8WeeksOut Adipropen Ultra Review

Adipropen Ultra is a high-stimulant "fat loss and energy" capsule made by 8WeeksOut Labs. The company was later renamed Dominant Nutrition LLC. The label describes it as a "high intensity energy fat loss formula". It is meant to be stacked with another 8WeeksOut product, Oxyvar. The directions are one capsule in the morning and/or one capsule 30 minutes before training. A bottle holds 90 capsules. According to the HelloPharmacist label database, the formula is a proprietary "Chinese Weight Loss Blend". The blend lists caffeine (1,3,7-trimethylxanthine), 1,3-dimethylamylamine (DMAA), methylsynephrine and rauwolscine (an alpha-yohimbine isomer). The other ingredients are gelatin, magnesium stearate, silicon dioxide and titanium dioxide. The listing gives no amount for any ingredient, so doses are undisclosed. The mechanisms below come from the general pharmacology of these ingredients. I did not find a manufacturer explanation. - **Caffeine:** It blocks adenosine receptors in the brain. This raises alertness and perceived energy. It also modestly raises metabolic rate and the release of fatty acids from fat tissue. - **DMAA:** It is a synthetic sympathomimetic with amphetamine-like effects. It stimulates the release of norepinephrine and blocks its reuptake. That drives up heart rate, blood pressure, focus and thermogenesis. - **Methylsynephrine (oxilofrine):** It is an adrenergic agonist related to ephedrine. It adds to the catecholamine-driven rise in energy expenditure and fat mobilisation. - **Rauwolscine:** It blocks alpha-2 adrenergic receptors. These receptors normally restrain fat breakdown in tissues such as stubborn fat stores. Blocking them is intended to allow more lipolysis, especially during exercise or fasting. Together, these ingredients are meant to raise sympathetic nervous system activity, mobilise stored fat and blunt fatigue. There are serious regulatory and safety concerns. The FDA's October 2021 warning letter to Dominant Nutrition (formerly 8 Weeks Out Labs) named ADIPROPEN ULTRA among the products it was selling. The letter said that marketing such products with drug-type claims makes them unapproved new drugs. The OPSS list of DMAA-containing supplements also includes Adipropen Ultra. The FDA has stated that dietary supplements containing DMAA are illegal. DMAA has been linked to raised blood pressure and heart rate, and to reports of strokes and heart attacks. The product should not be used by pregnant or nursing women. It is also a poor fit for anyone with cardiovascular conditions, anyone on stimulants or MAO inhibitors, and anyone subject to drug testing. It may no longer be sold by the manufacturer.