AgeImmune Brilliant D3+ Complex with K2 and Magnesium Review
Brilliant D3+ Complex with K2 and Magnesium is a doctor-formulated daily supplement from AgeImmune that brings together three nutrients: Vitamin D3, Vitamin K2, and bioavailable Magnesium Bisglycinate. The page presents the product as a single formula for immune support, strong bones, teeth, and healthy calcium utilization, and for muscle, nerve, and cardiovascular wellness. The product is sold as a 30 day supply. The label provides 5,000 IU (125 mcg) of Vitamin D3 as cholecalciferol, 100 mcg of Vitamin K2 as menaquinone-7, and 250 mg of magnesium as magnesium bisglycinate chelate, buffered, per serving of two capsules. The page lists 625% DV for Vitamin D3, 83% DV for Vitamin K2, and 60% DV for magnesium. The other ingredients are cellulose from a vegetarian capsule and organic rice hulls. The label does not list magnesium stearate, silicon dioxide, or titanium dioxide, which the page notes in its shopper questions. The recommended use is two capsules once daily with meals, preferably in the morning. The page explains that Vitamin D3 contributes to normal immune function and calcium absorption, and that Vitamin K2 and magnesium have roles in normal calcium metabolism, bone function, and muscle and nerve function. It states that the formula may suit adults who want these three nutrients in one routine rather than separate bottles. The product was doctor-formulated by Aleksander (Alex) Kanevsky, DC, a chiropractor, and the image captions describe it as produced in small batches and made in the USA. The page repeatedly advises consulting a clinician before use for people with a medical condition, people taking medication, and people who are pregnant or breastfeeding. It also says the formula does not replace medical advice or treatment. The statements have not been evaluated by the Food and Drug Administration, and the product is not intended to diagnose, treat, cure, or prevent any disease. The page also includes a shopper questions section, which explains that the formula uses magnesium bisglycinate chelate, buffered, and that Vitamin K-dependent proteins and magnesium have roles in normal calcium metabolism and bone function.
Product Focus: Bone HealthAlso covers:Muscles and joints
Tier ⓘ
Tier 2 · Rank 9
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 9 within Tier 2 for Bone Health; 9 of 71 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
89 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
97% of 1,226
Biohacker Mentions
10 of 10
Cost per month
$20
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Study, Trial or Testing Result Summary
Members Only85 human studies · 42 improved
85 human studies42 improved16 no effect193,963 people studied
Vitamin K2, at a full dose here, has the strongest support. Pooled trials in women after menopause with thinning bones found it raised spine and forearm bone density [1] and improved spine density [2]. The spine benefit showed up in women with thinning bones but not in those without [3]. In a three-year trial in healthy women after menopause, it slowed bone loss at the spine and hip neck [4]. In a one-year trial, 90 micrograms a day reduced hip bone loss in women after menopause but not in men [5]. Fewer fractures appeared only after one study was left out [2]. Vitamin D results are mixed. In older adults, 700 to 800 units a day cut hip fractures by 26 percent [6], but other reviews found no clear drop in fractures [7][8]. This product gives 5000 units a day, which is above the recommended daily limit, so members may choose to take less. The magnesium evidence comes only from animal studies of magnesium implants placed in bone, not from supplements taken by people [9][10]. Animal and cell studies are never counted.
See all 85 studies →Hide the studies
- In five observational studies of about 81,000 people, those with the highest dietary vitamin K1 intake had a 22% lower fracture risk than those with the lowest intake; this was diet, not vitamin K2 supplements.Vitamin K intake and the risk of fractures: A meta-analysis.
- In 11 trials of 43,869 postmenopausal women with osteoporosis, calcium plus vitamin D modestly improved pelvic bone density but not spine, neck of femur or total hip density, and did not reduce fractures.The effects of combined calcium and vitamin D supplementation on bone mineral density and fracture risk in postmenopausa…
- This review of smartphone apps for osteoporosis self-management did not test vitamin D supplements and found no significant effect on vitamin D intake.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- In trials of older adults, 700 to 800 IU a day of vitamin D cut hip fracture risk by 26% and other nonvertebral fractures by 23%, while 400 IU a day gave no significant benefit.Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
- Across nine trials with 6853 postmenopausal women with osteoporosis, vitamin K2 raised lumbar and forearm bone density more than control, with more mild side effects but no serious ones linked to it.Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and…
- Across 19 trials with 6759 postmenopausal women, vitamin K2 improved spine bone density in women with osteoporosis but not those without, and fracture reduction was only significant after excluding one study.Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of…
- Across 16 trials with 6425 postmenopausal women, vitamin K2 improved lumbar spine bone density, and fractures fell only after excluding one study, with no difference in side effects.Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-anal…
- Across 43 trials in 5,184 postmenopausal women, vitamin K gave the largest rise in a bone-formation marker (bone alkaline phosphatase), and vitamin K combined with vitamin D most effectively raised two other bone-formation markers.Effects of dietary supplements on bone turnover markers in women after menopause: a network meta-analysis.
- Across nine trials with 2570 postmenopausal women with osteoporosis, vitamin K2 improved most bone turnover markers, though bone density and fracture benefits were not measured.The effect of vitamin K2 supplementation on bone turnover biochemical markers in postmenopausal osteoporosis patients: a…
- Across 10 trials with 1346 people, vitamin K plus calcium raised lumbar spine bone density, with a clearer effect for vitamin K2 than for vitamin K1.The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled…
- Across eight trials with 971 people, vitamin K combined with vitamin D increased total bone density, with a stronger effect when vitamin K2 was used at under 500 micrograms a day.The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials…
- Across nine studies, vitamin D3 did not significantly reduce nonvertebral or vertebral fractures versus placebo or calcium alone, with only a borderline trend toward fewer falls.The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis.
- Across 13 trials, vitamin K reduced bone loss, and seven Japanese trials of menaquinone found far fewer vertebral, hip and other non-spine fractures.Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
- A pooled analysis of trials in middle-aged and older adults found vitamin K supplements raised lumbar spine bone density and improved bone protein carboxylation, but did not change other bone turnover markers.Effects of vitamin K supplementation on bone mineral density at different sites and bone metabolism in the middle-aged a…
- A review of 13 trials found small studies showed little or modest bone density benefit, while there was some evidence of fewer vertebral fractures in postmenopausal women, and no evidence for men.Menatetrenone for the treatment of osteoporosis.
- In 23 trials of 1,209 kidney transplant recipients, vitamin D analogues (2 trials, 51 patients) improved lumbar spine and femoral neck bone density versus no treatment, but no trial showed fewer fractures.Interventions for preventing bone disease in kidney transplant recipients: a systematic review of randomized controlled …
- In 18 small trials of 576 children with chronic kidney disease, vitamin D preparations lowered parathyroid hormone levels, but there were few data on growth or bone deformities and no clear differences between preparations.Interventions for metabolic bone disease in children with chronic kidney disease.
- Three small trials in 70 people with cystic fibrosis gave very low-quality evidence, so it is uncertain whether vitamin K changes bone density, though blood vitamin K rose and undercarboxylated osteocalcin fell.Vitamin K supplementation for cystic fibrosis.
- One small trial of 39 people with sickle cell disease found vitamin D3 for six weeks raised blood vitamin D and reduced pain days versus placebo, but no bone outcomes were reported and the evidence was low quality.Vitamin D supplementation for sickle cell disease.
- In nine trials of postmenopausal women without osteoporosis, vitamin D raised blood vitamin D and improved some bone remodeling measures, but only one study found fewer fractures, so a fracture benefit could not be confirmed.Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal wom…
- A review of randomized trials in women found vitamin K2 results for bone density and fractures were promising, though study limitations mean confirmation is needed.Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled tria…
- Seven trials in postmenopausal women lasting 2 years or more found high-dose vitamin K1 or K2 lowered undercarboxylated osteocalcin, improved femoral neck bone strength and reduced clinical fractures, though bone density changed little.High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature.
- In four mostly small open-label trials of 45 mg vitamin K2 in Japanese women with osteoporosis, smaller trials showed fewer spine fractures but the larger trial did not, and non-spine fractures did not differ.Vitamin K to prevent fractures in older women: systematic review and economic evaluation.
- In children on long-term a med treatment, vitamin K2 combined with alfacalcidol preserved bone density, but calcium with alfacalcidol prevented bone loss better than menatetrenone.Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review.
- This review of observational and intervention studies found that the evidence on vitamin K, including vitamin K2 supplements, and bone health, bone density and fractures is conflicting and unclear.Vitamin K and osteoporosis: Myth or reality?
- A review of ten studies on vitamin K for osteoporosis in postmenopausal women reported no outcome results in its abstract.The Anti-osteoporosis Effects of Vitamin K in Postmenopausal Women.
- In 500 elderly women with Alzheimer disease who all took 1000 IU of vitamin D2 plus calcium, adding risedronate for 18 months raised bone density 4.1% and cut hip fracture risk compared with placebo, but vitamin D itself was not tested alone and the paper was retracted.The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Al…
- Children whose mothers took 1000 IU of vitamin D3 daily during pregnancy had higher whole-body bone mineral content and density at ages 6-7 than children whose mothers took placebo.Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled…
- In 452 older men and women taking calcium and vitamin D, 500 micrograms a day of vitamin K1 for 3 years did not change bone density at the hip or spine compared with no vitamin K1.Effect of vitamin K supplementation on bone loss in elderly men and women.
- In 441 young Chinese women given milk powder with 1000 mg calcium and 80 mcg vitamin K1 or nothing for 2 years, bone density and bone turnover markers showed little difference between groups.Milk supplementation and bone health in young adult chinese women.
- In 440 postmenopausal women with low bone density, 5 mg a day of vitamin K1 for 2 to 4 years did not change bone density, but fewer women had clinical fractures (9 versus 20 on placebo).Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.
- In 381 healthy postmenopausal women taking calcium and vitamin D, 45 mg a day of vitamin K2 (MK4) or 1 mg of vitamin K1 for 12 months lowered undercarboxylated osteocalcin but did not change bone turnover or bone density compared with placebo.Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in heal…
- In 379 healthy older adults, 500 mcg per day of phylloquinone for three years did not change inflammation or bone-related cytokine levels compared with no supplement.Vitamin K, circulating cytokines, and bone mineral density in older men and women.
- In 325 postmenopausal women given 45 mg a day of vitamin K2 (MK-4) for three years, bone mineral content and femoral neck width increased and hip bone strength was maintained compared with placebo, though standard bone density did not change.Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women.
- In 311 middle-aged and older adults, 90 micrograms a day of vitamin K2 for one year reduced femoral neck bone loss in postmenopausal women compared with placebo, with no effect in men and no added benefit from calcium and vitamin D3.Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized C…
- In 244 healthy postmenopausal women, 180 micrograms a day of vitamin K2 (MK-7) for three years slowed bone density loss at the lumbar spine and femoral neck, but not the total hip, and reduced loss of vertebral height compared with placebo.Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women.
- In 242 elderly men with Parkinson disease who all took 1000 IU of vitamin D2, adding risedronate for 2 years raised bone density, but vitamin D was not compared against placebo and the paper was retracted.Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease.
- In 219 healthy young and older adults, 1000 micrograms a day of vitamin K1 (not K2) for two weeks lowered undercarboxylated osteocalcin but did not change other bone turnover markers.Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elde…
- In postmenopausal women aged 50 to 60, 1 mg of vitamin K1 daily plus minerals and vitamin D for 3 years reduced femoral neck bone loss compared with placebo, but had no effect on lumbar spine bone density.Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.
- In Japanese adults taking 100 micrograms of menaquinone-7 daily for 12 weeks, osteocalcin became more fully activated compared with placebo, and doses of 100 micrograms or more were suggested as effective.Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized C…
- In 148 postmenopausal women with low bone density taking 375 mcg of vitamin K2 (menaquinone-7) daily for 12 months, the internal structure of tibia bone was preserved compared with placebo, while bone density showed no difference.Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postm…
- In 148 postmenopausal women taking 375 mcg of vitamin K2 (menaquinone-7) daily for 12 months, an inactive form of bone protein fell sharply and a blood marker of metabolic health rose compared with placebo, but insulin sensitivity did not change.Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women:…
- In 142 postmenopausal women with osteopenia taking 375 mcg of vitamin K2 (MK-7) or placebo daily for 3 years, bone density and bone structure changes did not differ between the groups, although MK-7 raised carboxylated osteocalcin in the blood.The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-ye…
- In 122 postmenopausal women eating vitamin D enriched salmon twice weekly for 12 weeks, bone breakdown markers improved compared with a low vitamin D intake, though the amount of vitamin K was not stated.Reduced bone resorption by intake of dietary vitamin D and K from tailor-made Atlantic salmon: A randomized intervention…
- In 110 healthy children and adults, menaquinone-7 supplements helped most those with the greatest vitamin K deficiency, and adults over 40 may benefit most.Vitamin K status in healthy volunteers.
- In 105 women with osteoporosis taking meds, 45 mg a day of menatetrenone for 18 months did not change bone density compared with placebo.Read the study on PubMed (37338608) →
- In 94 lung and heart transplant recipients taking 180 mcg of vitamin K2 or placebo for 1 year, lumbar spine bone density was higher with vitamin K2 (borderline significant), with benefit seen in lung recipients but not heart recipients.Dietary vitamin K2 supplement improves bone status after lung and heart transplantation.
- In 92 postmenopausal women with osteoporosis, 45 mg a day of menatetrenone for 2 years increased lumbar spine bone density more than calcium alone.Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopa…
- In adults with type 2 diabetes and heart disease, 360 mcg of vitamin K2 daily for 6 months did not slow bone mineral density decline or arterial calcification compared with placebo.Six months vitamin K treatment does not affect systemic arterial calcification or bone mineral density in diabetes melli…
- In 63 postmenopausal women with osteoporosis, 45 mg a day of menatetrenone with calcium for 48 weeks increased lumbar spine bone density more than placebo with calcium.Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia.
- In 55 healthy prepubertal children, 45 mcg per day of menaquinone-7 for eight weeks improved osteocalcin carboxylation compared with placebo.The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children.
- In 50 women with cirrhosis, vitamin K2 (menatetrenone) over 2 years prevented lumbar spine bone loss, with bone density rising 0.1% at 1 year and falling only 0.5% at 2 years while the control group lost 2.2% and 4.6%.Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver.
- In 40 healthy postmenopausal Japanese women taking 1.5 mg of menaquinone-4 daily for 4 weeks, osteocalcin activation improved compared with placebo, with the largest change at 2 weeks.Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
- In 40 hemodialysis patients with low parathyroid hormone, 45 mg per day of menatetrenone for one year improved bone remodeling markers compared with a control group.Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level.
- In 34 early postmenopausal women with low bone density taking 45 mg of vitamin K2 daily for 2 years, a marker of vitamin K status improved, but bone density results were not reported as a clear gain and there was no placebo comparison.Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women.
- In 33 postmenopausal women taking a combination of vitamin K1 (1000 micrograms daily), vitamin D3, hop acids, and berberine for 14 weeks, a bone turnover marker (osteocalcin) fell by about 31% while placebo rose, though the vitamin K1 effect cannot be separated from the other ingredients.Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopa…
- In a small trial of 29 children with leukemia, those given 100 mcg of vitamin K2 (menaquinone-7) with vitamin D3 during chemotherapy showed early bone-protective changes over about 6 months compared with children receiving chemotherapy alone.Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective…
- In 20 patients starting a med treatment, 15 mg per day of menatetrenone for one year was linked to no significant bone density loss, while the group without it lost lumbar spine bone density.Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG).
- In 20 postmenopausal women with osteoporosis and prior wrist fractures, vitamin K over 2 weeks corrected the carboxylation defect in osteocalcin, with a similar result after vitamin K plus vitamin D, but bone density was not reported as an outcome.Carboxylation of osteocalcin in post-menopausal osteoporotic women following vitamin K and D supplementation.
- In 16 adults on long-term meds for neuromuscular disorders, adding vitamin K2 to risedronate for one year did not produce any extra change in bone turnover markers compared with risedronate alone.Read the study on PubMed (20190467) →
- In 15 young adults on a crossover diet study, a hydrogenated form of vitamin K1 (dihydrophylloquinone) at 200 mcg daily for 10 days was less absorbed and had no measurable effect on bone formation or breakdown markers, unlike regular vitamin K1.Effects of a hydrogenated form of vitamin K on bone formation and resorption.
- In young Indian women taking a protein drink fortified with calcium, vitamin D and 55 mcg of vitamin K for 6 months, bone turnover markers moved in a favorable direction compared with a low-protein placebo drink.Randomised Controlled Trial of Nutritional Supplement on Bone Turnover Markers in Indian Premenopausal Women.
- In healthy women given 1 mg of vitamin K daily, bone-related blood markers shifted and urinary calcium fell about 30% in women who lost calcium quickly, while the placebo-controlled trial in postmenopausal women ran for 3 months.Vitamin K-induced changes in markers for osteoblast activity and urinary calcium loss.
- In 82 premenopausal women, adding 80 micrograms of vitamin K1 to calcium-fortified milk for 16 weeks improved vitamin K levels but did not reduce bone turnover more than milk alone.Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in pr…
- In 69 patients with osteopenia or osteoporosis having lumbar spine surgery, adding vitamin K2 to vitamin D3 and calcium for 6 months increased complete spinal fusion rates compared with the control group.Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative…
- In 60 people with autoimmune diseases taking meds and meds, menatetrenone raised bone formation markers during the first month, but bone density and fracture rates did not differ from those not taking it after about 1.5 years.Efficacy of Vitamin K2 for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases.
- In 21 women with anorexia nervosa followed for about 0.9 years, those taking menatetrenone lost less lumbar bone density (2.8%) than those not taking it (6.9%).Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa.
- In 20 people with kidney disease starting prednisolone, adding 45 mg a day of menatetrenone for 10 weeks prevented the spine bone density loss seen with prednisolone alone.Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chro…
- In 12 healthy young adults, 90 mcg of vitamin K2 (menaquinone-7) added to daily olive oil for 2 weeks increased the active form of bone protein and decreased the inactive form compared with baseline.Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation.
- In healthy volunteers, MK-7 from natto was absorbed well, stayed in the blood much longer than vitamin K1, and carboxylated osteocalcin more completely; preparations of 50 mcg daily or more may interfere with meds.Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.
- In an open-label 2-year study of 241 osteoporosis patients, those taking 45 mg of vitamin K2 daily had fewer new fractures and lost less spine bone density than the untreated control group.Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.
- In 109 postmenopausal women with osteoporosis, 45 mg of menatetrenone daily for six months raised the active form of osteocalcin and lowered its inactive form compared with calcium, but urinary bone breakdown markers also rose after six months, and bone density was not measured.Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover …
- In 20 children with thalassemia taking 50 mcg of menaquinone-7 plus calcitriol for 1 year, lumbar spine bone density and Z-score improved, though this was an uncontrolled pilot study.The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy.
- In 20 severely disabled children and adults with bone thinning, bone density rose after 4 months of oral vitamin K2 and stayed higher through 12 months, though there was no control group and the dose was not stated.[Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia].
- In 15 healthy young men given menaquinone-4 in steps of 300, 600, 900 and 1500 mcg daily over 5 weeks, blood levels of活性 osteocalcin rose at 900 mcg daily or more, and the inactive form fell at 600 mcg daily or more.Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response st…
- In a Japanese cohort of 944 women followed for 3 years, eating more natto was linked to less bone loss, especially in postmenopausal women.Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-B…
- In Tuscany, Italy, most people who broke a hip from 2011 to 2015 were not taking vitamin D supplements, and only 30-35% were on cholecalciferol one year after the fracture; no bone outcome was measured against a comparison group.The use of cholecalciferol in patients with hip fracture.
- In 211 patients with chronic pancreatitis, vitamin K deficiency was the only factor linked to osteoporosis in men, with 32 percent of patients found to be vitamin K deficient.Vitamins D and K as Factors Associated with Osteopathy in Chronic Pancreatitis: A Prospective Multicentre Study (P-BONE …
- In a 2-year cross-sectional study of 116 pre- and post-menopausal obese and non-obese women, daily vitamin D and calcium intake was low and osteoporosis was less common in obese women, though blood vitamin D levels were within normal range.Dietary Pattern and Bone Health in Pre and Post-menopausal Obese Women.
- In 113 postmenopausal women, lower vitamin K status was linked to lower bone mass only in women who also had aortic calcification.Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study.
- In 16 Crohn's disease outpatients with a med-related bone loss, the vitamin K2 group showed no change in bone density after one year, while the alendronate group improved.Read the study on PubMed (19525577) →
- In 8 stable dialysis patients taking 45 mg of menatetrenone (vitamin K2) daily for 12 months, bone mineral density stayed at the same level, though some blood bone markers changed in mixed directions and there was no control group.Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients.
- In 8 female elite athletes taking 10 mg of vitamin K daily for one month, bone formation markers rose 15 to 20 percent and bone breakdown markers fell 20 to 25 percent in the low-estrogen group, with no control group.Improved bone metabolism in female elite athletes after vitamin K supplementation.
- In children with cystic fibrosis, higher vitamin K intake was suggested to bring bone and health benefits, based on bone markers at different doses.Vitamin K supplementation in cystic fibrosis.
- In Japanese patients with osteoporosis, vitamin K2 combined with EHDP worked better than either alone, while vitamin D3 plus vitamin K2 had little effect on spine bone density.[EHDP + vitamin D3 or vitamin K2].
Review Totals and Summary
Members Only1,226 reviews · 97% positive
1,226 reviews · Desertcart 566 · EBay 539 · Amazon 96 · AgeImmune 24 · Ubuy.mw 1
97% positive0% neutral3% negative
Buyers of AgeImmune Brilliant D3+ Complex with K2 and Magnesium are very happy with it. Across the stores it carries about 1,225 ratings, and the reviews that give stars are all 4 or 5. Only the capsule reviews are covered here; any reviews of other forms were left out. **What buyers say it did for them:** Many describe a general lift in how they feel. Several report more energy, easier waking, less muscle tension, better mood, deeper sleep, or less joint stiffness. One wrote, "I noticed better energy levels and less muscle tension after consistent use." Another said it is "the first vitamin D supplement I've taken that actually makes a difference." Some noticed results within days, others after a few weeks or months. The store summary notes that these effects are self-reported and often vague, and many reviews are short and general. **What they complain about:** There are almost no complaints. The only drawback mentioned is that the capsules are "a bit bigger" than usual, though the same reviewer says they are not hard to swallow. Nobody reported side effects or discomfort. **Taste, smell, pill size and form:** This is the most consistent praise. Reviewers say the capsules are "easy to swallow" and leave no aftertaste. One said they "go down easily, are mild on the stomach, and don't leave any lingering taste." Another says it is "one of few products that doesn't cause stomach sensitivity for me." One reviewer called them softgels. **Value for money:** The main appeal is convenience and cost: one bottle replaces separate D3, K2 and magnesium purchases. One buyer said, "Now instead of buying vitamin D3/K2 and magnesium separately, I purchase just one bottle." Another said "the price is great." Another said they could stop taking separate magnesium tablets. **Who it seems to suit:** People who want all three nutrients in one product and like a simple daily routine. Several chose it for bone, heart and immune support, or for winter. One said their vitamin D is low. Some older buyers liked it, with comments such as "Works great for older people" and "At my age this is necessary." Others liked the formula itself: enough D to balance the magnesium, the added K, and no magnesium stearate or dioxides. Repeat buyers of the brand call it consistent. Some reviews praise the seller's service and genuine products, but these say little about the capsules themselves. **Who it did not suit:** No reviewer said it did not work for them. The only caution is for people who are sensitive to larger capsules, since one reviewer found them a bit big. Several reviews give no detail at all, so the evidence for specific benefits is thin, even though the overall tone is warm.
Biohacker Summary
Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it
The product lists no single main ingredient in the panel's notes, so the three ingredients here are all described as smaller ingredients in this product, and the panel speaks about them at length. Magnesium drew the most comment, with most of the panel recommending or using it, mainly for sleep, and they favor glycinate or threonate forms, with doses of 400 mg of threonate before bed from two of them and 300 to 400 mg daily from diet and supplements from one. For vitamin D, several recommend it or take it, two take 5,000 IU of D3 in the morning, and a few say to take it with dietary fat for better absorption, while one says most people gain nothing from it unless they are deficient. Vitamin K2 was covered by three of them, who describe it as steering calcium into bones and away from arteries, with one taking 90 mcg in the morning and one pairing it with D3 and morning fats. Two of them also say magnesium helps the body use vitamin D, and none of them reported stopping any of these.
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Dr. Eric Berg · Vitamin D · neutral
- Lists Vitamin D as an ingredient found in sardines.
- Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
- Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
- Recommends Magnesium glycinate, noting its high absorption rate compared to magnesium oxide, and its support for energy, sleep, muscle relaxation, and vitamin D function.
- Dr. Berg states that when nutrients like magnesium are too low, fatigue and weakness can follow.
- Recommends pairing Vitamin D3 with K2, stating that K2 helps keep calcium out of soft tissues.
- Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
- Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
- Recommends focusing on magnesium to support stronger bones if a neck hump is associated with osteoporosis.
- Explains that leg and calf cramps are most often caused by low magnesium, with leafy greens being a top source.
- States that magnesium is a cofactor that allows B1 to work more efficiently.
- Recommends focusing on vitamin K2 to support stronger bones if a neck hump is associated with osteoporosis.
- Suggests that increasing vitamin D3 may help address the underlying problem of bruxism.
- States that magnesium is the most important mineral for energy production, as one cannot make energy without it.
Dr. Rhonda Patrick · Vitamin D · neutral
- Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
- Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
- Mentions that getting too little magnesium may play a role in declining testosterone levels.
- States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
- Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
- Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Mentions vitamin K as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Mentions magnesium as an important nutrient component for testosterone.
Dave Asprey · Vitamin K · recommends
- Explains that Vitamin K2 acts as a traffic cop for calcium, waving it into bones and away from arteries, and that grass-fed butter is one of the only foods with a real amount of K2.
- Looks at magnesium alongside protein to keep muscle for the long run.
- Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
- Takes Vitamin DAKE from Suppgrade Labs.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- States that magnesium can affect how the body responds to a supplement.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- Recommends taking vitamin K2 with vitamin D to keep calcium in the bones, and suggests kids also take it for stronger bones.
- Recommends Vitamin K2, stating it supports healthy calcium metabolism.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
Thomas DeLauer · Magnesium · recommends
- Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
- Recommends taking Vitamin K2 with Vitamin D3 in the morning, along with morning fats, to ensure calcium is directed to the bones and not deposited in arteries or soft tissue.
- Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
- Mentions that magnesium glycinate also helps a lot with sleep.
- Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
Andrew Huberman · Magnesium · recommends
- Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
- Discusses Magnesium Threonate as a tool for falling asleep.
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 90 mcg of Vitamin K2 in the morning for longevity.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning.
- Takes 90 mcg of Vitamin K2 in the morning.
Dr. Mark Hyman · Magnesium · recommends
- Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
- Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
Siim Land · Vitamin D · recommends
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Magnesium can be a useful addition for some people for sleep.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Notes that Vitamin K2 helps activate proteins involved in bone mineralization and calcium regulation.
- Mentions that prunes contain vitamin K, which is a factor in their ability to help with bone density.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends Vitamin K2 for bone health and calcium metabolism, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- Lists Vitamin K2 as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists leafy greens as a source of Vitamin K1.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Discusses vitamin K2, specifically the menaquinone forms, as crucial for arterial health and notes that it breaks down into MK-4 and MK-7.
- Explains that gut bacteria liberate K from the diet or make the K needed, and that poor absorption of vitamin K due to bacterial imbalances is linked to heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Has been taking Vitamin D3 K2 for over a decade.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
Bryan Johnson · Vitamin K · uses
- Takes 90 mcg of Vitamin K2 in the morning for general health.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- He takes 100 mcg of Vitamin K2 in the morning for general health.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
- Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
RAL Summary
Members OnlyTier 2 for Bone Health
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skeletal system, Musculoskeletal system
Combine with: To support bone health, pair this with a highly absorbable calcium source such as calcium citrate or microcrystalline hydroxyapatite if dietary intake is low, plus collagen peptides or boron and vitamin C for the bone matrix. Omega-3 fish oil complements the D3 and K2 for cardiovascular and inflammatory balance. If blood sugar support is still the goal, add a dedicated glycemic formula containing berberine, chromium picolinate, alpha-lipoic acid or Ceylon cinnamon, and consider extra magnesium glycinate if intake is low. Take fat-soluble D3 and K2 with a meal that contains fat, and check with a clinician if you take meds such as a med, since K2 can interfere.
Possible side effects: Vitamin K2 trials reported more mild side effects than control, with no serious ones. Reviewers reported no side effects, though one found the capsules a bit large.
Supplement Facts
Vitamin D3 5000 IU · Vitamin K2 100 mcg · Magnesium 250 mg
Supplement Facts
Serving Size 2 Capsules
Servings Per Container 30
Amount Per Serving% Daily Value
| Vitamin D3 | 5,000 IU | |
| Vitamin K2 | 100 mcg | |
| Magnesium | 250 mg |
Other ingredients: Cellulose (Vegetarian Capsule), Organic Rice Hulls.
Barcode (UPC) 199284771161 · Label source: Reverseagelab · Report a label change
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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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