Thorne Research Clear Focus Review
Thorne Clear Focus is presented as a fast-acting, caffeine-free nootropic formula that supports focus, memory, and mental clarity. The page describes it as combining a clinically studied sage extract with L-tyrosine to re-center attention and sharpen cognitive performance through targeted neurotransmitter pathways. The product is sold as 60 capsules, with a serving size of 2 capsules and 30 servings per container, for a listed price of $49, or $44.10 with a subscription at 10 percent off. Subscription options include delivery every 2 weeks, monthly, every 45 days, every 2 months, every 3 months, or every 4 months, with free shipping and the ability to pause, skip, or cancel. The page explains that many people experience a decline in focus and mental clarity in the afternoon and during periods of everyday stress, creating demand for non-stimulating solutions that do not rely on caffeine. Thorne states that just two capsules can work in as little as one hour to support key neurotransmitter activity and promote calm alertness and mental clarity. Listed benefits include support for short-term memory after a single dose, enhanced long-term memory and overall cognitive performance, improved attention and response accuracy, faster reaction time and information processing, and support for the production of dopamine, norepinephrine, and epinephrine involved in focus and alertness. Features include being non-habit-forming, caffeine-free and non-stimulating, and formulated with sageXtra, a patented sage extract standardized to 2.5 percent rosmarinic acid. The page suggests the product for people seeking a caffeine-free option for the afternoon slump, people experiencing mental fatigue, students during demanding periods, working professionals, and those wanting non-stimulating support for memory and attention during stress. The sageXtra ingredient is described as clinically validated in two one-dose trials, one in young adults aged 18 to 25 and one in older adults aged 65 to 90, with reported improvements in word recall and short-term memory after one hour and in information retrieval and accuracy after 2.5 hours. L-tyrosine is described as an amino acid and precursor to dopamine, norepinephrine, and epinephrine, which are presented as essential for mood, focus, and alertness, and necessary for thyroid hormone formation. The page states the product is third-party tested to verify label accuracy and to check for heavy metals, pesticides, and microorganisms. Warnings state the product is contraindicated for people with a history of hypersensitivity to its ingredients, that pregnant or nursing women and women trying to conceive should not use it, and that tyrosine is contraindicated with MAO inhibitor meds. The FAQ says the product may be taken daily or as needed, with the best timing 1 to 3 hours before a known period of mental fatigue.
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Study, Trial or Testing Result Summary
Members Only43 human studies · 27 improved
1 of these 43 human studies gave the ingredient by inhaler, not by mouth.
Sage is included at 333 milligrams, the same amount that worked in studies. In 20 healthy adults over 65, a single 333 milligram dose of sage extract improved memory and attention accuracy compared with placebo [1]. In 94 healthy adults aged 30 to 60, a combined sage extract taken daily for about a month improved working memory and accuracy [2]. In 42 older people with mild to moderate Alzheimer's disease, sage extract for 16 weeks gave better thinking scores than placebo [3]. Small trials of sage oil, taken by mouth or smelled, also improved memory and alertness [4][5][6]. L-tyrosine is 500 milligrams per serving, below the 2000 milligrams used in studies, so reaching the studied amount takes four servings a day. At that dose, a review found tyrosine helped protect working memory and processing under stress such as cold, heat or heavy mental load [7]. Single 2000 milligram doses reduced missed responses on an attention task [8] and sped up decisions [9], and cadets on a combat course had better memory [10]. However, the same dose worsened mental flexibility under high load in one trial [11], and higher doses hurt working memory in older adults [12]. Animal and cell studies are never counted.
See all 43 studies →Hide the studies
- A review of 15 mostly single-dose studies in healthy adults found tyrosine helped protect working memory and information processing under demanding conditions such as extreme weather or heavy mental load, but did little for exercise performance.Behavioral and cognitive effects of tyrosine intake in healthy human adults.
- A review of nine supplement ingredients including tyrosine for healthy adults found the evidence inconsistent, imprecise and often flawed, so no firm recommendations could be made.Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.
- A review of randomized trials in Alzheimer's disease found that several herbs, including sage (Salvia officinalis), showed positive effects, though sage was only one of many remedies reviewed.Natural remedies for Alzheimer's disease: A systematic review of randomized controlled trials.
- In 135 healthy adults, those who smelled common sage oil did better than those with no aroma on memory quality and secondary memory tests, and both sage aromas increased alertness.Differential effects of the aromas of Salvia species on memory and mood.
- In 94 healthy adults aged 30-60, 600 mg a day of a combined sage extract for 29 days improved working memory and accuracy tasks compared with placebo, both on the first day and after a month.The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans.
- In 80 young adults, a single 2000 mg dose of L-tyrosine did not change stress markers during a virtual reality shooter drill, but led to fewer missed responses on a Stroop task than placebo.Impact of L-theanine and L-tyrosine on markers of stress and cognitive performance in response to a virtual reality base…
- In 70 healthy volunteers, a single 2 g dose of tyrosine worsened cognitive flexibility under high mental load compared with placebo.Tyrosine negatively affects flexible-like behaviour under cognitively demanding conditions.
- In 60 older adults in residential care, inhaling a multi-oil blend that included clary sage for 10 minutes daily over 30 days improved sleep, orientation, memory and concentration compared with the control group; the effect of clary sage alone cannot be separated.Effects of inhaled aromatherapy on sleep quality and cognitive function in older adults: a randomised controlled trial.
- In 24 young adults with phenylketonuria (compared with 24 healthy controls), 4 weeks of high-dose tyrosine at 100 mg per kg body weight daily raised blood tyrosine about 200% but gave no benefit to brain function compared with placebo.Effect of high-dose tyrosine supplementation on brain function in adults with phenylketonuria.
- In 45 healthy young adults, a single 2 g dose of L-tyrosine did not change average working memory performance, but helped low performers and impaired high performers.Baseline-dependent effect of dopamine's precursor L-tyrosine on working memory gating but not updating.
- In 44 healthy adults taking a sage, rosemary and melissa extract for 2 weeks, overall word recall did not differ from placebo, but delayed recall improved in those under 63 years of age.A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditiona…
- In 42 tired office workers, four weeks of a five amino acid blend including tyrosine did not reduce fatigue but improved motivation and cognitive function after mental work compared with placebo.Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Wor…
- In 42 people aged 65-80 with mild to moderate Alzheimer's disease, 60 drops a day of sage extract for 16 weeks gave better cognitive outcomes than placebo.Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, rando…
- In 38 healthy non-smokers, a single 2 g dose of L-tyrosine showed a trend toward stronger nicotine effects on cognitive control, improving flexibility at the cost of stability.Increased dopamine availability magnifies nicotine effects on cognitive control: A pilot study.
- In 36 healthy adults, a single 50 microlitre dose of sage essential oil improved memory and attention task performance and reduced mental fatigue and increased alertness compared with placebo.Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive perf…
- In 32 healthy adults, single drinks combining sage with beetroot, ginseng and fruit extracts raised subjective energy and blood flow in the brain, mainly with apple and coffee berry, but the abstract reports no clear cognition benefit and the sage effect cannot be separated from the other ingredients.A Randomized, Crossover Study of the Acute Cognitive and Cerebral Blood Flow Effects of Phenolic, Nitrate and Botanical …
- In 30 healthy adults, single doses of 300 or 600 mg of dried sage leaf improved mood, and the 600 mg dose improved performance on a stressful multitasking test, while the 300 mg dose reduced performance at the later testing time.Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stres…
- In 28 healthy men, a single 2 g dose of tyrosine shortened decision response times without hurting accuracy, increased model-based learning and lowered physiological arousal compared with placebo.The catecholamine precursor Tyrosine reduces autonomic arousal and decreases decision thresholds in reinforcement learni…
- In 26 young healthy adults, a single tyrosine dose compared with placebo reduced the size of consciously perceived conflicts in one attention task but not another, and increased subliminally triggered conflicts in some situations.On the effects of tyrosine supplementation on interference control in a randomized, double-blind placebo-control trial.
- In 24 healthy older adults aged 61-72, a single tyrosine dose did not change stopping or anticipatory slowing overall, but older participants showed a greater harmful effect on anticipatory slowing than with placebo.Neuro-Cognitive Effects of Acute Tyrosine Administration on Reactive and Proactive Response Inhibition in Healthy Older …
- In 22 healthy adults, tyrosine compared with placebo improved mental flexibility by reducing the time cost of switching between tasks.Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance.
- In 21 military cadets during a week-long combat course, 2 g of tyrosine daily improved memory and tracking performance compared with a carbohydrate drink control.Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course.
- In 20 male college athletes, a single dose of a combined caffeine, theanine and tyrosine supplement improved movement accuracy during a performance test compared with placebo, without changing subjective ratings.Effects of acute caffeine, theanine and tyrosine supplementation on mental and physical performance in athletes.
- In 20 healthy participants exposed to lower body suction stress, tyrosine at 100 mg per kg of body weight raised pulse pressure and increased an attention-related brain response compared with placebo.L-tyrosine ameliorates some effects of lower body negative pressure stress.
- In 20 healthy adults over 65, a single 333-milligram dose of standardised sage extract improved secondary memory and accuracy of attention compared with placebo.An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers…
- In 17 adults aged 60 to 75, single higher doses of tyrosine were linked to poorer working memory performance, with the largest declines in those whose blood tyrosine rose most.Dose-Dependent Effects of Oral Tyrosine Administration on Plasma Tyrosine Levels and Cognition in Aging.
- In 16 healthy young adults under noise stress, a single dose of tyrosine (100 mg per kg of body weight) improved performance on two stress-sensitive thinking tasks compared with placebo, with no effect on mood or heart rate.Effect of tyrosine on cognitive function and blood pressure under stress.
- In 10 people with narcolepsy, 9 g of tyrosine daily for 4 weeks produced only a mild stimulant effect on some mood ratings and no clinically meaningful change in sleepiness or symptoms compared with placebo.Treatment of narcolepsy with L-tyrosine: double-blind placebo-controlled trial.
- In eight children with phenylketonuria on low-protein diets, three months of tyrosine in a double-blind crossover study was followed by better psychological test results, though practice effects from repeated testing may account for part of the gain.[Case studies of the effect of tyrosine administration in children with phenylketonuria on cognitive processes].
- In 8 participants doing a military-style load carry in heat, tyrosine at 150 mg per kg body weight did not change cognitive function, physical performance, or time-trial results compared with placebo.Tyrosine Ingestion and Its Effects on Cognitive and Physical Performance in the Heat.
- In 8 male volunteers exposed to cold, a single dose of L-tyrosine (150 mg per kg of body weight) improved accuracy on the hardest memory task compared with placebo.Tyrosine reverses a cold-induced working memory deficit in humans.
- Tyrosine supplementation improved convergent thinking, the focused problem-solving type of creativity, compared with placebo, but did not affect divergent brainstorming.Food for creativity: tyrosine promotes deep thinking.
- Tyrosine improved performance on a reversal learning task compared with placebo in a crossover trial, though it did not affect task switching and combining it with brain stimulation cancelled its benefit.Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study.
- In healthy adults aged 60 to 75, tyrosine did not raise the overall value they placed on a demanding memory task compared with placebo, but it raised it in less impulsive people and lowered it in more impulsive people.Catecholaminergic modulation of the cost of cognitive control in healthy older adults.
- In healthy men given alcohol, tyrosine either left unchanged or reduced the low mood alcohol caused in a crossover placebo-controlled study, but did not change alcohol-related memory impairment.Ethanol, monoamines, and affect.
- During about 13 hours of continuous night work with one night of lost sleep, a tyrosine dose of 150 mg per kg body weight reduced the usual decline in a psychomotor task and lowered lapses on a vigilance task compared with placebo, with benefits lasting about 3 hours.The effects of tyrosine on cognitive performance during extended wakefulness.
- In 90 healthy adults, smelling sage aroma improved memory and executive function tasks compared with no aroma, though a novel essential oil blend worked better than sage alone.Aroma of Genius Essential Oil Blend Significantly Enhances Cognitive Performance and Brain Metabolism in Healthy Adults.
- In two small crossover trials of healthy young adults (20 and 24 people), a single 50 microlitre dose of Spanish sage essential oil improved immediate word recall compared with placebo.Salvia lavandulaefolia (Spanish sage) enhances memory in healthy young volunteers.
- In 24 healthy young adults, single doses of 25 or 50 microlitres of sage essential oil improved memory speed (and secondary memory at the lower dose) and boosted alertness, calmness and contentedness compared with placebo.Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia …
- In 20 adults, a single dose of tyrosine taken one hour before testing improved working memory accuracy during a multitasking battery compared with placebo, though it did not change other tasks.Tyrosine improves working memory in a multitasking environment.
- In 15 subjects after cold water immersion, tyrosine given at 300 mg per kg body weight prevented the drop in match-to-sample performance seen with placebo, though step test performance declined on both cold trials.Dietary tyrosine benefits cognitive and psychomotor performance during body cooling.
- In 10 healthy young men given 6.5 grams of tyrosine 90 minutes before a hot-environment test, brain response timing and reaction time held closer to normal than with placebo, suggesting less heat-related slowing of thinking.Tyrosine ameliorates heat induced delay in event related potential P300 and contingent negative variation.
- In seven children with attention deficit disorder with hyperactivity, oral tyrosine produced no significant improvement in symptoms in a single-blind study.Effect of tyrosine on attention deficit disorder with hyperactivity.
Review Totals and Summary
Members Only21 reviews · 40% positive
Thorne.com shows 5 ratings in total for Thorne Research Clear Focus, and the themes below come from the five written reviews that could be read on its page, so this is a very small sample and the average rating is a low 2.6 out of 5. The summary did not separate reviews of other product forms, so I am treating all of these as feedback on the capsules. What buyers praise: The strongest praise comes from one verified buyer who says her focus and clarity improved after she started taking it. She describes waking earlier, around 5:00 AM, and feeling her clarity return. Another verified buyer felt great at first, with more energy and fewer naps during the first weeks. A second reviewer left only a one-word comment, "Good," with no detail about how the product worked for them. What buyers complain about: Two reviewers say the product did nothing for them. One, titled "Nada," says it had absolutely no effect and deserves less than one star. The most specific complaint is a sleep pattern. The buyer who first felt energetic says that about two weeks in she began waking around 2 or 3 AM and staying awake for a couple of hours. She continued for about a week before stopping, and says her experience changed after four days. Her review is cut off on the page by a "Read more" link, so the rest of her account could not be read. Hers is the only review describing a specific adverse pattern, and it is tied to the timing after starting the supplement. Overall split: Customers divide mostly between those who report noticeable improvements in focus and those who report no benefit at all. The reviews are brief, and most reviewers do not explain their experience in depth. Who it seems to suit: The reviews do not say clearly who it suits. Those who benefited mention better focus, clarity, energy and fewer naps. Anyone who is sensitive to sleep disruption may want to note the early-waking report, though it comes from a single reviewer. Taste, form and value: Nothing was said about taste, capsule size, packaging, or value for money. No one commented on the caffeine-free claim. Other details: All five reviews are marked as verified purchases on the Thorne page, and several are dated September and October 2026.
Biohacker Summary
Members Only8 of 10 recommend it
Sage is the main ingredient here, and four of the ten panelists spoke about it: three recommend it and one is neutral, mostly as a culinary herb or tea rather than a supplement. They suggest adding it to meat, salads, or coffee, or drinking it as tea, and they cite its plant compounds, its help with using fat, and its soothing effect on coughs and sore throats. One panelist said a claim about sage and long COVID has not been proven. Tyrosine is a smaller ingredient in this product, and several panelists use it for focus and dopamine, with doses of 500 to 1,000 milligrams, often taken in the morning on an empty stomach or paired with alpha GPC and coffee. Two panelists stopped taking it because of too much dopamine or overstimulation, and one warned that high tyrosine levels may shorten lives.
See all 9 biohackers →Hide the biohackers
Dr. Eric Berg · Sage · recommends
- Recommends adding sage to meat when cooking on the grill.
- Recommends foods high in L-tyrosine, such as meat, fish, eggs, and cheese, as it is a precursor to dopamine.
- Used to give L-tyrosine to people with ADHD to help with focus and calmness, but now recommends consuming foods high in L-tyrosine instead.
- Recommends adding sage to meals for its anti-cancer properties to potentially avoid colon cancer.
- Recommends putting garlic, thyme, and sage on meat or salad.
- Recommends sage as an herbal spice with special compounds.
- Recommends consuming sage as a natural herbal a med for candida.
- Lists sage as a natural remedy to get rid of gout.
- Recommends getting plenty of tyrosine by consuming high-quality animal protein to help balance dopamine and other neurotransmitters naturally.
- Recommends tyrosine, an amino acid, as a cofactor that helps the production of dopamine, which can be obtained by consuming adequate good protein sources.
- Recommends adding sage to meals to help with the detoxification process.
- Mentions sage as a source of a phytonutrient that can help increase nitric oxide.
- Recommends sage as a natural a med for infections.
- Recommends taking sage to help with excessive sweating, as it contains rosemarinic acid and is rich in vitamin B1.
Thomas DeLauer · Sage · recommends
- Recommends marjoram, rosemary, thyme, and sage, noting evidence that they increase PPAR alpha, programming cells to be better at using fats and reducing inflammatory cytokines.
- Recommends taking 500 to 1,000 milligrams of tyrosine, calling it a really simple and highly effective amino acid for thyroid function.
- Recommends tyrosine, stating that it is highly effective for repleting neurotransmitters like dopamine when levels are depleted, which helps with hunger drive and 'food noise'.
- Recommends 2 grams of tyrosine to replete neurotransmitters like dopamine when they are depleted, which can occur in a low-calorie state.
- Recommends sage as a good Mediterranean spice that can influence cells to utilize more fat by affecting PP alpha.
- Recommends taking tyrosine in the morning to support dopamine function, as it is a precursor to dopamine and helps compensate for the dopamine hits usually received from the sun.
- Recommends adding Rosemary or Sage to a Mediterranean-style burger.
- Recommends consuming more tyrosine because it converts into dopamine, and the enzyme that converts it is not fully saturated, meaning there is room for more dopamine conversion and a potential boost in mood.
- Finds it interesting that Ikarians consume a high amount of sage tea, noting that sage has been shown to impact cells in terms of fat adaptation and utilization, and suggests it would be easy to integrate.
- Mentions Sage as one of the Mediterranean herbs used by Vikings.
- Suggests that tyrosine, an amino acid building block for dopamine, can be very helpful for individuals with sleepy frontal lobes, such as the spontaneous brain type.
- Notes a study that found a correlation between higher protein consumption, specifically tyrosine, and improved working memory, episodic memory, and fluid intelligence.
- Suggests tyrosine might help with fatty acid metabolism and the switching of fuels.
- The study's dietary protocol included spices like sage.
Dr. Mark Hyman · Sage · neutral
- Suggests that the plant sage, which has high levels of phytochemicals that inhibit enzymes in the tryptophan pathway, might be a natural cure for long COVID, though it has not yet been proven.
- Mentions looking at tyrosine, which is connected with dopamine, norepinephrine, and epinephrine pathways.
- Recounts discovering a wild sage bush in Icaria that has higher levels of catechins than green tea, which are considered longevity molecules.
- Recommends tyrosine for dopamine production, which can be obtained from grass-fed and regeneratively raised beef, lamb, fish, chicken, nuts, seeds, eggs, and beans.
- Describes drinking Wild Sage Tea, noting it has as many powerful phytochemicals as green tea, which are known to increase longevity.
- Dr. Mark Hyman, after visiting a blue zone, recommends wild sage tea for its high content of epigalactic catechins, which are detoxifying, anti-inflammatory, support the immune system, and activate longevity switches by upregulating glutathione.
- Describes drinking wild sage tea in a Blue Zone, noting it is full of epigallocatechins, powerful compounds found in green tea, and activates longevity switches.
- Put a patient on L-Tyrosine, a precursor to dopamine, because he thought the patient had a dopamine deficiency.
- Used a sage wand with a smudge stick, a Native American way of clearing energy, to clear the heaviness in her house, which resulted in her daughter sleeping soundly.
- Notes that sage has good scientific evidence to help memory.
- Gave a patient tyrosine to help the body with the production of neurotransmitters.
- A clairvoyant friend bought a sage wand from Whole Foods and used it to clear heavy energy from Dr. Mark Hyman's house, which Dr. Mark Hyman participated in due to desperation and low risk.
- Used a sage wand, also known as a smudge stick, in their house to clear heavy energy, describing it as a low-risk intervention with high potential gain.
- Added tyrosine to Joey's regimen because a COMT gene variation left him unable to have enough dopamine in his brain, which made a significant difference in his brain function.
Ben Greenfield · Sage · neutral
- Ben discusses the idea of putting ground sage in coffee, suggesting it would be a good idea.
- Started using the Balance Protocol supplement protocol to replete his tyrosine levels, which were inadequate for turning tyrosine into thyroid hormone, dopamine, norepinephrine, and epinephrine.
- Says tyrosine helps her the next day if she is sleep deprived.
- Mentions tyrosine as a supplement that supports neurotransmitters and enhances focus, as suggested by a guest.
- Mentions L-tyrosine as a precursor to dopamine, which can help enhance dopamine production from the inside.
- Recommends L-Tyrosine as a great nootropic during the day, explaining it's a precursor that can make one feel happy, good, and focused, especially for those not eating red meat or following a carnivore diet.
- Ben asks about N-acetyl L-tyrosine, and Shawn explains it works synergistically as a dopamine precursor with paraxanthine to enhance dopamine neurotransmission.
- Mentions that many people are low in tyrosine, which is made from the essential amino acid phenylalanine, and this is a common issue related to thyroid function.
- Notes that residents of a longevity zone in Italy consume high amounts of wild herbs including sage.
- States that they give tyrosine intravenously.
- Notes that N-acetyl L-tyrosine is included in Ignite for its effect on neurotransmitters, contributing to the overall nootropic effect and brain function benefits.
- Ben mentions that Reacher Nutrition's brain blend contains tyrosine.
- Ben mentions sage tea is recommended for drying excess oils and preventing hands from sweating, similar to green tea, by soaking hands in it.
Dave Asprey · Sage · recommends
- Recommends sage, noting it decreases IL-6 and can be soothing as a tea for coughs or sore throats.
- Dave explains how L-tyrosine gives your brain the raw materials to make focus chemicals, and mentions the dose and timing that work.
- Uses L-Tyrosine, an amino acid, to provide the brain with raw ingredients to make dopamine and norepinephrine, which activate the focus switch. He takes 500 mg every morning and advises starting with that dose and working up if needed, ideally on an empty stomach.
- Mentions that some drivers might use tyrosine to balance some of the caffeine.
- Dave examines what this means for every guy stacking L-tyrosine nootropics or eating high-protein keto, as high tyrosine levels may be cutting years off men's lives.
- Dave Asprey mentions tyrosine as a supplement and cofactor that supports thyroid activation.
- Includes tyrosine in his Motivation 101 formula because it is a precursor for thyroid, dopamine, and stress hormones, and taking it in the morning usually boosts energy and motivation.
- Notes a Mendelian randomization analysis found that genetically higher tyrosine levels were associated with nearly one year shorter lifespan in men, reflecting lifelong endogenous levels, and advises understanding this signal if using tyrosine strategically.
- Recommends Tyrosine the day after doing ketamine to restore norepinephrine reserves.
- Takes tyrosine before bed, noting it is stimulating and helps make dopamine and norepinephrine.
- Warns that taking 5 grams of tyrosine can lead to overdoing it, causing high norepinephrine levels, nausea, shaking, and headaches.
Andrew Huberman · Tyrosine · neutral
- Mentions Tyrosine as a precursor to dopamine.
- Discusses L-Tyrosine as a neuromodulator for cognitive enhancement and focus.
- He recommends 500 mg to 1,000 mg of L-tyrosine, an amino acid precursor to dopamine, taken alone or in conjunction with alpha GPC, to increase focus without stimulant-based alertness.
- Uses 500 milligrams of L-Tyrosine in capsule form, often combined with Alpha-GPC and coffee, early in the day before workouts or concentrated mental work to increase dopamine transmission for concentration and focus.
- Discusses L-Tyrosine and its relation to dopamine, also mentioning combining tools.
- Discusses L-Tyrosine as a supplement that can increase dopamine.
- Takes 500 mg of L-Tyrosine in the morning for focus.
- He mentions that some people leverage the reciprocal relationship between the visual system and dopamine by taking things like L-tyrosine to increase dopamine, but he prefers behavioral tools first.
- Lists L-Tyrosine as a compound to increase dopamine.
- Discusses L-Tyrosine and dopamine, cautioning about preexisting conditions.
Siim Land · Tyrosine · warns
- Warns that L-tyrosine is an 'adrenaline booster' found in pre-workouts that gives the body more ingredients to make adrenaline, which can lead to overstimulation.
- Recommends supplementing with L-tyrosine as a dopamine agent that can suppress prolactin and increase testosterone.
- Noticed that his tyrosine levels go up if he generally eats more protein, as it is not heavily utilized by exercise.
- Has taken tyrosine in the past to help with dopamine levels and as a nootropic, but is not currently taking it because his baseline dopamine levels are already high.
- Tried supplementing tyrosine but it made him 'too high dopamine' and didn't work for him, questioning why Bryan Johnson takes it in the evening.
- Discusses Tyrosine in comparison to L-Theanine.
- Lists tyrosine as one of the supplements Bryan Johnson takes with dinner.
Peter Attia · Tyrosine · neutral
- Considers tyrosine an interesting supplement that may be beneficial for improving reaction time, noting they tinkered with it a little bit.
Dr. Rhonda Patrick · Tyrosine · neutral
- Dr. Rhonda Patrick explores supplemental tyrosine.
RAL Summary
Members OnlyTier 4 for Focus and Memory
Sage at its studied dose has consistent support for memory and attention, and tyrosine helps mainly under stress with mixed results, but only 42% of the 26 reviews are positive. Because the studies and the reviews disagree, the product sits at tier 4.
Take 4 servings a day (8 capsules) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 6 of the 43 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system
Combine with: For cognitive support, Clear Focus pairs well with omega-3 fish oil (EPA/DHA) for neuronal membrane health, a B-complex with methylated folate and B12 for neurotransmitter and homocysteine support, and magnesium (L-threonate or glycinate) for synaptic function and calm. Lion's mane and citicoline can complement it for nerve growth and acetylcholine support. If the user's actual goal is cellular and DNA repair, they should add targeted products such as NMN or nicotinamide riboside with TMG, resveratrol or pterostilbene, CoQ10 or ubiquinol, alpha-lipoic acid, and a quercetin and fisetin protocol, ideally after consulting a healthcare provider.
Possible side effects: Studies noted that higher tyrosine doses could worsen some thinking tasks, especially in older adults. One reviewer reported waking at 2 or 3 in the morning about two weeks after starting.
Supplement Facts
L-Tyrosine 500 mg · Sage extract † 333 mg
| L-Tyrosine | 500 mg | † |
| Sage extract (leaf) (Salvia officinalis)† | 333 mg | † |
Other ingredients: Hypromellose (derived from cellulose) capsule, Ascorbyl Palmitate.
Directions: Take 2 capsules daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749016359 · Label source: Reverseagelab · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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