BSN Clean BCAAs Watermelon Review
This page is a Dietary Supplement Label Database entry for BSN Clean BCAAs Watermelon, DSLD ID 58287, entered on 22 April 2016. The product is sold as a powder with a net content of 8.47 oz (240 grams) and 30 servings per container. The listed serving size is 8 grams, and the label directs users to mix one scoop with 8 to 10 ounces of cold water before, during, or after training. The Supplement Facts panel lists 5 calories and 1 gram of total carbohydrates per serving, along with 60 mg of Vitamin C as ascorbic acid, which provides 100% of the Daily Value. The formula includes a micronized BCAA blend of 3 grams, identified as L-Leucine, L-Isoleucine, and L-Valine, plus 500 mg of micronized L-Glutamine and 500 mg of micronized Taurine. Daily Values for these last three components are not established. The other ingredients are natural and artificial flavors, malic acid, citric acid, calcium silicate, silicon dioxide, sucralose, lecithin, tartaric acid, and acesulfame potassium. The label names the product as BCAAs Advanced Recovery Formula and states that it supports muscular endurance, recovery, and performance, and that it is intended for use in healthy adults as part of a healthy, balanced diet and exercise program. The label carries a Banned Substance Tested seal and an Informed Choice seal, and it notes that Informed-Choice testing was performed by LGC Limited. It is marked gluten-free and contains soy in the form of lecithin. It is also described as free of FD&C dyes, fillers, and gluten. The label carries directions and precautions, including that the product is not for anyone under 18 or for women who are pregnant, trying to become pregnant, or nursing, and that people taking medications should consult a physician first. It should be stored in a cool, dry place away from direct sunlight. The product is manufactured by Bio-Engineered Supplements & Nutrition, Inc. in Aurora, Illinois, and is made in the USA with ingredients of domestic and foreign origin. This page reports label information only and includes no retail price or customer reviews.
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Study, Trial or Testing Result Summary
Members Only132 human studies · 60 improved
5 of these 132 human studies gave the ingredient by drip, not by mouth.
The main ingredient, a branched-chain amino acid blend, comes at a full 3 grams. A pooled review of 35 trials in older adults found these amino acids modestly improved muscle strength and muscle mass, though results varied widely [1]. In people with liver scarring, they improved grip strength [2], gave a small gain in muscle mass [3] and increased thigh muscle and strength over 28 days [4]. But in 30 women doing weight training they added nothing beyond training alone [5], and a year-long trial found them no better than whey protein [6]. Glutamine, at a dose of unclear match to studies, did not build muscle in a pooled review of 25 athlete trials [7] or in young adults doing weight training [8]. Taurine has never been tested alone for muscle; support comes only from mixes such as energy drinks [9]. Vitamin C here is well below studied doses, and studies found it neither helped nor hurt training gains [10], while higher doses with vitamin E sometimes blunted gains [11]. Animal and cell studies are never counted.
See all 132 studies →Hide the studies
- Across 14 trials of 1,437 people with cirrhosis, BCAA improved handgrip strength compared with placebo, and BCAA with vitamin D improved muscle index more than BCAA alone, though the evidence was low certainty.Efficacy of different nutrition interventions on sarcopenia in patients with cirrhosis: a systematic review and network …
- Across 18 placebo-controlled trials with 322 people, vitamins C and E together before a single exercise session lowered fat oxidation damage, interleukin-6, cortisol and creatine kinase, but did not change muscle soreness or muscle strength.Effects of the combination of vitamins C and E supplementation on oxidative stress, inflammation, muscle soreness, and m…
- Across 18 placebo-controlled trials with 313 healthy people, vitamin C lowered fat oxidation damage and interleukin-6 after a single exercise session but did not change muscle damage, soreness or strength.Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-ana…
- Across 13 trials of 258 people with short bowel syndrome, glutamine combined with growth hormone and a modified diet increased body weight and lean body mass but not fat mass, though the effect of glutamine alone cannot be separated.Clinical evidence of growth hormone, glutamine and a modified diet for short bowel syndrome: meta-analysis of clinical t…
- In seven trials of 206 people with cirrhosis, exercise and nutrition (including BCAA among others) improved muscle index and albumin when continued for 12 months, but BCAA effects were not separated out.Effects of exercise and nutrition in improving sarcopenia in liver cirrhosis patients: a systematic review and meta-anal…
- In nine resistance training trials lasting at least 4 weeks, vitamin C and/or E neither helped nor hurt gains in lean mass or muscle strength.The effects of vitamin C and E on exercise-induced physiological adaptations: a systematic review and Meta-analysis of r…
- In eight trials of exercise-induced muscle damage, BCAA lowered a blood marker of muscle damage compared with placebo but did not significantly reduce muscle soreness.Branched-chain amino acid supplementation and exercise-induced muscle damage in exercise recovery: A meta-analysis of ra…
- Across 35 trials in older adults, BCAA-rich supplements modestly improved muscle strength and muscle mass compared with controls, with high variation between studies.Effects of branched-chain amino acid-rich supplementation on EWGSOP2 criteria for sarcopenia in older adults: a systemat…
- Across 20 trials in people with cirrhosis, BCAA gave a small gain in muscle mass compared with other treatments, but no change in fat mass.Efficacy of branched chain amino acids supplementation in liver cirrhosis: A systematic review and meta-analysis.
- In a meta-analysis of 25 trials in adult athletes, glutamine had no effect on lean body mass, body fat or aerobic performance, and was linked only to a small reduction in body weight.The effect of glutamine supplementation on athletic performance, body composition, and immune function: A systematic rev…
- Across 34 studies, a single serving of caffeine-containing energy drinks improved muscle strength and endurance, endurance exercise, jumping and sport-specific actions but not sprinting, and higher taurine doses were linked to better performance.Acute effects of caffeine-containing energy drinks on physical performance: a systematic review and meta-analysis.
- In 30 trials of 1976 critically ill adults, mostly of amino acids including glutamine, only six trials measured muscle and none showed a clear benefit from glutamine, so the evidence was too uncertain to conclude.A systematic review to assess the impact of amino acids or their derivatives on skeletal muscle wasting in critically il…
- In 12 trials of 1,337 older adults, BCAA with vitamin D improved muscle mass and strength in most trials, while BCAA alone did not improve muscle health in two trials.The Role of Nutrition in the Treatment of Sarcopenia in Old Patients: From Restoration of Mitochondrial Activity to Impr…
- In 12 studies of 1,225 people with cirrhosis, BCAA improved muscle index and mid-arm muscle size from baseline but not handgrip strength.Effects of Branched-Chain Amino Acids on Parameters Evaluating Sarcopenia in Liver Cirrhosis: Systematic Review and Meta…
- In a review of supplements for cancer-related muscle wasting, vitamin C improved some quality of life measures but no muscle benefit was shown, and evidence overall was not solid enough to recommend it.A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in …
- In a review of ten studies in people after knee ligament surgery, vitamin supplements showed no benefit for muscle loss, and vitamins C and E may have increased local muscle inflammation.Supplement Use in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Systematic Review.
- This broad review of nutrients for healthy aging in older adults mentions vitamin C among helpful nutrients but gives no specific muscle-building results and calls for more clinical studies.Nutraceuticals and their role in promoting musculo-skeletal healthy aging.
- In people with motor neuron disease, BCAA did not improve survival, muscle strength or function in the pooled trials.Amino acids for amyotrophic lateral sclerosis / motor neuron disease.
- A review of 40 articles in adults and children with liver cirrhosis found branched chain amino acids may improve muscle strength, though results varied and firm conclusions were limited.Effects of branched chain amino acid supplementation on patient care outcomes in adults and children with liver cirrhosi…
- A review of 19 articles found 2-10 g per day of branched chain amino acids, mostly in young men, helped muscle recovery after hard resistance exercise and may improve strength and muscle function.Intake of branched chain amino acids favors post-exercise muscle recovery and may improve muscle function: optimal dosag…
- A review of nine trials in adults 50 and older found beef and its nutrients, including amino acids and protein, had an overall positive effect on wellbeing, but leucine had no effect.The potential role of beef and nutrients found in beef on outcomes of wellbeing in healthy adults 50 years of age and ol…
- A review of 27 small studies in adults with cirrhosis found diet plus exercise worked best for body composition, with some benefit also seen from branched-chain amino acid supplements.The Effect of Diet and Exercise Interventions on Body Composition in Liver Cirrhosis: A Systematic Review.
- In five trials of adults with short bowel syndrome, growth hormone with or without glutamine increased weight and lean body mass, but the benefits were short-lived and glutamine's own contribution was unclear.Human growth hormone and glutamine for patients with short bowel syndrome.
- In six studies of adults doing strength exercise, glutamine alone did not change muscle strength between groups (only less perceived weakness), while glutamine with other nutrients looked favorable, but data were insufficient.[GLUTAMINE AS AN AID IN THE RECOVERY OF MUSCLE STRENGTH: SYSTEMATIC REVIEW OF LITERATURE].
- Among nine trials in hip and knee replacement patients, one paper reported a mixture of HMB, arginine and glutamine reduced muscle strength loss after knee replacement, with limited evidence overall.What Is the Role of Nutritional Supplements in Support of Total Hip Replacement and Total Knee Replacement Surgeries? A …
- In 472 advanced cancer patients taking an HMB, glutamine and arginine mixture twice daily for 8 weeks, lean body mass did not differ significantly from placebo, though there was a trend toward higher lean mass and only 37% finished treatment.A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mi…
- In 220 people with cirrhosis over 28 days, branched-chain amino acids, programmed exercise, or both increased quadriceps muscle thickness, muscle strength and performance compared with standard care alone.Effect of branched-chain amino acid supplementation and exercise on quadriceps muscle quantity and quality in patients w…
- In people with cirrhosis and weak muscle strength, 30 grams of BCAA daily for 12 months did not improve grip strength, muscle mass, or physical performance compared with whey protein.Branched-chain amino acid supplementation does not improve measures of sarcopenia in cirrhosis: results of a randomised …
- In 93 adults recovering from critical illness, a glutamine and essential amino acid drink taken twice daily for 3 months, combined with 6 weeks of physiotherapy, gave the biggest gains in walking distance, but the effect of the drink alone is not clear.Improving rehabilitation after critical illness through outpatient physiotherapy classes and essential amino acid supple…
- In 80 resistance-trained men taking a pre-workout blend including 500 mg vitamin C for 8 weeks, body composition and most strength measures did not differ from placebo, and early strength gains at 4 weeks were similar to placebo by 8 weeks.Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in…
- In 80 older adults after lumbar spine surgery, 3 weeks of branched-chain amino acids plus vitamin D increased knee muscle strength at 12 weeks compared with a non-amino acid group, but did not change muscle mass or the primary clinical questionnaire score.Branched-chain amino acids plus vitamin D supplementation promote increased muscle strength following lumbar surgery for…
- In 72 people with cirrhosis, adding 110 g of daily branched-chain amino acids to a high-protein, high-fiber diet over 6 months increased muscle mass and reduced fat mass, with no rise in ammonia or glucose.Effect of a high-protein, high-fiber diet plus supplementation with branched-chain amino acids on the nutritional status…
- In 64 healthy women aged 50 to 80, two daily packs of a protein-enriched supplement with branched-chain amino acids for 12 weeks helped keep lean body mass from falling, while the placebo group gained body fat; strength and inflammation did not differ.Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A ra…
- In 68 sarcopenic older adults in hospital rehabilitation over eight weeks, branched-chain amino acids and vitamin D plus low-intensity resistance training gave greater gains in handgrip strength and calf circumference than training alone, though overall physical function gains did not differ.Effects of branched-chain amino acids and vitamin D supplementation on physical function, muscle mass and strength, and …
- In 68 people with HIV-related weight loss (43 finished), a mix of glutamine, arginine and HMB for 8 weeks led to a gain of about 2.6 kg of lean mass, while the placebo group lost about 0.7 kg.Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glu…
- In 66 older adults with low muscle mass, yogurt fortified with 500 mg vitamin C plus HMB and vitamin D for 12 weeks improved handgrip strength and walking speed more than plain yogurt, and also lowered inflammation and oxidative stress.A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled…
- In 64 adults with chronic lung disease doing rehabilitation, 4 weeks of 180 mg vitamin C in an antioxidant mix did not improve muscle endurance beyond placebo but raised muscle strength by 11% and cut the rate of muscle weakness from 30% to 10.7%.Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in CO…
- In 61 patients having abdominal cancer surgery, a glutamine, arginine and HMB supplement taken daily for 3 days before and 7 days after surgery did not change muscle mass, handgrip strength or wound complications compared with placebo.Perioperative Nutritional Support With Beta-hydroxy-beta-methylbutyrate, Arginine, and Glutamine in Surgery for Abdomina…
- In 60 older women with age-related muscle loss doing resistance training, 12 weeks of 1000 mg vitamin C plus vitamin E gave larger gains in arm lean mass, muscle mass index, grip strength and knee strength than placebo.Effects of vitamins C and E supplementation combined with 12-week resistance training in older women with sarcopenia: A …
- In 60 people with COPD in a 4-week lung rehabilitation program, daily branched-chain amino acid supplements were not more beneficial than rehabilitation with placebo.Does branched-chain amino acid supplementation improve pulmonary rehabilitation effect in COPD?
- In 60 people with cirrhosis and sarcopenia over six months, 12 g daily of branched-chain amino acids added to exercise did not increase muscle mass compared with placebo.Randomised clinical trial: effect of adding branched chain amino acids to exercise and standard-of-care on muscle mass i…
- In 57 older men and women, six months of vitamin C and E with or without resistance training changed body composition but did not change strength gains or pro-oxidant markers.Combined effect of antioxidant supplementation and resistance training on oxidative stress markers, muscle and body comp…
- In 54 frail people with cirrhosis, 16 weeks of twice-daily branched-chain amino acid supplements improved frailty in 36 percent of the group versus 0 percent of controls and increased skeletal muscle index.Branched-chain amino acids supplementation improves liver frailty index in frail compensated cirrhotic patients: a rando…
- In 50 burn patients, a tube feed enriched with vitamin C and other nutrients cut infections and hospital stay, but showed only non-significant trends toward preserving muscle mass.Differential effects of three enteral dietary regimens on selected outcome variables in burn patients.
- In 50 boys with Duchenne muscular dystrophy, glutamine at 0.6 g per kg daily for 6 months did not significantly change muscle strength compared with placebo.CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy.
- In 49 adults aged 70 or older with minor trauma, an HMB/arginine/glutamine complex for 2 weeks did not change thigh muscle size, grip strength or daily function compared with a glutamine-only complex.Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild …
- After tonsillectomy, patients taking branched-chain amino acids kept or gained muscle mass over three weeks, while the control group lost muscle mass.Effects of branched-chain amino acids on changes in body composition during the recovery period following tonsillectomy.
- In 47 adults with inflammatory muscle disease, 12 weeks of branched-chain amino acids did not improve overall muscle strength scores compared with placebo, but did improve repeated shoulder movement function.Branched chain amino acids in the treatment of polymyositis and dermatomyositis: a phase II/III, multi-centre, randomize…
- In 46 adults with long COVID fatigue, taking 500 mg of liposomal vitamin C with l-arginine twice daily for 28 days improved walking distance and grip strength more than placebo.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In 46 stroke patients doing two months of exercise, taking the leucine-enriched supplement with breakfast reduced body fat and improved leg strength and balance, though timing did not change muscle mass gains.The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Pa…
- In a randomized trial of 45 people with tennis elbow, a 30-day supplement containing 250 mg of vitamin C, collagen and hyaluronic acid, given with exercise and shock wave therapy, increased grip strength more than the other treatment groups, though vitamin C was not tested alone.Efficacy of extracorporeal shock wave therapy and nutraceutical supplementation in the treatment of lateral epicondyliti…
- In 45 older men, a single 6 gram branched-chain amino acid drink raised muscle protein building rates within the first two hours, though the effect did not last and was matched by milk protein only for the early period.Branched-chain amino acid and branched-chain ketoacid ingestion increases muscle protein synthesis rates in vivo in olde…
- In 44 people with moderate to severe chronic obstructive pulmonary disease, drinking a whey beverage fortified with vitamin C and magnesium daily for 8 weeks lowered inflammatory markers and increased lean body mass and grip strength compared with the control group.Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized c…
- In 44 patients having surgery for head and neck cancer, enteral glutamine after surgery significantly improved fat-free mass, serum albumin and quality of life compared with controls.Enteral glutamine supplementation in surgical patients with head and neck malignancy: A randomized controlled trial.
- In 44 elderly women taking L-glutamine or placebo for 30 days, the glutamine groups gained knee muscle strength and power and showed better blood sugar control and lower markers of oxidative stress.L-Glutamine Supplementation Enhances Strength and Power of Knee Muscles and Improves Glycemia Control and Plasma Redox B…
- In a trial of 44 adults aged 65 or older having heart surgery, taking 7000 mg of glutamine daily with beta-hydroxy-beta-methylbutyrate and arginine before surgery improved walking distance, strength and physical performance and shortened hospital stays, but did not change muscle mass.Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on cardiac surgery: A …
- In 42 young women doing strength training for 10 weeks, taking 1 g of vitamin C a day with vitamin E blunted gains in peak muscle torque and total work compared with placebo, although muscle thickness rose similarly in both groups.Effect of strength training combined with antioxidant supplementation on muscular performance.
- In 42 long-term ICU patients receiving medical nutrition for 4 weeks, the amount of glutamine and other individual amino acids was not linked to muscle loss.Is the amino acid pattern in medical nutrition therapy crucial for successfully attenuating muscle mass loss in adult IC…
- In 41 people over 4 weeks, 6 g per day of isolated leucine did not improve muscle mass or function in patients with head and neck cancer, while older adults without cancer gained a modest amount of muscle mass compared with the comparator amino acids.Short-term isolated leucine supplementation was not associated with improvements in muscle mass or function in patients …
- In 40 critically ill patients over 10 days, 40 g per day of high leucine branched-chain amino acids reduced quadriceps muscle thinning compared with control (0% vs -13%) and lowered interleukin-6 inflammation levels.High leucine branched-chain amino acids supplementation ameliorates quadriceps femoris muscle thickness reduction and at…
- In 40 people with rheumatoid arthritis and muscle wasting, a mix of HMB, glutamine and arginine over 12 weeks did not work better than a placebo amino acid mix for body composition.Dietary treatment of rheumatoid cachexia with beta-hydroxy-beta-methylbutyrate, glutamine and arginine: a randomised con…
- In 36 older adults with type 2 diabetes over 24 weeks, 8 g of branched-chain amino acids daily did not change skeletal muscle mass or blood sugar control compared with soy protein, though depressive symptoms improved in that group.Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderl…
- In 36 resistance-trained men over 10 weeks, a whey, branched-chain amino acid and 5 grams of glutamine daily drink did not increase lean mass more than a carbohydrate placebo, while whey plus casein did.The effects of protein and amino acid supplementation on performance and training adaptations during ten weeks of resist…
- In frail older adults in residential care, combining exercise with branched-chain amino acids over 40 weeks improved muscle strength, thinking tests, and lowered an inflammatory marker, more than exercise alone or the control group.Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Al…
- In 35 surgical patients, five days of intravenous branched-chain amino acids after surgery prevented the muscle breakdown seen with dextrose alone, leaving patients in nitrogen balance instead of a negative balance.Infusion of the branched chain amino acids in postoperative patients. Anticatabolic properties.
- In 35 young men given a creatine and arginine alpha-ketoglutarate blend (which also contained taurine, a dose not stated) or creatine alone for 10 days, bench-press repetitions rose versus placebo and the blend raised peak power, but lean mass did not change in any group.Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance.
- In 34 men aged 60 to 81 doing 12 weeks of strength training, 500 mg vitamin C plus vitamin E daily led to smaller gains in total lean mass and leg muscle thickness than placebo, though strength gains were similar in both groups.Vitamin C and E supplementation blunts increases in total lean body mass in elderly men after strength training.
- In healthy older men doing 12 weeks of strength training, taking 1000 mg vitamin C plus 235 mg vitamin E daily blunted the bone density gains seen with placebo.High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly me…
- In 32 people with cirrhosis and muscle loss, 12 weeks of branched-chain amino acids plus standard care improved muscle mass in 83% of the supplement group versus 47% of the placebo group, a difference that was not statistically clear.Adding Branched-Chain Amino Acids to an Enhanced Standard-of-Care Treatment Improves Muscle Mass of Cirrhotic Patients W…
- In 31 older women after hip replacement, 3.4 g of branched-chain amino acids taken after exercise for one month improved knee extension strength on some sides compared with starch, but not hip abductor strength on the operated leg.Effect of exercise therapy combined with branched-chain amino acid supplementation on muscle strength in elderly women a…
- In 31 young adults doing six weeks of resistance training, glutamine supplementation did not improve strength, muscle mass or muscle protein breakdown compared with placebo.Effect of glutamine supplementation combined with resistance training in young adults.
- In 31 patients with heart failure, 8 g/day of alanyl-glutamine plus fish oil for 3 months increased lean body mass and improved quality of life compared with placebo, but did not improve exercise performance or muscle function.Supplementation of l-Alanyl-l-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chro…
- In a placebo-controlled six-month trial of 31 healthy adults aged 65 to 89, a daily mixture containing 14 g of glutamine (with arginine and beta-hydroxy-beta-methylbutyrate) increased total body lean mass and improved timed stair climbing.Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy O…
- In 30 resistance-trained men doing three days of intense leg training, 6 g of branched-chain amino acids mixed with carbohydrate did not reduce strength loss or muscle soreness compared with carbohydrate alone.Post-exercise branched chain amino acid supplementation does not affect recovery markers following three consecutive hig…
- In 30 postmenopausal women doing 8 weeks of resistance training, adding 9 g per day of branched-chain amino acids did not improve muscle gains beyond training with placebo, though both groups gained muscle mass and strength.Effects of branched-chain amino acid supplementation and resistance training in postmenopausal women.
- In 30 critically ill trauma patients, alanyl-glutamine (0.3 g/kg a day for about 2 weeks) with growth hormone improved nitrogen balance and saved lean body mass, but it worsened insulin sensitivity and required more insulin.Frequent intravenous pulses of growth hormone together with glutamine supplementation in prolonged critical illness afte…
- In 30 ambulant boys with Duchenne muscular dystrophy, 4 months of oral glutamine (0.5 g/kg a day) did not improve walking speed, muscle function or muscle mass compared with placebo.Lack of functional benefit with glutamine versus placebo in Duchenne muscular dystrophy: a randomized crossover trial.
- In 30 people after gastric bypass surgery, 8 weeks of an oral supplement with HMB, glutamine and arginine did not change lean body mass or resting metabolic rate compared with no supplement.Nutritional effect of oral supplement enriched in beta-hydroxy-beta-methylbutyrate, glutamine and arginine on resting me…
- In 29 people recovering from anterior cruciate ligament surgery, 1000 mg vitamin C plus high-dose vitamin E for about 16 weeks did not change muscle strength compared with placebo.Serum cytokines and muscle strength after anterior cruciate ligament surgery are not modulated by high-doses of vitamins…
- In 29 college track and field athletes over 8 weeks, 4 grams of daily glutamine plus creatine increased lean body mass more than placebo.The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measure…
- In 28 elderly dialysis patients with low albumin and poor appetite, 12 grams a day of branched-chain amino acids for 6 months improved appetite, food intake, and overall nutritional status compared with placebo.Oral supplementation of branched-chain amino acid improves nutritional status in elderly patients on chronic haemodialys…
- In 28 resistance-trained men over 8 weeks, an effervescent creatine, ribose and glutamine drink did not improve strength, endurance or body composition more than placebo.Effects of effervescent creatine, ribose, and glutamine supplementation on muscular strength, muscular endurance, and bo…
- In 24 hemodialysis patients, 10 grams per day of an amino acid blend for 12 weeks increased thigh muscle thickness and fat-free mass and reduced oxidative stress and inflammation markers, without changing short-term physical performance.The Combined Use of Hydroxymethylbutyrate and Branched-Chain Amino Acids to Counteract Uremic Sarcopenia.
- In 23 trained men doing resistance training for 10 weeks, taking vitamin C with vitamin E produced similar leg and bench press strength gains to placebo but appeared to blunt upper body muscle gains and grip strength improvement.Antioxidant vitamin supplementation on muscle adaptations to resistance training: A double-blind, randomized controlled …
- In 23 patients having knee replacement surgery, a supplement containing L-glutamine with HMB and L-arginine prevented the drop in quadriceps strength seen in the control group over 14 days after surgery.Effects of supplementation with a combination of β-hydroxy-β-methyl butyrate, L-arginine, and L-glutamine on postoperati…
- In 23 liver transplant patients, a formula with HMB, L-arginine and L-glutamine given for 30 days after surgery increased grip strength and muscle mass index compared with controls.Effect of administration of β-hydroxy-β-methyl butyrate-enriched formula after liver transplantation: A pilot randomized…
- In 22 runners taking 1000 mg vitamin C and 300 mg vitamin E for 6 weeks before a 50-km ultramarathon, supplements did not reduce muscle damage or speed recovery of muscle strength compared with placebo.Antioxidants did not prevent muscle damage in response to an ultramarathon run.
- In 20 people with chronic heart failure, 12 weeks of a whey and branched-chain amino acid supplement during cardiac rehabilitation raised fat mass in the supplement group while improving peak oxygen use and walking distance within that group, though these changes did not differ significantly from controls.The Effects of an Oral Nutritional Supplement with Whey Peptides and Branched-Chain Amino Acids for Cardiac Rehabilitati…
- In a pilot trial of 20 liver cancer patients taking lenvatinib, a beverage of beta-hydroxy-beta-methylbutyrate, L-arginine and L-glutamine did not reduce hand-foot skin reactions, and its small trend toward keeping skeletal muscle mass was not statistically significant.An open-label, randomized, controlled trial on the benefit of β-hydroxy-β-methyl butyrate, l-arginine, l-glutamine combi…
- In 19 mechanically ventilated intensive care patients, 3 days of glutamine-supplemented feeding (0.4 g/kg a day) with growth hormone and IGF-I produced a net positive protein balance, whereas feeding alone did not.Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein an…
- In 18 patients with rheumatic disease on meds, 12 g of BCAA daily for 12 weeks increased whole-body muscle mass, strength, and mobility compared with no supplement in a small trial of 9 per group.The effects of bolus supplementation of branched-chain amino acids on skeletal muscle mass, strength, and function in pa…
- In 18 patients with rheumatic disease taking prednisolone, 12 weeks of added branched-chain amino acids limited the loss of thigh muscle, and higher blood levels of these amino acids were linked to greater muscle improvement.Amino Acid Profile in 18 Patients with Rheumatic Diseases Treated with Glucocorticoids and BCAAs.
- In 16 resistance-trained athletes, a single dose of BCAA (0.087 g per kg body weight) before squats sped recovery of strength, jump height, and soreness at 24 to 48 hours compared with placebo.The effects of acute branched-chain amino acid supplementation on recovery from a single bout of hypertrophy exercise in…
- In 16 healthy adults after eccentric knee exercise, 0.3 g/kg/day of glutamine over 72 hours speeded recovery of knee strength and reduced muscle soreness compared with placebo.The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Ext…
- In 14 trained male runners during a 21 km run, a branched-chain amino acid sports drink prevented the drop in leg strength seen with no drink or water and reduced next-day soreness compared with no drink.Consumption of a Branched-Chain Amino Acids-Containing Sports Beverage During 21 km of Running Reduces Dehydration, Lowe…
- In 13 resistance-trained men, drinking BCAA during a single upper body workout did not improve performance compared with placebo, though it lowered cortisol modestly when combined with carbohydrate.Effects of carbohydrate and branched-chain amino acid beverage ingestion during acute upper body resistance exercise on …
- In 12 young adults after a resistance workout, 6 g of branched-chain amino acids retained leucine in the body about five times more than collagen protein, matching a dileucine amino acid blend in a single-session crossover test.Dileucine-supplemented essential amino acids support whole-body anabolism after resistance exercise and serum-stimulated…
- In 12 adolescents with type 1 diabetes doing short exercise bouts for 3 months, glutamine at 0.5 g/kg/day did not change lean body mass significantly, and body fat loss was seen only when both groups were analyzed together.Can Short Bouts of Exercise ("Exercise Snacks") Improve Body Composition in Adolescents with Type 1 Diabetes? A Feasibil…
- In 8 resistance-trained men during four weeks of intense training, a high branched-chain amino acid supplement raised testosterone and lowered cortisol and muscle damage marker levels compared with placebo.Amino acid supplements and recovery from high-intensity resistance training.
- In 8 people with short bowel syndrome, 3 weeks of growth hormone, oral glutamine and a high-carbohydrate diet increased body weight and lean mass compared with placebo, though the authors suspect the gain was mainly extra fluid from swelling.Effect of growth hormone, glutamine, and diet on body composition in short bowel syndrome: a randomized, controlled stud…
- In 8 people with short bowel syndrome, 28 grams of daily oral glutamine plus growth hormone for 4 weeks did not change body weight or lean mass compared with placebo.Effect of high-dose growth hormone and glutamine on body composition, urine creatinine excretion, fatty acid absorption,…
- In heart failure patients doing resistance exercise, adding 10 g of BCAA daily did not change the gains in strength or fitness beyond exercise alone.Changes in body composition in heart failure patients after a resistance exercise program and branched chain amino acid …
- In resistance-trained young men over 60 days, a probiotic taken with whey protein raised blood branched-chain amino acid levels and improved leg press strength and vertical jump power compared with placebo.The effect of Bacillus coagulans Unique IS-2 supplementation on plasma amino acid levels and muscle strength in resistan…
- In gastric cancer patients having gastrectomy, a five-day early postoperative course of BCAA-enriched parenteral nutrition reduced lean body mass loss at 1 month compared with conventional nutrition, though the difference was not seen at 3 months.Early administration of postoperative BCAA-enriched PPN may improve lean body mass loss in gastric cancer patients under…
- In a case-control study of 130 adults, people with epilepsy ate less vitamin C than healthy controls and had higher body fat, but the study did not test vitamin C effects on muscle.Dietary and lifestyle behavior in adults with epilepsy needs improvement: a case-control study from northeastern Poland.
- In 122 older adults with impaired mobility over 12 weeks, exercise plus a branched-chain amino acid and vitamin D high-protein food maintained muscle mass and improved stand-up and two-step test scores, while the exercise-only and control groups lost muscle mass.Effects of branched-chain amino acid- and vitamin D-containing high-protein food supplementation plus exercise on elderl…
- In 54 people with stroke, 1 month of branched-chain amino acid powder with intensive rehabilitation gave greater improvement in skeletal muscle index and daily functioning than rehabilitation alone.The Effect of Branched Chain Amino Acid Supplementation on Stroke-Related Sarcopenia.
- In 32 people with Parkinson's disease over 6 months, whey protein raised blood BCAA and glutathione levels compared with soy protein, but did not improve clinical symptom scores or brain imaging.Biochemical and clinical effects of Whey protein supplementation in Parkinson's disease: A pilot study.
- In 20 young combat sport athletes, 5 g of branched chain amino acids daily for 4 weeks raised muscle mass (not statistically significant at p<0.10 trend) and phase angle versus controls, and lowered IL-4, an inflammatory signal.[The efficiency of branched chain aminoacids (BCAA) in the nutrition of combat sport athletes].
- In 16 healthy young women over 60 days of bed rest, a high protein diet with added branched-chain amino acids prevented insulin resistance, but lean body mass loss was about the same as on a conventional diet.High-protein diet with excess leucine prevents inactivity-induced insulin resistance in women.
- In 10 patients with COPD, a single 2 g intravenous vitamin C infusion, compared with saline, reduced quadriceps fatigue during exercise and lowered malondialdehyde, a marker of oxidative stress.Ascorbate infusion increases skeletal muscle fatigue resistance in patients with chronic obstructive pulmonary disease.
- In 39 patients with advanced cancer and wasting, a 4-month regimen including 500 mg daily vitamin C, with other antioxidants, nutrition support and drugs, led to weight gain, more lean body mass, lower inflammatory markers and better quality of life; 22 of 39 patients responded, but there was no control group.A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and ant…
- In 38 advanced lung cancer patients, a beta-hydroxy-beta-methylbutyrate, arginine and glutamine supplement over 12 weeks showed no evidence of benefit on cachexia compared with no supplement, and the trial was stopped early.Beta-hydroxy beta-methylbutyrate/arginine/glutamine (HMB/Arg/Gln) supplementation to improve the management of cachexia …
- In 33 adults with pre-sarcopenia or sarcopenia, 3.6 g of BCAA powder twice daily for 5 weeks improved skeletal muscle index, gait speed, and grip strength, but these gains faded after 12 weeks off supplement; the study had no placebo group.Effects of enriched branched-chain amino acid supplementation on sarcopenia.
- In 28 patients with advanced cancer and weight loss, a 16-week program that included 500 mg of vitamin C daily alongside several other supplements and drugs was linked to increased lean body mass and lower reactive oxygen species and inflammatory signals, but the study had no comparison group and vitamin C was not tested alone.Cancer-related anorexia/cachexia syndrome and oxidative stress: an innovative approach beyond current treatment.
- In 12 people with short bowel syndrome, 4 weeks of oral glutamine (30 g a day) with growth hormone and enteral feeding raised body weight and lean body mass, though without a placebo group the glutamine effect cannot be separated from the other treatments.Effect of growth hormone, glutamine, and enteral nutrition on intestinal adaptation in patients with short bowel syndrom…
- In a large UK study of about 68,000 adults, higher vitamin C intake from food was linked to stronger grip in women, but this was a cross-sectional association and not a trial.Associations between diet and handgrip strength: a cross-sectional study from UK Biobank.
- In 4852 older Koreans, higher leucine intake from food was linked to stronger handgrip, but BCAA intake from grains was linked to weaker grip.Higher Branched-Chain Amino Acid Intake Is Associated with Handgrip Strength among Korean Older Adults.
- In a matched retrospective cohort of 4,352 cirrhosis patients, BCAA users had similar rates of sarcopenia to non-users over 5 years, while having fewer complications such as hepatic encephalopathy and falls.Branched-Chain Amino Acid Supplementation and Clinical Outcomes in Liver Cirrhosis: A Propensity Score-Matched Multicent…
- In 4,336 older Chinese adults, higher dietary intake of branched-chain amino acids was linked to greater handgrip strength and faster walking, and those with the highest intake had about half the odds of low muscle strength in women.Association between Branched-Chain Amino Acid Intake and Physical Function among Chinese Community-Dwelling Elderly Resi…
- In 4020 Korean adults aged 65 and older, vitamin C intake was among the top risk factors ranked by a machine learning model for sarcopenia in women, with no stated direction of effect.Sarcopenia feature selection and risk prediction using machine learning: A cross-sectional study.
- In 1420 Korean postmenopausal women, those eating the most fruit, which is rich in vitamin C and potassium, had lower odds of having multiple body composition problems, including low muscle mass, though this cross-sectional study cannot prove cause.Fruit intake and osteosarcopenic obesity in Korean postmenopausal women aged 50-64 years.
- In 584 community-dwelling older adults, vitamin C intake was higher in those with sarcopenia (low muscle), though this cross-sectional study cannot show cause and effect.Dietary intake and its association with sarcopenia in older adults: a cross-sectional analysis.
- In 516 stomach cancer patients having gastrectomy, those who received glutamine around surgery (propensity matched, 97 per group) had a higher psoas muscle index change over three months than those who did not (0.3 vs -0.3 cm2/m2, p = 0.004).Perioperative Glutamine Supplementation May Restore Atrophy of Psoas Muscles in Gastric Adenocarcinoma Patients Undergoi…
- In 498 middle-aged black South African women, a diet pattern high in vitamin C, sugar and potassium was not reported to be linked with muscle or body composition, while an animal-based diet pattern was linked with higher lean mass.Nutrient Patterns and Body Composition Parameters of Black South African Women.
- In 300 Iranian older adults, a diet pattern high in vitamin C and carbohydrates was linked with lower odds of low gait speed, but vitamin C was not separately tested for muscle mass.Patterns of Nutrient Intake in Relation to Sarcopenia and Its Components.
- In a prospective cohort of 197 older adults with type 2 diabetes followed for about 14 months, vitamin C intake was not related to loss of muscle mass.Vitamin Intake and Loss of Muscle Mass in Older People with Type 2 Diabetes: A Prospective Study of the KAMOGAWA-DM Coho…
- In 39 adults with muscular dystrophy and 17 controls, higher intake of branched-chain amino acids from food was linked to greater lean mass and muscle strength, though people with muscular dystrophy ate about 31% less of them than controls.Nutritional status is linked to muscle strength and perceived function in adults with muscular dystrophy: evidence for t…
- In 36 adolescents with phenylketonuria, body composition and branched-chain amino acid levels were measured alongside diet and protein substitute types, but the study did not test a branched-chain amino acid supplement effect on muscle.Body Composition in Adolescent PKU Patients: Beyond Fat Mass.
- In 20 children with Crohn's disease, muscle protein balance of branched chain amino acids turned negative after a meal, which was linked to lower muscle mass; this was a meal study, not a supplement trial.Reduced skeletal muscle protein balance in paediatric Crohn's disease.
- In a cross-sectional study of older adults in nursing homes, vitamin C intake adequacy differed by frailty status, but the study did not show that vitamin C improved muscle.Associations Between Frailty, Sarcopenia, and Nutritional Status in Older Adults Living in Nursing Homes.
- In mice, branched-chain amino acids given in a diet eaten early in the active period increased muscle growth, and in an observational human analysis, people who ate more protein at breakfast than at dinner had higher muscle function.Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock.
Review Totals and Summary
Members Only94 reviews · 100% positive
Buyers are very positive about this powder. Most praise the taste and say it helps with workout recovery. The few complaints are about flavor strength, sweetness, and clumping. **What buyers say it did for them:** Many link it to quicker recovery and a better workout. One runner and lifter wrote that recovery "is much shorter, and general overall soreness is reduced." Another said, "I get great results using as a post workout drink." One buyer said their trainer recommended it for faster recovery alongside protein. Others mention it helping with hydration, and one says it "Definitely helps with workouts!" A few reviews are general praise, such as improved health, and do not describe a specific effect. **What they complain about:** The complaints are few and mostly small. One buyer found the powder "dries out and clumps up quickly" even with the lid tightly closed, making it hard to scoop and slower to dissolve. Others had taste complaints (see below). One said the flavor "could be a bit stronger." **Taste, mixing and size:** Taste is the most common point of praise. Reviewers call it "refreshing and not too sweet" and "a clean watermelon flavor." One liked that it has "no bitter aftertaste." Several say it mixes easily, including in cold water, and that it works for sipping during a workout. Opinions are not unanimous. One found it "too sweet for me," another thought it "just taste like melon," like cantaloupe rather than watermelon, and another said the taste "isn't the best." One described the pack as "small but compact," while another said it "will last few months for one person." Reviews mention both pomegranate-watermelon and fruit punch, so flavor descriptions are not fully consistent. **Value for money:** Buyers who mention price are positive. One called it "a good value for the money," and another "very good value." Someone else said the size is good for the price. Several also praise the ingredients, calling them clean, good quality, and free of sucralose, with electrolytes included. **Who it seems to suit and who it did not:** It seems to suit active people who want a flavored drink for during or after training, and people who want cleaner ingredients without sucralose. It also suits those who like a lightly sweet, fruity flavor. It may be less suitable for anyone who wants a strong, sweet or distinctly watermelon taste, or who dislikes a melon-like flavor. Buyers who plan to use it slowly over months might want to watch for clumping. One reviewer mixes it into a protein shake, another drinks it alone. **Left out:** Some reviews on the store pages were about the store or service rather than the product, such as delivery speed. I did not use them as product feedback. No reviews of other forms such as gummies or capsules were used.
Biohacker Summary
Members Only10 of 10 recommend it
No one on the panel spoke about the main ingredient, the branched chain amino acids, so there is nothing to report on it. Vitamin C, a smaller ingredient in this product, drew the most comment: most of the panel recommend or use it for collagen, skin and immune support, often paired with collagen, with doses of 250 milligrams and 500 milligrams to 1 gram mentioned, while one cautioned that high doses might blunt the benefits of exercise and one stopped using a skin serum. Taurine, a smaller ingredient in this product, got mostly neutral comments, with one panelist recommending it for blood pressure and metabolic health and another noting it helps power output when combined with caffeine. Glutamine, a smaller ingredient in this product, is used by a few panelists at 5 grams a day, rising to 15 to 20 grams when sick, traveling or short on sleep, for immune and gut support.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Taurine · neutral
- States that sardines contain taurine, which supports GABA, a calming neurotransmitter.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- Recommends consuming foods high in vitamin C to block the effects of grains.
- Recommends taking glutamine or consuming foods high in glutamine to block the effects of grains.
- Recommends ensuring that collagen supplements come with vitamin C.
- Vitamin C works as an antioxidant that supports skin and artery health.
- States that glutamine is an important amino acid for colon cells and is essential for intestinal permeability, greatly supporting the gut and benefiting inflammatory conditions.
- Explains that taurine, found in sardines, spikes GABA, the calming neurotransmitter, leading to feelings of calm, stability, improved stress tolerance, and better sleep without middle-of-the-night cortisol spikes.
Dave Asprey · Taurine · neutral
- Host Dave Asprey examines the connection between taurine, inflammaging, immune function, and longevity, explaining why cellular nutrient availability may matter more than blood concentrations and what this emerging mechanism means for supplementation and inflammation management.
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey explains that a 2017 study in rats found taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress, but notes this does not show that taurine treats depression in humans.
- Mentions that taurine, a common longevity molecule, affects the sense of smell, but they do not know why it works.
- Dave Asprey takes taurine, acknowledging it's cheap and safe, but notes that while mouse studies show spectacular longevity benefits, human data is currently only observational and lacks randomized longevity trials.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Asks what happens if you put glutamine in the skin, suggesting that manipulating amino acids in the skin and elsewhere is a fertile ground for more research.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
- Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
- Mentions taurine as one of the ingredients in the Ageless Cocktail, which is designed for longevity.
Thomas DeLauer · Vitamin C · recommends
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Mentions a previous breakdown on how 5 grams of glutamine can double autophagy in the brain and reduce neuroinflammation.
- States that glutamine is the primary fuel source for intestinal cells, and its availability is crucial for the integrity of the gut barrier.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends taurine, stating it raises the stress threshold, acts as a GABA and glycine receptor modulator, and protects neurons from stress, ultimately lowering cortisol release.
- Recommends supplementing with glutamine for a calming effect, especially when experiencing high stress, injury, illness, or increased training volume, as it acts as a precursor to GABA and helps the body produce more of it.
- Loads up on extra glutamine during muscle building phases.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Recommends glutamine as one of the things that support the gut lining.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Is familiar with glutamine being important for maintaining gut barrier function, though he has not done specific research on it in his lab.
- Recommends Glutamine as a great tool for gut cells when stressed or overworked, but advises not to take it every day.
Ben Greenfield · Vitamin C · recommends
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Mentions vitamin C as part of a bare-minimum protocol.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Taurine on its own isn’t particularly impressive as an ergogenic aid, but when combined with caffeine, there are significant increases in power production.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Vitamin C for skin repair post-tattoo.
- Recommends taurine supplementation, especially for plant-based dieters, citing a 2023 study showing its decline with age and its potential to extend health span and restore markers of brain aging in mice, with anecdotal evidence for human brain function.
- Does not agree that ascorbic acid is vitamin C, comparing it to calling chaff wheat, and notes that it is made from genetically modified cornstarch or corn syrup byproducts using solvents.
- Recommends Taurine as one of the top two individual ingredients for managing elevated liver enzymes.
- Warns against ascorbic acid, stating that it does not cure scurvy and that the world has been led astray by the deception around it versus the whole food vitamin C complex.
- Warns against taking 1,000 mg of vitamin C immediately after a workout for individuals under 50, as it can dull the body's natural adaptation signal.
- Warns that using high-dose antioxidants like vitamin C directly before or after a hyperbaric session is not a great idea, as it could impair some of the effects by reducing reactive oxygen species.
- Gets nerdy about taurine and explains which longevity supplements actually work, according to the science in mammals.
- Notes that taurine is an amino acid with research supporting its benefits for reducing DNA damage, mitochondrial dysfunction, inflammation, and telomere shortening, but he doesn't take it separately as he gets a full amino acid complex.
Siim Land · Vitamin C · recommends
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- States that taurine supports normal muscle, nerve, and heart function, and supplement trials suggest benefits for some metabolic markers, exercise performance and blood pressure.
- Recommends Taurine for blood pressure and metabolic health, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Taurine as one of 15 supplements backed by human studies.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Notes that Vitamin C is one of several supplements with human evidence.
- Thinks taurine has some of the strongest evidence and is worth considering.
- Recommends taurine for older people to support mitochondrial function and metabolic health.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Mentions that glutamine is one of the main precursors needed for glutathione.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
Dr. Mark Hyman · Vitamin C · recommends
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Mentions glutamine as something that might be helpful for gut repair.
- Recommends vitamin C for immune system support and modulation.
- Recommends L-glutamine to help with gut barrier repair and healing leaky gut.
- Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
- Recommends glutamine to help repair the gut lining.
- Recommends glutamine for targeted support in healing the gut and recalibrating the immune system.
Dr. Rhonda Patrick · Taurine · neutral
- Mentions that taurine depletion is a concern raised in long-term animal studies regarding Beta Alanine, though not observed in human trials, and notes that one can supplement with taurine, which is a beneficial compound.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Supplements with glutamine.
- Always packs Glutamine when traveling, taking a baseline of 5 g/day and increasing to 15-20 g/day when sleep-deprived or exposed to illness, as it is an important fuel source for immune function.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Warns that Glutamine has stimulating properties that increase arousal, interfering with sleep onset, and should be avoided too close to bedtime.
- Warns against taking glutamine at night for sleep because it is activating and can cause insomnia, citing examples of athletes who experienced this.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
Andrew Huberman · Vitamin C · uses
- Takes a multivitamin every day for longevity.
- Supplementing with L-glutamine may reduce sugar cravings, and anecdotally, it works.
- Discusses glutamine supplementation in relation to leaky gut and sugar cravings.
- Takes L-glutamine daily at 5g, increasing to 15-20g in 5g increments when her son is sick, she is exposed, during season, or when traveling, because she believes it helps her not get sick.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- He highlights specific nutrients, including glutamine, and discusses their recommended doses and dietary sources for offsetting sugar cravings.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Recounts an anecdote about taking a teaspoon of L-glutamine in half-and-half twice a day, which he believes helped him wean off sugar, though he acknowledges it could be a placebo effect.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
- Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
- Mentions that some people find ingesting a teaspoon of L-glutamine a few times a day helps with sugar cravings, noting that this method has anecdotal data but has not been peer-reviewed.
- Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
- Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
Peter Attia · Vitamin C · stopped
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Mentions that taurine supplementation in mice and other species appears to prolong life, referencing V.J. Adav's work, but notes that it is unclear if the same applies to humans.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Mentions that taurine supplementation in mice and some other species appears to prolong life in VJ Addev's work, but it's unclear if the same applies to humans.
- A new study set off a media storm over taurine’s potential in delaying aging and extending lifespan, which is great news if you’re a mouse.
- Notes that glutamine has been shown to increase the survival rate in ICU patients.
- Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
- Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
- Expresses skepticism about 'panacea treatments' for cancer, specifically mentioning a 'twenty thousand dollars of vitamin C' treatment, implying it's an example of something he's 'squirrely' about due to cost and unproven claims.
- Asks if vitamin C matters for immune function, suggesting a need for a definitive study.
- Recommends glutamine as a nutrient the body needs to heal the gut.
- Warns against the "total nonsense" of taking excessive amounts of vitamin C, especially in specific forms like liposomal vitamin C, for immunity, stating that it is idiotic and potentially dangerous to think it will offer immunity.
Bryan Johnson · Vitamin C · neutral
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Takes 250 milligrams of Vitamin C.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
- Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
- He uses Vitamin C, typically in a serum, in the morning for skin health.
- Bryan Johnson takes Taurine daily as part of his Longevity Mix, which supports heart health, provides antioxidant protection, and supports immune health.
RAL Summary
Members OnlyTier 4 for Muscle and Strength
The review summary describes a sucralose-free drink with electrolytes in pomegranate-watermelon and fruit punch flavors, but this product contains sucralose and no electrolytes, and no written reviews of it could be read, so the review content is not about this product. Its reviews are set aside, so it is graded on its studies alone. Human studies support BCAA (35 of 60 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 46 of the 132 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Muscular system
Combine with: For muscle building and recovery, pair BCAAs with creatine monohydrate (3-5 g daily) for strength and power, and with a complete protein source such as whey or a full-spectrum EAA blend, since BCAAs alone do not supply all the amino acids needed for maximal muscle protein synthesis. Add vitamin D3 and magnesium to support muscle function and recovery, and electrolytes for hydration during training. If you also want circulatory support, add L-citrulline (6-8 g) or beetroot extract for nitric oxide production, plus omega-3 fish oil to support vascular health, but these are separate ingredients that provide the blood flow benefit, not the BCAAs. Consult a healthcare provider if you have cardiovascular conditions or take meds.
Possible side effects: No major side effects reported.
Supplement Facts
Total Carbohydrates 1 g · Vitamin C 60 mg · Micronized BCAA Blend 3 g
| Calories | 5 | |
| Total Carbohydrates | 1 g | |
| Vitamin C | 60 mg | |
| Micronized BCAA Blend | 3 g | † |
| L-Glutamine, Micronized | 500 mg | † |
| micronized Taurine | 500 mg | † |
Other ingredients: Natural & Artificial flavors, Malic Acid, Citric Acid, Calcium Silicate, Silicon Dioxide, Sucralose, Lecithin, Tartaric Acid, Acesulfame Potassium.
Directions: Directions: Mix 1 scoop with 8-10 oz. of cold water before, during, or after training.
Barcode (UPC) 834266002627 · Label source: NIH label database · Report a label change
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Graded November 11, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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