Apollon Nutrition Bare Knuckle - Non-Stimulant Nitrate Infused Pre-Workout V6 Review
Bare Knuckle V6 is presented as an upgrade to the original Bare Knuckle formula, designed as a stimulant-free pre-workout that the brand says pushes performance further. The page says the formula is loaded with massive clinical-level doses, heavy nitrate technology, extreme focus support, full performance hydration and advanced pump ingredients, and that it contains zero proprietary blends, zero fillers and zero stimulants. The brand states that every ingredient was selected for a purpose and every dose was built to perform. The page groups the formula into several areas. For pumps and blood flow, it lists 10,000mg L-Citrulline, 4,200mg Arginine Nitrate (NO3-T), 508mg Vaso-Drive AP and 400mg Grape Seed Extract, and it says the result is explosive pumps, enhanced vascularity and increased nitric oxide production. For focus, it lists 6,000mg L-Tyrosine, 800mg Alpha GPC and 400mcg Huperzine A, and it claims tunnel-vision focus without crash, jitters or heart-racing overstimulation. For performance and hydration, it lists 6,400mg Beta Alanine, 5,000mg Betaine Anhydrous, 3,000mg Taurine, Himalayan Pink Salt with Potassium, and AstraGin for absorption, and it says the product supports endurance, power output, hydration, muscular performance and recovery. The page explains dosing by scoop. Each tub provides 40 half servings or 20 full servings. The brand says a half scoop already hits harder than most non-stim formulas, while a full scoop is more aggressive. It advises new users to assess their tolerance first and describes the product as feeling more like a strong pre-workout than a typical stim-free formula. The page names its intended users as late-night trainers, athletes cycling off stimulants, pump chasers, strength athletes, focus-driven lifters, and anyone tired of weak stim-free formulas. The product is sold in the grape, pineapple blackberry margarita and strawberry margarita flavours, with a one-time purchase price of $64.99 and a subscription option. The page also carries a Prop 65 style lead warning and the brand's commitment statement covering evidence-based formulation, third-party lab testing, transparent ingredients and US manufacturing. The page does not print a full supplement facts panel or a barcode in the text provided.
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Study, Trial or Testing Result Summary
Members Only41 human studies · 19 improved
The label lists only nitrates at 20.5 grams per serving. That is far above the roughly 400 milligrams used in studies and probably reflects the whole scoop rather than the nitrate content, so the true nitrate dose cannot be confirmed. The citrulline and beta alanine named in the store listing were not graded here. For blood flow, the nitrate evidence is mixed. A pooled review of 14 trials in people with heart failure or high lung blood pressure found nitrates raised the heart's pumping output during exercise and slightly lowered resting blood pressure, but did not improve oxygen use [1]. A pooled review of 11 trials in people with chronic lung disease found better blood vessel function and exercise capacity [2]. In adults with high blood pressure, a single nitrate-rich beetroot juice drink improved blood vessel lining function and heart blood supply [3], and in another small trial it lowered blood pressure and improved small vessel blood flow in muscle [4]. Other trials found no benefit. Six weeks of nitrate did not help exercise or blood vessel widening in heart failure [5], and 16 weeks did not lower blood pressure or artery stiffness in early high blood pressure [6]. Animal and cell studies are never counted.
See all 41 studies →Hide the studies
- Across 14 trials of 469 people with heart failure or pulmonary hypertension, nitrates raised heart output and stroke volume during exercise and slightly lowered resting blood pressure and right atrial pressure, but did not improve oxygen use.Systematic review and meta-analysis of nitrates/nitrites in patients with heart failure or pulmonary hypertension.
- Across 11 trials of 287 people with chronic lung disease, dietary nitrate improved blood vessel function and exercise capacity and eased breathlessness.Dietary nitrate supplementation to enhance exercise capacity in patients with COPD: Evidence from a meta-analysis of ran…
- In five observational studies of 63,155 adults, higher vegetable nitrate intake was linked to lower heart disease risk and death, with benefits levelling off at moderate intake.Associations between Vegetable Nitrate Intake and Cardiovascular Disease Risk and Mortality: A Systematic Review.
- In 12 crossover trials in older adults, six reported better blood pressure or blood flow with dietary nitrate and six found no improvement.Performance and Health Benefits of Dietary Nitrate Supplementation in Older Adults: A Systematic Review.
- A review of 37 human and 14 animal studies found vascular benefits of dietary nitrate mainly in healthy people, with limited evidence in people at risk of heart disease.Nitrate, the oral microbiome, and cardiovascular health: a systematic literature review of human and animal studies.
- A review of 11 randomized trials found beetroot juice, a nitrate source, may lower blood pressure in healthy and hypertensive people.Dietary Nitrate from Beetroot Juice for Hypertension: A Systematic Review.
- A review of 29 studies found dietary nitrate seemed to improve function of large blood vessels, while effects on small blood vessels appeared modest.The effect of dietary nitrate on macro- and microvascular function: A systematic review.
- In 84 people with heart failure with preserved ejection fraction, six weeks of potassium nitrate raised blood nitric oxide metabolites but did not improve exercise capacity, work performed, vasodilatory reserve or quality of life compared with potassium chloride.Potassium Nitrate in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
- In 81 adults aged 30-70, three days of sodium nitrate compared with sodium chloride had no effect on brain blood flow responses to breath-holding or visual stimulation.APOE gene-dependent BOLD responses to a breath-hold across the adult lifespan.
- In 39 young and 36 older adults, two weeks of nitrate-rich beetroot juice lowered mean arterial blood pressure in older adults by about 4 mmHg but not in young adults, and blood vessel dilation was not improved in older adults.Ageing modifies the oral microbiome, nitric oxide bioavailability and vascular responses to dietary nitrate supplementat…
- In 66 people with early-stage high blood pressure, 16 weeks of high-nitrate vegetable powder (about 400 mg nitrate) did not lower blood pressure or improve artery stiffness more than low-nitrate powder (about 50 mg).No Difference between the Efficacy of High-Nitrate and Low-Nitrate Vegetable Supplementation on Blood Pressure after 16 …
- In 62 overweight and obese older adults, 13 weeks of beetroot juice at low, medium or high nitrate doses did not change blood flow in the brain's frontal cortex or thinking performance compared with placebo.Incremental Doses of Nitrate-Rich Beetroot Juice Do Not Modify Cognitive Function and Cerebral Blood Flow in Overweight …
- In 58 adults aged 65 and older with isolated systolic hypertension, 12 weeks of 40-60 mg sustained-release isosorbide mononitrate did not reduce pulse pressure more than placebo, and vascular function did not improve.Sustained-release isosorbide mononitrate as adjuvant treatment in isolated systolic hypertension in the elderly.
- In 40 healthy adults, a single drink of beetroot juice changed blood flow in the front of the brain during mental tasks and improved one cognitive test compared with placebo.Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-co…
- In 38 young adults, a single dose of beetroot juice lowered resting blood pressure similarly in Black and White participants, but the drop occurred in males and not in females.Acute beetroot juice reduces blood pressure in young Black and White males but not females.
- In 37 adults with treated high blood pressure, a single 500 mL drink of nitrate-rich beetroot juice improved endothelial function and heart blood supply compared with placebo.Acute Effects of Dietary Nitrate on Central Pressure and Endothelial Function in Hypertensive Patients: A Randomized, Pl…
- In 29 overweight adults on a 14-day calorie-restricted diet, adding nitrate-rich beetroot juice improved small-blood-vessel blood flow and endothelial function and slowed thinking-test times (TMT-B) compared with calorie restriction alone, while blood pressure changes were similar between groups.Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves …
- In 25 adults with long COVID, 14 days of beetroot juice providing about 600 mg nitrate did not change flow-mediated artery dilation compared with placebo.Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in…
- In 22 healthy volunteers who gave blood, beetroot juice taken for 48 hours afterward reduced the oxygen cost of moderate exercise and cut the drop in peak cycling power from 5.0% to 2.7% compared with placebo juice.Dietary nitrate supplementation attenuates the reduction in exercise tolerance following blood donation.
- In 21 people with narrowed leg arteries, 8 weeks of sodium nitrate reduced the rise in systolic blood pressure during a cold-water stress test, while placebo did not.Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease.
- In 20 healthy adults aged 60 to 75, seven days of beetroot juice did not change resting or exercise blood pressure or heart function compared with placebo.Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults: a randomi…
- In 18 untreated adults with high blood pressure, a single drink of nitrate-rich beetroot juice lowered blood pressure at rest and during arm squeezing, and improved blood flow in muscle small vessels compared with a nitrate-free drink.Dietary nitrate improves muscle microvascular reactivity and lowers blood pressure at rest and during isometric exercise…
- In 18 abdominally obese men, a single drink of potassium nitrate did not change artery widening or artery reactivity compared with a placebo drink.Acute Effects of Inorganic Nitrate Intake on Brachial and Femoral Flow-Mediated Vasodilation, and on Carotid Artery Reac…
- In 15 healthy older men, a single dose of beetroot juice with 800 mg nitrate improved blood vessel widening in the thigh artery compared with placebo juice, with no change in blood pressure.Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Old…
- In 15 adults aged 56 to 71 with treated hypertension, about 800 mg of dietary nitrate daily from beetroot juice for 4 weeks did not change forearm blood flow or 24-hour or home blood pressure compared with placebo juice.Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood…
- In 15 healthy men, a single 140 ml dose of nitrate-rich beetroot juice lowered systolic blood pressure by about 7 mmHg and diastolic by about 6 mmHg compared with nitrate-depleted juice, though the size of the response varied widely between individuals.Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placeb…
- In 14 young adults, a single dose of beetroot juice reduced nerve signals that tighten blood vessels at rest and during handgrip exercise compared with placebo, but blood pressure did not change significantly.Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof…
- In 13 healthy young men, beetroot juice taken 2.5 hours before maximal forearm handgrip exercise did not change oxygen delivery, blood lactate, or exercise performance, though oxygen cost per unit of force was lower.Influence of acute dietary nitrate supplementation on oxygen delivery/consumption and critical impulse during maximal ef…
- In 12 young men, a single dose of nitrate-rich beetroot juice (about 13 mmol nitrate) lowered central blood pressure slightly at all times of day but did not change brachial blood pressure or time to exhaustion in cycling.Influence of acute dietary nitrate supplementation timing on nitrate metabolism, central and peripheral blood pressure a…
- In 12 participants, a single dose of nitrate-rich beetroot juice lowered diastolic blood pressure by about 2 mmHg compared with placebo juice, and the drop was linked to higher red blood cell S-nitrosothiol levels.Relationships between nitric oxide biomarkers and physiological outcomes following dietary nitrate supplementation.
- In 11 healthy young adults, drinking 140 mL of beetroot juice before 3 hours of sitting prevented the drop in leg artery endothelial function seen after placebo.Prior beetroot juice ingestion offsets endothelial dysfunction following prolonged sitting.
- In 10 hypertensive postmenopausal women, a single nitrate-rich supplement improved blood vessel control during arm exercise compared with a nitrate-poor placebo, although blood pressure did not differ.Impact of Acute Dietary Nitrate Supplementation during Exercise in Hypertensive Women.
- A single 140 mL dose of nitrate-rich beetroot juice lowered mean arterial pressure in 10 healthy men but did not change blood flow to the fingers during cold water immersion compared with placebo.Effects of acute dietary nitrate supplementation on cold-induced vasodilation in healthy males.
- In 8 moderately trained adults taking nitrate-rich beetroot juice for 5 days, muscle energy recovery after exercise in low oxygen was faster and muscle oxygen delivery improved compared with placebo.Dietary nitrate accelerates postexercise muscle metabolic recovery and O2 delivery in hypoxia.
- In 7 healthy adults, 3 days of a daily 25 mL beetroot juice shot did not change skin reactive hyperaemia, though diastolic blood pressure fell.Cutaneous reactive hyperaemia is unaltered by dietary nitrate supplementation in healthy humans.
- In 6 healthy young men, 5 days of beetroot juice with about 400 mg nitrate restored compensatory forearm blood vessel widening during reduced blood pressure and improved exercise capacity compared with placebo juice.Dietary nitrate restores compensatory vasodilation and exercise capacity in response to a compromise in oxygen delivery …
- In elderly adults given dietary nitrate for 4 weeks in a placebo-controlled trial, blood levels of an inflammatory protein fell, vascular function improved, and central systolic blood pressure dropped.Modulation of circulating macrophage migration inhibitory factor in the elderly.
- Three days of beetroot juice providing about 450 mg nitrate daily increased skin blood vessel widening during heat stress at control sites and lowered blood pressure during heat stress, though resting blood pressure did not change significantly.Augmented reflex cutaneous vasodilatation following short-term dietary nitrate supplementation in humans.
- A single dose of beetroot powder nitrate improved arterial stiffness at all doses tested, and aortic systolic blood pressure dropped by about 4 mmHg only at the highest dose (800 mg), while brachial blood pressure did not change.The dose-response effects of nitrate-rich beetroot ingestion on cardiovascular and endothelial function: a randomised co…
- In 25 people with stable COPD, 8 days of beetroot juice raised exhaled nitric oxide but did not improve lung gas exchange surface area or exercise performance compared with placebo juice.Influence of dietary nitrate supplementation on lung function and exercise gas exchange in COPD patients.
- This review found no link between nitrate dose and changes in peak muscle power across healthy adults, athletes, older adults and some clinical groups, and calls for more research on dosing.Effects of dietary nitrate supplementation on peak power output: Influence of supplementation strategy and population.
Review Totals and Summary
Members Only69 reviews · 92% positive
The store shows 69 ratings in total (Apollon Nutrition website, via Judge.me), with an average of 4.62 out of 5. The themes below come from the written reviews that could be read on that page, and only a handful of those include any text, so the written detail is very thin even though the rating count is not. Most ratings are five stars, with a small share of lower ones. All the written comments concern the powder, so no other forms needed to be set aside. What buyers praise most is the stimulant-free positioning. Kent Fiedor, the most detailed reviewer, says the formula contains the essential ingredients he wants without caffeine, and he highly recommends it. Performance feedback is also positive. One reviewer titled their comment "Insane Focus and Pump," which fits the page's emphasis on pumps, blood flow and mental focus from its nootropic ingredients. Another reviewer, Grayson F, left only a title, "Straight Gas," which hints at a strong energising effect even without caffeine, though there is no review text to confirm any details. One short review simply loves the taste and calls it a great pre-workout. The main complaint is taste. One reviewer says the performance is great but the taste is bad. Opinion on flavour is therefore mixed: one person loves it and another dislikes it. The comments are too brief to say anything about mixing, texture or aftertaste, so flavour-sensitive buyers should choose their flavour carefully. On dosing, Kent Fiedor started with a half scoop because of the formula's beta alanine content. He also added extra L-citrulline to his routine and planned to move up to a full scoop. This suggests that people sensitive to beta alanine may want to begin with a half serving and adjust gradually. As for who it seems to suit, the product appeals to people who want a pre-workout without caffeine or other stimulants, and to those who care about pumps and focus. It may also suit users who are happy to tweak their own dosing, such as starting low or adding extra citrulline. Nothing in the written feedback speaks to value for money or price. Several of the ratings are just stars with a title or a store invitation note and no body text. They add to the overall average without adding written detail. The written themes overall are strong focus and pump, appreciation for a stim-free option, mixed views on taste, and the tip to start with a half scoop. Anyone looking for detailed long-term feedback will not find it here, because the written comments are short and recent.
Biohacker Summary
Members Only10 of 10 recommend it
Nitrates are the main ingredient here, and the panel is split by source. Of the eight panelists who spoke about them, four recommend them and one uses them, mainly from beetroot and leafy greens or powders, to widen blood vessels, improve blood flow, and support workout power and endurance. One panelist advises taking them 60 to 90 minutes before training, with the largest carb meal, and another pairs them with creatine; one panelist noted the benefit is not seen in elite athletes. Three panelists are neutral, and several warn against nitrates in processed and cured meats, linking them to cancer risk, migraines, depression, and inflammation, while one explains that plant nitrates behave differently thanks to vitamin C. Other cautions include avoiding nitrates for cluster headaches, one warning about arterial stiffness, and one claiming nitrates block iodine absorption, and no one said they stopped taking them.
See all 8 biohackers →Hide the biohackers
Dr. Eric Berg · Nitrates · neutral
- Dietary nitrates, once converted into nitric oxide, may help relax blood vessels and support healthy circulation.
- Warns that chemical nitrates in processed meats can break down into harmful things, create oxidation, and increase the risk for certain types of cancer.
- Warns that nitrates, when exposed to high heat, can turn into carcinogens.
- Lists nitrates as a top cause of iodine deficiency.
- Warns that nitrates, another waste product from fertilizers, block iodine absorption.
- Warns that nitrates, specifically sodium nitrate used to preserve processed meats, increase the risk of cancer. He distinguishes these from nitrates found in celery juice.
- Recommends increasing nitrates from foods like beets, spinach, kale, and other leafy greens to improve nitric oxide production.
- States that watercress has naturally occurring nitrates, which are good for the inside of the arteries, may help make arteries less stiff, help keep blood pressure from going too high, and may also help with exercise performance.
- States that beets are loaded with natural nitrates that help to support blood pressure and arteries.
- Warns that nitrates, found in tap water at 10 times the recommended level, are known to cause cancer.
Peter Attia · Nitrates · recommends
- Recommends avoiding foods with nitrates for patients with cluster headaches.
- Explains that nitrates, found in beetroot, are converted to nitric oxide in the body, which helps with vasodilation and improves blood circulation, thereby boosting V2 Max. However, he notes that this effect is not observed in elite athletes.
- Discusses nitrates and athletic performance.
Dave Asprey · Nitrates · recommends
- Recommends taking a source of nitrates with creatine to improve blood flow, leading to greater muscle perfusion and power output.
- Recommends combining BFR with nitrates to help with nitric oxide production, provided the necessary enzymes are present to break down nitrate into nitrite.
- Dave Asprey shares next-level stacking strategies by combining creatine with nitrates to maximize both mental and physical results and for peak performance.
- Dave Asprey warns that nitrates, found in cured meats like salami, hot dogs, and bacon, may cause mania, euphoria, hyperactivity, and insomnia due to their conversion into nitrosamines by gut bacteria.
- Eating foods high in nitrates, such as celery, spinach, chard, arugula, and cabbage, can increase nitric oxide levels throughout the body.
Thomas DeLauer · Nitrates · recommends
- Recommends using nitrates as a performance enhancer, consuming nitrate-rich foods or powders 60 to 90 minutes before a workout or mentally demanding task, and with the largest carb meal for blood sugar and metabolic control.
- Warns that nitrates can cause potential atherosclerotic issues, such as arterial stiffness, and can impact the brain, advising to avoid them when possible.
- Recommends taking products high in nitrates, such as food products like tomatoes and beets, or supplements, to improve tissue quality and enhance power output during workouts.
- Recommends taking products high in nitrates to enhance tissue quality and maximize performance during training and recovery days.
- Warns that nitrates in added processed meats can drive depression, noting that some supermarkets now label products as nitrate-free.
- Warns against large amounts of nitrates and nitrites in soups, as they can convert in the stomach and combine with proteins to create harmful nitrosamines.
- States that nitrates and nitrites are not as bad as people think, often coming from celery powder, but prefers celery powder over artificial nitrites.
- Recommends getting dietary nitrates to improve the ATP coupling phase by increasing oxygen availability and phosphocreatine synthesis.
Siim Land · Nitrates · uses
- States he eats plenty of dietary nitrates from beetroot and other vegetables.
- Recommends supplementing with nitrates, found in beetroot juice, as it has been shown to improve VO2 max by increasing oxygen delivery to muscles through nitric oxide-induced vasodilation.
- Explains that nitrates, found in vegetables like beets and greens, are beneficial for the oral microbiome, acting as a prebiotic to favor good bacteria and reduce pathogenic ones like P. gingivalis.
- Warns that nitrates, found in processed meats, lead to inflammation.
- Recommends foods high in nitrates like arugula, certain lettuces, or beetroot to further enhance nitric oxide production and blood flow delivery during exercise, helping to deliver collagen peptides.
Ben Greenfield · Nitrates · recommends
- Recommends eating a diet rich in nitrates, such as arugula and beetroot, for erection quality.
- Ben warns that nitrates and nitrites, found in cured meats, have been linked to cancer in lab animals and humans, especially when consumed in high amounts or without natural nutrients like vitamin C.
- Is not convinced that nitrates and nitrites are carcinogenic, noting that the body naturally produces large amounts of them and that the chemical structure is identical to those found in foods.
Dr. Mark Hyman · Nitrates · neutral
- Discusses the proposed mechanism that processed meat's high concentration of nitrates and nitrites, which are food additives, may promote insulin resistance by forming carcinogenic nitrosamines under high heat.
- Mentions that nitrates in ultra-processed meats can drive depression.
- Warns that nitrates, found in deli meats, are significant chemical triggers for migraines.
- Advises cutting down on nitrates in the diet to prevent cancer.
- Dr. Hyman advises against nitrates found in deli meats as a chemical trigger for migraines.
- Dr. H lists nitrates from deli meat as a chemical trigger that can cause migraines.
Dr. Rhonda Patrick · Nitrates · neutral
- Rhonda clarifies that nitrates, found in plants, tend to form beneficial nitric oxide rather than harmful nitrosamines due to the presence of vitamin C in plants, which shifts the pathway.
RAL Summary
Members OnlyTier 3 for Circulation
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Muscular system
Combine with: For vascular and blood flow support, this pairs well with magnesium (glycinate or taurate) to support vessel relaxation, omega-3 fish oil (EPA/DHA) for endothelial function, and CoQ10 for cardiovascular energy metabolism. Vitamin C or other polyphenols (such as pomegranate or grape seed extract) may help protect nitric oxide from oxidation. Citrulline can be complemented with L-arginine or agmatine, and taurine and potassium may add support for circulation and fluid balance. For true blood pressure goals, consider potassium-rich foods, magnesium, hawthorn, and a product designed for blood pressure, under medical guidance.
Possible side effects: No major side effects reported in the studies. One reviewer disliked the taste, and another started with a half scoop because of the beta alanine content.
Supplement Facts
Potassium 25 mg · L-Citrulline 5000 mg · Beta Alanine 3200 mg
| Calories | 5 | |
| Total Carbohydrate | 1 g | |
| Total Sugars | 0 g | |
| Sodium | 100 mg | |
| Potassium | 25 mg | |
| L-Citrulline | 5,000 mg | † |
| Beta Alanine | 3,200 mg | † |
| L-Tyrosine | 3,000 mg | † |
| Betaine Anhydrous | 2,500 mg | † |
| Arginine Nitrate | 2,100 mg | † |
| Taurine | 1,500 mg | † |
| Alpha GPC 50% | 400 mg | † |
| Vaso-Drive AP (Casein Hydrolysate) | 254 mg | † |
| Himalayan Pink Salt | 250 mg | † |
| Grape Seed Extract (Vitis Vinifera) (Seed) | 200 mg | † |
| AstraGin (Panax Notoginseng (Root) and Astragalus Membranaceous (Root)) | 25 mg | † |
| Huperzine A | 200 mcg | † |
Other ingredients: Natural & Artificial Flavors, Citric Acid, Malic Acid, Sucralose.
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Graded November 7, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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