Thorne Leaky Gut Support Review
Tier ⓘ
Tier 4 · Rank 1
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 1 within Tier 4 for Teeth; 2 of 2 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only56 human studies · 38 improved
56 human studies38 improved9 no effect6,647 people studied
Most of the mouth and gum research on these ingredients used rinses, gels or toothpastes placed in the mouth, not swallowed supplements like this one. Two swallowed forms were studied at doses this product meets. In 48 people with gum inflammation, 80 milligram curcumin capsules taken for 28 days reduced gum inflammation and bleeding more than placebo, but did not change plaque [1]. In 75 teenage girls, 0.1 grams of Indian frankincense extract daily for 2 weeks lowered gum inflammation, plaque and bleeding [2]. Reviews found curcumin rinses and gels worked about as well as a standard antiseptic rinse for plaque and gum inflammation [3][4]. However, a curcumin rinse did not prevent mouth ulcers in people with braces [5]. Aloe vera rinses reduced plaque and gum bleeding in several trials [6][7][8]. Some trials found aloe toothpaste no better than regular toothpaste. Glutamine applied in the mouth improved mouth hygiene in hospital patients, but it was not swallowed [9]. Guar gum has no human studies on teeth. This product has no counted reviews. Animal and cell studies are never counted.
See all 56 studies →Hide the studies
- Across 26 randomized trials with 1266 people, curcumin worked about as well as chlorhexidine for plaque, gum inflammation and bleeding, but chlorhexidine reduced pocket depth and attachment loss more in the short term, with similar results after one month.Effect of curcumin compared to chlorhexidine on clinical variables of periodontal health: A systematic review and meta-a…
- Across nine trials with 420 patients or sites, curcumin added to deep cleaning worked about as well as chlorhexidine for pocket depth, attachment loss, gum inflammation and plaque, though the evidence was low quality.Clinical efficacy of curcumin versus chlorhexidine as an adjunct to scaling and root planing for the treatment of period…
- Across six randomized trials with 320 people, curcumin mouthwash reduced plaque and gum inflammation about as well as chlorhexidine, with no significant difference between them.Curcumin mouthwashes versus chlorhexidine in controlling plaque and gingivitis: A systematic review and meta-analysis.
- In three trials of adults with gum disease, adding aloe vera to deep cleaning reduced pocket depth and improved attachment level up to 12 months compared with control, though the authors said evidence was limited.CLINICAL EFFECT OF LOCAL ALOE VERA USE AS AN ADJUNCT TO PERIODONTAL THERAPY: A SYSTEMATIC REVIEW AND META-ANALYSIS.
- Across 10 randomized trials, toothpastes and gels with natural ingredients, including aloe vera, improved gum health more than regular toothpastes and gels, and aloe vera consistently showed benefit.Natural Agents for the Improvement of Gingival Health: Systematic Review and Meta-Analysis of Randomized Clinical Trials…
- In six trials with 1358 people, aloe vera mouthwash reduced plaque and gum inflammation, was comparable to chlorhexidine for gum inflammation but inferior for plaque, and had fewer side effects.Efficacy of aloe vera mouthwash versus chlorhexidine on plaque and gingivitis: A systematic review.
- In nine trials with 358 orthodontic participants, aloe vera reduced gum inflammation by over 40% compared with chlorhexidine, and other natural products also improved gum health.Evaluating the Therapeutic Properties of Natural Products in Orthodontic and Surgical Treatment of Dentofacial Deformiti…
- In three trials with 135 people with braces, organic products including aloe vera mouth rinse reduced plaque and gum bleeding over follow-up of up to 15 days.A systematic review on the effectiveness of organic unprocessed products in controlling gingivitis in patients undergoin…
- Two trials in people with gingivitis found aloe vera toothpastes worked similarly to control toothpastes for plaque and gum inflammation, with high risk of bias.Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review.
- A review of 20 trials found herbal mouthrinses reduced plaque and gum inflammation compared with placebo rinses, and turmeric was among five herbs that did better than chlorhexidine, though risk of bias limits the conclusions.Effect of herbal mouthrinses on dental plaque formation and gingival inflammation: A systematic review.
- A review of 14 clinical trials found that in most of them curcumin reduced plaque, gum inflammation, gum bleeding and bacteria counts in gingivitis, was as effective as chlorhexidine mouthwash, and caused no serious side effects.The Effects of Curcumin in the Treatment of Gingivitis: A Systematic Review of Clinical Trials.
- A review of three clinical trials and five lab studies found that curcumin improved gum health and inhibited gum disease bacteria and their biofilms.Antibacterial Activity of Curcumin Against Periodontal Pathogens: A Systematic Review.
- In 345 healthy people rinsing twice daily for 30 days, aloe vera mouthwash reduced gum bleeding and plaque versus placebo, as well as chlorhexidine did, without side effects.Effect of Aloe vera mouthwash on periodontal health: triple blind randomized control trial.
- In 300 patients after brain surgery, mouth care with a 5% glutamine solution lowered rates of oral debris, mouth sores, bad breath and dryness compared with saline care, and reduced the variety of mouth bacteria.Effectiveness of Glutamine Oral Care in Reducing Oral Mucositis and Improving Oral Health After Neurosurgery: A Randomiz…
- In 300 healthy people rinsing for 4 days without brushing, aloe vera mouthwash reduced plaque regrowth versus saline placebo, similar to chlorhexidine, with no side effects.Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial.
- In 152 school children aged 8-14, rinsing with aloe vera mouthwash for 4 weeks lowered plaque, gum inflammation and cavity-causing bacteria compared with placebo, similar to chlorhexidine.The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children.
- In 150 patients after lower wisdom tooth surgery, aloe vera mouthwash reduced dry socket similar to chlorhexidine, but chlorhexidine was better for wound opening and pain by day 7.Aloe vera vs chlorhexidine in preventing alveolar osteitis.
- In 96 adults over 4 days without brushing, aloe vera mouthwash gave less plaque and fewer mouth bacteria than water, similar to cetylpyridinium chloride but less effective than chlorhexidine on plaque.Aloe vera mouthwashes can be a natural alternative to chemically formulated ones - A randomized-controlled trial.
- In 80 dental students using a turmeric mouthrinse twice daily for 2 weeks, mouth bacteria counts fell about as much as with chlorhexidine mouthwash.Antibacterial efficacy of manuka honey, ocimum sanctum, curcuma longa and 0.2% chlorhexidine mouthwash on the level of s…
- In 75 teenage girls with moderate gum inflammation, 0.1 g of frankincense extract or 0.2 g of powder daily for 2 weeks lowered gum inflammation, plaque and bleeding scores, with the biggest drops when combined with professional teeth cleaning.The effect of Frankincense in the treatment of moderate plaque-induced gingivitis: a double blinded randomized clinical …
- In 70 young orthodontic patients using curcumin or placebo mouthwash twice daily for 28 days, curcumin did not prevent mouth ulcers or change plaque after treatment, but it lowered pain scores in the first two weeks.Effectiveness of curcumin mouthwash in preventing traumatic ulcers in orthodontic patients.
- In 60 people with gingivitis rinsing twice daily for 30 days, an aloe vera mouthwash reduced plaque, gum inflammation and bleeding as well as chlorhexidine did.Efficacy of Ocimum sanctum, Aloe vera and chlorhexidine mouthwash on gingivitis: A randomized controlled comparative cli…
- In 60 patients with gum inflammation, aloe vera mouthwash twice daily for 1 month reduced plaque, though Triphala mouthwash reduced gum inflammation and bleeding more.Comparative Evaluation of Triphala, Aloe vera, and Chlorhexidine Mouthwash on Gingivitis: A Randomized Controlled Clinic…
- In 60 patients with deep cavities, placing aloe extract in the cavity as a disinfectant led to healthy pulp in 16 of 20 teeth after 18 months, compared with 13 of 20 in the untreated control group.The Effect of Aloe vera and Chlorhexidine as Disinfectants on the Success of Selective Caries Removal Technique: A Rando…
- In 60 healthy adults with experimental gum inflammation, curcumin gel applied twice daily for 29 days raised gum fluid inflammation markers much less than chlorhexidine gel, though gum redness, plaque and bleeding still rose in all groups.Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental gingivitis.
- In 54 people (healthy gums or gum disease), curcumin gel applied weekly for four weeks after deep cleaning improved plaque, pocket depth and attachment level more than deep cleaning alone at six weeks, and saliva procalcitonin fell in both treated groups.Efficacy of curcumin gel as an adjunct to scaling and root planing on salivary procalcitonin level in the treatment of p…
- In 50 people with gum inflammation after teeth cleaning, a mouthwash containing five herbal extracts including frankincense, used twice daily for 2 weeks, improved gum health about as much as chlorhexidine mouthwash.Effect of an herbal mouthwash on periodontal indices in patients with plaque-induced gingivitis: A cross-over clinical t…
- In 48 people with braces, curcumin nanomicelle plus light therapy cut cavity-causing bacteria by 99.98% by day 120 and lowered white spot lesion scores more than the other groups at 90 and 120 days.Effect of nanomicelle curcumin-based photodynamic therapy on the dynamics of white spot lesions and virulence of Strepto…
- In 45 women with rheumatoid arthritis and gum disease, a curcumin and essential oil mouthwash added to deep cleaning reduced plaque and arthritis markers over six weeks, though chlorhexidine gave the largest pocket depth reduction.Efficacy of a mouthwash containing essential oils and curcumin as an adjunct to nonsurgical periodontal therapy among rh…
- In 43 children with 60 baby teeth needing root canal treatment, a filling mixed with curcumin powder had success rates over 9 months similar to the standard zinc oxide eugenol filling, which performed best.Clinical and Radiographic Evaluation of Various Herbal Products Used with Zinc Oxide as an Obturating Material in Primar…
- In 40 intellectually disabled adolescents over 30 days, aloe vera toothpaste reduced gum inflammation, plaque and yeast counts more than triclosan toothpaste, with no negative side effects.Antiplaque, Antifungal Effectiveness of Aloevera Among Intellectually Disabled Adolescents: Pilot Study.
- In a 28-day trial of 40 adults with gum inflammation, an aloe vera mouthwash twice daily reduced plaque and bleeding, with results similar to povidone-iodine but weaker than a probiotic mouthwash or chlorhexidine.Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the tr…
- In 37 children with deep tooth decay in baby teeth, acemannan used as a pulp capping material had a 72.73 percent clinical and radiographic success rate at six months, similar to calcium hydroxide (70.0 percent), with better tissue healing on histology.Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary…
- In 36 children with deep cavities, light therapy with a curcumin-based photosensitizer significantly reduced bacteria in the decayed dentin, with no significant difference from a toluidine blue gel.Assessment of the effect of photodynamic therapy on the reduction of bacteria in deep dental caries lesions of primary t…
- In a 12-month trial of 35 young adults having lower wisdom teeth removed, a 50 mg acemannan sponge placed in the socket led to greater socket bone healing than blood clotting alone at every follow-up, and a 20 mg sponge helped at 3 months.Acemannan-induced tooth socket healing: A 12-month randomized controlled trial.
- In 35 teenagers with braces, curcumin light therapy did not reduce plaque over three months, though it lowered gum bleeding at one month, similar to a chlorhexidine varnish.Longitudinal effect of curcumin-photodynamic antimicrobial chemotherapy in adolescents during fixed orthodontic treatmen…
- In 30 patients after scaling and root planing, a gel containing aloe leaf juice powder and postbiotics reduced gum pocket depth and bleeding over 6 months, but it worked no better than a chlorhexidine gel.Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf …
- In 30 people with gingivitis, curcumin mouthwash added to deep cleaning improved gum and plaque scores over three weeks more than deep cleaning alone and performed about as well as chlorhexidine.Efficacy of curcumin in the treatment of chronic gingivitis: a pilot study.
- In 30 adults with chronic gum disease, a natural curcumin gel placed in pockets reduced pocket depth and attachment loss over 30 days, with a greater reduction than chlorhexidine gel in the same patients.Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a l…
- In 30 people with diabetes and gum disease, liposomal curcumin gel with deep cleaning gave the greatest improvement in gum measures and lowered inflammatory markers over 12 weeks, more than curcumin gel or placebo gel.Sustained Release of Liposomal Curcumin: Enhanced Periodontal Outcomes in Diabetic Patients.
- In 25 people with type 2 diabetes and gum pockets, curcumin light therapy added to deep cleaning gained attachment at three months, but pocket and bleeding reductions occurred in all groups including deep cleaning alone over six months.Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the tr…
- In 25 people with chronic gum disease, a 2% curcumin gel placed under the gums with deep cleaning gave better bleeding, pocket depth, and attachment results than 0.2% chlorhexidine gel over three months.A Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2% Chlorhexidine Gel Adjunctive to Scaling and Roo…
- In 24 orthodontic patients, curcumin with a surfactant and blue light reduced harmful oral bacteria in saliva about as well as chlorhexidine rinse.Oral Decontamination of Orthodontic Patients Using Photodynamic Therapy Mediated by Blue-Light Irradiation and Curcumin …
- In 21 people having two teeth pulled, a turmeric gel placed in one socket healed better and caused less pain by day 7 than a placebo gel in the other socket.Efficacy of topical curcuma longa in the healing of extraction sockets: A split-mouth clinical trial.
- In 20 dental students with gingivitis, using aloe vera toothpaste for 30 days improved plaque and gum scores about as much as fluoride toothpaste, with no significant difference between them.Clinical Efficacy of Aloe Vera Toothpaste on Periodontal Parameters of Patients with Gingivitis-A Randomized, Controlled…
- In 20 volunteers, an 8-week curcumin and melatonin toothpaste significantly lowered levels of certain gum disease bacteria compared with a standard placebo toothpaste.A Randomized Clinical Study of a Curcumin and Melatonin Toothpaste Against Periodontal Bacteria.
- In 18 people, light therapy with curcumin or Photogem produced only small drops in mouth bacteria that cause tooth decay, with the significant reduction seen mainly with Photogem.Evaluation of Antimicrobial Photodynamic Therapy against Streptococcus mutans Biofilm in situ.
- In 10 people with chronic gum disease, curcumin gel applied after deep cleaning reduced plaque and pocket depth more than deep cleaning alone over four weeks, though attachment gains were not significant.Efficacy of Curcumin as an Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients: A Randomized Controlle…
- Turmeric and curcumin chips placed in periodontal pockets released most of their content within 80 hours, and plaque and gum scores improved from baseline in the treated patients.Comparative evaluation of the efficacy of turmeric and curcumin as a local drug delivery system: a clinicomicrobiologica…
- In a split-mouth trial after tooth extraction, a nanocurcumin membrane placed in the socket produced thicker gum tissue at two months than the untreated side, but did not significantly change bone repair.Nanocurcumin-containing Spongy Membrane for Improving the Quality of Hard and Soft Tissues in the Extracted Tooth Area: …
- In 60 primary molar teeth needing pulp treatment, fresh aloe extract succeeded in only 6.9% of teeth after 12 months, compared with 71.4% for MTA, so aloe was clearly worse.Comparative Evaluation of Fresh Aloe barbadensis Plant Extract and Mineral Trioxide Aggregate as Pulpotomy Agents in Pri…
- In 60 patients over 8 weeks, a 1% turmeric extract rinse after deep cleaning improved gum measures from baseline and killed gum disease bacteria similarly to chlorhexidine, but plaque and gum scores improved less than with chlorhexidine.Antimicrobial Activity of Curcuma longa L. Extract on Periodontal Pathogens.
- In 48 people with gum inflammation or mild gum disease, 80 mg nano-curcumin capsules for 28 days reduced gum inflammation and bleeding more than placebo at 14 and 28 days, with no change in plaque.Oral nano-curcumin on gingival inflammation in patients with gingivitis and mild periodontitis.
- In 40 people with chronic gum disease using aloe vera tooth gel for 3 months, gum and plaque measures improved, but only one of three harmful gum bacteria dropped, and propolis gel worked better.Comparison of Plaque Inhibiting Efficacies of Aloe Vera and Propolis Tooth Gels: A Randomized PCR Study.
- In 12 people with gum disease, adding a turmeric gel and blue light to deep cleaning kept harmful gum bacteria from returning for 6 weeks, compared with cleaning alone.Anti-Early Stage of Bacterial Recolonization Effect of Curcuma longa Extract as Photodynamic Adjunctive Treatment.
- In 16 volunteers, a 1% turmeric extract reduced plaque more than two other plant extracts, and its effect on gingivitis was significant after 2 weeks.Comparative assessment of medicinal plant extract efficacy against plaque and gingivitis: A case-control study.
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Curcumin is the main ingredient here, and most of the panel recommends or uses it, mainly to calm inflammation and support joints, with some also citing brain, mood and energy benefits. Several favor forms that absorb better, such as a phytosomal form, a nanoparticle form, or curcumin taken with black pepper, and one pairs a well absorbed curcumin with high dose omega-3. A few stay neutral and stress that no supplement replaces sleep, food, exercise and stress care, one says it is not a substitute for other treatments, and another does not recommend high dose curcumin for general use without a doctor's guidance. One panelist advises avoiding curcumin during pregnancy. Glutamine is a smaller ingredient in this product, and those who mention it take it for gut repair, immune support or fewer sugar cravings, with daily doses of 5 grams and up to 15 to 20 grams when sick or traveling.
See all 10 biohackers →Hide the biohackers
Dave Asprey · Curcumin · uses
- Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
- Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
- Asks what happens if you put glutamine in the skin, suggesting that manipulating amino acids in the skin and elsewhere is a fertile ground for more research.
- Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
- Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
- Dave Asprey mentions that supplements like curcumin support pain relief and mood.
- Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
- Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
- Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
- Recommends L-glutamine to support the gut barrier.
- Recommends aloe vera juice or liquids to strengthen the entire digestive tract.
- Mentions that curcumin also has anti-parasitic properties and is useful.
- Recommends combining specific nutrients like curcumin with red meat consumption to bind to iron and pull it out, rather than absorb it.
- Gave his yoga teacher glutamine to help with brain fog and autoimmune issues, which helped his energy return.
Dr. Eric Berg · Curcumin · neutral
- Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
- Notes that Curcumin barely absorbs without black pepper.
- Recommends taking glutamine or consuming foods high in glutamine to block the effects of grains.
- Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
- Dr. Eric Berg states that curcumin may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
- States that glutamine is an important amino acid for colon cells and is essential for intestinal permeability, greatly supporting the gut and benefiting inflammatory conditions.
- Lists curcumin as an epigenetic factor that may help with cancer prevention.
- Curcumin is a compound that delivers powerful antioxidant and anti-inflammatory effects.
- States that curcumin, found in turmeric, delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health, mental well-being, and more.
- Suggests that curcumin can be beneficial to counter some of the effects of a hypoxic state in cancer and inflammation.
- States that curcumin, a potent compound in turmeric, can naturally alleviate pain and inflammation, and a study found that 1500 mg of turmeric with black pepper produced results comparable to a med without side effects.
- Recommends increasing curcumin for best kidney health.
- Notes that glutamine is an amino acid that promotes gut healing.
- Mentions that carnivore can help increase glutamine, which is a healing amino acid for the gut.
Thomas DeLauer · Curcumin · recommends
- Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
- States that glutamine is the primary fuel source for intestinal cells, and its availability is crucial for the integrity of the gut barrier.
- Recommends supplementing with glutamine for a calming effect, especially when experiencing high stress, injury, illness, or increased training volume, as it acts as a precursor to GABA and helps the body produce more of it.
- Loads up on extra glutamine during muscle building phases.
- Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
- Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
- Recommends glutamine as one of the things that support the gut lining.
- Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
- Is familiar with glutamine being important for maintaining gut barrier function, though he has not done specific research on it in his lab.
- Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
- Recommends Glutamine as a great tool for gut cells when stressed or overworked, but advises not to take it every day.
- Mentions that glutamine is a main source of fuel for the gut and is also important for muscles, and a lack of it can lead to leaky gut during intense exercise.
- States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
- Recommends taking 5 to 10 grams of glutamine daily, stating that it directly feeds the cells lining the gut, thereby improving gut permeability and protecting the gut mucosal layer.
Siim Land · Curcumin · recommends
- Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Curcumin as one of 15 supplements backed by human studies.
- Thinks curcumin has some of the strongest evidence and is worth considering.
- Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- Mentions that glutamine is one of the main precursors needed for glutathione.
- States that curcumin, unless contaminated, is not going to raise liver enzymes.
- Did not see a big extension from curcumin in their tests.
- Mentions that it is infeasible to obtain sufficient curcumin from food.
- Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
- States that glutamine is a good gut supplement that helps heal the gut lining, recommending it periodically for gut healing purposes.
- Mentions aloe vera as a natural agent with an SPF of 7, which can be used as a complementary ingredient in sunscreens but is insufficient as a primary sunscreen.
- Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
- Places Curcumin in the 'god tier' for longevity, based on its ability to extend lifespan in a few animal models and consistent human study findings of lower inflammation, better lipid profiles, and improved metabolic health.
- Recommends supplementing glutamine to address intestinal inflammation and permeability, as it maintains tight junctions and intestinal permeability, with a meta-analysis showing 30 grams a day for less than two weeks reduced intestinal permeability.
Dr. Mark Hyman · Curcumin · recommends
- States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
- Mentions glutamine as something that might be helpful for gut repair.
- Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
- Recommends curcumin as an anti-inflammatory supplement that can be helpful.
- Recommends L-glutamine to help with gut barrier repair and healing leaky gut.
- States that curcumin helps to lower broader inflammatory levels in the body.
- Recommends glutamine to help repair the gut lining.
- Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
- Recommends glutamine for targeted support in healing the gut and recalibrating the immune system.
- Lists curcumin as a phytochemical that helps mitochondrial function.
- Mentions curcumin from turmeric as an example of a powerful phytochemical that affects the body.
- Notes that curcumin is an amazing NRF2 activator, but its bioavailability is only 5% compared to sulforaphane from home-grown broccoli sprouts.
- Recommends a curcumin supplement with black pepper (piperine) for indigestion, including reflux, noting that a recent trial found it as effective as a med.
- Recommends glutamine, an amino acid, for its ability to help soothe the gut lining.
Dr. Rhonda Patrick · Curcumin · neutral
- Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
- Asks if curcumin can slow aging.
- Supplements with glutamine.
- Always packs Glutamine when traveling, taking a baseline of 5 g/day and increasing to 15-20 g/day when sleep-deprived or exposed to illness, as it is an important fuel source for immune function.
- Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
- Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
- Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
- Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
- Warns that Glutamine has stimulating properties that increase arousal, interfering with sleep onset, and should be avoided too close to bedtime.
- Warns against taking glutamine at night for sleep because it is activating and can cause insomnia, citing examples of athletes who experienced this.
- Uses 5 grams of L-Glutamine to support gut-immune axis integrity and may reduce infection risk during travel.
- Says L-Glutamine has been added to their supplement stack recently, convinced by Dr. Rhonda Patrick on its benefits.
- Rhonda's current supplement routine includes Glutamine.
- Rhonda's regimen includes ~5.6g/day of L-glutamine with her morning coffee, upping it to 20g if she feels illness coming on.
Ben Greenfield · Curcumin · neutral
- Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
- States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
- Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
- Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
- Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
- Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
- Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
- Mentions curcumin as a polyphenol that can confer benefits when consumed.
- Mentions glutamine as a supplement that provides glucose to the brain, supporting neurotransmitter functions, as suggested by a guest.
- Recommends curcumin to reduce inflammation, especially when combined with the Weber laser treatment.
- Recommends taking about five grams of L-glutamine with each meal for around four to eight weeks to help heal a leaky gut.
- Tells people to take curcumin to block the secondary function of cancer pulling other things like glutamate and converting it through gluconeogenesis.
- Recommends taking about 5 grams of glutamine powder with each meal as a simple way to reduce IBS issues.
- Recommends topical aloe vera for hair growth, noting that dermarolling can enhance its absorption.
Andrew Huberman · Curcumin · neutral
- Discusses curcumin as a supplement for prenatal care and sperm health.
- Supplementing with L-glutamine may reduce sugar cravings, and anecdotally, it works.
- Discusses glutamine supplementation in relation to leaky gut and sugar cravings.
- Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
- Takes L-glutamine daily at 5g, increasing to 15-20g in 5g increments when her son is sick, she is exposed, during season, or when traveling, because she believes it helps her not get sick.
- He highlights specific nutrients, including glutamine, and discusses their recommended doses and dietary sources for offsetting sugar cravings.
- Recounts an anecdote about taking a teaspoon of L-glutamine in half-and-half twice a day, which he believes helped him wean off sugar, though he acknowledges it could be a placebo effect.
- Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
- Mentions that some people find ingesting a teaspoon of L-glutamine a few times a day helps with sugar cravings, noting that this method has anecdotal data but has not been peer-reviewed.
- Includes curcumin in his diet because it has been shown to stimulate GLP-1.
- Discusses L-glutamine supplementation for leaky gut, noting it is controversial with no randomized controlled trials, but some people swear by it, possibly due to increasing L cells.
- Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
- Mentions curcumin in the context of 5-alpha reductase.
- States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
Peter Attia · Curcumin · uses
- Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
- Says that patients can use an aloe vera plant if they have it for skin reactions from radiation.
- Notes that glutamine has been shown to increase the survival rate in ICU patients.
- States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
- Recommends glutamine as a nutrient the body needs to heal the gut.
- Warns that glutamine is essential for the immune system and gut health, so blocking it with drugs for cancer treatment must be done strategically to avoid compromising these systems. He also notes that tumor cells use glutamine as fuel, so it's a double-edged sword.
- Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
- Would make a smoothie with whey protein isolate, glutamine, glucosamine, and flaxseed oil for recovery after his run.
- Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
- Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.
Bryan Johnson · Curcumin · warns
- Advises avoiding Curcumin during pregnancy.
RAL Summary
Members OnlyTier 4 for Teeth
Human studies, mostly of rinses and gels, support aloe vera, curcumin and frankincense for gum health. The two swallowed trials of curcumin and frankincense were small [1][2], and with no reviews the product cannot rank above emerging.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 9 of the 56 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Oral health, Digestive system, Immune system
Possible side effects: The studies reported no side effects from the aloe vera rinses. No reviews were available.
Supplement Facts
L-Glutamine 2.5 g · Partially Hydrolyzed Guar Gum† 1 g · Aloe Vera 250 mg
Supplement Facts
Serving Size One Scoop (5.6 g)
Servings Per Container 30
Amount Per Serving% Daily Value
| L-Glutamine | 2.5 g | † |
| Partially Hydrolyzed Guar Gum† | 1 g | † |
| Aloe Vera | 250 mg | † |
| Curcumin Phytosome†† | 250 mg | † |
| Indian Frankincense Phytosome†† | 250 mg | † |
† Daily Value not established.
Other ingredients: Flavors, Citric Acid, Rebaudioside A.
Directions: Mix 1 scoop with at least 5-6 ounces of water one to two times daily or as recommended by your health-care practitioner.
Label source: Reverseagelab · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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