard drugs for 3 months raised regulatory immune cell levels more than standard drugs alone, alongside lower disease activity scores.Vitamin D: does it help Tregs in active rheumatoid arthritis patients.
- In 40 postmenopausal women, 2 mcg a day of active vitamin D3 for 2 weeks slightly raised CD3 and CD8 T cell counts while 1 mcg a day changed nothing and CD4 cells were unchanged.The effect of 1,25(OH)2 vitamin D3 on CD4+/CD8+ subsets of T lymphocytes in postmenopausal women.
- In 39 women with early rheumatoid arthritis, a single 300,000 IU dose of vitamin D3 added to standard treatment improved general health over 3 months, but did not change immune cell subtypes or bone-cell precursors.Vitamin D and immunomodulation in early rheumatoid arthritis: A randomized double-blind placebo-controlled study.
- In 38 hemodialysis patients, 12 weeks of vitamin D3 normalized blood vitamin D levels but did not change monocyte counts, T helper cell frequencies, or inflammation markers compared with placebo.Influence of cholecalciferol supplementation in hemodialysis patients on monocyte subsets: a randomized, double-blind, p…
- In 38 people with relapsing multiple sclerosis, high-dose vitamin D3 (20,400 IU every other day) reduced sugar-chain branching on T and natural killer cells but mostly did not change immune cell numbers compared with low-dose.Effect of vitamin D supplementation on N-glycan branching and cellular immunophenotypes in MS.
- In 32 people given 2,000 IU of vitamin D daily for 10 weeks before a tetanus booster shot, antibody response was slightly higher than with placebo, while other immune measures were similar.Efficient tetanus toxoid immunization on vitamin D supplementation.
- In 28 healthy adults with an induced chemical skin rash, a single 200,000 IU dose of vitamin D3 reduced skin inflammation in all participants, with effects lasting 6 weeks.Vitamin D3 and deconvoluting a rash.
- In 22 hospitalized people with mild COVID-19 and heart disease, 10,000 IU of vitamin D3 daily reduced inflammatory markers and was linked to less severe illness, fewer hospital days, and lower death rate than placebo.Vitamin D3 supplementation in COVID-19 patients with cardiovascular disease and gut dysbiosis.
- In HIV-infected adults in a flu vaccine trial, taking vitamin D supplements did not improve the immune response to the vaccine.Vitamin D supplementation does not increase immunogenicity of seasonal influenza vaccine in HIV-infected adults.
- In a 3-month supplementation study of breastfeeding mothers and infants, higher maternal vitamin D status was linked to lower infant TNF levels and stronger infant immune cell responses to challenge, with some responses tied to the infant's own vitamin D.Maternal Vitamin D Status Correlates to Leukocyte Antigenic Responses in Breastfeeding Infants.
- Among 180 COVID-19 patients, those with vitamin D deficiency were hospitalized more often (41.3% vs 12.5%), and those given vitamin D3 recovered from hospital about 5 days sooner than deficient patients.Importance of Vitamin D3 in COVID-19 Patients.
- In 16 people with cystic fibrosis, 3 months of vitamin D2 or D3 was linked to lower T cell activation markers in a dose-dependent way compared with controls.Vitamin D treatment modulates immune activation in cystic fibrosis.
- In infertile women with low vitamin D, supplementation (23 tested before and after) lowered the ratio of Th1 to Th2 immune cells, and 11 of 23 (47.8%) reached sufficient vitamin D levels.Vitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women.
- In 18 older adults low in vitamin D, taking 6,400 IU of vitamin D3 daily for 14 weeks strengthened the skin immune response to a chickenpox virus antigen and reduced inflammatory cell build-up.Vitamin D3 replacement enhances antigen-specific immunity in older adults.
- In healthy young adults in Cape Town given high-dose vitamin D3 in winter, HIV-1 replication in blood cells fell, circulating white blood cells rose, and winter-associated anemia reversed.High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africa…
- In people with inflammatory bowel disease, 12 weeks of vitamin D was linked to lower disease activity and inflammation markers and shifts in immune responses to gut bacteria, with no control group.Multi-omics reveal vitamin D regulation of immune-gut microbiome interactions and tolerogenic pathways in inflammatory b…
- In 250 Nigerian children under five with respiratory infections compared with 250 without, blood vitamin D was slightly lower in those with infections and lowest in those with lower respiratory infections.Vitamin D and Acute Respiratory Infections in Children.
- In 414 severely ill COVID-19 patients, lower vitamin D3 blood levels on admission were linked to higher inflammation markers, longer stays, more ventilator days and death.Cholecalciferol level and its impact on COVID-19 patients.
- In 80 adults with dengue, lower blood vitamin D levels were linked to more severe disease, but no supplement was given.Association of systemic vitamin D on the course of dengue virus infection in adults: a single-centre dengue cohort study…
- In 16 children with vitamin D deficient rickets compared with 15 healthy children, low vitamin D went along with fewer T cells and more frequent infections; no supplement was tested.Lymphocyte subpopulations in children with vitamin D deficient rickets.
- In a large population study of adults in Catalonia, cholecalciferol was linked to slightly lower COVID-19 infection risk (4.0% vs 4.2%), and both forms were linked to better outcomes only in people reaching blood levels of 30 ng/ml or higher, while calcifediol overall did not reduce infection or death.Vitamin D supplementation and COVID-19 risk: a population-based, cohort study.
- In healthy German adults followed for 24 weeks after COVID-19 vaccination, antibody response did not differ by vitamin D blood level.Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults.
- In 12 healthy volunteers, a nasal dose of 400 IU cholecalciferol did not produce detectable levels of the antimicrobial peptide hBD-2, while bacterial lysates did.Human β-defensin-2 induction in nasal mucosa after administration of bacterial lysates.
- In laboratory dishes, vitamin D changed activation markers on immune T-cells, but in 10 healthy people blood vitamin D levels were not significantly linked to those markers.Vitamin D modulates the expression of HLA-DR and CD38 after in vitro activation of T-cells.
Review Totals and Summary
Members Only7,469 reviews · 93% positive
Spring Valley D3 1000 IU softgels get mostly positive feedback, with about 7,070 ratings across the stores. Buyers like how easy they are to swallow and the low price, while a smaller group is unhappy about a label and product change. **What buyers say it did for them:** Several people say they take it because a doctor recommended it, and one reports a change in their levels. "Have noticed a different with my Vitamin D levels since I started" is how one buyer put it. Another says "I'm always coming up low on vit D and my doctor recommended these." One buyer takes a capsule at bedtime and finds it fits good sleep habits. The store summary also mentions people who describe it as working well, and one who sees it as reliable insurance for an older adult. Some gift buyers say recipients kept asking for more. **What they complain about:** The sharpest complaint is about a switch in the product. One reviewer says it "Used to be Vitamin D3" and that the ingredients changed without notice. Another ordered D3, but the bottle says only vitamin D, and plans to return it. The store summary raises other problems: capsules sticking together in a hot, humid climate, a bottle that arrived opened with the cotton missing, and one buyer who found the 25 mcg strength was half the dose they usually buy. **Taste, smell, pill size and form:** Ease of swallowing is the most repeated point. Reviewers call them "nice easily swallowed gel caps" and say "The soft gels are very easy to take." One notes "no aftertaste," and the store summary agrees that they are small with no noticeable taste. One reviewer, living where it is hot and humid, wished for a tablet instead of a softgel. **Value for money:** Price is a strong draw. One buyer says "the price and count is better than if I buy the 2,000 IU item," taking two softgels a day as their doctor ordered. The store summary says reviewers often find the brand cheaper or more affordable than alternatives, and one calls it a good deal. One buyer says the low price misled them about the dose until they read the label. **Who it suits and who it did not:** It seems to suit people whose doctor has recommended vitamin D, people who dislike large pills, and those on a budget. One reviewer mentions sensitive stomachs being fine with them. It suits less well anyone who needs the label to say D3 specifically, or who wants a higher dose per capsule than 1,000 IU. People in hot, humid places may find the capsules stick together. Reviews of other forms of the product, such as gummies, capsules or powder, were left out of this summary.
Biohacker Summary
Members Only7 of 10 recommend it
Vitamin D is the only ingredient here, and the panel leans clearly in favor: about half recommend it and most of the rest say they take it, while a few stay neutral. Their reasons include low sun exposure, support for bones, brain and mood, muscles, and immune function, and one panelist says most people are deficient and benefit from supplementing. Vitamin D3 is the form they name, often taken in the morning, and doses range from 5000 IU a day for several of them to a suggested minimum of 10,000 IU a day from one, with a few aiming for blood level targets instead. Panelists say to take it with dietary fat for better absorption, and one pairs it with vitamin K2, while another says there is little point in supplementing unless you are deficient. No one said they stopped taking it.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin D · neutral
- Lists Vitamin D as an ingredient found in sardines.
- Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
- Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
- Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
- Suggests that increasing vitamin D3 may help address the underlying problem of bruxism.
- Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
- States that magnesium is needed to absorb vitamin D.
- Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
- Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
Dr. Rhonda Patrick · Vitamin D · neutral
- Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
- States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
- Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
- Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
Thomas DeLauer · Vitamin D · recommends
- Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Recommends getting vitamin D, suggesting it can be obtained while walking.
- States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
- Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
Dr. Mark Hyman · Vitamin D · uses
- Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
- Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Mentions vitamin D as a key nutrient for supporting immune function.
- States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
Dave Asprey · Vitamin D · uses
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
- Recommends Vitamin D as one of the most important supplements for overall health.
- Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
- Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
Siim Land · Vitamin D · recommends
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
- Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
- Recommends taking Vitamin D in the morning or at lunch with fat.
- Notes that Boron improves vitamin D.
- Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
Ben Greenfield · Vitamin D · recommends
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Has been taking Vitamin D3 K2 for over a decade.
- Notes that sunlight influences more than just vitamin D production.
- Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
- Recommends getting enough vitamin D for blood pressure management.
- Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
- Recommends using hormone building blocks like vitamin D for hormone optimization.
- Notes that vitamin D deficiency is the most common deficiency.
Bryan Johnson · Vitamin D · uses
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
Andrew Huberman · Vitamin D · neutral
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 5000 IU of Vitamin D3 in the morning.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 5,000 IU of Vitamin D3 in the morning for general health.
- Takes 5000 IU of Vitamin D3 every day for longevity.
- Takes 5,000 IU of Vitamin D3 in the morning.
Peter Attia · Vitamin D · uses
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
- Discusses evaluating vitamin D, understanding deficiency, and optimal levels.
RAL Summary
Members OnlyTier 4 for Immune Health
The tier rests on a misread of the evidence: only 19 of 52 human studies showed improvement, 21 showed no effect, and the largest placebo-controlled trials found no immune benefit, so the studies disagree rather than show a clear improvement. So it is graded Tier 4, lower than the rules alone gave.
Take 2 servings a day (2 softgels) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 21 of the 52 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Immune system, Respiratory system
Combine with: Vitamin D3 works best alongside vitamin K2 (MK-7), which helps direct calcium into bones rather than soft tissues, and magnesium, which is required to activate vitamin D. Take it with a fat-containing meal for better absorption. For immune support, pair it with zinc and vitamin C. For bone health, add calcium (if dietary intake is low) and K2. If your real goal is blood sugar support, consider adding evidence-backed ingredients such as berberine, chromium picolinate, alpha-lipoic acid, or Ceylon cinnamon, and discuss any use with a healthcare provider, especially if you take meds. Magnesium also supports healthy glucose metabolism and complements vitamin D.
Possible side effects: No major side effects were reported in the studies, though in one asthma trial African American participants had more colds while taking vitamin D. Reviews mention softgels sticking together in hot, humid weather.
Supplement Facts
Vitamin D 1000 IU
Other ingredients: Soybean Oil, Gelatin, Glycerin, Corn Oil.
Directions: SUGGESTED USE: Adults, take one softgel daily, preferably with a meal.
Label source: NIH label database · Report a label change
Sizes and barcodes: 100 Softgel(s), UPC 6 81131 07165 9 (not checked yet); 450 Softgel(s), UPC 6 05388 00924 1 (off market)
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Our articles on this subject
- Vitamin D2 vs D3: Which Form Raises Your Vitamin D More?Article · Oct 31, 2026
- Peter Attia's Supplement List: What He Takes and What the Trials SayArticle · Sep 20, 2026
Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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