Thorne Radiant Skin Complex Review
Product Focus: Sexual Health for WomenAlso covers:Skin
Tier ⓘ
Tier 4 · Rank 1
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 1 within Tier 4 for Sexual Health for Women; 3 of 3 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
Finding the lowest prices at the stores now. This takes a few seconds.
Study, Trial or Testing Result Summary
Members Only35 human studies · 29 improved
10 of these 35 human studies gave hyaluronic acid by injection, not by mouth.
35 human studies29 improved4 no effect1,985 people studied
This product contains three ingredients at full label doses: eggshell membrane at 400 milligrams, a botanical blend at 225 milligrams and hyaluronic acid at 120 milligrams, all taken by mouth. No human studies were found for eggshell membrane or the botanical blend for women's sexual function. Most of the research on hyaluronic acid used gel or injections placed in or around the vagina, not capsules. A pooled analysis of three placebo-controlled trials in postmenopausal women found better sexual function scores and less dryness, with no serious side effects [1]. A trial of 116 postmenopausal women found that a single injection session improved sexual function and reduced dryness and painful sex at 12 weeks [2]. Daily vaginal gel for 12 weeks improved sexual function in 104 women, while lubricants used as needed did not [3]. However, other trials found the gel worked no better than a water-based lubricant, another moisturizing gel or vaginal estrogen [4][5][6]. Hyaluronic acid taken by mouth, as in this product, has only been tested in small studies that mixed it with other ingredients, so these results may not apply to this supplement. Animal and cell studies are never counted.
See all 35 studies →Hide the studies
- A pooled analysis of bladder-instilled hyaluronic acid with or without chondroitin sulphate for chronic bladder conditions reported improved pain and urinary symptoms, and also an improvement in sexual function and quality of life.Hyaluronic acid and chondroitin sulphate instillation in chronic bladder diseases: a meta-analysis.
- Pooling three placebo-controlled trials in postmenopausal women, hyaluronic acid improved female sexual function scores, vaginal dryness-related quality of life and vaginal health, with no serious side effects.Hyaluronic acid for vaginal health and quality of life in postmenopausal women: A systematic review and meta-analysis of…
- A review of eight trials in 539 women with breast cancer found sexual function scores improved with all treatments except testosterone and lidocaine, including hyaluronic acid (only 12 women), though hyaluronic acid did not change vaginal hormone response.Management of genitourinary symptoms in patients with breast cancer: an updated systematic review of available evidence …
- In a review of 10 studies of treatments for painful bladder syndrome, data on bladder-instilled hyaluronic acid and sexual function were conflicting.Interstitial Cystitis/Bladder Pain Syndrome Treatment: A Systematic Review of Sexual Health Outcomes.
- In a review of 136 studies of non-estrogen treatments for menopause genitourinary symptoms, hyaluronic acid improved signs of vaginal atrophy but was not listed among the treatments that improved sexual function.Nonestrogen Therapies for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review.
- In 116 postmenopausal women with vaginal atrophy, a single injection session of hyaluronic acid gel improved sexual function scores and reduced dryness and painful intercourse more than placebo at 12 weeks.Hyaluronic acid injection to treat symptoms of vulvovaginal atrophy in postmenopausal women: A 12-week randomised, place…
- In 80 postmenopausal women with vaginal atrophy, 3 months of hyaluronic acid vaginal gel improved sexual function scores and symptoms, but the improvements were also seen with a water-based lubricant, with only dryness favoring the gel in one analysis.Treatment of vulvo-vaginal atrophy with hyaluronate-based gel: a randomized controlled study.
- In 60 postmenopausal women with vaginal atrophy, a multi-ingredient vaginal gel containing hyaluronic acid used for about 15 weeks improved all sexual function domains and total score compared with placebo.Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenop…
- In a pilot trial of 57 postmenopausal breast cancer survivors starting aromatase inhibitors, a hyaluronic acid vaginal moisturizer with coaching gave better sexual function scores at 6 months than a prebiotic moisturizer, with only a trend for less painful sex versus usual care.A pilot randomized trial to prevent sexual dysfunction in postmenopausal breast cancer survivors starting adjuvant aroma…
- In 53 women in menopausal transition, 30 days of hyaluronic acid vaginal gel improved sexual function scores, but this was no different from a polycarbophil moisturizing gel, so it gave no added benefit.Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausa…
- In 49 women with menopausal genitourinary symptoms, 12 weeks of vaginal hyaluronic acid improved sexual function scores over time, but the improvement did not differ from vaginal estrogen.A randomized, pilot trial comparing vaginal hyaluronic acid to vaginal estrogen for the treatment of genitourinary syndr…
- In a 12-month randomized study of 28 women with recurrent bacterial cystitis, bladder instillations of hyaluronic acid with chondroitin sulfate improved sexual function along with urinary symptoms compared with a med prevention.Effectiveness of intravesical hyaluronic acid/chondroitin sulfate in recurrent bacterial cystitis: a randomized study.
- In 20 postmenopausal women, three hyaluronic acid injections given a month apart improved sexual function more than platelet rich plasma injections did, with no complications reported.Injection of hyaluronic acid versus platelet rich plasma for treatment of vulvovaginal atrophy in post-menopausal female…
- In a small randomized crossover pilot of women with recurrent urinary tract infections, a daily oral mix of hyaluronic acid, chondroitin, N-acetylglucosamine and vitamin C over 3 months was linked to better sexual function scores than the control group at 3 months, though the trial had no placebo and lacked long-term follow-up.Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary…
- In 104 postmenopausal women (50 using the gel, 54 using lubricants as needed), 12 weeks of daily hyaluronic acid vaginal gel significantly improved sexual function and no benefit was seen in the comparison group.Vaginal health and quality of sexual life of postmenopausal women on hyaluronic acid and Biosaccharide Gum-1 vaginal gel…
- In 31 women using oral contraceptives with painful sex, a hyaluronic acid vaginal gel used daily for 12 weeks improved painful sex and sexual function, though estriol gel worked better for painful sex.A comparison between vaginal estrogen and vaginal hyaluronic for the treatment of dyspareunia in women using hormonal co…
- In a small Italian cohort of 20 postmenopausal women with genitourinary syndrome, adding an oral supplement containing collagen peptides and hyaluronic acid to vaginal laser treatment produced larger gains in sexual function scores than laser alone, but the study was small, not placebo-controlled, and did not report study length.Impact of Vaginal Carbon Dioxide Laser Therapy Alone Versus Its Combination With Oral Bioactive Collagen Peptides, Ultra…
- In 115 postmenopausal women with vaginal atrophy, a single hyaluronic acid injection session raised sexual function scores from 4 weeks and the improvement was maintained up to 52 weeks.Hyaluronic acid injection to treat symptoms of vulvovaginal atrophy and improve sexual function in postmenopausal women:…
- In 101 postmenopausal cancer survivors with vaginal dryness, a non-hormonal hyaluronic acid gel used two to five times a week improved sexual function and vaginal symptoms over 24 weeks, with more frequent use working better for symptom relief.A single-arm, prospective trial investigating the effectiveness of a non-hormonal vaginal moisturizer containing hyaluro…
- In 85 postpartum women, applying a hyaluronic acid vaginal gel every three days for 12 weeks raised sexual function scores more than expectant management did.Efficacy and safety of prolonged-release hyaluronic acid derivative vaginal application in the postpartum period: a pros…
- In 50 postmenopausal women with vulvovaginal atrophy, four intradermal injections of polynucleotides with hyaluronic acid over about 10 weeks improved vaginal health and sexual function scores, with no side effects reported.Efficacy of intradermal hyaluronic acid plus polynucleotides in vulvovaginal atrophy: a pilot study.
- In a single-arm study of 43 endometrial cancer survivors using a hyaluronic acid vaginal gel for up to 24 weeks, female sexual function index scores rose significantly from the start, with no control group.A single-arm clinical trial investigating the effectiveness of a non-hormonal, hyaluronic acid-based vaginal moisturizer…
- In 40 postmenopausal women, one hyaluronate vaginal pessary every 3 days for 3 months improved vaginal health, sexual function and symptoms, with no severe side effects reported.Effectiveness of hyaluronate-based pessaries in the treatment of vulvovaginal atrophy in postmenopausal women.
- In 40 breast cancer survivors with vaginal atrophy, five treatments of vaginal oxygen with hyaluronic acid over about two months raised sexual function scores and reduced pain during sex, with benefits lasting 30 days after treatment.Vaginal oxygen plus hyaluronic acid on genito-urinary symptoms of breast cancer survivors.
- In 30 women with bladder pain syndrome, intravesical hyaluronic acid over six months improved urinary symptoms and pain, but did not change sexual function scores.Urinary and psychological outcomes in women with interstitial cystitis/bladder pain syndrome following hyaluronic acid t…
- In 30 menopausal women with vulvar lichen sclerosus, two hyaluronic acid complex injections a month apart reduced dryness and improved lubrication and orgasm scores at 6 months, with no side effects reported.Hybrid cooperative complexes to decrease VAS score and enhance sexual function in women with vulvar lichen sclerosus.
- In 26 women with vulvar-vaginal atrophy, hyaluronic acid injections given monthly improved genital symptoms and sexual function over 6 to 12 months, with the global sexual function score rising by 58%.First Use of Thermal Stabilized Hyaluronic Acid Injection in One-Year Follow-Up Patients with Genitourinary Syndrome.
- In 20 women with vaginal atrophy, multipoint vaginal injections of cross-linked hyaluronic acid reduced painful intercourse and dryness and improved all sexual function domains at 8 weeks, with 19 of 20 women reporting some improvement.Evaluation of the effect of multipoint intra-mucosal vaginal injection of a specific cross-linked hyaluronic acid for vu…
- In an uncontrolled study of 20 women with vaginal laxity and genitourinary atrophy, radiofrequency treatment combined with hyaluronic acid injection into the labia skin was followed by clinical improvement, higher satisfaction and increased tissue elastin and collagen, though the study had no control group and did not report treatment length.Hyaluronic Acid and Radiofrequency in Patients with Urogenital Atrophy and Vaginal Laxity.
- In an uncontrolled study over three months, a hyaluronic acid vaginal lubricant significantly improved sexual function scores and reduced dryness, irritation and pain during sex in women with vaginal dryness.Prospective, multicenter, uncontrolled study on the effectiveness and safety of a hyaluronic acid water-based vaginal lu…
- In 98 women of reproductive age with recurrent urinary infections, a daily tablet combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for 6 months was followed by better sexual function scores, with only 7.1% having a repeat infection.Orally Administered Combination of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin in the Prevention of Po…
- In 61 women with bladder pain syndrome, bladder instillations of hyaluronic acid with chondroitin sulfate or chondroitin sulfate alone improved all sexual function domains after six months, with no difference between the two treatments.Outcomes of intravesical chondroitin-sulfate and combined hyaluronic-acid/chondroitin-sulfate therapy on female sexual f…
- In 15 women with vulvar atrophy and lichen sclerosus, two hyaluronic acid injections improved sexual function and quality of life scores over six months, with no side effects reported.Dermoscopy for monitoring therapeutic response to hybrid cooperative complexes of hyaluronic acid in women with vulvar l…
- In a retrospective review of 12 women with painful vestibular conditions, hyaluronic acid injections into the vestibule improved sexual function and pain scores at 45 days, but five of 12 women reported return of painful intercourse by phone 3 months later.Vestibular hyaluronic acid injection in provoked vestibulodynia patients and its effect on pain and sexual function: A p…
- In 42 women given hyaluronic acid filler in the back wall of the vagina, sexual function and pelvic muscle measures improved at 6 and 12 months, with no control group.Hyaluronic Acid Fillers for Vaginal Augmentation: Efficacy and Safety.
Review Totals and Summary
Members OnlyWhat buyers say
No written reviews read yet.
Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Hyaluronic acid is the main ingredient, and the panel leans positive: four of the ten list a latest position of recommends, one uses it, three are neutral, and one warns. Most take or suggest it to hydrate skin and keep it firm, plump and smooth, and a few also point to joint health, with one panelist taking 300 milligrams a day for joints and another noting that 30 milligrams added small skin benefits alongside vitamin C and hydrolyzed collagen. Panelists mention serums on the skin, food sources like bone broth, and pairings with collagen, vitamin C and hypochlorous acid, while one suggests using it after sun exposure. The cautions are that one panelist says it only works on a surface layer and does not fix the root causes of facial aging, one notes its studies are fewer than those for collagen, and one guest warns that injected fillers are often misused and can last for decades. No one on the panel said they stopped using it.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Hyaluronic Acid · recommends
- Likes working with Pique for healthy skin, specifically their Radiant Skin Duo, which combines BT Fountain (electrolytes, ceramides, hyaluronic acid) and Sun Goddess Matcha (antioxidants, L-theanine) to support hydration and skin barrier from the inside.
- Mentions hyaluronic acid as a nice hydrating ingredient.
- Dr. Hyman mentions hyaluronic acid as a lubricant used in traditional orthopedic treatments for osteoarthritis.
Bryan Johnson · Hyaluronic Acid · recommends
- Considers hyaluronic acid essential for their routine, stating it retains moisture, giving the skin extra firmness and texture, and helps counteract the decrease in levels that occurs with age, leading to dehydrated skin.
- Uses hyaluronic acid as part of his nighttime skincare routine.
- Takes 300 milligrams of hyaluronic acid a day for joint health.
Dave Asprey · Hyaluronic Acid · recommends
- Explains that hyaluronic acid is gradually laid down through access points in the shaft for girth enhancement, using six syringes of filler per treatment. He notes that the body slowly absorbs it, and men usually need a top-off every 18 months to maintain their goal girth.
- States that he hardly ever uses a moisturizer and doesn't believe topical hyaluronic acid is necessary to make skin look good if it's not dry.
- Advises looking into rehydrating skin with hyaluronic acid eventually.
- Uses hyaluronic acid in his osteoarthritis patients, especially before regenerative procedures, to get cells into a better state by blocking inflammation.
- Notes that hyaluronic acid is a component of collagen and helps with joints and wrinkles, and is used in facial fillers.
- Mentions that hyaluronic acid is supposed to be helpful for floaters.
- Discusses hyaluronic acid supplements and their benefits for skin, noting that it helps keep skin young.
Siim Land · Hyaluronic Acid · neutral
- Notes that red light therapy increases hyaluronic acid in the skin, which supports skin elasticity.
- Notes that the addition of 30 mg of hyaluronic acid provided some small additional benefits for skin health when combined with vitamin C and hydrolyzed collagen.
- Notes that there are a few clinical trials on hyaluronic acid reducing skin wrinkles and dryness, but a smaller amount of studies compared to collagen.
- States that red light therapy increases hyaluronic acid in the skin, which supports skin elasticity.
- States that red light therapy increases hyaluronic acid in the skin, which supports skin elasticity.
- States that topical hyaluronic acid lacks evidence for skin benefits because it doesn't get absorbed well, although some newer products have modified molecular structures to improve absorption.
- Includes hyaluronic acid in his 'all out' supplement stack.
- Recommends hyaluronic acid for skin anti-aging, noting it helps with skin hydration.
- Notes that hyaluronic acid, which maintains lubrication and skin hydration, starts decreasing in the skin after age 25, with a 75-year-old having only a quarter of the amount of a 19-year-old.
- Notes that hyaluronic acid content in the skin decreases by about 10% per decade, contributing to skin aging.
- Highlights that Nordic Kodo collagen has eggshell membrane, which has been shown to support joint function.
- Recommends consuming 500 milligrams of hydrolyzed eggshell membrane for additional benefits to joint health and to improve joint pain.
Ben Greenfield · Hyaluronic Acid · uses
- Combined hyaluronic acid with exosomes and did a full facial.
- Recommends a hyaluronic acid serum after applying hypochlorous acid because hypochlorous acid can be drying, and hyaluronic acid is a hydrating molecule that works well with it.
- Mentions that hyaluronic acid is involved in the Wing Lift protocol.
- Recommends using hyaluronic acid after sun exposure to maintain overall skin health.
- Ben's guest, Dr. Cameron Chestnut, warns that hyaluronic acid fillers are often misused and misunderstood, as they last for decades rather than months, leading to problematic gel collection and migration.
- Mentions hyaluronic acid for the joints as an ingredient in the NOVOS supplement.
- Ben explains that the biodegradable hydrogel used for 3D bioprinting scaffolds is made up of hyaluronic acid.
- Uses hyaluronic acid, which helps with wrinkles and radiant skin, as part of the Gut to Glow supplement when traveling.
- Mentions that he includes hyaluronic acid in his products because it synergizes with BPC-157's effect on collagen networks.
- Includes hyaluronic acid for synovial fluid support.
Dr. Eric Berg · Hyaluronic Acid · warns
- Notes that hyaluronic acid, while a natural remedy for skin hydration, only works on a superficial layer and does not address the root cause of facial aging, which involves muscles and bones.
- Dr. Berg recommends prioritizing foods rich in hyaluronic acid or those that support its production, such as bone broth, organ meats, chicken skin, nuts, seeds, or snow mushrooms, to add moisture and boost skin hydration.
Andrew Huberman · Hyaluronic Acid · neutral
- Reviews data on ingesting or topically applying hyaluronic acid to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
- Explains that hyaluronic acid is a natural component of the skin that holds water, providing a plump and moist look characteristic of youthful skin, and mentions dermatologists suggest supplementation or topical application.
Peter Attia · Hyaluronic Acid · neutral
- Notes that hyaluronic acid injections are doing better than cortisone for joint pain, and that combining hyaluronic acid with PRP seems more effective than other treatments, though not astronomically so.
- Mentions that hyaluronic acid injections are another treatment option that performs better than cortisone over a year.
- Says he would give hyaluronic acid in the hip, even though it's not FDA approved for that application, as it can be used off-label and some studies suggest it can help.
- Peter Atia discusses hyaluronic acid fillers, noting they are a constituent of skin, very safe, biocompatible, and reversible with an enzyme.
Thomas DeLauer · Hyaluronic Acid · recommends
- Recommends supplementing with hyaluronic acid, noting its role in collagen formation by providing an elastic component and drawing water for supple, smooth, and flexible skin and hair.
- Explains that hyaluronic acid draws moisture into the collagen matrix, making it flexible and functional, and recommends it for supporting collagen production.
Dr. Rhonda Patrick · Hyaluronic Acid · neutral
- Dr. Rhonda Patrick explores oral hyaluronic acid.
RAL Summary
Members OnlyTier 4 for Sexual Health for Women
Hyaluronic acid helps sexual function when used in or around the vagina [1][2], but this product is taken by mouth, which has little direct testing, and there are no reviews yet, so the evidence is thin.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 4 of the 35 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Reproductive system, Skin
Possible side effects: The studies, which used vaginal hyaluronic acid, reported no serious side effects; no reviews were available.
Supplement Facts
OVOLUX Eggshell Membrane 400 mg · eternalyoung Botanical Blend 225 mg · Hyaluronic Acid 120 mg
Supplement Facts
Serving Size 2 Capsules
Servings Per Container 30
Amount Per Serving% Daily Value
| OVOLUX Eggshell Membrane | 400 mg | † |
| eternalyoung Botanical Blend | 225 mg | † |
| Hyaluronic Acid | 120 mg | † |
† Daily Value not established.
Other ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Ascorbyl Palmitate.
Directions: Take 2 capsules daily or as recommended by your health-care practitioner.
Label source: Reverseagelab · Report a label change
Show entire label
More sexual health for women products
Members OnlyThe highest ranked for the same goal
Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings