California Gold Nutrition Lutein with Zeaxanthin from Marigold Extract Review
California Gold Nutrition presents its Lutein with Zeaxanthin supplement, specifically formulated with 20 mg of these vital carotenoids, available in a convenient bottle of 60 veggie softgels. This product is designed to support overall macular health and aid in recovery from exposure to blue light, a common concern in today's digital world. Lutein and Zeaxanthin are powerful antioxidant carotenoids, naturally derived from Marigold flowers (M Gold Extract), which are crucial for protecting the body's cells from the damaging effects of free radicals. Their role extends significantly to the health and wellness of our eyes, making this supplement a key addition to an adult's daily regimen for maintaining optimal vision. The formulation of California Gold Nutrition Lutein with Zeaxanthin prioritizes purity and dietary inclusivity. These softgels are non-bovine, making them suitable for both vegetarians and vegans. Furthermore, the product adheres to strict quality standards, being formulated without gluten, GMOs, or soy, catering to individuals with specific dietary sensitivities or preferences. The manufacturing process takes place in a 3rd Party Audited cGMP Registered (Certified) Facility, underscoring the brand's commitment to quality and safety. This dedication is part of what California Gold Nutrition refers to as "The Gold Standard in Dietary Supplements" and "The Gold Difference," emphasizing a focused approach to wellness and rigorous CGN Testing. Each bottle contains 60 softgels, providing 60 total servings, assuming a serving size of one softgel. The item comes in a compact bottle, with product dimensions of 3.25 x 1.75 x 1.75 inches and a weight of 1.6 ounces. First made available on September 16, 2019, this supplement from California Gold Nutrition is positioned as an antioxidant and brightening agent for adult users. It's important to note the legal disclaimer that statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Consumers are advised to read labels and directions before use, and consult with a healthcare professional for medical advice. This product aims to offer a reliable and high-quality option for those seeking to support their eye health with essential carotenoids.
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Study, Trial or Testing Result Summary
Members Only81 human studies · 52 improved
This product gives 20 mg of lutein and 1 mg of zeaxanthin a day, both from marigold flowers, and both at doses that have worked in studies. A pooled analysis of 20 randomized trials with 1,764 people found these pigments raised the protective pigment in the back of the eye more than placebo [1]. A pooled analysis of 9 trials found 10 or 20 mg of lutein a day improved sharpness of vision and contrast sensitivity, with bigger effects at higher doses and longer use [2]. In 120 healthy drivers, 20 mg of lutein daily for a year improved contrast and glare sensitivity, especially at night [3]. Zeaxanthin doses as low as 1 mg taken with lutein raised eye pigment over 12 months. A review of 13 trials with 85,321 people ranked lutein and zeaxanthin second, after zinc, for improving sharpness of vision in age related macular degeneration [4]. In a large 5 year trial of 4,203 older adults, 10 mg lutein plus 2 mg zeaxanthin did not significantly slow progression to advanced macular degeneration in the main analysis [5], though later analyses suggested about 9 to 10 percent lower risk [6][7]. Lutein did not prevent eye disease in premature babies. Animal and cell studies are never counted.
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- Across 13 randomized trials with 85,321 people, lutein and zeaxanthin ranked second (after zinc) for improving visual acuity in age-related macular degeneration.Efficacy of different nutrients in age-related macular degeneration: A systematic review and network meta-analysis.
- Across 20 randomized trials of 938 people with age-related macular degeneration and 826 healthy people, lutein, zeaxanthin and meso-zeaxanthin supplements raised the density of protective pigment in the macula more than placebo.Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density.
- In 8 randomized trials with 1,176 macular degeneration patients, lutein and zeaxanthin improved visual acuity and contrast sensitivity compared with placebo, with larger benefit at higher doses.Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration.
- In 5 trials with 666 preterm infants, lutein and zeaxanthin probably reduced severe retinopathy of prematurity (stage 3 and above) but had little or no effect on retinopathy of any stage.Lutein and zeaxanthin for reducing morbidity and mortality in preterm infants.
- Pooling 3 randomized trials of 406 preterm babies, oral lutein and zeaxanthin did not reduce the rate of retinopathy of prematurity compared with placebo.Lutein supplementation and retinopathy of prematurity: a meta-analysis.
- Across 9 randomized trials covering 920 eyes (855 with age-related macular degeneration), lutein at 10 or 20 mg a day increased macular pigment density, visual acuity and contrast sensitivity, with larger effects at higher doses and longer treatment.Effects of lutein supplementation in age-related macular degeneration.
- A review of 24 meta-analyses found that higher dietary lutein intake was linked to lower risk of age-related macular degeneration and age-related cataracts, among other outcomes.Green leafy vegetable and lutein intake and multiple health outcomes.
- A review of 20 records on glaucoma found that higher carotenoid intake showed a protective trend and higher macular pigment was largely linked to better visual performance in glaucoma eyes.Carotenoids in the Management of Glaucoma: A Systematic Review of the Evidence.
- A review of 18 studies on diabetic retinopathy found early trials where carotenoid supplements raised blood and macular pigment levels alongside better visual performance.A Systematic Review of Carotenoids in the Management of Diabetic Retinopathy.
- In 13 studies of children up to age 12, macular pigment density was more strongly linked to thinking skills than to vision, and the link with visual function remained unclear."Analysis of Macular Pigment Optical Density in Childhood: A Systematic Review".
- In 9 randomized trials on myopia, carotenoids including lutein modestly improved macular pigment and reduced visual fatigue, but there was no consistent reduction in myopia progression.Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.
- In 4203 older adults at risk of advanced macular degeneration, adding 10 mg lutein and 2 mg zeaxanthin daily for a median of 5 years did not significantly reduce progression to advanced disease compared with placebo, though it may be a safer substitute for beta carotene.Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (A…
- In 4203 older adults at risk of advanced macular degeneration, adding 10 mg lutein and 2 mg zeaxanthin daily to the standard eye vitamin formula modestly lowered the risk of advanced disease (about 10% lower), and the risk was about 18% lower than with beta carotene, in follow-up analyses.Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No…
- In 4203 older adults at risk of macular degeneration, daily lutein 10 mg plus zeaxanthin 2 mg for about 4.7 years did not significantly change cataract surgery rates or vision loss, though people with the lowest dietary intake had fewer cataract surgeries.Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4.
- In a further analysis of trial data from 1684 white older adults followed for about 5 years, common risk genes for macular degeneration did not change how people responded to lutein and zeaxanthin supplements.No CFH or ARMS2 Interaction with Omega-3 Fatty Acids, Low versus High Zinc, or β-Carotene versus Lutein and Zeaxanthin o…
- In a follow-up analysis of two large trials in people with geographic atrophy, lutein and zeaxanthin (10 mg and 2 mg daily) slowed the spread of damage toward the center of the retina in those taking the vitamin formula without beta carotene, but did not change the overall area of damage.Oral Antioxidant and Lutein/Zeaxanthin Supplements Slow Geographic Atrophy Progression to the Fovea in Age-Related Macul…
- In a trial of 303 people with eye fatigue given a lutein and plant extract blend for 45 days, a machine learning model predicted the best dose for each person, with 39 of 58 test subjects predicted to benefit most from the highest dose and 2 not expected to benefit.A Machine Learning Based Dose Prediction of Lutein Supplements for Individuals With Eye Fatigue.
- In 225 non-smoking adults with retinitis pigmentosa taking vitamin A, 12 mg of lutein daily for 4 years did not change the main visual field measure but slowed loss of side vision on one secondary test.Clinical trial of lutein in patients with retinitis pigmentosa receiving vitamin A.
- In 172 people with non-wet age-related macular degeneration, taking 10 mg lutein with 1 mg zeaxanthin and omega-3 fatty acids daily for 12 months increased macular pigment and improved best-corrected visual acuity compared with placebo.Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD…
- In 150 healthy adults aged 65 to 70, 13.7 grams of goji berry drink daily for 90 days raised plasma zeaxanthin by 26% and total antioxidant capacity by 57%. The placebo group developed macular thinning and drusen, while the goji group stayed stable. The dose of zeaxanthin itself was not reported.Goji berry effects on macular characteristics and plasma antioxidant levels.
- Over 12 months, people with non-wet age-related macular degeneration taking a daily capsule with 1 mg zeaxanthin and 10 mg lutein (or twice that dose) had higher blood levels of these carotenoids and higher macular pigment than placebo. The higher dose also improved blood fat profile.Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized tr…
- In 120 healthy drivers, 20 mg lutein daily for 1 year raised macular pigment and serum lutein and improved contrast and glare sensitivity, especially at night, compared with placebo.Lutein supplementation improves visual performance in Chinese drivers: 1-year randomized, double-blind, placebo-controll…
- In 120 people with a parent who had neovascular age-related macular degeneration, 6 months of a lutein, zeaxanthin and omega-3 supplement did not change macular pigment compared with placebo, even though blood levels of lutein and zeaxanthin rose.Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial.
- In 114 preterm infants born at 32 weeks or earlier, daily lutein and zeaxanthin until discharge did not reduce the occurrence of retinopathy of prematurity compared with placebo.Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled …
- In 110 adults, 20 days of daily 6 mg lutein, 1 mg zeaxanthin and 100 mg elderberry extract significantly reduced dry eye symptom scores compared with the start of the study.Effect of Dietary Supplementation with Lutein, Zeaxanthin, and Elderberries on Dry Eye Disease (DED) and Immunity: A Ran…
- In 109 adults with one wet macular degeneration eye, adding lutein, zeaxanthin, DHA, resveratrol and hydroxytyrosol to the standard AREDS formula for 12 months did not change visual acuity compared with the standard formula alone, though it raised blood lutein and zeaxanthin and lowered some inflammatory markers.A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration.
- In 108 Chinese adults with early age-related macular degeneration, 10 mg zeaxanthin plus 10 mg lutein daily for 48 weeks raised blood levels and macular pigment compared with placebo.Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration.
- In 100 patients with chronic central serous chorioretinopathy, an antioxidant tablet containing lutein for 6 months improved best-corrected vision and reduced fluid under the retina by 28.6%, while the placebo group showed no meaningful change.A Multicenter Randomized Controlled Study of Antioxidant Supplementation with Lutein for Chronic Central Serous Choriore…
- In 92 healthy young adults, four months of zeaxanthin (20 mg daily) or a mixed zeaxanthin and lutein product improved visual processing speed compared with placebo, raising flicker fusion thresholds about 12% and shortening visual reaction time about 10%.A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficien…
- In 72 adults with early macular degeneration, 10 mg of lutein daily for a year raised macular pigment, and visual acuity held steady or improved in some patients compared with placebo, which declined.Lutein supplementation over a one-year period in early AMD might have a mild beneficial effect on visual acuity: the CLE…
- In 70 people with early macular degeneration, 10 mg daily lutein for 1 year reduced a blood marker of complement system activation (sC5b-9), while placebo caused it to rise; no vision outcome was reported.Lutein supplementation leads to decreased soluble complement membrane attack complex sC5b-9 plasma levels.
- In 70 adults who used screens more than 6 hours a day, 6 months of lutein with zeaxanthin improved tear tests and eye recovery from light exposure compared with placebo, but self-reported eye strain and sleep did not differ.The effects of lutein/ zeaxanthin (Lute-gen®) on eye health, eye strain, sleep quality, and attention in high electronic…
- In 69 young healthy adults, a lutein and zeaxanthin supplement for four months raised macular pigment and speed of visual processing, while placebo produced no change.A randomized placebo-controlled study on the effects of lutein and zeaxanthin on visual processing speed in young health…
- In 67 adults with early age-related macular degeneration, three carotenoid supplements raised macular pigment over 3 years, and contrast sensitivity improved, with the meso-zeaxanthin blends giving the broadest gains.Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular deg…
- In 63 people with and without age-related macular degeneration, 2 mg of zeaxanthin daily with varying lutein and meso-zeaxanthin raised macular pigment at all measured spots over 8 weeks. Response was similar in both groups, except one formulation gave a larger gain at the outer edge in the eye disease group.Macular response to supplementation with differing xanthophyll formulations in subjects with and without age-related mac…
- In 31 adults with Alzheimer's disease and 31 age-matched controls, a macular carotenoid supplement with 10 mg lutein taken for 6 months raised macular pigment and improved contrast sensitivity, but did not change cognitive test scores.The impact of supplemental macular carotenoids in Alzheimer's disease: a randomized clinical trial.
- In 60 children aged 5 to 12, gummies with 10 mg lutein and 2 mg zeaxanthin daily for 180 days improved focus, episodic memory and visuospatial working memory compared with placebo, and reduced eye strain and fatigue.Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Doubl…
- In 59 healthy young adults, taking macular carotenoids for one year raised macular pigment and improved contrast sensitivity compared with placebo.Contrast Sensitivity and Lateral Inhibition Are Enhanced With Macular Carotenoid Supplementation.
- In 59 young adults, 6 months of daily macular xanthophylls at 13 mg or 27 mg raised macular pigment and improved several memory and attention scores compared with placebo.Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cog…
- In 54 people with high myopia over 3 months, high-dose zeaxanthin from Lycium barbarum raised macular pigment more than high-dose lutein alone, while low-dose zeaxanthin did not differ significantly from low-dose lutein.Macular pigment optical density responses to different levels of zeaxanthin in patients with high myopia.
- In 52 people with early age-related macular degeneration, a blend with 2 mg zeaxanthin plus high-dose meso-zeaxanthin and lutein for 12 months raised macular pigment and improved contrast sensitivity at several spatial frequencies.Supplementation with three different macular carotenoid formulations in patients with early age-related macular degenera…
- In 50 smokers with dry skin, oral antioxidants including lutein lowered oxidative stress in the blood by 40%, and the lutein intake was linked to better overall vision.Protective effects of oral antioxidants on skin and eye function.
- In 49 women aged 60 to 80 taking 12 mg of lutein daily for 4 months, macular pigment density rose at one point on the retina compared with placebo, and blood lutein levels increased.The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation.
- In 44 healthy adults, a daily tablet with 1.2 mg zeaxanthin plus meso-zeaxanthin and lutein raised blood levels of lutein and zeaxanthin and increased central macular pigment over 6 months, compared with placebo. No adverse clinical changes were found.Supplementation with all three macular carotenoids: response, stability, and safety.
- In 43 healthy people, 14 days of a multi-ingredient supplement containing lutein and zeaxanthin largely restored normal retinal blood flow response to oxygen after an inflammatory challenge, compared with placebo.Antioxidative capacity of a dietary supplement on retinal hemodynamic function in a human lipopolysaccharide (LPS) model…
- In 40 healthy older adults, eating one avocado a day for six months raised macular pigment density and blood lutein, while a potato or chickpea control did not raise macular pigment, and avocado eaters also improved memory and working memory.Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized, Controlled Trial.
- In 40 adults with early-stage age-related macular degeneration, taking 8 mg epilutein with 2 mg lutein daily for 2 months raised macular pigment density more than 10 mg lutein alone did, though the lutein-only group's macular pigment fell at the first month and was lower at the end than at the start.Epilutein for Early-Stage Age-Related Macular Degeneration: A Randomized and Prospective Study.
- In 39 Japanese patients with one-eye macular degeneration, 20 mg of lutein daily for six months raised blood lutein, and macular pigment rose significantly only in the beeswax capsule group, so the eye benefit was not fully confirmed.Effects of Lutein Supplementation in Japanese Patients with Unilateral Age-Related Macular Degeneration: The Sakai Lutei…
- In 36 adults, a supplement with 10 mg lutein, 2 mg zeaxanthin and 10 mg meso-zeaxanthin taken for 6 months raised macular pigment and improved visual acuity and contrast sensitivity compared with placebo, while the lutein and zeaxanthin-only version did not improve these measures.The impact of macular pigment augmentation on visual performance using different carotenoid formulations.
- In 36 healthy Japanese volunteers taking one of two lutein and zeaxanthin supplements for up to 6 months, blood levels rose but macular pigment did not increase significantly on average, and responses varied between individuals.Changes in Macular Pigment Optical Density and Serum Lutein Concentration in Japanese Subjects Taking Two Different Lute…
- In 31 healthy people with an atypical macular pigment pattern, 8 weeks of 20 mg lutein plus 2 mg zeaxanthin daily did not significantly raise macular pigment at any measured spot.Macular carotenoid supplementation in subjects with atypical spatial profiles of macular pigment.
- In 31 adults with non-proliferative diabetic retinopathy, 10 mg daily of lutein for 36 weeks improved contrast sensitivity at low spatial frequency, with a slight gain in visual acuity, though the advantage over placebo was not statistically significant.Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy.
- In 30 people with wet macular degeneration over 6 months, adding micronutrients including lutein and zeaxanthin to anti-VEGF injections was associated with better visual acuity than anti-VEGF injections alone.Beneficial Effects of Micronutrient Supplementation in Restoring the Altered Microbiota and Gut-Retina Axis in Patients …
- In 28 healthy young adults, daily macular carotenoid supplements of about 7 to 27 mg for 12 weeks raised macular pigment compared with placebo, with the 13 mg dose giving the most benefit for the amount taken.Serum and retinal responses to three different doses of macular carotenoids over 12 weeks of supplementation.
- In 28 eyes of people with intermediate age-related macular degeneration, six months of a supplement containing 4 mg of zeaxanthin daily increased macular electrical response in the central retina, while placebo showed no change. Retinal and choroidal structure did not change.Effects of Macuprev® Supplementation in Age-Related Macular Degeneration: A Double-Blind Randomized Morpho-Functional St…
- In 27 healthy adults aged 45 to 65, eating 28 g of goji berries five times a week for 90 days raised macular pigment density and skin carotenoids, while a supplement providing 6 mg lutein and 4 mg zeaxanthin did not change macular pigment.Goji Berry Intake Increases Macular Pigment Optical Density in Healthy Adults: A Randomized Pilot Trial.
- In 25 people with age-related maculopathy, 6 mg of lutein with vitamins and minerals taken daily for 9 months did not change contrast sensitivity compared with placebo.Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a rando…
- In 20 adults with non-exudative age-related macular degeneration, a kale extract providing 10 mg lutein and 3 mg zeaxanthin daily for 4 weeks raised blood xanthophylls and macular pigment compared with placebo oil.Age-related macular degeneration: Effects of a short-term intervention with an oleaginous kale extract--a pilot study.
- In 16 healthy women, a lutein complex taken daily for 3 weeks increased blood flow in the retina and lowered diastolic blood pressure compared with placebo.Lutein Complex Supplementation Increases Ocular Blood Flow Biomarkers in Healthy Subjects.
- In 13 participants doing two hours of close reading, a lutein, zeaxanthin and blackcurrant supplement for two weeks produced measurable differences in brain and eye signals of visual fatigue compared with placebo.The effect of lutein supplementation on visual fatigue: a psychophysiological analysis.
- Taking lutein or zeaxanthin at 10 or 20 mg daily for 6 to 12 months raised macular pigment density by about 14 to 15 percent, with lutein deposited mainly in the center of the retina.Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin - the LUXEA (LUtein Xantho…
- In older adults, 12 months of 12 mg daily lutein and zeaxanthin compared with placebo improved the strength of the brain's visual processing signal at 5 and 10 Hz.Dietary Carotenoids Lutein and Zeaxanthin Change Brain Activation in Older Adult Participants: A Randomized, Double-Mask…
- In healthy adults who work at screens, 8 weeks of a daily capsule with 10 mg lutein, 2 mg zeaxanthin and 6 mg astaxanthin improved eye-hand coordination after screen work and raised macular pigment, but did not clearly improve smooth eye tracking.Effects of Astaxanthin, Lutein, and Zeaxanthin on Eye-Hand Coordination and Smooth-Pursuit Eye Movement after Visual Dis…
- In a control group of 75 people with dry age-related macular degeneration taking a polyvitamin containing lutein for 6 months, central visual field improved slightly in 43 patients, with no improvement in peripheral vision.Long term results of age-related macular degeneration therapy with prednisolone acetate--special refer to peripheral vis…
- In 30 patients having eye surgery for a macular hole, a lutein and zeaxanthin dye used to stain the eye membrane during surgery was compared with a Brilliant Blue dye, and both groups had good results with visual acuity improving by about 30 percent overall.Vital dyes in macular hole surgery.
- In an open-label pilot of 40 adults with early dry macular degeneration, 90 days of a twice-daily capsule containing ZeaLutein improved self-reported vision scores, and the share with abnormal grid test results fell from 77.5% to 40%, with no side effects reported.An Open-Label Pilot Study on Macumax Supplementation for Dry-Type Age-Related Macular Degeneration.
- In 16 healthy Japanese adults taking 4 mg of zeaxanthin daily (with 20 mg lutein) for 16 weeks, macular pigment and skin carotenoid levels rose steadily, with no serious side effects. There was no control group.Effect of an antioxidant supplement containing high dose lutein and zeaxanthin on macular pigment and skin carotenoid le…
- In 10 people taking 6 mg of lutein daily for 40 days, macular pigment density increased in some participants and reached a plateau after about 30 days.[Objective determination of optical density of xanthophyll after supplementation of lutein].
- In eight people with macular telangiectasia type 2 taking 10 or 20 mg of zeaxanthin daily for two years, some reported subjective vision gains but no objective visual improvement was measured, and one person developed reversible crystals in the retina.MACULAR PIGMENT DISTRIBUTION RESPONSES TO HIGH-DOSE ZEAXANTHIN SUPPLEMENTATION IN PATIENTS WITH MACULAR TELANGIECTASIA T…
- Among about 8,200 older adults followed for roughly 10 years, those eating the most lutein and zeaxanthin had a lower risk of progressing to late macular degeneration.Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies …
- In a 10-year follow-up of 3882 people from a supplement trial, those who had taken lutein and zeaxanthin had a lower rate of progression to late age-related macular degeneration than those who had not (hazard ratio 0.91), and lutein and zeaxanthin carried no significant increase in lung cancer risk unlike beta carotene.Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degen…
- In 3115 adults followed for about 9.6 years, dietary lutein plus zeaxanthin intake was not significantly associated with cataract presence or development, although higher riboflavin and B12 intake were linked to fewer lens opacities.The Association of Dietary Lutein plus Zeaxanthin and B Vitamins with Cataracts in the Age-Related Eye Disease Study: AR…
- In 431 mother and child pairs, lutein and zeaxanthin intake during pregnancy, estimated from food questionnaires, was not linked to contrast vision or visual acuity in the children at age 11 to 12 years.Lutein and Zeaxanthin Intake during Pregnancy and Visual Function in Offspring at 11-12 Years of Age.
- In 400 adults aged 50 to 84, higher blood carotenoid and vitamin E levels were not consistently linked to less cloudiness of the eye lens overall, with some links appearing only in certain subgroups.Serum carotenoids and tocopherols and severity of nuclear and cortical opacities.
- In 254 adults with early macular degeneration followed for 7 years, higher dietary lutein and zeaxanthin intake was linked to more disease progression, the opposite of the expected direction, though the authors suggest people may have changed their diets after learning of their condition.Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration.
- In 241 mother and infant pairs, higher maternal intake of choline, lutein and zeaxanthin, and higher DHA status, were linked to several measures of infant brain activity, though not all links were in the same direction.Neuroprotective nutrients in pregnancy and infant brain function.
- In 215 adults in Mexico, higher blood levels of lutein and zeaxanthin were linked to more macular pigment, and more daily sunlight exposure was also linked to higher levels.Environmental and Nutritional Determinants of Macular Pigment in a Mexican Population.
- In 180 healthy adults, macular pigment density was not related to eye length, front chamber depth or back chamber depth, so these measurements do not need to be adjusted for in macular pigment studies.Macular pigment and ocular biometry.
- In 128 healthy Singapore adults, lower blood levels of lutein and zeaxanthin were associated with less favorable retinal blood vessel measurements, though this was an association study and not a supplement trial.Association of serum lutein and zeaxanthin with quantitative measures of retinal vascular parameters.
- In 98 adults aged 45 and older, higher blood carotenoid levels and diets richer in lutein and zeaxanthin were linked to more macular pigment, and the lowest fruit and vegetable eaters had less.Diet and serum carotenoid concentrations affect macular pigment optical density in adults 45 years and older.
- In a small group of people with choroideremia, a 6 month daily 20 mg lutein supplement raised lutein levels and macular pigment but did not change central vision sensitivity.Macular pigment and lutein supplementation in choroideremia.
Review Totals and Summary
Members Only48,098 reviews · 100% positive
This California Gold Nutrition Lutein with Zeaxanthin from Marigold Extract has received overwhelmingly positive feedback, with approximately 48098 ratings across various stores, all of which are 4 or 5 stars. This indicates a very high level of customer satisfaction. **What buyers say it did for them** Many users report positive impacts on their eye health and vision. Some experienced an "indirectly boosting night vision" and found it easier for their eyes to adapt to twilight and darkness. Others noted that their "eyes feel less tired when working on the computer" and that their "vision seems clearer, especially in the evening." The supplement is also valued for its antioxidant properties, with some taking it as a "key defenses against Age Related Macular Degeneration." It is also mentioned to help support eye muscles. **Complaints** While overall satisfaction is high, a few users expressed uncertainty about the product's immediate or significant effects. Some were "not sure - that this did much of anything for my eyes," while others stated, "I am still waiting out in the benefits." These comments often came from users who experienced no negative side effects but also hadn't perceived dramatic positive changes yet, sometimes attributing this to a need for more consistent use. **Taste, smell, pill size or form** The physical attributes of the supplement are generally well-received. Customers frequently describe the pills or softgels as "small and easy to swallow, with no unpleasant taste." Many appreciate that they are "very easy to swallow even without water." The product is made from marigold extract, and the formula is noted to be natural and free from unnecessary additives. The packaging is also described as good and strong. **Value for money** Customers consistently view this product as offering good value. Reviews frequently highlight it as "Very good value for the buck" and praise its "Excellent quality for the price." The brand's association with iHerb is also seen as a guarantee of quality, reinforcing the perception of good value. The dosage of 20mg Lutein and 1mg Zeaxanthin is considered sufficient for a day. **Who it seems to suit and who it did not** This supplement appears to be particularly beneficial for individuals experiencing specific vision challenges, such as "night blindness" or difficulty adapting to low light conditions. It also appeals to those seeking support for general eye health, including after procedures like LASIK surgery, or as a preventative measure against age-related eye conditions. Users who are consistent with their daily intake seem to report more benefits. It did not seem to suit those looking for very rapid or dramatic changes, or those who struggled with consistent daily use.
Biohacker Summary
Members Only5 of 10 recommend it
Lutein and zeaxanthin, the main ingredients, drew a mostly positive but mixed response from the panel, with about half recommending them and several staying neutral. Most of those who spoke focused on eye health, describing them as pigments that gather in the retina, filter blue light and may help protect against macular degeneration, and a few also pointed to brain and cognition benefits, and one to sleep. Doses mentioned were 4 to 5 milligrams of zeaxanthin and 5 to 20 milligrams a day of lutein, with one panelist noting that studies used 10 to 20 milligrams and that the data are still emerging. Several preferred getting them from foods such as eggs, kale and green leafy vegetables, with avocado noted as helping absorption, while others take them as supplements, one as part of a combined eye formula. One panelist stopped taking 20 milligrams of lutein a day after about a year because his skin turned slightly yellow, and another described the evidence for cataract protection as mixed and weak.
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Dr. Eric Berg · Zeaxanthin · neutral
- Notes that eggs contain zeaxanthin, which can help the retina and improve night vision.
- Notes that eggs contain lutein, which can help the retina and improve night vision.
- Mentions that egg yolks provide zeaxanthin, a carotenoid that accumulates in the retina and helps support eye health.
- Mentions that egg yolks provide lutein, a carotenoid that accumulates in the retina and helps support eye health.
- Mentions that eggs contain zeaxanthin, an antioxidant that blocks blue radiation from the eyes, protecting against macular degeneration.
- Highly recommends consuming zeaxanthin from egg yolks to protect the eye.
- Mentions that eggs contain lutein, an antioxidant that blocks blue radiation from the eyes, protecting against macular degeneration.
- Highly recommends consuming lutein from egg yolks to protect the eye.
- Dr. Berg mentions that eggs contain Zeaxanthin, which supports the eyes.
- Dr. Berg mentions that eggs contain Lutein, which supports the eyes.
- Mentions that eggs also contain lutein, which is another important nutrient that supports brain health and cognitive health.
- States that lutein is very important for the brain, as the brain preferentially accumulates it to protect against damage to the myelin sheath.
- Dr. Berg notes that egg yolks have carotenoids like zeaxanthin, which are good for the internal part of the arteries.
- Dr. Berg notes that egg yolks have carotenoids like lutein, which are good for the internal part of the arteries.
Siim Land · Lutein · neutral
- Notes that Lutein is one of several supplements with human evidence.
- Supplementing lutein and zeaxanthin 5-20 mg/day improves macular pigment optical density (MPOD), a marker of eye health, in people with healthy eyes.
- Supplementing lutein and zeaxanthin 5-20 mg/day improves macular pigment optical density (MPOD), a marker of eye health, in people with healthy eyes.
- Tried 20 milligrams of lutein during this period to see if it affects eye strain.
- Tried 5 milligrams of zeaxanthin during this period to see if it affects eye strain.
- States that the main reason people take lutein and zeaxanthin is for eye health, and there is human clinical evidence that they improve eye health, reduce eye fatigue, and digital eye strain.
- Decided to try out lutein and zeaxanthin for 30 days to see if he noticed any changes on his eyesight, and he noticed less digital eye strain, slightly less blurry vision, and less dry eyes.
- Decided to try out lutein and zeaxanthin for 30 days to see if he noticed any changes on his eyesight, and he noticed less digital eye strain, slightly less blurry vision, and less dry eyes.
- Will be trying lutein and zeaxanthin at 20mg and 5mg a day, respectively, for eye health, reducing digital eye strain, and protecting his eyes from excessive blue artificial light.
- Places Lutein and Zeaxanthin in the 'god tier' because several clinical trials demonstrate their effectiveness in improving eyesight.
- Lists Zeaxanthin as one of his favorite 'god tier' supplements, based on research.
- Includes lutein in his 'all out' supplement stack and confirms he is currently taking it.
- Includes zeaxanthin in his 'all out' supplement stack and confirms he is currently taking it.
- Notes that lutein and zeaxanthin also have slight skin anti-aging benefits due to being powerful antioxidants, and improve inflammation, oxidized LDL, and blood sugar.
Dr. Rhonda Patrick · Zeaxanthin · neutral
- Zeaxanthin may be among the most evidence-backed carotenoids for longevity. It accumulates in the brain, where higher levels are associated with greater crystallized intelligence, and supplementation can improve some measures of cognitive function. Evidence also suggests it may slow progression to advanced macular degeneration in high-risk individuals.
- Lutein may be among the most evidence-backed carotenoids for longevity. It accumulates in the brain, where higher levels are associated with greater crystallized intelligence, and supplementation can improve some measures of cognitive function. Evidence also suggests it may slow progression to advanced macular degeneration in high-risk individuals.
- Consumes lutein through kale, noting its accumulation in the retina and brain for visual and cognitive function, and that avocado increases its absorption.
- Notes that lutein, a carotenoid found in kale, builds up in the retina and brain, helping to protect against macular degeneration and is linked to faster cognitive processing and better fluid intelligence.
- Zeaxanthin may improve cognition, even in younger adults. It accumulates in the retina, where it helps neutralize light-driven oxidative damage linked to macular degeneration risk, and also accumulates in the brain, where higher blood levels are associated with better fluid and crystallized intelligence.
- Lutein may improve cognition, even in younger adults. It accumulates in the retina, where it helps neutralize light-driven oxidative damage linked to macular degeneration risk, and also accumulates in the brain, where higher blood levels are associated with better fluid and crystallized intelligence.
- Zeaxanthin directly supports both vision and cognition in ways we can measure. Clinical trials show that supplementing it reduces risk of age-related macular degeneration and protects retinal function.
- Lutein directly supports both vision and cognition in ways we can measure. Clinical trials show that supplementing it reduces risk of age-related macular degeneration and protects retinal function.
- Lutein is a carotenoid essential for eye health and protection against age-related macular degeneration. It also accumulates in the brain, where it’s been shown to improve cognition in older adults.
- Is no longer taking zeaxanthin.
- Is no longer taking lutein.
- Rhonda's current supplement routine includes Lutein & zeaxanthin.
- Rhonda's current supplement routine includes Lutein & zeaxanthin.
- Mentions that the multivitamin used in the study contained lutein, which is known to accumulate in the brain and retina and influence cognitive and visual function.
Thomas DeLauer · Zeaxanthin · recommends
- Highlights zeaxanthin as showing the strongest association with lower sleep disorder risk and recommends a dose of 4 mg, especially for those with high screen exposure, as it filters blue light at the retina level.
- Highlights lutein as showing the strongest association with lower sleep disorder risk and recommends a dose of 20 mg, especially for those with high screen exposure, as it filters blue light at the retina level.
- Recommends zeaxanthin, found in eggs, as a carotenoid that accumulates in the brain and functions as an antioxidant, protecting neurons from inflammatory and oxidative damage.
- Recommends lutein, found in eggs, as a carotenoid that accumulates in the brain and functions as an antioxidant, protecting neurons from inflammatory and oxidative damage.
- Notes that lutein is beneficial for eye health and that studies have shown a correlation between higher lutein intake and less cognitive decline.
- Recommends lutein, found in eggs, for both long-term and short-term memory improvement.
- Explains that lutein, often touted for eye health, also accumulates in the brain and is a powerful antioxidant for driving down reactive oxygen species.
- Notes that eggs contain zeaxanthin, which is tremendous for the eyes.
- Recommends lutein, specifically the FloraGLO form, for its benefits in reducing visceral fat, improving body composition, and positively impacting cardiometabolic health.
- States that lutein might be one of the most potent cardiometabolic things one could take, citing research showing a significant difference in the risk of cardiovascular disease, heart attacks, stroke, and metabolic syndrome with higher lutein levels.
- Notes that zeaxanthin, a carotenoid, is good for eye health and accumulates in the brain, being associated with improved cognition.
- Notes that lutein, a carotenoid, is good for eye health and accumulates in the brain, being associated with improved cognition.
- Recommends lutein as an inexpensive antioxidant, particularly good for the eyes, and notes it can be found in yellow bell pepper and eggs.
- Notes that avocados increased the body's lutein levels, a powerful free radical scavenger, which likely contributed to the reduction in oxidized LDL.
Dave Asprey · Zeaxanthin · recommends
- Recommends getting nutrients like zeaxanthin from real food or Vision 101 for eyesight.
- Recommends getting nutrients like lutein from real food or Vision 101 for eyesight.
- Recommends zeaxanthin, an antioxidant related to lutein, for improving eyesight.
- Recommends lutein, an antioxidant stored in the retina, which acts like natural sunglasses and helps the body handle blue light.
- Recommends supplements like lutein and astaxanthin, which are scientifically shown to improve eye resilience and ability to see.
- Mentions great studies on lutein for vision and recommends looking at vision formulas that contain it.
- Mentions zeaxanthin as an important plant pigment that covers the fovea and macula in the eyes, absorbing 60% of blue light in a healthy eye. He notes that age-related macular degeneration is often linked to a lack of these nutrients and too much blue light.
- Mentions lutein as an important plant pigment that covers the fovea and macula in the eyes, absorbing 60% of blue light in a healthy eye. He notes that age-related macular degeneration is often linked to a lack of these nutrients and too much blue light.
- Dave Asprey takes lutein, which is also made by bacillus indicus HU36, for eye health.
- Takes massive doses of astaxanthin, lutein, and other protective things when flying to combat increased cosmic radiation and biological stress.
Dr. Mark Hyman · Lutein · neutral
- States that lutein, a carotenoid, is concentrated in the macula and protects the eye from blue light and also protects the retina and brain.
- States that zeaxanthin, a carotenoid, is concentrated in the macula and protects the eye from blue light and also protects the retina and brain.
- Green leafy vegetables contain lutein, which is great for eyes.
- Recommends lutein-rich foods as important antioxidants and anti-inflammatory compounds.
- Notes that lutein was among the compounds identified to regulate inflammation in a clinical trial.
- Believes that a lack of lutein from green vegetables is a factor driving Alzheimer's and dementia.
Ben Greenfield · Zeaxanthin · uses
- Ben Greenfield's guest was taking zeaxanthin as part of their protocol.
- Ben Greenfield's guest was taking lutein as part of their protocol.
- Includes lutein in their Lumat blue product along with methylene blue, phycocyanin, riboflavin, green tea extract, and quercetin.
- Ben says that the little bar he took has lutein in it.
- States that pigments like lutein and astaxanthin are photo modulators that pick up light in various wavelengths and translate them into photonic quantum energy sources.
- Mentions that pigments like lutein are photo modulators that pick up light in various wavelengths and translate them into photonic quantum energy sources.
- Ben Greenfield's dog, Homer, who has a genetic predisposition to progressive retinal atrophy, is given lutein to support his eye structure health and scavenge free radicals.
- Eating zeaxanthin-containing foods, such as corn, saffron, and leafy greens, may help the performance of our stem cells for organ regeneration.
- Is loving Vaso Lutein, an oral supplement, for his vision and is hopeful it will help him get rid of glasses, especially when combined with eye exercises.
- Mentions Zeaxanthin as a plant compound known to enhance vision.
- Recommends zeaxanthin, found in dark leafy green vegetables, as a natural vision enhancer that ancestors consumed.
- Recommends lutein, found in dark leafy green vegetables, as a natural vision enhancer that ancestors consumed.
- Ben Greenfield recommends zeaxanthin as a nutrient that is really important for the retina and vision, noting that dark leafy greens and egg yolks are good sources.
- Ben Greenfield recommends lutein as a nutrient that is really important for the retina and vision, noting that dark leafy greens and egg yolks are good sources.
Andrew Huberman · Lutein · recommends
- Discusses lutein as a supplement for maintaining long-term eye health.
- Notes that supplementing with lutein can help offset some detrimental effects of age-related macular degeneration, but only for individuals with moderate to severe conditions, as studies did not show significant improvement for those with normal vision or low-degree degeneration.
- Recommends lutein as part of the AREDS2 supplementation for slowing the progression of dry macular degeneration.
- Recommends zeaxanthin as part of the AREDS2 supplementation for slowing the progression of dry macular degeneration.
- Discusses lutein as a supplement that can potentially help with age-related macular degeneration, noting that the data are still emerging. He mentions that some people report enhanced vision from taking lutein at 20 milligrams per day, and studies have explored dosages of 10 to 20 milligrams per day.
- Mentions zeaxanthin as a compound that, along with lutein and astaxanthin, is being explored for its potential to help with age-related macular degeneration, though he notes that the data are still emerging.
- Corrects a previous misstatement, clarifying that Lutein (L-U-T-E-I-N) is the molecule that may help offset moderate to severe age-related macular degeneration and potential vision loss as one gets older.
- Mentions Lutein as a compound that may assist in supporting visual health and possibly improve vision.
- Discusses a study showing that lutein supplementation can help offset detrimental effects of age-related macular degeneration, but only for individuals with moderate to severe conditions, not for those with normal vision or low-degree macular degeneration.
- Mentions Zeaxanthine as a compound that may assist in supporting visual health and possibly improve vision.
- Mentions that Zeaxanthin has been shown to offset some of the disruption in vision that occurs with aging.
- Discusses lutein as a molecule in many vision supplements, noting that studies show it can help offset detrimental effects of age-related macular degeneration, but only for individuals with moderate to severe conditions.
- Notes that supplementing with zeaxanthin can be beneficial for slowing the progression of age-related macular degeneration, though the degree of offset is slight but robust. He personally is not taking zeaxanthin at this time.
Peter Attia · Lutein · neutral
- Mentions that there is mixed, weak evidence suggesting lutein and zeaxanthin might be protective for cataract, as they are also antioxidants.
Bryan Johnson · Lutein · stopped
- Stopped taking lutein because it caused his skin to turn a little yellow after taking 20 milligrams a day for about a year.
RAL Summary
Members OnlyTier 2 for Eye Health
Both ingredients are at studied doses, and several pooled analyses, the largest covering 85,321 people, show lutein and zeaxanthin improve eye pigment, sharpness of vision and contrast sensitivity [4][1][2]. The tier reflects strong study support plus very positive buyer ratings.
Where the evidence disagrees: 16 of the 81 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Eyes and vision
Combine with: To enhance the benefits of Lutein and Zeaxanthin for comprehensive eye health, consider combining them with Omega-3 fatty acids (especially DHA), which are vital for retinal structure and function. Antioxidants like Vitamin C and E can offer additional protection against oxidative stress in the eyes. Zinc is also beneficial as it plays a role in eye health and the metabolism of other nutrients. For broader antioxidant support and reduced eye fatigue, Astaxanthin can be a powerful addition. Lastly, Bilberry extract is often used to support vision, particularly in low light conditions.
Possible side effects: No major side effects reported. In long term follow-up, lutein and zeaxanthin did not significantly raise lung cancer risk, unlike beta carotene.
Supplement Facts
Lutein 20 mg · Zeaxanthin 1 mg
| Lutein (from Marigold Extract) (Tagetes erecta)(flower) | 20 mg | † |
| Zeaxanthin (from Marigold Extract) (Tagetes erecta)(flower) | 1 mg | † |
Directions: Take 1 softgel daily, with food. Best when taken as directed by a qualified healthcare professional.
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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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