California Gold Nutrition, CollagenUP, Hydrolyzed Marine Collagen Peptides with Hyaluronic Acid and Vitamin C Review
California Gold Nutrition CollagenUP, 7.26 oz (206 g), is presented as a marine sourced collagen peptide product with hyaluronic acid and vitamin C. The listing highlights an unflavored, non-bovine, hydrolyzed fish collagen, with non-animal source hyaluronic acid and vitamin C. The brand says the product supports healthy hair, skin, nails, joints and bones. It describes the collagen as enzymatically hydrolyzed, broken down into bioavailable peptides, and formulated without gluten, GMOs, or soy. It is produced in a third party audited cGMP registered facility and carries the brand's 100% Gold Guarantee. The pack is a resealable pouch for easier storage. The description explains that collagen, hyaluronic acid, and vitamin C all contribute to the health and wellbeing of the musculoskeletal system. It says the unflavored powder can be quickly added to a favorite drink. It explains that the powder contains type I and type III collagen, which are two of the five main types, and lists types I, II, III, IV and V with where each is found in the body. It notes that hyaluronic acid is a component of connective tissue and can provide the fluid matrix for joint lubrication, skin hydration, and repair, and that vitamin C plays a role in collagen production and assists in antioxidant protection. The listing describes a typical amino acid profile per serving, including glycine at 1,071 mg, glutamic acid at 543 mg, proline at 531 mg, and arginine at 475 mg, and notes values may vary slightly from batch to batch. The product is said to be tested by an independent ISO-certified lab, with results shared through iTested Verified Reports. The suggested use is one scoop daily mixed in 6 to 8 ounces of room temperature water or juice, taken on an empty stomach at least 1 hour before or 2 hours after meals. Each serving is one 5 gram scoop with about 41 servings per container. The supplement facts list 20 calories, 4 g protein, 90 mg vitamin C as calcium ascorbate at 100% daily value, 20 mg sodium, 5 g hydrolyzed marine collagen, and 60 mg hyaluronic acid as sodium hyaluronate. The product contains fish and is not manufactured with milk, eggs, shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten, though it is made in a facility that processes other allergens. Warnings include keeping out of reach of children, consulting a healthcare professional before use, storing in a cool dry place, and protecting from heat, light, and moisture. The label notes that the product is packaged by weight, not volume, that settling occurs over time, and that color shift and taste may vary. It also says the pouch contains a food-grade moisture absorber and should not be eaten.
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Study, Trial or Testing Result Summary
Members Only47 human studies · 39 improved
6 of these 47 human studies gave the ingredient by injection, not by mouth.
The main ingredient, marine collagen peptides, is given at 5 grams a day, a full studied dose. A review of 26 trials with 1,721 people found collagen taken by mouth improved skin hydration and elasticity more than placebo [1]. A review of 19 trials with 1,125 people, almost all women, found about 90 days of collagen reduced wrinkles and improved elasticity and hydration [2]. In 69 women aged 35 to 55, 2.5 or 5 grams daily for 8 weeks improved elasticity, though moisture did not change significantly [3]. A newer review noted most collagen trials had a high risk of bias [4]. For hyaluronic acid, taken by mouth, a review of 7 placebo-controlled trials found better hydration, elasticity and wrinkle depth [5]. However, a trial in 87 women found adding 30 milligrams of hyaluronic acid to collagen and vitamin C gave no extra benefit over collagen alone [6]. Whether this product's 60 milligrams matches the studied dose is unclear. Most vitamin C skin studies used creams or serums on the skin [7], and 500 milligrams by mouth daily for 12 weeks did not improve hydration or elasticity. The 90 milligrams here is a much smaller amount. Animal and cell studies are never counted.
See all 47 studies →Hide the studies
- Across 26 randomized trials with 1,721 people, hydrolyzed collagen taken by mouth improved skin hydration and elasticity more than placebo.Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis.
- Across 19 randomized trials with 1,125 people (95% women), hydrolyzed collagen taken for about 90 days reduced wrinkles and improved skin elasticity and hydration compared with placebo.Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
- In a review of 30 trials for sun-damaged skin, one small study showed benefit from vitamin C applied to skin compared with placebo, while tretinoin had the strongest evidence.Interventions for photodamaged skin.
- Pooling 6 studies, hyaluronic acid injections improved skin hydration and radiance but did not significantly change skin elasticity or melanin index compared with controls.The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis.
- Combining 7 placebo-controlled trials, oral hyaluronic acid significantly improved skin hydration, elasticity and wrinkle depth, while firmness, wrinkle volume and water loss showed only non-significant trends.Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction.
- In 24 studies of 1,410 patients, mostly women, hyaluronic acid fillers persisted 60-86.4% at 12 months and 50-86% at 24 months, with rare long-term side effects.Clinical Durability of Hyaluronic Acid-Based Dermal Fillers for Facial Application: A Systematic Review.
- A review of 32 studies with 1236 people found vitamin C and retinol products earned the top recommendation grade for anti-aging skin care, with few side effects.Cosmeceuticals for antiaging: a systematic review of safety and efficacy.
- Across 11 placebo-controlled trials with 805 people using 2.5 to 10 grams daily for 4 to 24 weeks, oral collagen increased skin elasticity, hydration and dermal collagen density with no reported adverse events.Oral Collagen Supplementation: A Systematic Review of Dermatological Applications.
- A review of seven trials with 139 volunteers found skin treated with vitamin C looked smoother, less wrinkled and lighter, but hydration improved as much with placebo.Efficacy of topical vitamin C in melasma and photoaging: A systematic review.
- A review of seven studies found that all used vitamin C with other ingredients or treatments, so its own effect on wrinkles could not be clearly determined.Clinical Efficacy of Topical Vitamin C on the Appearance of Wrinkles: A Systematic Literature Review.
- A review of 10 publications found almost all reported that oral collagen improved skin health, and it discussed possible ways it works.Collagen supplementation for skin health: A mechanistic systematic review.
- In 25 randomized trials, hydrolyzed collagen beat placebo for skin hydration in 10 of 15 trials, elasticity in 10 of 13, and wrinkles in 9 of 10, though most trials had a high risk of bias.Efficacy and safety of hydrolyzed collagen supplementation on skin health outcomes: a systematic literature review of ra…
- A review of 37 articles on lip rejuvenation found hyaluronic acid was the most used agent with few side effects, and one report showed 94.3% improvement in lip fullness one month after re-treatment.Perspectives and challenges in lip rejuvenation: a systematic review.
- A review found combined hyaluronic acid and calcium hydroxylapatite fillers gave high rated facial improvement and satisfaction with minor side effects, with a slight decline after six months.Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechan…
- In 87 women aged 40-65 taking collagen with 80 mg vitamin C daily for 16 weeks, skin density, texture and wrinkles improved, but elasticity and hydration did not change significantly.The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin De…
- In 72 women aged 35 or older, a daily collagen and vitamin C drink for 12 weeks improved skin hydration, elasticity, roughness and density more than placebo.A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Cont…
- In 69 women using a vitamin C derivative cream twice daily for 8 weeks on one side of the face, wrinkles around the eyes improved compared with placebo cream on the other side.Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
- In 69 women aged 35 to 55 taking 2.5 or 5 grams of collagen peptides daily for 8 weeks, skin elasticity improved significantly more than with placebo, while moisture changes were not significant.Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, plac…
- In 64 patients after laser treatment for acne scars, an antioxidant serum with vitamin C used for 14 days improved healing and skin hydration compared with saline on the other side of the face.Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fract…
- In 64 people taking 1000 mg of low-molecular-weight collagen peptide daily for 12 weeks, skin hydration, wrinkling and elasticity improved more than with placebo with no side effects.Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Rand…
- In 60 women aged 20-50 with facial melasma, a multi-ingredient serum containing a small amount of vitamin C used for 5 months reduced pigmentation about as much as 4% hydroquinone, with better hydration, skin barrier function and tolerance in the serum group.Evaluation of the Efficacy of a Serum Containing Niacinamide, Tranexamic Acid, Vitamin C, and Hydroxy Acid Compared to 4…
- In 50 women aged 30-65, a serum with vitamin C, vitamin E and raspberry leaf extract applied to one side of the face for 8 weeks improved skin color, elasticity, radiance, smoothness, scaliness and wrinkles compared with the untreated side.Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell cultu…
- In 50 healthy adults, 12 weeks of green tea catechins plus vitamin C twice daily protected only one skin elastic fiber protein (fibulin-5) from sun-simulating light damage, with no difference from placebo for other collagen and elastic components.Ultraviolet radiation-induced degradation of dermal extracellular matrix and protection by green tea catechins: a random…
- In 32 healthy volunteers, 500 mg daily vitamin C for 12 weeks did not improve skin hydration or elasticity beyond baseline, and adding it to collagen peptides did not enhance the collagen effect.Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study.
- In 31 adults aged 30 to 65, applying a vitamin C, E and ferulic acid serum daily for 12 weeks after microneedle treatment reduced neck wrinkles more (29.9% vs 18.0%) and improved elasticity (12.9% vs 2.3%) compared with placebo on the other side of the neck.Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuven…
- In 24 Korean women, a vitamin C microneedle patch applied twice daily for 12 weeks produced significant reductions in crow's feet wrinkle roughness, with no side effects reported.Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles.
- In a randomized, double-blind study of 19 adults with sun-damaged facial skin, applying a vitamin C serum daily for 3 months improved skin texture and wrinkling more than the vehicle serum on the other side of the face, as shown by skin surface measurements and clinical grading.Use of topical ascorbic acid and its effects on photodamaged skin topography.
- In 15 women aged 19-40 exposed to air pollution particles for 4 days, a vitamin C, ferulic acid and vitamin E serum applied to the back protected collagen and elastin and reduced markers of inflammation and oxidative stress in skin biopsies.Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter.
- In a double-blind trial of women with sun-aged skin, a 5% vitamin C cream applied daily for 6 months improved overall skin appearance and surface texture compared with the vehicle cream and was well tolerated.Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. …
- In 76 women with moderate sun-aged skin, injections of hyaluronic acid combined with platelet-rich plasma worked significantly better than hyaluronic acid injections alone on skin hydration, firmness and satisfaction scores.Comparative analysis of effects induced by hyaluronic acid and its combined formula on skin functional parameters in sec…
- In 80 people who had repeat Juvéderm filler in nasolabial folds, wrinkle scores stayed mild at 48 weeks, 78-90% responded, and 60% less filler was needed than at first treatment.Duration of wrinkle correction following repeat treatment with Juvéderm hyaluronic acid fillers.
- In 33 women, a cream with 3% vitamin C applied daily to the forearm for four months increased the density of dermal papillae, the small skin structures that carry capillaries, from 4 weeks onward compared with the cream base alone.Topically applied vitamin C increases the density of dermal papillae in aged human skin.
- In a half-face study of 27 Japanese women with dark sun spots, a vitamin C derivative lotion applied twice daily for 24 weeks gave a weak lightening effect on the spots, but pigmentation scores did not differ from the placebo lotion.Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.
- In placebo-controlled tests including 25 volunteers for one month and a 12-week usage study, a face cream with 3% vitamin C lowered skin oxidative stress, increased the number of dermal papillae, and significantly reduced facial wrinkles.Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy.
- In a split-face trial of 24 adults with sun-damaged skin, using a handheld device to push vitamin C into the skin twice a week for 8 weeks improved pore tightening and skin hydration on the treated side compared with baseline, with no adverse reactions recorded.Efficacy of handheld iontophoresis device in enhancing transdermal vitamin C delivery: A split-face clinical trial.
- A hydrogel carrying ascorbyl palmitate, a vitamin C form, moisturized skin better than a placebo gel in both short-term and long-term tests.Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nan…
- Creams containing 1% of a fat-soluble vitamin C derivative increased skin moisture and improved skin smoothness in volunteers over 15 days of use.Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: stability studies and in vivo efficacy.
- In 1462 people applying a retinaldehyde and hyaluronic acid fragment cream daily for 90 days, overall photoaging, wrinkles (up to 34% less) and skin elasticity signs (about 32% better) improved significantly.Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging.
- In 44 women using a niacinamide and hyaluronic acid formula for two months, fine lines, wrinkles and smoothness improved, and in 30 other women skin biopsies showed lower activity of aging-related inflammatory genes.Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin …
- In 40 women using an antioxidant serum containing hyaluronic acid daily for 90 days, signs of skin aging improved significantly and the serum was well tolerated.Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in re…
- In 34 people treated on the face, neck, chest and hands with hyaluronic acid jetted into the skin (not a supplement taken by mouth), wrinkle scores on the face and neck fell by about 39% and 30% at 1-3 months, and 80% were satisfied.Clinical results of skin remodeling using a novel pneumatic technology.
- In 31 women aged 43 to 65 without a control group, a vitamin C, vitamin E and green tea serum applied twice daily for 12 weeks improved wrinkles, smoothness, radiance and skin density.Novel Vitamin C and E and Green Tea Polyphenols Combination Serum Improves Photoaged Facial Skin.
- In 30 Chinese women using hyaluronic acid microneedle patches under the eyes three times a week for 4 weeks, skin firmness increased and crow's feet and eye bags significantly reduced.Efficacy and safety testing of dissolving microarray patches in Chinese subjects.
- In 30 Chinese women given two hyaluronic acid injection sessions four weeks apart, skin hydration and water loss improved significantly by week 12, while elasticity changes were not significant.Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in As…
- In 20 women with sun-aged hands, weekly hyaluronic acid microinjections for 4 weeks increased a skin ultrasound marker of photoaging by 31.3%, improving it in 15 of 19 who finished.Mesotherapy for skin rejuvenation: assessment of the subepidermal low-echogenic band by ultrasound evaluation with cross…
- In 129 patients with skin aging, one hybrid filler treatment led physicians to rate all patients as improved in facial appearance at 9 months, with only minor side effects.HArmonyCa™ hybrid filler to restore connective tissue: An Italian real-life retrospective study.
- In 42 patients with 74 frown-line wrinkles, ultrasound showed an artery at the wrinkle in 30 lines (filler skipped there) and lateral in 44, where filler was injected safely to correct the wrinkles.Safe Glabellar Wrinkle Correction With Soft Tissue Filler Using Doppler Ultrasound.
Review Totals and Summary
Members Only338,100 reviews · 93% positive
The California Gold Nutrition CollagenUP powder has garnered overwhelmingly positive feedback, with 100% of star ratings being 4 or 5 stars across approximately 10918 ratings. Buyers generally find the powder convenient to mix and easy to take, with only minor complaints about taste and smell. **What buyers say it did for them:** Customers appreciate the overall quality and convenience of this collagen powder. Many highlight the comprehensive formula, noting that "The combination of marine collagen, hyaluronic acid, and vitamin C makes it a great all-in-one product." The product is often described as a "very good quality collagen powder." General satisfaction is high, with one reviewer reporting that their spouse "was very happy with the product and had no complaints." However, the available feedback does not contain specific details from reviewers about results related to joint, skin, hair, or nail health. **What they complain about:** The primary area of criticism for this product revolves around its taste and smell. While generally considered mild, some users found that "The flavor and smell aren't perfect." These minor issues are often accepted as a trade-off for a dietary supplement, and complaints about taste and smell are typically mild rather than severe. **Taste, Smell, and Form:** The powder form is consistently praised for its ease of use and mild characteristics. It "mixes well with water and has a very mild taste." Its versatility is also a recurring positive, with users finding it "Good to mix in with yogurt or smoothie on the go." The mild taste and good mixability contribute significantly to its convenience, making it easy to incorporate into daily routines without strong flavors or textures. **Value for Money:** The provided customer feedback does not explicitly discuss the product's value for money. **Who it seems to suit and who it did not:** This collagen powder appears to suit individuals looking for a convenient and easy-to-mix supplement. Satisfaction extends beyond primary users, as evidenced by a reviewer noting that a spouse "was very happy with the product and had no complaints." While taste and smell are mentioned as minor considerations, they do not seem to significantly detract from overall satisfaction for most users. There is no indication in the feedback of specific groups for whom the product did not work.
Biohacker Summary
Members Only10 of 10 recommend it
Collagen is the main ingredient, and most of the panel recommends or uses it, with five recommending it, three using it, two neutral and one who stopped. People take it mainly for skin, with others citing joints, connective tissue, muscle, recovery and sleep. Two panelists gave a dose of 2.5 to 5 grams a day for at least eight weeks for skin elasticity, three take 10 grams in the morning, and one suggests 15 grams an hour before working out, while one adds collagen powder to coffee and another mixes it into a pudding. One panelist warns that collagen will not repair a damaged gut wall, one says it is less effective for building muscle than whey, one says lifestyle matters more, and one no longer takes it. Vitamin C is a smaller ingredient in this product, and panelists mostly recommend it as a partner to collagen because the body needs it to make collagen.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Collagen · recommends
- Recommends collagen as it is critical for healthy aging, supporting connective tissues, skin health, and cardiovascular health.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Dr. Eric Berg discusses sodium in relation to blood pressure, noting that the ratio between sodium and potassium matters.
- States that hydration is water plus electrolytes like sodium, implying its importance for proper hydration.
- Recommends collagen powder as an alternative to bone broth, to be put in coffee, for its benefits in building connective tissue and providing glycine for sleep.
- Mentions that grass-fed liver is loaded with collagen.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- Recommends around 3000 to 4000 mg of sodium each day to maintain healthy hydration levels, which is equal to about 1½ to 2 teaspoons of salt per day.
- Recommends consuming 3,000 to 4,000 mg of sodium per day to stay hydrated, which is about 1 and 1/2 teaspoons of salt. He explains that most people do not consume enough salt, leading to low blood volume and various symptoms.
- States that the body is begging for collagen if one experiences weak ligaments and tendons, joint pain, wrinkles or saggy skin, thin dry fragile hair, brittle slow growing nails, loss of muscle, increased need for longer repair after exercise, and bone loss.
- States that reducing salt isn’t always the best solution for high blood pressure, emphasizing the importance of the sodium-to-potassium ratio.
Siim Land · Collagen · recommends
- Recommends taking Collagen 1 hour before exercise with vitamin C to support joint collagen synthesis.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Mentions that sodium is a mineral necessary for making collagen.
- Recommends Collagen for joints, skin and connective tissue, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Collagen as one of 15 supplements backed by human studies.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Takes 10 grams of collagen peptides a day, which provides 3 grams of glycine.
- 30% of collagen is glycine, as glycine is every third amino acid in the collagen triple helix.
- Notes that Vitamin C is one of several supplements with human evidence.
- Recommends marine collagen peptides, citing a study where 5g daily for 12 weeks reduced AGE levels and improved insulin sensitivity.
- Mentions that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Notes that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Mentions that glycine makes up one-third of collagen.
Thomas DeLauer · Collagen · uses
- Says he takes collagen to take care of his gut.
- Uses Element's 500 mg sodium cans first thing in the morning to prime his day and enhance workout performance, noting that the pump is often driven by sodium.
- Recommends collagen as a direct dietary source of glycine, suggesting a 15g serving of pure collagen. He advises taking it an hour before a workout for connective tissue benefits or before bed on rest days to help with sleep.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses Element's 500 mg sodium cans first thing in the morning to prime his day and help with workout performance and pump.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends taking 15 grams of collagen an hour before working out to target connective tissue, as it has been shown to double a marker of collagen synthesis and help rebuild tendons and ligaments that are loaded harder with age.
- Always eats collagen, considering it one of the most underrated things they do for sustainability and recovery, as it supports connective tissue protein synthesis.
- Mentions that if curling fingers are due to a collagen issue, there's a case for taking collagen peptides to help rebuild connective tissue.
- Has been starting his day with 500 to 1,000 milligrams of sodium before coffee, noticing a significant difference in mental acuity before going to the gym.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Suggests that the amount of sodium in restaurant food makes a difference in how one feels, implying a negative impact.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
Dave Asprey · Collagen · uses
- States he made collagen into a billion-dollar industry because he needed it for his joints due to Ehlers-Danlos syndrome.
- Recommends taking collagen for better skin health.
- Recommends taking vitamin C for better skin health.
- Dave Asprey agrees with taking collagen, but warns that using bone broth and collagen to repair a compromised gut wall is like trying to rebuild a collapsed house using nothing but craft glue, as it doesn't provide the rapid high demand energy gut cells need.
- States that currently, he is only taking vitamin C and vitamin D.
- Mentions Puori CP1 Pure Collagen as a sponsor, offering a discount on a subscription.
- Notes that eating collagen can break down into amino acids and create a signaling molecule that tells the body the skin has been injured, leading to thicker skin.
- Explains that One Skin uses collagen amino acids in their formula because they are hygroscopic and help hold water, acting as natural moisturizing factors.
- Has updated his stance on collagen, now believing there may be some benefit for certain populations in having collagen peptides, especially since they are small and get absorbed.
- Recommends that people who feel bad try more sodium, as it often works, especially for those with low blood pressure and anxiety.
- Dave and Jenny walk through the biohacking protocol that helped her son recover from autism, including collagen and hypermobility support.
- Recommends increasing collagen intake, specifically about 20 grams of collagen protein, for individuals with hypermobility, but warns against exceeding this amount due to oxalate concerns.
- Dave Asprey warns that collagen supplements have small, short-term effects on skin, mostly from industry-funded studies, and explains that the body breaks it down into amino acids, not directly targeting skin; he suggests taking cheaper protein if protein-deficient.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
Ben Greenfield · Collagen · recommends
- Mentions that two separate meta-analyses found real improvement in skin elasticity when people consumed 2.5 to 5 g of collagen peptides a day for eight weeks.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Recommends 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least 8 weeks to improve skin elasticity and address sagging skin.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions vitamin C as part of a bare-minimum protocol.
- Recommends 2.5-5 g/day of hydrolyzed collagen for at least 8 weeks, citing a meta-analysis that found real improvement in skin elasticity.
- Recommends starting with collagen for body remodeling.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- A new meta-analysis reviewed the existing evidence on collagen supplementation and found that collagen peptides may support several aspects of health, including skin aging, osteoarthritis symptoms, fat-free mass, tendon quality, and markers of metabolic health.
- Notes that while sodium is known to affect blood pressure, the balance between sodium and magnesium is also important, and isolated sodium chloride in ultra-processed foods is more problematic than sodium from other sources.
- The latest meta-analysis on collagen backs up collagen benefits for skin aging, osteoarthritis, fat-free mass, tendon quality, and overall metabolic health, with effective doses ranging from 5 to 15g.
- Recommends collagen for skin repair post-tattoo.
- Recommends Vitamin C for skin repair post-tattoo.
Bryan Johnson · Collagen · uses
- Takes 10 grams of Collagen in the morning for muscle.
- Considers hyaluronic acid essential for their routine, stating it retains moisture, giving the skin extra firmness and texture, and helps counteract the decrease in levels that occurs with age, leading to dehydrated skin.
- Consumes collagen peptides at 4:55 am.
- Uses collagen peptides as an ingredient in Nutty Pudding.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 g of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Warns that Taco Bell's beefy five-layer burrito contains 1,290 mg of sodium, almost maxing out the daily reasonable consumption recommended by the American Heart Association, and that sodium increases blood volume, putting pressure on blood vessels.
- Uses hyaluronic acid as part of his nighttime skincare routine.
- Warns against excess sodium, stating it can negatively affect the ability to absorb and hold onto calcium intake.
Dr. Mark Hyman · Collagen · neutral
- Dr. Hyman mentions collagen supplements in the context of skin aging.
- Likes working with Pique for healthy skin, specifically their Radiant Skin Duo, which combines BT Fountain (electrolytes, ceramides, hyaluronic acid) and Sun Goddess Matcha (antioxidants, L-theanine) to support hydration and skin barrier from the inside.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Is on 'team collagen' and believes there's enough data to support collagen consumption, noting that it sends signals to help the body build better collagen, though lifestyle factors are more important.
- Mentions hyaluronic acid as a nice hydrating ingredient.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Adds Peak's marine collagen to his routine for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- States that sodium is essential for fluid balance, nerve signaling, and muscle function, and that low levels can cause weakness, confusion, and dizziness, while high levels may indicate dehydration or too much salt.
Andrew Huberman · Collagen · uses
- Takes 10 grams of Collagen in the morning for muscle.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of collagen in the morning for muscle.
- Takes 10-20 grams of Collagen every day for muscle.
- Takes a multivitamin every day for longevity.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Uses Element, which contains sodium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
- Takes 10 grams of Collagen in the morning for skin health.
- He takes 10 grams of Collagen in the morning for skin health.
- Explains how salt (sodium) affects mental and physical performance, as well as cellular health, and how the brain monitors sodium levels to regulate thirst and fluid balance.
Dr. Rhonda Patrick · Collagen · stopped
- Is no longer taking collagen.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Advises limiting sodium, ideally closer to 1,500 mg/day and not above 2,300 mg/day, for a diet linked to longer life.
- Warns that most people get too much sodium.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
- Uses Hydrolyzed Collagen Peptides as a source of glycine and proline to support connective tissue and skin health.
- Rhonda's current supplement routine includes Vitamin C.
Peter Attia · Collagen · neutral
- Explains that collagen has a much lower quality amino acid composition than whey and tends to be rich in only a handful of amino acids like glycine and proline, making it less effective for muscle protein synthesis.
- Peter discusses lifestyle factors impacting blood pressure, including sodium.
- Mentions that dietary sodium guidelines are around 5 grams per day, but some newer information suggests 8 to 10 grams might be acceptable before concern.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Warns that for individuals with gene polymorphisms making them sensitive to salt, a higher sodium intake can significantly increase blood pressure.
- Advises that collagen protein is not a very complete protein and suggests supplementing it with something else if consumed, despite his wife's preference for it.
- Says that based on current data, there is no benefit in myofibrillar or muscle connective tissue protein synthesis using collagen versus whey or casein, especially in exercising individuals. He warns that using collagen as a sole supplemental protein source compromises myofibrillar muscle protein synthesis due to its poor amino acid balance.
- States that as a scientist, he hasn't seen evidence that collagen leads to greater connective tissue protein synthesis rates in muscle, but if he were recovering from a hip or knee injury, he would take a protein supplement with some collagen to ensure enough glycine and proline for ligaments, tendons, bone, and cartilage.
- Notes that hyaluronic acid injections are doing better than cortisone for joint pain, and that combining hyaluronic acid with PRP seems more effective than other treatments, though not astronomically so.
- Mentions that hyaluronic acid injections are another treatment option that performs better than cortisone over a year.
- Says he would give hyaluronic acid in the hip, even though it's not FDA approved for that application, as it can be used off-label and some studies suggest it can help.
RAL Summary
Members OnlyTier 2 for Younger-Looking Skin for Women
Two large reviews of randomized trials show collagen peptides taken by mouth improve skin hydration, elasticity and wrinkles, and this product gives a full 5 gram dose [1][2]. Reviews are overwhelmingly positive, at 93% of a very large count.
Where the evidence disagrees: 2 of the 47 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skin
Combine with: To further enhance skin health and anti-aging benefits, consider combining this product with a broad-spectrum antioxidant like Astaxanthin or CoQ10 to protect skin cells from oxidative damage. Omega-3 fatty acids (EPA/DHA) can also be beneficial for maintaining skin barrier function and reducing inflammation, contributing to a smoother, more hydrated complexion. Additionally, Silica can support collagen production and skin strength.
Possible side effects: Studies of oral collagen reported no side effects or adverse events. Buyers mention only mild complaints about taste and smell.
Supplement Facts
Vitamin C 90 mg · Hydrolyzed Marine Collagen Peptides 5 g · Hyaluronic Acid 60 mg
| Calories | 20 | |
| Protein | 5 g | |
| Vitamin C (as Calcium Ascorbate) | 90 mg | 100% |
| Sodium | 20 mg | 1% |
| Hydrolyzed Marine Collagen Peptides | 5 g | † |
| Hyaluronic Acid (as Sodium Hyaluronate) | 60 mg | † |
Other ingredients: None.
Directions: Combine 1 scoop (approximately 5.15 grams♦) with 6-8 fl oz of purified water or juice. Drink on an empty stomach at least 1 hour before or 2 hours after meals, or as recommended by a healthcare professional.
Label source: iHerb · Report a label change
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Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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