Thorne Research Perimenopause Complete Review
Thorne Perimenopause Complete is a multi-herbal formula presented as a way to ease 12 of the most common symptoms of the natural perimenopause transition. The page describes it as combining clinically studied herbal extracts with a targeted amount of vitamin B6 to help improve sleep, balance mood and emotional well-being, and decrease hot flashes. It is NSF Certified for Sport. The product is sold as 60 capsules with a serving size of 2 capsules and 30 servings per container, taken once daily. The page lists a price of $52 for one-time purchase, or $46.80 with a subscription at 10 percent off, with subscription frequency options from every 2 weeks up to every 4 months and an HSA/FSA eligibility note. The page explains that the perimenopause transition can begin as early as the late 30s and can last for years, with shifting hormones often leaving women feeling confused, exhausted, and unheard. Common signs listed include difficulty falling or staying asleep, brain fog, hot flashes or night sweats, low energy and fatigue, mood changes, irritability or anxious feelings, and vaginal dryness with changes in libido. The formula features EstroG-100, described as a patented herbal blend of three extracts: Cynanchum wilfordii, Phlomoides umbrosa, and Angelica gigas, rooted in traditional Korean medicine. The page states that across five clinical trials involving over 300 women, EstroG-100 was shown to significantly alleviate menopausal symptoms. Lifenol, a patented hops extract standardized to contain the phytoestrogen 8-prenylnaringenin, is included to help alleviate menopausal hot flashes and is said to support healthy bone structure in postmenopausal women. Pyridoxal 5' phosphate, the active form of vitamin B6, is included as a cofactor for dopamine and serotonin, with the stated aim of supporting mood, emotional resilience, and restful sleep. Listed benefits are grouped into sleep and nighttime comfort, mood and emotional balance, physical comfort, and long-term wellness. Claims include supporting restful sleep, helping decrease night sweats, helping reduce hot flashes, supporting joint comfort, reducing temporary pins and needles sensations in hands and feet, supporting healthy bone structure, and helping alleviate vaginal dryness. The page notes that studies showed significant improvements in total menopause symptom severity after 12 weeks, with some women noticing hot flash improvements in as little as 2 weeks. The page also covers the sourcing of hops from Germany, the plant-based nature of the product, and that it is gluten free, dairy free, and soy free. Warnings state that the product is contraindicated in individuals with a history of hypersensitivity to any ingredient, that pregnant or nursing individuals should not use it, and that there are no known adverse interactions at publication date. The FAQ states it is a non-hormonal formula without estrogen or synthetic hormones and may be used during perimenopause, menopause, and postmenopause.
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Study, Trial or Testing Result Summary
Members Only41 human studies · 18 improved
This product itself was tested in 3 human studies.
Studies of the three-herb blend in this product point to fewer menopause symptoms. In a 12 week placebo-controlled trial, 120 women after menopause were enrolled and 70 were analyzed. Those taking two capsules daily had fewer mild, moderate and severe hot flashes than placebo by week 6 [1]. In a 12 week placebo-controlled trial of 64 women before, during and after menopause, symptom scores fell from 29.5 to 11.3 on the blend versus 29.2 to 23.7 on placebo, and vaginal dryness eased more [2]. A 5 week placebo-controlled trial of 80 women gave the same blend dose together with gamma-aminobutyric acid and found less hot flashes, stress and mood swings and better sleep [3]. A 12 week study of 60 women with no comparison group found symptoms improved and reported no side effects [4]. Hop tablets lowered symptom scores and hot flash counts more than placebo over 12 weeks in 120 women [5], though another trial found a hop extract helped at 6 weeks but not at 12 weeks [6]. Hops did not change sex hormone levels or blood clotting [7]. Vitamin B6 reaches a full dose only at three servings a day, and its evidence is for premenstrual symptoms rather than menopause, with mixed results [8][9]. Animal and cell studies are never counted.
See all 41 studies →Hide the studies
- A review of 31 randomized trials with 3254 women found vitamin B6, calcium and zinc consistently eased the psychological symptoms of premenstrual syndrome, though only one trial had low risk of bias.Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age:…
- A review of premenstrual syndrome treatments covered pyridoxine among many interventions, but the abstract gives no result for it.Premenstrual syndrome.
- A review of randomized trials of natural products for premenstrual syndrome suggested vitamin B6 may be effective, though the evidence was weaker than for calcium.Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review.
- A review of 14 studies in women found vitamin B6 with magnesium reduced premenstrual anxiety but not when taken alone, while B6 alone reduced anxiety in older women.The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women:…
- A review of observational studies linked vitamin B6 and other nutrient deficiencies in postmenopausal women to higher risk of chronic disease, without testing B6 supplements specifically for hormone health.A systematic review on the impact of nutrition and possible supplementation on the deficiency of vitamin complexes, iron…
- A review of 33 randomized trials of plant estrogens, including hops among many others, found improved urogenital menopause symptoms and sexual function, with vaginal use working best; hops were not assessed on their own.Impact of phytoestrogens on treatment of urogenital menopause symptoms: A systematic review of randomized clinical trial…
- In 617 women with premenstrual symptoms treated for three cycles, pyridoxine did not beat placebo on individual symptoms but gave significantly greater overall improvement.Controlled trial of pyridoxine in the premenstrual syndrome.
- In 180 post-menopausal women with mild cognitive impairment, 25 mg pyridoxine daily for 6 months improved thinking scores and lowered homocysteine and beta-amyloid, but did not significantly change overall menopause quality of life.A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and qualit…
- In 124 women starting a low-dose birth control pill, 150 mg vitamin B6 daily for 30 days did not reduce side effects significantly more than placebo.Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive.
- In 120 women with severe premenstrual syndrome, 300 mg of pyridoxine daily for 3 months cut symptoms by 45.3%, similar to the 39.4-46.1% reduction on placebo, and less than a med, propranolol or a med.A double-blind trial of four medications to treat severe premenstrual syndrome.
- In 120 women with early menopausal symptoms, hop tablets taken for 12 weeks lowered menopausal symptom scores and the number of hot flashes more than placebo.The effect of Hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes: A randomized placebo-controlled tri…
- In 81 women with cyclic breast pain before periods, a vitamin compound containing pyridoxine did not reduce pain more than placebo, which worked even better.[Pre-menstrual cyclic mastalgia].
- In 80 menopausal women taking EstroG-100 (514 mg) with GABA (50 mg) as needed for one week and then daily for four weeks, hot flashes, stress, mood swings, headaches, sleep, depression, tension and sexual function improved more than with placebo.Effect of a novel nutraceutical combination of EstroG-100 and γ-aminobutyric acid (GABA) in attenuating symptoms of meno…
- In 78 women with premenstrual syndrome, 80 mg of vitamin B6 daily for three menstrual cycles reduced symptoms with a medium effect and 60% were in full remission, similar to a broad micronutrient formula, with no placebo group.A Pilot Randomized Treatment-Controlled Trial Comparing Vitamin B6 with Broad-Spectrum Micronutrients for Premenstrual S…
- Vitamin B6 was only used as a placebo in this trial of misoprostol before endometrial biopsy in 72 women, so it does not test B6 for women's hormones.Randomized trial of oral misoprostol before endometrial biopsy.
- In 70 postmenopausal women analyzed (120 randomized) who took two capsules of a herbal extract daily for 12 weeks, mild, moderate and severe hot flashes were reported less than with placebo by week 6.Estro G-100 herbal extract and hot flashes in postmenopausal women: A randomized double-blinded controlled trial.
- In 67 menopausal women, hop extract at 100 mcg beat placebo for menopausal symptoms at 6 weeks but not at 12 weeks, the 250 mcg dose worked less well, and hot flush scores improved more than placebo at 6 weeks.A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alle…
- In 64 women before, during and after menopause, 12 weeks of a three-herb extract lowered overall menopause symptom scores (29.5 to 11.3) much more than placebo (29.2 to 23.7) and also improved vaginal dryness.The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-c…
- In 63 postmenopausal women, hop vaginal gel used daily for a week and then twice weekly for two months improved sexual function as much as vaginal estradiol, with no adverse events.Effect of Humulus lupulus L. (Hop) on Postmenopausal Sexual Dysfunction: A Randomized Clinical Trial.
- In a randomized trial of 60 women with premenstrual syndrome, 100 mg of pyridoxine daily for 3 months significantly reduced symptom scores compared with a placebo tablet, with fewer side effects than bromocriptine.Role of bromocriptine and pyridoxine in premenstrual tension syndrome.
- In a double-blind trial of 55 women with moderate to severe premenstrual mood changes, 150 mg of vitamin B6 daily over two months improved dizziness, vomiting, poor performance and reduced social activity before periods, but a significant amount of physical and mood symptoms remained.The effects of vitamin B6 supplementation on premenstrual symptoms.
- In 44 women over one menstrual cycle, 50 mg of vitamin B6 taken with 200 mg of magnesium reduced anxiety-related premenstrual symptoms more than placebo, while vitamin B6 alone showed no clear overall difference.A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxie…
- In a pilot study of 42 women taking a blend that includes vitamin B6 for three months, mood and affective symptoms improved within the supplement group, but there was no difference from placebo, suggesting a placebo effect.Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controll…
- In 32 women who completed a six-month crossover trial of 50 mg daily pyridoxine, emotional symptoms such as depression, irritability and tiredness improved significantly compared with placebo, but other premenstrual symptoms did not.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 25 postmenopausal women with high homocysteine, 3 months of oral estradiol lowered homocysteine but also lowered blood vitamin B6 by about 25 to 38 percent compared with placebo; no vitamin B6 dose was given.Oral estradiol decreases plasma homocysteine, vitamin B6, and albumin in postmenopausal women but does not change the wh…
- In a small double-blind crossover trial of 8 college women taking birth control pills, 100 mg of vitamin B6 daily for 4 weeks lowered depression scores by about 20%, while placebo raised them by about 11%.Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Dou…
- In a double-blind crossover study of 19 women with premenstrual tension and 19 symptom-free controls, vitamin B6 treatment did not significantly improve premenstrual symptoms compared with placebo, although a blood serotonin measure rose with treatment in both groups.Platelet serotonin uptake and effects of vitamin B6-treatment in premenstrual tension.
- In women with premenstrual symptoms, adding vitamin B6 with a med and/or dydrogesterone did not significantly change blood sodium, potassium or hormone levels compared with women without symptoms.Hormones and electrolytes in premenstrual syndrome.
- In 30 young women with premenstrual symptoms, both groups took vitamin B6 and calcium daily for 3 months, and the group that also did treadmill exercise three times a week had lower symptom scores and lower prolactin, oestradiol and progesterone levels, but the study does not test vitamin B6 alone and does not report the control group's hormone changes.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 24 women, those using combined birth control pills and controls had similar vitamin B6 status markers when given 0.8, 2.0 or 20 mg of pyridoxine daily; 0.8 to 2.0 mg daily appeared enough to maintain normal levels.Urinary 4-pyridoxic acid, plasma pyridoxal phosphate, and erythrocyte aminotransferase levels in oral contraceptive user…
- In 24 women, 15 of whom used oral contraceptives, vitamin B6 repletion with 0.8 to 20 mg daily normalized most nutrition markers, but the tryptophan load test stayed abnormal in contraceptive users.Vitamin B6 requirements of women using oral contraceptives.
- In 24 women, birth control pill users and controls handled methionine similarly; 2.0 mg of pyridoxine daily restored normal methionine metabolism in both groups, while 0.8 mg did not.Metabolism of methionine in oral contraceptive users and control women receiving controlled intakes of vitamin B6.
- In a small placebo-controlled study of women with premenstrual tension, a multivitamin and multimineral supplement that corrected vitamin B6 and magnesium deficiencies improved symptoms at the appropriate dose.Clinical and biochemical effects of nutritional supplementation on the premenstrual syndrome.
- In 100 postmenopausal women with vaginal atrophy, a hop-containing vaginal gel used for 12 weeks markedly reduced dryness and other symptoms, with no treatment-related side effects, in an open study without a control group.Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and…
- In a single-arm study of 60 Indian postmenopausal women with moderate-to-severe symptoms, twice-daily EstroG-100 for 12 weeks significantly improved menopause symptoms, with no control group and no side effects reported.Evaluation of Efficacy and Safety of EstroG-100® in Alleviating Menopausal Symptoms in Postmenopausal Women in India: A …
- In a pilot study of healthy postmenopausal women taking a multi-herb morning and evening capsule (containing hops) for 2 months, hot flashes dropped and sleep and menopause scores improved, with no control group.Morning/evening menopausal formula relieves menopausal symptoms: a pilot study.
- In menopausal women given escalating doses of a standardized hops extract, sex hormone levels and blood clotting were not affected, and no acute toxicity was seen, though the active compounds stayed in the blood for over 20 hours.Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.
- In a retrospective survey of 630 women with premenstrual syndrome, daily pyridoxine doses of 100 to 200 mg were reported to give good or partial relief in most patients, with no reports of nerve damage.Pyridoxine in the treatment of premenstrual syndrome: a retrospective survey in 630 patients.
- In a survey of 310 Australian women, vitamins including B6 were among the treatments women found most effective for premenstrual symptoms, yet women who took vitamin B6 had higher overall symptom scores.Premenstrual symptoms in general practice patients. Prevalence and treatment.
- In 108 women, lower dietary intake of vitamin B6 was linked to more severe premenstrual symptoms in some groups, but this survey did not test a supplement and cannot show cause.Premenstrual syndrome and beyond: lifestyle, nutrition, and personal facts.
- In laboratory tests, hops extract bound to estrogen receptors in breast cancer cells and acted like estrogen, showing it contains plant estrogens.Estrogen and progestin bioactivity of foods, herbs, and spices.
Review Totals and Summary
Members Only22,842 reviews · 98% positive
Across the stores this capsule carries about 22,842 ratings. The written feedback I have is small and positive, centered on relief from night sweats and hot flashes, though one store page shows an average of only 3.5 out of 5 with some low star ratings that go unexplained. **What buyers say it did for them:** Hot flashes and night sweats are the one theme. Several reviewers describe a clear change in a symptom they were watching. One says, "Half way through my first bottle the night sweats and hot flashes stopped." Another reports "no more hot flashes, I love it." A third says it "has helped so much with my hot flashes at night" and plans to reorder. A skeptical buyer says it reduced how often she wakes up sweaty, and she notices more sweating on nights after a missed dose. She calls it "Definitely not a placebo affect." She frames this as help with night sweats at least, not a complete fix. Reviewers describe the change as arriving within weeks, sometimes within the first month. **What they complain about:** The written reviews contain no complaints. The one store page that shows a rating breakdown has six two-star and four one-star ratings, but nothing in the visible text explains them. I can't tell you what those lower raters disliked, so the 3.5 average on that page is a caution without a stated reason. **Taste, smell, pill size, or form:** Nothing is said about taste, smell, or pill size. No other forms of the product (gummies, powder) appeared in the material I had, so none were left out. **Value for money:** Price isn't discussed in the written feedback. The only hint of value is a buyer's intent to reorder, which suggests she found it worth continuing. **Who it seems to suit and who it did not:** It seems to suit women in perimenopause or menopause whose main trouble is night sweats and hot flashes. One reviewer researched supplements and concluded that different formulas suit different symptoms. She had been on another product that didn't help her main symptoms, and this one worked better for her within a month. Her review is cut off, so I can't say more. The reviews give no evidence about benefits for sleep, mood, joints, or bones, so those are unaddressed. Who it did not suit is unknown, since the low ratings come with no explanation. **Bottom line:** The written feedback is narrow but consistent. If hot flashes and night sweats are your main concern, buyers report relief. Keep in mind that the reviews are few and mostly short and enthusiastic, and some lower ratings remain unexplained.
Biohacker Summary
Members Only6 of 10 recommend it
Vitamin B6, the main ingredient, drew mixed views from seven of the ten panelists, with about half recommending it and several urging caution. Those in favor take it for nervous system support, estrogen and histamine breakdown, PMS, and making serotonin and melatonin, and they pair it with magnesium, folate, B12 or other B vitamins. Several prefer the active form called pyridoxal-5-phosphate (P5P) and warn against the synthetic form, pyridoxine hydrochloride, which one panelist says is common in multivitamins and energy drinks. Doses were rare: one panelist cited 50 to 100 for estrogen metabolism, and another says he takes 1 gram each morning. Two panelists warn that too much B6 is linked to nerve damage, and one of them does not supplement it for that reason. Hops, a smaller ingredient in this product, was tried by one panelist, who found it curbed his appetite.
See all 8 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin B6 · warns
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- States that high vitamin B6 levels can be linked to peripheral neuropathy.
- Mentions vitamin B6 as a required cofactor for Vitamin D to be properly absorbed and used by the body.
- States that Vitamin D needs K2, magnesium, zinc, B6, boron, and even vitamin A to do its job, emphasizing that vitamins rarely work alone.
- Recommends P5P as the active form of vitamin B6, advising against pyridoxine HCl which is inactive and may not convert properly due to genetic issues.
- Warns that unconverted vitamin B6 can accumulate in the body and affect the nervous system, worsening nerve pain, especially if the liver is sluggish, bile is insufficient, or glutathione is low. He advises not to exceed 50 mg per day.
- Mentions that if one doesn’t have enough vitamin B6, it may seem that magnesium is not working.
- Mentions that vitamin B6 is necessary for magnesium to get into cells.
Dr. Mark Hyman · Vitamin B6 · uses
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
- Believes that if functional testing is done to replete deficiencies like vitamin D and B12 before someone stops their medication, withdrawal symptoms can be completely eliminated.
- States that Vitamin B6, at 50 to 100, is important for estrogen metabolism.
- Recommends Vitamin B6 to support histamine metabolism and gave it to a patient two times a day to help her body break down histamine.
- Dr. Hyman recommends vitamin B6 for easing PMS symptoms, stating it is important for estrogen metabolism.
- Advises moving away from some over-the-counter gummy vitamins due to their high sugar content, which can lead to kids consuming a mouthful of sugar.
- Dr. Hyman highlights the importance of B12, B6, and folate, noting that high homocysteine levels, which indicate inadequate function of these B vitamins, are associated with high blood pressure and diabetes in pregnancy.
- Notes that deficiencies in nutrients like vitamin B6 can cause low magnesium.
- Recommends B6 as a methylating vitamin needed for detoxification.
- States that at the Ultrawell Center, they use hops, an herb, as part of their toolbox to help patients with sleep.
- Mentions using hops as part of a formula at the Ultra Wellness Center to help patients with sleep.
Thomas DeLauer · Vitamin B6 · recommends
- Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
- Recommends vitamin B6 to support GABA production and find balance for mental clarity.
- Mentions B12 as a critical B vitamin for reducing homocysteine.
- Notes that depending on one's diet, adding a good multivitamin might be beneficial, specifically recommending a methylated multivitamin for better absorption and utilization.
- Says his kids love taking Hiya multivitamins because they are sweetened with monk fruit and have no sugar, making it a fun ritual for them.
- Thomas DeLauer, a dad of two young kids, recommends Hiaa Kids Multivitamins as a fun and beneficial chewable multivitamin, sweetened with monk fruit, that helps establish a good routine for kids.
- Recommends Hop Water, which contains water, hops, and nootropics like 5-HTP, as a solution for those who want to reduce alcohol consumption.
- Warns against taking synthetic Vitamin B6 (pyridoxine or pyridoxine HCL) because it can cause peripheral neuropathy and clogs B6 receptors for a long time.
- Recommends Hop Water, a drink made from hops with nootropics, as a substitute for alcohol to give a buzz without the alcohol, and notes it is carried by Thrive Market.
- Says that while he's not the biggest fan of giving kids a bunch of supplements, he understands his kids don't always eat everything he wants them to, and Hyatt multivitamins help them get additional vitamins. He also says his kids love them and he probably eats more of them than his kids do.
- Drinks hop water, which is water made from hops that tastes a bit like beer and contains 5-HTP and nootropics to provide a fun buzz without damaging the body.
- Discusses that Vitamin B6 is beneficial for eyesight and can reduce the risk of advanced macular degeneration, likely by helping to break down homocysteine which can damage eye vessels.
- Notes that the multivitamin he takes uses methylcobalamin for B12, which he considers superior to cyanocobalamin, a cheap shortcut.
- Highly recommends Hop Water, a beverage that uses the essence of hops without alcohol, and combines adaptogens like maca and 5-HTP, which helps him fall asleep and curbs his appetite.
Dave Asprey · Vitamin B6 · neutral
- Mentions Vitamin B6 as playing a role in methylation pathways.
- Warns that the synthetic form of vitamin B6 found in almost all multivitamins and energy drinks binds to B6 receptors for a thousand days, making them unavailable for the beneficial form.
- Says they would take a bunch of their Wild Lights Vitamin B6 if they had to eat almonds, to try and pass them.
- Warns about formulating with Vitamin B6.
- Identifies P5P, a bioactive form of vitamin B6, as a great cofactor for melatonin production, helping the body naturally produce the hormone.
- Recommends feeding the tryptophan pathway with vitamin B6, as it is depleted by birth control and its depletion can lead to depression.
- Mentions P5P in the context of epigenetic alterations, comparing it to vitamin B6.
- Recommends supplementing with Vitamin B6 if homocysteine levels are high, indicating a methylation issue or B12/folate deficiency.
Ben Greenfield · Vitamin B6 · recommends
- Recommends Vitamin B6 for the conversion of tryptophan to serotonin and then melatonin in the pineal gland.
- Tried Kolkurb, an active ingredient called Mar from hops extract, an hour before a meal and found it worked effectively to induce satiety, despite its extremely bitter taste.
- Ben Greenfield has tried Calocurb, an extract of bitter hops, multiple times after lunch and found he had to force himself to eat dinner due to appetite suppression.
- Lists vitamin B6 as a vitamin that, when combined with others, has a neuroprotective effect on the brain.
- Leland ensures adequate Vitamin B6 for patients to optimize endogenous melatonin production.
- Ben recommends HIYA Kids Multivitamin as a pediatrician-approved, superpowered chewable multi that is zero sugar, non-GMO, vegan, dairy-free, allergy-free, gelatin-free, and nut-free, formulated with 12 organic fruits and veggies and 15 essential vitamins and minerals.
- Warns that most typical children's vitamins are basically candy in disguise, containing two teaspoons of sugar, unhealthy chemicals, and gummy junk that growing kids should never eat.
- Ben mentions that tryptophan and vitamin B6 are necessary to produce melatonin.
- States that up to 85% of the vitamin B6 made in the body can be produced by species in the gut, highlighting the gut's role as a 'small pharmacy' for vitamin production.
- States that they use some vitamin B6.
- Explains that Vitamin B6 (P5P) helps with about 30 of magnesium's enzymatic reactions, including serotonin and dopamine manufacturing, and is involved in the absorption of magnesium.
- Ben recommends Thorne Vitamin B Complex for healing nerve damage.
- Recommends German beers because they are strict about ingredients, typically containing only water, hops, yeast, and malted barley or wheat, making them cleaner and free from harmful additives.
- Ben recommends hops, the herb that flavors beer, at about 100 milligrams per day, as it has been shown to reduce estrogen levels by inhibiting aromatase, the enzyme that converts testosterone into estrogen.
Siim Land · Vitamin B6 · neutral
- Mentions that insufficient vitamin B6 can raise prolactin levels.
- Recommends B12 for vegans, noting it is a standard vitamin found in animal products.
- Is experimenting with serine plus vitamin B6 to impact homocysteine levels, a mechanistic hypothesis he is testing.
- Takes 1 gram of Vitamin B6 from DoNotAge in the morning for longevity.
- Mentions vitamin B6 as another example where the principle of metabolic conversions from plant to animal forms applies, with genetic variations affecting the ability to get B6 from plant foods.
Andrew Huberman · Vitamin B6 · warns
- Does not supplement B6 due to evidence that overs-supplementing vitamin B, especially B6, is problematic because of peripheral nerve damage.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, though there are no human data yet.
- Recommends P5P, which is vitamin B6, as a dopamine agonist to help with low drive and motivation.
- Described how some people take vitamin B6 to reduce prolactin levels and thereby reduce the duration of the refractory period, but he is not suggesting anyone do this.
- Mentions Vitamin B6 as a mild prolactin inhibitor.
- Huberman states that he used to take a couple hundred milligrams of vitamin B6 after major events to offset the post-achievement low, noting it seemed to have a positive effect, but advises caution for those with diabetic neuropathy.
- Notes that some people are exploring the use of P5P, a metabolite of vitamin B6 known to suppress prolactin, as a way to buffer the post-MDMA crash, but there are no human data yet.
- He mentions that B6 and NMN are where the Krebs cycle starts to kick in, and all B vitamins basically run that entire circle.
Dr. Rhonda Patrick · Vitamin B6 · recommends
- Dr. Patrick states that people with a specific gene polymorphism in the NPF3 gene, which affects vitamin B6 levels, may need to increase their dietary intake of B6 and/or supplement with vitamin B6.
- Vitamin B6 can suppress the production of Advanced Glycation End products.
- Dr. Rhonda Patrick explores high-dose vitamin B6.
- Notes that very high doses of vitamin B6 can overcome a specific mutation in the ornithine aminotransferase enzyme, preventing progressive blindness.
RAL Summary
Members OnlyTier 3 for Hormone Balance for Women
Two placebo-controlled trials of this exact herbal blend found fewer menopause symptoms and 98% of 22852 reviews are positive, which would reach tier 2, but four biohackers on our panel warn against it, so it drops to tier 3 [1][2].
Take 3 servings a day (6 capsules) to match the dose that worked in the studies.
This product itself was tested in 3 human studies.
Where the evidence disagrees: 11 of the 41 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system, Nervous system
Combine with: For its intended use in women, this product pairs well with vitamin D3 and K2 plus calcium for bone density support as estrogen declines, omega-3 fish oil for cardiovascular and mood support, and a B-complex with methylated folate and B6 for energy and mood. Additional options include ashwagandha or an adaptogen for stress and cortisol balance, and magnesium glycinate in the evening for sleep, though total magnesium intake should be monitored to avoid excess. For men seeking hormone support, better choices are zinc, vitamin D3, boron, ashwagandha, and fenugreek or tongkat ali, ideally after checking testosterone levels with a clinician. Black Cohosh should be used cautiously with liver conditions or hepatotoxic medications.
Possible side effects: No major side effects reported; the open study of the blend reported no side effects and hops did not change hormone levels or blood clotting.
Supplement Facts
Vitamin B6 30 mg · EstroG-100® Botanical Blend† 514 mg · Hops extract 85 mg
| Vitamin B6 | 30 mg | |
| EstroG-100® Botanical Blend† | 514 mg | † |
| Hops extract | 85 mg | † |
Other ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Ascorbyl Palmitate.
Directions: Suggested Use: Take 2 capsules daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749015963 · Label source: Reverseagelab · Report a label change
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Members OnlyThe highest ranked for the same goal
Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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