Thorne Advanced Iron Complex Review
Product Focus: Occasional Heartburn: Fast ReliefAlso covers:Digestion
Tier ⓘ
Tier 4 · Rank 6
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 6 within Tier 4 for Occasional Heartburn: Fast Relief; 15 of 18 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only21 human studies · 10 improved
1 of these 21 human studies gave the ingredient by drip, not by mouth.
21 human studies10 improved8 no effect19,719 people studied
No study tested this iron and B vitamin formula, or any of its ingredients alone, for fast relief of occasional heartburn. Iron, at a full dose, is not an established heartburn remedy. In a placebo-controlled trial of 102 pregnant women, iron-rich water did not change indigestion scores [1]. A small survey linked iron and vitamin supplements with more heartburn [2], and a review of 7 trials named heartburn as a common iron side effect, with fewer stomach side effects when iron was taken every other day [3]. One study without a comparison group saw heartburn ease in pregnant women on a gentler iron form [4]. Vitamin B12, also at a full dose, eased indigestion in 34 people with low B12 and a stomach infection, but there was no comparison group [5]. Vitamin B12, vitamin B6 and folate were part of a multi-ingredient blend that relieved reflux in a large trial, so their own effect is unknown [6]. For folate, vitamin B6 and vitamin C, it is unclear whether this product's doses match the studied doses. Their evidence rests mostly on diet surveys that show links but not cause [7][8][9], and the vitamin B6 findings disagree [10]. The iron and folate amounts are above the daily recommended limit, so members may take less. Animal and cell studies are never counted.
See all 21 studies →Hide the studies
- Across 7 trials with 594 adults with iron deficiency anemia, taking oral iron every other day raised blood iron levels as well as daily dosing and caused fewer side effects such as nausea, metallic taste and bowel changes; heartburn was named as a common side effect but was not separately reported.Daily versus alternate day oral iron therapy in iron deficiency anemia: a systematic review.
- In about 2,965 patients having iodine-stained esophageal screening, a vitamin C spray cut acute side effects, and with the weaker iodine it also reduced heartburn within one week, compared with distilled water; this is heartburn caused by the iodine stain, not everyday heartburn.Effectiveness of Vitamin C Solution in Reducing Adverse Reactions Caused by Painless Lugol Chromoendoscopy: A Multicente…
- In 351 people with acid reflux, a combination supplement that included vitamin B12 led all 176 users to report complete symptom regression after 40 days, compared with 65.7% of those taking 20 mg a med (a standard acid-reducing drug), but B12 was not tested on its own.Read the study on PubMed (16948779) →
- In 240 patients having iodine-stained esophageal screening, a 20 mL spray of 2% vitamin C lowered acute and late symptom scores versus saline, and caused less acid regurgitation or heartburn than sodium thiosulfate (33% vs 15%); this is irritation from the iodine stain, not everyday heartburn.The safety and efficacy of 2% vitamin C solution spray for relief of mucosal irritation caused by Lugol chromoendoscopy:…
- In 196 people with chronic atrophic gastritis, folic acid was used as the comparison treatment for 6 months and did worse than the herbal Moluodan at easing upper-stomach pain, belching and fullness, so it showed no clear benefit for heartburn-type symptoms.Randomized double-blind clinical trial of Moluodan () for the treatment of chronic atrophic gastritis with dysplasia.
- In 102 pregnant women who could not tolerate iron tablets, drinking 48 ml of iron-rich mineral water (about 10 mg iron) daily did not change indigestion scores compared with placebo, though iron stores fell less than with placebo.A randomized trial investigating an iron-rich natural mineral water as a prophylaxis against iron deficiency in pregnanc…
- In 49 adults with constipation-type irritable bowel syndrome, a drink with 2 mg vitamin B6, inulin and menthol taken for 2 weeks improved bowel symptoms but caused noticeable heartburn in 10 of 25 people who drank it.[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
- In 15 healthy people given a meal with an infused solution of nitrous acid plus vitamin C, reflux-related relaxations of the esophageal sphincter increased and acid exposure in the esophagus rose compared with a plain acid control.Nitrogenous chemicals generated from acidification of saliva influence transient lower oesophageal sphincter relaxations…
- In a study of 11,690 people who had endoscopy and diet records, higher dietary vitamin B6 intake was linked to lower odds of non-erosive reflux disease, though this does not prove cause.Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.
- In a case-control study of 918 people, higher dietary folate intake was linked to lower risk of reflux esophagitis, an inflamed food pipe, though this is an association and not proof of benefit.Intakes of dietary folate and other B vitamins are associated with risks of esophageal adenocarcinoma, Barrett's esophag…
- In a case-control study of 537 people in China, higher dietary vitamin C intake was linked to lower risk of reflux esophagitis, but this was a food intake association rather than a supplement trial.Dietary intake and risk for reflux esophagitis: a case-control study.
- In a case-control study of 150 women with reflux and 300 controls in Iran, higher dietary vitamin B6 intake was linked to higher odds of reflux disease.Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.
- In a case-control study of 431 people, those who ate diets high in vitamin C had lower odds of reflux disease, Barrett esophagus and esophageal cancer, but this was an observational association from diet, not a supplement trial.Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma.
- In a survey of 382 anemia patients, vitamin C use had mixed outcomes for treatment side effects such as heartburn, and no clear benefit was shown.Impact of Side Effects on Anemia Therapy Compliance.
- In a cross-sectional study of 328 young adults, lower dietary vitamin B6 intake was linked to higher overall gastrointestinal symptom scores, but vitamin B6 intake was not directly linked to reflux status.Health cooking at home: can cooking skills reduce gastrointestinal symptoms, cross sectional study?
- In 200 arthritis patients taking a med with folic acid over about 41 months, heartburn was more common in those with raised red blood cell size, and folic acid did not change the overall side-effect rate.Read the study on PubMed (2068578) →
- In a small study of dyspepsia patients, those with organic dyspepsia ate less vitamin C than matched controls, and functional dyspepsia patients also had lower vitamin C intake, but the study measured diet only and did not test vitamin C for relief.Food and nutrient intakes and eating patterns in functional and organic dyspepsia.
- In 50 pregnant urban Black women, taking vitamin and iron supplements was linked with more heartburn, constipation and sleep trouble, though this was a small survey and not a controlled test.Dietary practices and pregnancy discomforts among urban blacks.
- In 34 people with Helicobacter pylori infection and low vitamin B12, 1000 mcg daily for 3 months shortened stomach emptying time and reduced dyspepsia scores, with no control group.The impact of B(12) treatment on gastric emptying time in patients with Helicobacter pylori infection.
- In 27 second-trimester pregnant women with iron deficiency anemia taking 30 mg of microsomal ferric pyrophosphate tablets, heartburn and other symptoms were noticeably reduced within about 30 days, though the study had no placebo group.Efficacy and Safety of Microsomal Ferric Pyrophosphate Supplement for Iron Deficiency Anemia in Pregnancy.
- In a rat study of prenatal stress, folic acid reduced stomach hypersensitivity and nerve overactivity by increasing the DNMT1 enzyme and lowering the ASIC1 ion channel, but this was tested only in animals, not people.DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult o…
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
On iron, the main ingredient, the panel is split: three of the ten recommend it, one uses it, four are neutral, and two give cautions or stopped. Those who recommend it say to test first and replenish when levels are low, citing brain function, keeping muscle, and women of childbearing age who are deficient, and one panelist who uses it says he feels less sore in training. One warns that excess iron can add aging cells that drive inflammation, another warns that low blood counts do not always mean a need for more iron, and one stopped because years of trying every form, including eating meat, never raised his levels. No one gave a dose or a preferred form of iron, and the neutral comments were mostly about food sources and how well iron is absorbed. Vitamin C, folate and B12 are smaller ingredients in this product, and the panel mostly speaks well of vitamin C for collagen and immune support.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Iron · neutral
- Identifies iron as the Achilles' heel of cancer, as it is needed for its DNA to replicate.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Notes that birth control pills deplete the body of folate, which is needed for the brain to make serotonin.
- Mentions that grass-fed liver has heme iron, the most bioavailable form of iron that prevents anemia.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- Dr. Berg warns that too much iron can be damaging to the body and advises focusing on food sources to avoid overconsumption.
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
- Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
Dr. Mark Hyman · Iron · neutral
- Mentions iron as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
- Notes that some people may need a little bit extra folate with a supplement.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Notes that a woman patient had very low iron.
- Optimized a child's nutrient status with folate, as the child had low folate levels and was not eating greens.
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
Siim Land · Iron · neutral
- Mentions that iron is a mineral necessary for making collagen.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Notes that Vitamin C is one of several supplements with human evidence.
- States that excess iron promotes oxidative stress and inflammation, which increases heart disease risk.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
- States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- Notes that iron deficiency is found in children with premature graying of hair and that some people get gray hair due to iron deficiency.
Thomas DeLauer · Iron · neutral
- Compares iron content in spinach (2.7mg) and beef (2.6mg), but emphasizes that beef's heme iron absorbs at about 25%, while spinach's non-heme iron absorbs at 2-8%.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
- Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
- Recommends iron from meat, specifically red meat and beef liver, stating that it is a crucial part of the mechanistic triad for thyroid hormone function and is iron-dependent for iodine incorporation into thyroid hormone.
- Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
- Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
- Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
- Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
Andrew Huberman · Iron · recommends
- States that Iron is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes a multivitamin every day for longevity.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Warns that excess iron will increase the number of senescent cells in the body, which accumulate as people get older and cause inflammation and cancer. He notes that people who are healthy and have a fairly vegetarian diet often have slightly low iron levels but super amounts of energy.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
- Notes that about 50% of the population is iron deficient.
- Mentions that the podcast will review the role of iron in treating depression.
- States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
- States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
- Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
- Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
Ben Greenfield · Iron · recommends
- Recommends testing for and replenishing iron if levels are low, as it can affect the ability to maintain or preserve muscle, especially for those on GLP-1s.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Mentions vitamin C as part of a bare-minimum protocol.
- Recommends methylfolate as an active form of folate that the body can use directly without conversion.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Vitamin C for skin repair post-tattoo.
- Recommends bioavailable folate, not synthetic folic acid, as folate deficiencies seem to impact hearing health in older individuals.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Notes that one can eat iron-rich foods or supplement with iron, but still feel exhausted if iron is not the missing piece, emphasizing that focusing on a single mineral in isolation can support a number on a lab test rather than the system itself.
- Mentions iron as a common deficiency.
- Recommends introducing methylfolate into the diet to address high homocysteine levels.
- Recommends a nutritious diet including iron, as it is critical for brain development.
- Does not agree that ascorbic acid is vitamin C, comparing it to calling chaff wheat, and notes that it is made from genetically modified cornstarch or corn syrup byproducts using solvents.
Bryan Johnson · Iron · stopped
- Has had low iron for 11 years and despite eating meat and trying all forms of iron supplementation at different times and sequences, none of it worked to raise his iron or ferritin levels.
- Had low iron for 11 years, with ferritin averaging 38 ng/mL, and has finally boosted it back to healthy levels.
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Takes 10 milligrams of heme iron to get his iron levels up, as they are borderline.
- Takes 250 milligrams of Vitamin C.
- Recommends adequate Iron for hair health, noting it is in the Blueprint stack.
- Recommends supplementing with iron for brain health for both the mother and the baby during pregnancy.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
- Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
- He uses Vitamin C, typically in a serum, in the morning for skin health.
- Recommends supplementing with folate for brain health for both the mother and the baby during pregnancy.
Dave Asprey · Iron · warns
- Warns that if a doctor diagnoses anemia, one should not assume they just need more iron, as low hemoglobin doesn't always mean low iron and the issue can sometimes be how well the body is using iron.
- Recommends taking vitamin C for better skin health.
- States that folate can affect how the body responds to a supplement.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Recommends methylfolate as a better option than folic acid.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
- Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for iron, which is associated with impaired recovery.
- Recommends Vitamin C as the real biological fix for deep focus issues, explaining how the brain hoards it at levels 100 times higher than blood and how to bypass the blood-brain barrier.
- Dave Asprey notes that 80% of their clients have a problem absorbing certain forms of folate, and when the exact form of folate or folinic acid is dialed in, clients experience shifts, with the brain waking up as one of the first improvements.
Dr. Rhonda Patrick · Iron · uses
- Recently found out he needed to get on an iron supplement and noticed he gets less sore in his training after taking it.
- Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Advises that menstruating women should ensure they are getting enough iron.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Notes that dark leafy greens are a great source of folate.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
Peter Attia · Iron · recommends
- Recommends iron supplements for women of reproductive age who are iron deficient.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Notes that deficiencies in certain vitamins and minerals, such as iron, can be a cause of hair loss in women.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
- Delves into the crucial yet often overlooked topic of iron and iron deficiency.
- Explains that humans consume about 10 to 20 milligrams of iron per day, absorbing roughly 10% of that, which is 1 to 2 milligrams per day, perfectly offsetting the 1 to 2 milligrams lost daily.
- Peter emphasizes the importance of consuming an adequate amount of iron daily to prevent deficiency.
- Takes Jarrow methylfolate to keep homocysteine levels below nine, taking the lower of two available strengths once a day.
- Takes Jarrow methylfolate, a methylated version, once a day at the lower of two strengths, to keep homocysteine levels below nine.
- Mentions that in a mouse model for obesity, the amount of folate given to the mother mouse during pregnancy affects the epigenetics of her offspring, leading to changes in coat color and obesity.
RAL Summary
Members OnlyTier 4 for Occasional Heartburn: Fast Relief
The evidence is thin and indirect. The positive results come from diet surveys and a multi-ingredient blend [7][6], while iron showed no benefit for indigestion in a placebo-controlled trial [1]. No reviews were counted, so the emerging tier fits.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 8 of the 21 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Blood
Possible side effects: Iron supplements can cause heartburn, nausea, a metallic taste and bowel changes, with fewer stomach side effects when taken every other day. A drink containing vitamin B6 with other ingredients caused heartburn in 10 of 25 people.
Supplement Facts
Vitamin B12 300 mcg · Vitamin B6 5 mg · Vitamin C 15 mg
Supplement Facts
Serving Size 1 Capsule
Servings Per Container 60
Amount Per Serving% Daily Value
| Vitamin B12 | 300 mcg | |
| Vitamin B6 | 5 mg | |
| Vitamin C | 15 mg | |
| Folate | 667 mcg DFE | |
| Iron | 36 mg |
Other ingredients: Leucine, Microcrystalline Cellulose, Silicon Dioxide, Hypromellose (derived from cellulose) capsule.
Directions: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.
Label source: Reverseagelab · Report a label change
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Our articles on this subject
- Folate vs Folic Acid: What the Studies Show About Each FormArticle · Oct 29, 2026
- Supplement Safe Upper Limits: How Much Is Too Much, Nutrient by Nutrient, and How to Check Your StackArticle · Oct 16, 2026
Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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