BetterYou D3000 Vitamin D Daily Oral Spray Review

Product Focus: Blood SugarAlso covers:HormonesMetabolism
Tier ⓘ
Tier 2 · Rank 39
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 39 within Tier 2 for Blood Sugar; 39 of 82 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
68 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
95% of 1,800
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members Only39 human studies · 13 improved
39 human studies13 improved16 no effect327,504 people studied

Each spray serving gives 75 micrograms of vitamin D, a full dose compared with the studies, though above the usual daily upper limit, so members can take less. In people with type 2 diabetes, two large pooled analyses found that vitamin D modestly lowered fasting blood sugar, the long-term blood sugar marker and insulin resistance. The benefit was largest in people low in vitamin D and with higher doses over shorter periods [1][2]. In adults with prediabetes, three placebo-controlled trials found vitamin D cut the risk of developing diabetes by 15% over about 3 years [3]. In pregnant women, 53 trials found about 36% less pregnancy diabetes [4]. The evidence is not all positive. A trial of 22,220 older adults taking 2000 units daily for about 5 years found no significant drop in diabetes risk [5]. Another pooled analysis of people with prediabetes found no change in fasting blood sugar, although the glucose tolerance test improved [6]. Overall, vitamin D seems to help blood sugar modestly, mostly in people who are low in it. Animal and cell studies are never counted.

See all 39 studies →Hide the studies

Review Totals and Summary

Members Only1,800 reviews · 95% positive
1,800 reviews · Google Shopping 1,800
95% positive0% neutral5% negative

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

Vitamin D is the only ingredient here, and the panel leans clearly in favor: all ten spoke about it, and most either take it or recommend it. People take it because food and sun rarely supply enough, especially in fall and winter or with limited sun exposure, and they link it to bone strength, brain and mood, immune function, muscle, and longevity. The form named most often is vitamin D3, and three of them take 5,000 IU in the morning, while one suggests at least 10,000 IU a day and others aim for blood levels, such as 40 to 100 ng/mL depending on who is speaking. Several say to take it with dietary fat for better absorption, and two pair it with vitamin K2 for calcium and bone health. One panelist cautions that supplementing is pointless for most purposes unless you are deficient, and no one said they stopped taking it.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin D · neutral
    • 8 Nov 2026 · neutral · Facebook ↗
      Lists Vitamin D as an ingredient found in sardines.
    • 7 Nov 2026 · recommends · Facebook ↗
      Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
    • 7 Nov 2026 · neutral · Instagram ↗
      Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
    • 6 Nov 2026 · recommends · Podcast ↗
      Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
    • 6 Nov 2026 · recommends · YouTube ↗
      Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
    • 5 Nov 2026 · recommends · Podcast ↗
      Suggests that increasing vitamin D3 may help address the underlying problem of bruxism.
    • 2 Nov 2026 · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 1 Nov 2026 · neutral · YouTube ↗
      States that magnesium is needed to absorb vitamin D.
    • 31 Oct 2026 · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
  • Dr. Rhonda Patrick · Vitamin D · neutral
    • 8 Nov 2026 · neutral · Instagram ↗
      Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
    • 4 Nov 2026 · neutral · Instagram ↗
      States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
    • 28 Oct 2026 · recommends · YouTube ↗
      Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
    • 5 Oct 2026 · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 24 Sep 2026 · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
    • 22 Jul 2026 · neutral · YouTube ↗
      Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
  • Thomas DeLauer · Vitamin D · recommends
    • 5 Nov 2026 · recommends · YouTube ↗
      Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
    • 11 Sep 2026 · recommends · YouTube ↗
      Recommends getting vitamin D, suggesting it can be obtained while walking.
    • 6 Sep 2026 · recommends · Instagram ↗
      States that vitamin D is best obtained from the sun, but getting it from food definitely helps, and notes its role as a hormone influencing many cells.
    • 1 Sep 2026 · recommends · Instagram ↗
      Recommends D3, suggesting a dose of 2000-4000 IU, and notes that MK-7 slowed bone loss over three years.
  • Dr. Mark Hyman · Vitamin D · uses
    • 4 Nov 2026 · uses · YouTube ↗
      Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
    • 29 Oct 2026 · neutral · YouTube ↗
      Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
    • 26 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 8 Oct 2026 · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
    • 5 Oct 2026 · neutral · Podcast ↗
      Mentions vitamin D as a key nutrient for supporting immune function.
    • 5 Oct 2026 · recommends · YouTube ↗
      States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
  • Dave Asprey · Vitamin D · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 9 Oct 2026 · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
    • 3 Sep 2026 · recommends · YouTube ↗
      States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
    • 29 Aug 2026 · recommends · YouTube ↗
      Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
    • 18 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin D as one of the most important supplements for overall health.
    • 12 Aug 2026 · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
    • 28 Jul 2026 · uses · YouTube ↗
      Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
  • Siim Land · Vitamin D · recommends
    • 31 Oct 2026 · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 24 Oct 2026 · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks vitamin D has some of the strongest evidence and is worth considering.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
    • 26 Aug 2026 · recommends · Instagram ↗
      Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
    • 23 Aug 2026 · neutral · X ↗
      Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
    • 17 Aug 2026 · recommends · X ↗
      Recommends taking Vitamin D in the morning or at lunch with fat.
    • 14 Aug 2026 · neutral · X ↗
      Notes that Boron improves vitamin D.
    • 5 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin D because microglia contain Vitamin D receptors, and Vitamin D helps keep the immune system properly regulated, with low levels associated with greater neuroinflammation and a higher risk of autoimmune conditions.
  • Ben Greenfield · Vitamin D · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 20 Aug 2026 · uses · YouTube ↗
      Has been taking Vitamin D3 K2 for over a decade.
    • 8 Aug 2026 · neutral · Instagram ↗
      Notes that sunlight influences more than just vitamin D production.
    • 8 Aug 2026 · recommends · YouTube ↗
      Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
    • 18 Jul 2026 · recommends · YouTube ↗
      Recommends getting enough vitamin D for blood pressure management.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
    • 7 Jun 2026 · recommends · Facebook ↗
      Recommends using hormone building blocks like vitamin D for hormone optimization.
    • 6 May 2026 · neutral · X ↗
      Notes that vitamin D deficiency is the most common deficiency.
  • Bryan Johnson · Vitamin D · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 3 Jul 2026 · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 14 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 8 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 7 Apr 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
  • Andrew Huberman · Vitamin D · neutral
    • 21 Sep 2026 · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 7 Aug 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 20 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 13 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 12 Jul 2026 · uses · X ↗
      He takes 5,000 IU of Vitamin D3 in the morning for overall health.
    • 6 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 22 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for general health.
    • 17 Jun 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 every day for longevity.
    • 6 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
  • Peter Attia · Vitamin D · uses
    • 4 Jan 2026 · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 6 Aug 2025 · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 3 Aug 2025 · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 10 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 6 Jul 2025 · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
    • 8 Jun 2025 · recommends · YouTube ↗
      Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
    • 17 Mar 2025 · neutral · Instagram ↗
      Discusses evaluating vitamin D, understanding deficiency, and optimal levels.

RAL Summary

Members OnlyTier 2 for Blood Sugar

Several large pooled analyses show modest improvements in blood sugar and diabetes risk with vitamin D, especially in people who are low in it [1][2][3], and 95% of 1,800 reviews are positive.

Where the evidence disagrees: 16 of the 39 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Endocrine system, Metabolic system

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: No major side effects reported. The dose is above the usual daily upper limit, so members may prefer to take less.

Supplement Facts

Vitamin D 75 mcg
Supplement Facts
Serving Size 0.13 mL
Servings Per Container 100
Amount Per Serving% Daily Value
Vitamin D75 mcg

Other ingredients: Water, Xylitol, Acacia Gum, Sunflower Lecithin, Potassium Sorbate, Citric Acid, natural Peppermint Oil.

Directions: How to use Initial use: press the pump 3 times to get the liquid flowing. Shake well before every use. Carefully spray into your mouth, taste and swallow. Replace cap after use. Directions Use 1 spray daily.

Barcode (UPC) 000096032879 · Label source: NIH label database · Report a label change

Show entire label
The BetterYou D3000 Vitamin D Daily Oral Spray label, 0.51 Fluid Ounce(s); 15 Milliliter(s)
D3000 Vitamin D Daily Oral Spray, 0.51 Fluid Ounce(s); 15 Milliliter(s)

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Our articles on this subject

Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.