Thorne Berberine 500 mg Review

Berberine is a supplement derived from various plants, commonly used to support metabolic health, including maintaining healthy blood sugar and cholesterol levels.

Product Focus: CholesterolAlso graded for:Blood SugarWeight and Metabolism for WomenAlso covers:HeartDigestionMetabolism

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Evidence ⓘ

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How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.

Positive Reviews

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Biohacker Mentions

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Cost per month

$30

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Study, Trial or Testing Result SummaryMembersHuman studies

Berberine is present at 900 mg a day, the 600 mg daily dose that has in studies, and the research for cholesterol is . A pooled analysis of 18 placebo-controlled trials with 1788 adults found berberine bad cholesterol, total cholesterol and triglycerides compared with placebo over 4 to 24 weeks, though it caused stomach side . …

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Review Totals and SummaryMembers11,910 reviews

11,910 reviews · IHerb 5,834 · Amazon 5,661 · Thorne 283 · Walmart 113 · Target 19

Berberine 500mg receives reviews across major retailers like Amazon, iHerb, Walmart, and Target, with users frequently highlighting in their and wellness routines. customers mention taking Berberine 500mg for its purported metabolic support and describe seeing noticeable results in areas like blood sugar management, energy levels, and digestive comfort. …

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Biohacker SummaryMembersWhat our biohacker panel says

of the panel or uses berberine, the main ingredient here, and the top reason is blood sugar control, with seven or speaking to it, followed by cholesterol and artery , insulin sensitivity, and sleep. Two of them take 500 mg with meals, and one 500 mg three times with meals; one says doses up to 750 mg or a gram felt fine with a , carbohydrate-rich meal. …

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RAL SummaryMembersOur verdict

Berberine is dosed the amount that in trials, and pooled analyses show it bad and total cholesterol versus placebo. Reviews are and biohackers it.

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More DetailsMembersBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system, Digestive system, Metabolic system. Combine with and possible side are for members.

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Supplement FactsBerberine HCl 450 mg · Berberine Phytosome / Phospholipid Complex from Pea, Sunflower, Grape Seed) 550 mg

Supplement Facts

Serving Size Two Capsules

Servings Per Container 30

Amount Per Serving% Daily Value

Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata)	450 mg	†
Berberine Phytosome (Berberis aristata Extract (Root) / Phospholipid Complex from Pea, Sunflower, Grape Seed)	550 mg	†

† Daily Value not established.

Directions: Take 1-2 capsules two times daily with food or as recommended by your health-care practitioner.

Barcode (UPC) 693749048008 · Label source: Pureformulas · Report a label change

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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.