Blueprint Bryan Johnson Advanced Antioxidants Review

No study of this product or its ingredients showed biological age turned back. The strongest support comes from lycopene, at a full dose here. In 126 healthy men, 15 mg daily for 8 weeks raised antioxidant enzymes and cut DNA damage in white blood cells compared with placebo ^[1]. A 12 mg dose lowered DNA damage in older women ^[2], but a 3 week trial in 105 men found no change ^[3]. Astaxanthin, also at a full dose, lowered an oxidative damage marker and one inflammation signal in pooled trials ^[4] and improved skin moisture and elasticity ^[5]. Other pooled results called its antioxidant effect unclear ^[6], and a one year trial found no change ^[7]. Lutein at 10 mg lowered fat damage and sugar-damaged proteins over 32 weeks ^[8], though a trial in 175 men found no change ^[9]. The 2 mg of zeaxanthin is below the 12 mg lutein and zeaxanthin mixes that helped memory and skin ^[10][11]. Vitamin K1 is backed only by diet surveys linking it to longer telomeres and slower aging, which do not prove cause ^[12][13]. Vitamin K2 was tested only as a skin cream, not a pill ^[14]. Animal and cell studies are never counted.

The main ingredients here are astaxanthin, zeaxanthin and lycopene, and the panel leans positive on astaxanthin most of all. Of the five who spoke about astaxanthin, three recommend it or use it, mainly for eye health and to reduce oxidative stress, one is neutral and notes it has human evidence, and one has stopped after trying it, while another says they love it and could not live without it despite weaker anti-aging numbers. On zeaxanthin, three panelists spoke: one recommends getting it from real food or an eye formula, another recommends 4 milligrams especially for heavy screen users to filter blue light, and one is neutral but says it may be among the best backed carotenoids for brain and eye health. Only one or two spoke on lycopene, with one recommending it for skin and one neutral, citing tomato data on lung health. Vitamin K is a smaller ingredient in this product, and most of the panel takes or recommends vitamin K2, often 90 to 100 micrograms in the morning or paired with vitamin D, for bone and calcium health.

Combine with: For bone health, pair this with the nutrients that actually drive bone mineralization: vitamin D3 (1,000-2,000 IU daily, adjusted to blood levels) to support calcium absorption, vitamin K2 (MK-7, 90-180 mcg) to direct calcium into bone, magnesium (glycinate or citrate, 200-400 mg), and calcium from diet or a supplement if intake is low (roughly 1,000-1,200 mg total daily). Collagen peptides and boron may add support, and resistance training and adequate protein are important. Keep the antioxidants for general oxidative stress support, and talk to a clinician about high-dose vitamin E, especially if taking meds.