ANSI Pro-Series BCAA 1000 Review

The ANSI Pro-Series BCAA 1000 is a branched chain amino acid supplement listed in the Dietary Supplement Label Database under DSLD ID 21003. The record was entered on 25 April 2013 from an NIH source. The product is sold as a bottle of 60 capsules, and the label lists a serving size of 2 capsules with 30 servings per container. Each serving provides 800 mg of L-Leucine, 100 mg of L-Isoleucine and 100 mg of L-Valine, all listed as free form and usp. The label notes that no Daily Value has been established for these amino acids. The other ingredients are Kosher Bovine Gelatin, Microcrystalline Cellulose and Magnesium Stearate. The product is classified under the Amino acid/Protein product type with a capsule supplement form. Its listed dietary claims are nutrient and structure/function. The intended target group is adults aged 18 to 50 years, and the label marks the product as kosher and gluten free. The label directions say to consume 2 BCAA 1000 capsules one to two times per day. It advises taking them between meals, 30 minutes before a workout, and or immediately after a workout, or as directed by a qualified health consultant. The label states that the product supports muscle recovery and describes an 8 times more powerful 8:1:1 leucine ratio. The brand says BCAAs have been used by bodybuilders, strength trainers and endurance athletes to activate muscle synthesis and reduce muscle breakdown caused by intense training. The label says the product is designed by and made exclusively for Advanced Nutrient Science Intl., Largo, FL, USA. It is manufactured in an FDA registered and GMP certified facility and is listed as made in the U.S.A. The label carries several seals and symbols, including GMP, gluten free, banned substance free BSF, and Quality Products CHECKDED. Precautions say to consult a physician before use if there are any medical conditions, to keep the product out of reach of children, and not to take it if pregnant or nursing. The label advises storing the product in a cool, dry place. The FDA disclaimer states that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. The FDA statement of identity is dietary supplement, and the formulation statement says the product does not contain gluten. This page is a label record only. It shows no price, no customer ratings and no written reviews. The page also lists other ANSI Pro-Series labels, including Fast Gain 3000 and Iso-Gro 62 flavours, but those are separate products and are not part of this record.

Product Focus: Muscle and Strength
Tier ⓘ
Tier 4 · Rank 72
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 72 within Tier 4 for Muscle and Strength; 114 of 119 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
33 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
– no stars shown, 55 reviews
Biohacker Mentions
9 of 10

Study, Trial or Testing Result Summary

Members Only83 human studies · 38 improved

1 of these 83 human studies gave the ingredient by drip, not by mouth.

83 human studies38 improved20 no effect17,604 people studied

Leucine is the main ingredient here, at a full daily amount. Leucine-rich protein supplements improved muscle strength, mass and performance in older adults with age-related muscle loss [1]. A leucine and vitamin D enriched whey drink added a small amount of muscle and improved chair-stand performance, but not grip strength [2]. A larger pooled analysis reported gains in muscle, grip and walking speed, though the evidence was rated low quality [3]. Leucine taken on its own, without added protein, mostly did not help. It did no better than placebo in frail older adults doing strength training [4], and it added nothing in midlife women who were lifting weights [5]. A review concluded that leucine alone did not work, while leucine paired with protein did [6]. Isoleucine and valine are both well below the doses studied. The amino acid mixes containing them gave mixed results: some trials showed small lean mass gains [7][8], while others showed no added muscle or strength [9][10][11]. Animal and cell studies are never counted.

See all 83 studies →Hide the studies

Review Totals and Summary

Members Only55 reviews
55 reviews · GNC 31 · MaxMuscle 19 · Life Pro Nutrition 5

These themes come from reviews of comparable 1,000 mg BCAA capsules, not from ANSI-specific reviews, which I could not find. Customers like the convenience of capsules. They are portable, tasteless and don't need mixing, which makes them an easy add to a gym bag or a fasted morning routine. Many users say they notice a subjective benefit, such as feeling less sore or recovering better, especially while cutting calories or training hard. One reviewer said they could tell a difference on the days they skipped the capsules. Some people credit the capsules with helping them stay consistent with an amino acid routine, because the format is simpler than flavored powders. The most common complaint is dose. Many buyers point out that the BCAA content per capsule is small, and that a full serving of several capsules adds up to only a couple of grams. One critic calculated that they would need a dozen or more capsules to match the BCAAs in a single serving of a high-end whey protein. Others say the cost per gram of BCAAs is poor next to powders, and that powders deliver larger doses. Swallowing is another recurring issue. Some users find the capsules large or hard to take in multiples, and taking several at once is a nuisance. A few mention that the very fine powder inside can come up as a burp or reflux if the capsule is taken without enough water. In one case, the powder came up through the nose and mouth. Skeptical reviewers also question whether BCAAs help at all for people who already eat enough protein. They say they felt no change in strength or size and see the product as a placebo or an unnecessary extra. Several recommend whole protein or complete essential amino acid products as better value. Reports of side effects were uncommon, with occasional mentions of stomach upset or a bitter aftertaste. Overall, buyers see these capsules as a convenient but low-dose supplement, and satisfaction depends heavily on expectations.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it

Most of the panel recommends leucine, with eight of ten giving a latest position of recommends, one saying they use it, and one warning. They take it because it acts as the main signal that switches on muscle building, and several say it matters more as people get older. Doses cluster around 2 to 3 grams per meal, with a few going to 3 to 5 grams per meal, one suggesting 1 gram in a capsule with a meal, and two pointing to roughly 8 or 9 grams a day; one panelist mentioned a pre-workout drink that mixes leucine with protein powders and L-citrulline, and another favors a two-molecule form called dileucine. Several say food such as beef, whey, eggs and other animal protein can supply enough, and two say supplementing adds little if you already eat plenty of high quality protein. Cautions came from a few panelists who raised worries about high leucine levels and aging or disease risk, and one panelist said it tastes horrible; isoleucine and valine, smaller ingredients in this product, were each mentioned by one panelist in passing.

See all 9 biohackers →Hide the biohackers
  • Ben Greenfield · Leucine · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      Describes leucine as the 'ignition' that turns on the signal for muscle protein synthesis, and that a sufficient dose is needed to hit the dose response and then have other essential amino acids to maintain the signal.
    • 9 Jul 2026 · recommends · YouTube ↗
      States that leucine is the primary trigger for muscle protein synthesis and recommends an essential amino acid blend with about 40% leucine for maximum stimulation.
    • 15 Apr 2026 · recommends · X ↗
      Recommends pulsing with compounds like leucine for maintaining and building muscle and maximizing muscle protein synthesis.
    • 20 Feb 2025 · recommends · YouTube ↗
      Recommends Dileucine as a next-generation supplement for muscle recovery and protein synthesis, stating it delivers 86% more leucine to muscles and triggers 60% more protein synthesis than regular leucine, especially when paired with exercise.
    • 28 Dec 2024 · uses · YouTube ↗
      Dave Pascoe mixes up a concoction of different protein powders, leucine, and L-citrulline as a pre-workout drink.
    • 12 Dec 2024 · neutral · Podcast ↗
      Discusses the role of leucine in boosting muscle protein synthesis on plant-based diets.
    • 17 Aug 2024 · uses · YouTube ↗
      Mixes leucine into a concoction of protein powders before his workout.
    • 30 May 2024 · neutral · Podcast ↗
      Discusses a study that claimed escalating doses of leucine from animal-based protein could cause issues with monocytes and macrophages, potentially leading to atherosclerosis, but he refutes the generalizability of these findings to humans.
    • 4 Jan 2024 · warns · YouTube ↗
      Warns against using only leucine, as it induces only a short, transient response in muscle protein synthesis, which is not enough for long-term gains in muscle mass and function.
    • 20 Jul 2023 · recommends · YouTube ↗
      Suggests that Urolithin A blends well with branched-chain amino acids like leucine and isoleucine, making them top things to stack with.
    • 20 Jul 2023 · Isoleucine · recommends · YouTube ↗
      Suggests that Urolithin A blends well with branched-chain amino acids like leucine and isoleucine, making them top things to stack with.
    • Date not recorded · Isoleucine · recommends · Website ↗
      Recommends Isoleucine, as found in Kion Aminos, stating it is important for blood sugar regulation, muscle development and repair, and energy regulation.
    • Date not recorded · Valine · recommends · Website ↗
      Recommends Valine, as found in Kion Aminos, stating it is needed for muscle fiber firing, tissue repair, and the maintenance of proper nitrogen balance in the body.
  • Dr. Eric Berg · Leucine · recommends
    • 22 Oct 2026 · recommends · Podcast ↗
      The amino acid leucine is important for muscle growth, but getting sufficient protein is just as essential for maintaining muscle mass.
    • 18 Oct 2026 · neutral · YouTube ↗
      Mentions that animal protein provides leucine, an amino acid beneficial for muscle building.
    • 23 Sep 2026 · recommends · Podcast ↗
      Recommends getting enough leucine, a key amino acid for muscle growth, to help prevent and correct muscle loss.
    • 22 Jul 2026 · neutral · Podcast ↗
      Explains that leucine is an essential amino acid that signals muscles to grow, and its requirements increase with age, making it important for maintaining muscle after menopause.
    • 23 Oct 2025 · neutral · YouTube ↗
      Mentions that eggs contain all essential amino acids, including leucine, which is a key amino acid for building muscle.
    • 2 Oct 2025 · neutral · YouTube ↗
      Notes that the amino acid leucine, found in animal protein, stimulates insulin.
    • 21 Oct 2024 · neutral · Podcast ↗
      Notes that red meat contains leucine, an amino acid that triggers the synthesis of muscle.
    • 10 Apr 2023 · neutral · YouTube ↗
      Explains that leucine is essential for muscle growth and that plant-based proteins often lack sufficient amounts of it.
    • 7 Apr 2023 · neutral · YouTube ↗
      Notes that leucine is a potent stimulus for muscle production and is often low in plant-based foods.
    • 19 Aug 2021 · recommends · YouTube ↗
      Highlights leucine as an essential amino acid that has been found to stimulate muscle growth and prevent muscle loss, making it good for muscle atrophy.
    • 27 Dec 2019 · Valine · neutral · Podcast ↗
      Dr. Berg lists Valine as one of the three types of Branched Chain Amino Acids.
    • 27 Dec 2019 · Isoleucine · neutral · Podcast ↗
      Dr. Berg lists Isoleucine as one of the three types of Branched Chain Amino Acids.
    • 16 Jul 2013 · Valine · recommends · YouTube ↗
      Dr. Berg recommends consuming Valine, which increases muscle repair, as part of a supplement before bed every night.
    • 16 Jul 2013 · Isoleucine · recommends · YouTube ↗
      Dr. Berg recommends consuming Isoleucine, a recovery amino acid, as part of a supplement before bed every night.
  • Thomas DeLauer · Leucine · recommends
    • 19 Oct 2026 · recommends · YouTube ↗
      Identifies leucine as the primary trigger for the mtorc1 pathway, which is the master switch for muscle protein synthesis, and recommends 2 to 3 grams per meal for those under 40, and 3 to 4 grams for those over 40.
    • 25 Sep 2026 · neutral · Facebook ↗
      Explains that leucine is important for muscle, with beef, whey, milk, and sardines clearing the 2-3g leucine threshold per meal, and that the threshold increases with age.
    • 21 Sep 2026 · neutral · Facebook ↗
      States that leucine is what flips the switch for muscle protein synthesis, and that adding leucine and essential amino acids to a small dose of whey can match the effect of a full 25-gram dose of protein.
    • 6 Jun 2026 · neutral · YouTube ↗
      Notes that leucine, an important amino acid for muscle growth, activates mTOR signaling after exercise, triggering the first step in building new muscle, and that leucine plus carbs together have the strongest signaling effect.
    • 24 Feb 2026 · recommends · YouTube ↗
      Recommends taking 3 to 5 grams of leucine with meals, especially for older individuals who may struggle to meet minimum protein requirements, as it can help preserve muscle and increase muscle protein synthesis.
    • 23 Dec 2025 · recommends · YouTube ↗
      Recommends protein sources that are high in leucine as a '401k of your fat burner' because they lead to more metabolically active lean tissue, especially for people dropping weight.
    • 26 Nov 2025 · recommends · YouTube ↗
      Explains that leucine skyrockets mTor and phosphorylates P7S6K, which is exactly what one wants to be activating, especially post-workout but throughout the day if trying to build muscle and recover.
    • 30 Aug 2025 · Isoleucine · neutral · YouTube ↗
      Mentions that some people believe avoiding isoleucine is key to the sugar diet, potentially increasing FGF-21.
    • 22 Aug 2025 · neutral · YouTube ↗
      Notes that leucine, found in whey protein, is highly anabolic and can help add muscle even without significant resistance training, which takes stress off the liver.
    • 26 May 2025 · recommends · YouTube ↗
      Advises considering the leucine content of proteins and the ileal digestibility to maximize protein absorption for muscle growth.
    • 28 Apr 2025 · neutral · YouTube ↗
      Notes that mTor is activated by branch chain amino acids, particularly leucine, and that higher circulating leucine generally leads to higher mTor activity.
    • 27 May 2024 · Isoleucine · neutral · YouTube ↗
      Mentions isoleucine as one of the best amino acids for stimulating GLP-1 and thus hunger suppression.
    • 27 May 2024 · Valine · neutral · YouTube ↗
      Mentions valine as one of the best amino acids for stimulating GLP-1 and thus hunger suppression.
    • 26 Aug 2020 · Isoleucine · neutral · YouTube ↗
      Notes that increased levels of isoleucine in the blood, observed during fasting, are a strong indicator that fasting could have powerful rejuvenation effects that improve aging by preserving muscle and combating sarcopenia.
  • Dr. Rhonda Patrick · Leucine · recommends
    • 30 Sep 2026 · recommends · YouTube ↗
      Notes that foods high in leucine are going to really support muscle protein synthesis.
    • 5 Dec 2024 · recommends · YouTube ↗
      Explains that Leucine is the critical signal driving robust activation of mTOR, which plays key roles in skeletal muscle growth by driving muscle protein synthesis and recovery, but also notes a study suggesting Leucine might activate mTOR in the vascular system, promoting plaque buildup.
    • 30 Jul 2024 · neutral · YouTube ↗
      Highlights that leucine is an amino acid with strong signaling properties, stimulating the mTOR pathway and setting off the anabolic cascade for muscle protein synthesis.
    • 3 Jul 2023 · neutral · YouTube ↗
      Mentions that leucine, a branched-chain amino acid, and other essential amino acids may be partially protective against declines in muscle mass, but not entirely effective against strength declines.
    • 6 Dec 2022 · neutral · YouTube ↗
      Discusses leucine as an amino acid that kick-starts the muscle-growth process, noting that 2 to 3 grams may be important for older individuals to kick-start that process, but does not recommend it as a supplement if consuming high-quality animal-based protein sources.
    • 29 Jun 2022 · warns · YouTube ↗
      Warns that leucine is extraordinarily bitter and requires food science to mask its taste. He also states that leucine supplementation should be a last resort, advocating for a food-first approach.
    • Date not recorded · neutral · Website ↗
      Identifies leucine as a major activator of mTORC1, which is critical for muscle protein synthesis.
    • Date not recorded · neutral · Website ↗
      Notes that leucine is the highest affinity amino acid sensor for mTORC1, explaining why branched-chain amino acids, particularly leucine, are used to enhance muscle growth or prevent degradation during exercise. He believes 5 grams during a workout is probably not harmful.
  • Dr. Mark Hyman · Leucine · recommends
    • 10 Aug 2026 · recommends · YouTube ↗
      Dr. Mark Hyman, agreeing with the guest, highlights leucine as a primary amino acid important for muscle protein synthesis.
    • 14 Jan 2026 · neutral · YouTube ↗
      States that leucine is important for muscle health and is the rate-limiting amino acid for turning on the switch that starts muscle building.
    • 25 Jun 2025 · recommends · YouTube ↗
      Recommends leucine, an amino acid, for making muscle.
    • 11 Sep 2024 · neutral · YouTube ↗
      Highlights leucine as an essential amino acid that is nearly highest in protein sources and acts as a unique amino acid for metabolic signaling, like a switch that turns on muscle building.
    • 19 Apr 2024 · recommends · YouTube ↗
      States that high amounts of leucine, an amino acid mostly found in animal protein, are needed to activate the switch to turn on muscle building, specifically about 2.5 grams per serving.
    • 23 Feb 2024 · warns · YouTube ↗
      Warns that leucine, which is much higher in animal protein, is the rate-limiting step for building muscle, and without 2.5 grams in a protein meal, the switch to build muscle won't be turned on.
    • 5 Feb 2024 · neutral · YouTube ↗
      Explains that leucine is very low in plant proteins and is necessary to trigger protein synthesis, which is critical for building muscle.
    • 15 Jan 2024 · neutral · YouTube ↗
      Mentions that leucine is important for building muscle and that some plant proteins are 'jacked up' with extra amino acids and leucine, citing an example of a plant protein with 2.5 grams of leucine.
    • 5 Jan 2024 · recommends · YouTube ↗
      Recommends supplementing with leucine, an amino acid critical for activating muscle synthesis, especially for those on a vegan diet, as plant proteins are typically low in it.
    • 18 Oct 2023 · recommends · YouTube ↗
      Recommends eating for leucine, an amino acid that comes in the right amounts to feed skeletal muscle.
    • 18 Oct 2023 · Valine · recommends · YouTube ↗
      Recommends eating for valine, an amino acid that comes in the right amounts to feed skeletal muscle.
    • 18 Oct 2023 · Isoleucine · recommends · YouTube ↗
      Recommends eating for isoleucine, an amino acid that comes in the right amounts to feed skeletal muscle.
  • Andrew Huberman · Leucine · recommends
    • 25 Jun 2026 · recommends · YouTube ↗
      Suggests that adding free leucine, perhaps one gram in a capsule with a normal meal, can significantly boost protein synthetic response, especially for plant-based individuals.
    • 30 Oct 2025 · warns · YouTube ↗
      Suggests that leucine, because it triggers cellular growth by activating the mTOR pathway, is actually pro-aging, similar to growth hormone and testosterone, offering immediate benefits at the expense of long-term health.
    • 25 Apr 2025 · neutral · YouTube ↗
      Andrew Huberman explains that leucine is an essential amino acid important for inducing muscle protein synthesis, and it is found in high levels in sources like whey protein, beef, chicken, and eggs.
    • 10 Apr 2025 · neutral · Podcast ↗
      Discusses leucine.
    • 24 Jun 2024 · recommends · YouTube ↗
      States that leucine is uniquely stimulating to skeletal muscle and recommends consuming closer to 9 grams of leucine per day, which is two to three times the RDA, for optimal muscle health.
    • 18 Dec 2023 · warns · YouTube ↗
      Notes that leucine, isoleucine, and valine, which are branch chain amino acids, make insulin go up.
    • 18 Dec 2023 · Valine · warns · YouTube ↗
      Notes that leucine, isoleucine, and valine, which are branch chain amino acids, make insulin go up.
    • 18 Dec 2023 · Isoleucine · warns · YouTube ↗
      Notes that leucine, isoleucine, and valine, which are branch chain amino acids, make insulin go up.
    • 7 Nov 2022 · recommends · YouTube ↗
      Explains that leucine is almost exclusively responsible for increasing muscle protein synthesis when protein is consumed, but supplementing with leucine does not make people more muscular because muscle building involves both synthesis and degradation.
    • 27 Dec 2021 · warns · YouTube ↗
      Suggests that leucine, by triggering cellular growth through the mTOR pathway, could be pro-aging, and that maximizing muscle growth through such supplements might come at the expense of long-term health.
    • 6 Sep 2021 · recommends · YouTube ↗
      Huberman states that the amino acid leucine is vital for cell growth, including muscle growth, due to its relationship with the mTOR pathway, and suggests ingesting it early in the day for maintaining or increasing muscle mass.
    • 21 Jun 2021 · neutral · YouTube ↗
      Clarifies that Leucine, an amino acid, is important for muscle building, muscle growth, and strength, distinguishing it from Lutein.
  • Dave Asprey · Leucine · warns
    • 3 Feb 2026 · warns · YouTube ↗
      States that very low levels of leucine are probably promoting high levels of protection against aging and diseases, but also promoting frailty, and high levels of this amino acid could be a risk for developing a number of diseases.
    • 23 May 2023 · recommends · YouTube ↗
      Recommends ensuring enough Leucine, specifically two and a half grams, to activate muscle protein synthesis, otherwise consumed protein may not be effective.
    • 25 Apr 2023 · neutral · YouTube ↗
      States that 2.5 grams of leucine are needed in a meal to activate mTOR and stimulate muscle synthesis.
    • Date not recorded · recommends · Website ↗
      Recommends consuming leucine, which preserves body muscle and is found in higher amounts in animal foods.
  • Peter Attia · Leucine · recommends
    • 26 Sep 2025 · recommends · YouTube ↗
      States that leucine is critical for muscle protein synthesis and recommends around 8 or 9 grams a day for optimal muscle health.
    • 21 Sep 2025 · recommends · YouTube ↗
      Recommends two to three grams of leucine a day for muscle health, with optimal health probably around eight or nine grams.
    • 30 Aug 2024 · neutral · YouTube ↗
      Recounts a story where a vegan doctor chastised him for suggesting ingesting five grams of leucine during a workout due to its negative effect on mTOR and potential link to cancer, which Peter Attia found amusing.
    • 25 May 2024 · warns · YouTube ↗
      Warns that there is no benefit to supplementing leucine specifically if one is already consuming enough high-quality protein, and notes that leucine tastes horrible.
    • 24 Apr 2024 · neutral · YouTube ↗
      Mentions that estimations suggest two to three grams of Leucine in a meal will induce a rapid increase in circulating Leucine, stimulating muscle protein synthesis.
    • 22 Apr 2024 · recommends · YouTube ↗
      Highlights that leucine content is an important factor in the anabolic response, and adding free leucine to casein can increase its anabolic effect.
    • 18 Apr 2024 · recommends · YouTube ↗
      Recommends tracking amino acids and ensuring 2 to 4 grams per serving of leucine for muscle mass.
    • 14 Mar 2024 · neutral · YouTube ↗
      Discusses experiments on Leucine and its effect on muscle protein turnover and fat metabolism.
    • 9 Mar 2024 · neutral · YouTube ↗
      Mentions Leucine as one of the four signals that regulate mTOR, which is involved in protein synthesis.
    • 25 Sep 2023 · neutral · YouTube ↗
      Explains that leucine binds to a protein called sestrin, which acts as its receptor, and the crystal structure shows how leucine is nestled in a small pocket, making it difficult to mimic its anabolic effects with other molecules.
  • Siim Land · Leucine · uses
    • 18 Aug 2024 · uses · YouTube ↗
      Despite high protein and whey intake, Siim Land's leucine levels remain low, hovering around 70, which he attributes to increased muscle mass and the body fighting infection.
    • 18 Aug 2024 · Isoleucine · neutral · YouTube ↗
      Notes that his isoleucine levels went down because he is taking leucine, which is a branch chain amino acid.
    • 15 Mar 2024 · neutral · YouTube ↗
      States that leucine is associated with longevity, and most studies indicate that higher levels are important for longevity.
    • 15 Mar 2024 · Valine · recommends · YouTube ↗
      Suggests supplementing with valine because studies show that higher levels are related to longevity, and his own levels tend to be lower.
    • 10 Feb 2024 · neutral · YouTube ↗
      Mentions that leucine, an essential amino acid, acts as a signal for muscle protein synthesis, though not as strong as resistance training.
    • 22 Oct 2023 · recommends · YouTube ↗
      Siim Land, agreeing with the guest, states that 2.5 grams of Leucine per meal maximizes anabolic protein synthesis in the muscle, ensuring muscle tissue maintenance.
    • 23 Nov 2022 · neutral · YouTube ↗
      Identifies leucine as an essential amino acid that is most responsible for increasing mTOR activation and muscle protein synthesis, linking it to protein intake, aging, and cancer.
    • 27 Aug 2022 · recommends · YouTube ↗
      Recommends consuming at least 2.5 grams of leucine to reach the optimal intake for muscle protein synthesis.
    • 30 Jan 2022 · neutral · YouTube ↗
      Explains that leucine is a critical amino acid for turning on MTOR and promoting protein synthesis, and while it is pro-growth, its impact on aging is complex.
    • 29 Dec 2021 · neutral · YouTube ↗
      Explains that leucine is the most anabolic amino acid responsible for mTOR activation, with a threshold of around 2 to 3 grams.
    • 10 Mar 2019 · recommends · YouTube ↗
      States that leucine-rich foods like eggs and dairy are the highest sources of leucine, which activates mTOR.
    • 18 Feb 2019 · neutral · YouTube ↗
      States that leucine specifically activates mTOR C1 the most and promotes muscle protein synthesis.

RAL Summary

Members OnlyTier 4 for Muscle and Strength

The review summary comes from comparable 1,000 mg BCAA capsules by other makers, not from reviews of this ANSI product, so it is set aside. Its reviews are set aside, so it is graded on its studies alone. Human studies support L-Leucine (10 of 24 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 20 of the 83 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system

Combine with: For muscle building and recovery, pair BCAAs with creatine monohydrate (3-5 g daily) for strength and power, and whey or a complete protein source, since BCAAs alone provide only 3 of the 9 essential amino acids and are less effective without the rest. Add vitamin D3 and magnesium to support muscle function and recovery, and electrolytes or citrulline malate for hydration and endurance during training. If the goal is weight management, consider green tea extract (EGCG) with caffeine, soluble fiber such as glucomannan, or berberine for metabolic support, while keeping adequate protein intake to preserve lean mass during a calorie deficit. Consult a healthcare provider before combining supplements, especially with medications or existing conditions.

Possible side effects: No major side effects reported.

Supplement Facts

L-Leucine 800 mg · L-Isoleucine 100 mg · L-Valine 100 mg
Supplement Facts
Serving Size 2 Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
L-Leucine800 mg†
L-Isoleucine100 mg†
L-Valine100 mg†
† Daily Value not established.

Other ingredients: Kosher Bovine Gelatin, Microcrystalline Cellulose, Magnesium Stearate.

Directions: DIRECTIONS: As a dietary supplement, consume 2 BCAA 1000(TM) capsules 1-2 times per day. For best results take between meals, 30 minutes before workout and/or immediately after workout or as directed by your qualified health consultant.

Barcode (UPC) 689570405097 · Label source: NIH label database · Report a label change

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Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.